Search Results (107)

The results of a multiscale study of fault and fracture geometry, distribution, density, and intensity are reported for Mesozoic platform carbonates cropping out along the axial zones of the southern Apennines fold-and-thrust belt, Italy. By integrating field structural observations with digital outcrop analysis, the study focuses on Cretaceous limestone rocks exposed along natural creeks and artificial trails of the Castelsaraceno area, Raparo Mt., southern Italy. There, the limestone beds are bounded by mm- to cm-thick marly–clayey interbeds, forming a well-layered succession made up of a few m-thick bed packages bounded by several cm-thick clayish interlayers. The carbonate multilayer was first affected by thrust tectonics, with the formation of low-angle intra-carbonate thrust faults and fault bend-folding. Then, the multilayer was crosscut by extensional–transtensional high-angle faults, which displaced the previously formed contractional structural elements, and allowed carbonate exhumation from shallow crustal depths. At outcrop scales, thrust-related deformation was solved by low-angle joints and veins, rare high-angle stylolites, and low-angle sheared fractures displaying reverse kinematics. Quantitative analyses of fracture density (P20) and intensity (P21) conducted on selected portions of the thrust fault zones indicate that the low-angle joints and veins attain their highest values in the vicinity of the main slip surfaces, whereas they are almost absent in the surrounding carbonate host rocks. Plio-Quaternary transtensional deformation was solved by NW–SE- and NE–SW striking faults. The latter fault set, nicely exposed along the flanks of the Raganello Creek, was characterized by right-lateral components of slip. Incipient faults, with ca. 1 cm throw, are made up of vertically discontinuous slip surfaces, which crosscut single bed packages and abut against clayish interlayers. The slip surfaces form conjugate geometries, and are associated to high-angle fractures and veins striking NE–SW, dissecting the bed packages. The fault core is virtually absent, whereas the damage zones are very discontinuous along dip. The P20 values computed for the high-angle fractures and veins increase toward the slip surfaces, whereas the P21 values remain nearly constant. These data are interpreted as being due to fault nucleation processes associated with fracture nucleation within the limestone rocks. NE–SW striking small faults displaying throws between 10 and 60 cm are comprised of through-going main slip surfaces crosscutting multiple bed packages, and poorly developed, discontinuous fault cores flanked by m-thick damage zones. The damage zones include sub-parallel high-angle shear fractures, fractures and veins showing a positive correlation between P20 and P21, whose values increase in the vicinity of the main slip surfaces. Such a positive correlation is interpreted as due to fault growth by linkage and coalescence of pre-existing high-angle fractures, and formation of fault-related joints and veins at the extensional quadrants of single shear fractures. Similarly, large-scale NE–SW striking mature faults with throws on the order of tens of meters, made up of a m-thick fault core and 10 s of m-thick damage zones including sub-parallel fractures and veins, also show a positive P20 and P21 correlation. The main outputs of this work are synthesized into a conceptual model illustrating the transition from thrust-related deformation to extensional–transtensional faulting, documenting the evolution of fracture networks from incipient-to-small-to-mature faults. Full article

Since the Mesozoic, the Chengdao-Zhuanghai area of the Jiyang Depression in eastern China has undergone multiple tectonic movements, leading to extensive fault development in Mesozoic strata. This study analyzes fault features and evolution using seismic, well logging, and mud logging data to clarify the major characteristics of Mesozoic faults and the impact of their sealing capacity on hydrocarbon migration and accumulation. It quantitatively evaluates sealing capacity using a fuzzy evaluation method based on fault plane effective normal stress, shale gouge ratio, and tightness factor, and discusses hydrocarbon-related impacts using well testing and production data. The results showed that the major faults are secondary and tertiary normal faults, predominantly ramp-flat or listric in cross section, with NW, NNW, NNE (NE), and nearly EW strikes and dips of 50–70°; the Chengbei Fault has the largest throw (2–3.2 km) and the longest extension (45.94 km). These faults transition from reverse to normal during Fangzi Formation deposition. The Chengbei 30 North and 304 Faults exhibit poor sealing capacity (hydrocarbon migration), whereas the Chengbei, Chengbei 20, Chengbei 30 South, and Zhuanghai 104 South Faults exhibit good sealing capacity (trap formation and hydrocarbon entrapment). This study provides guidance for the exploration of hydrocarbon-enriched fault block reservoirs near major faults. Full article

There is a need to develop a native human heart valve substitute that is optimally designed, cost-effective, possesses an adequate lifespan, requires minimal anticoagulant medication, and features minimal turbulence and pressure variations within the cardiovascular system. Polymer heart valves, due to their design which allows blood to flow centrally through the valve, are the most promising prosthetic heart valve type for future hemodynamic enhancement. The search continues to mitigate premature mechanical failure of polymer valves and to improve their effectiveness through in vitro experiments. The leaflet must withstand repeated stress from millions of opening and closing cycles without degrading or compromising its functionality. In exploring new materials, two different carbothane materials were employed to improve valve durability and facilitate fabrication utilizing compression moulding. Computational modelling and finite element analysis were used to simulate the response of various materials, designs, and manufacturing techniques to complex loading conditions encountered by polymer valves. A systematic thickening of leaflet regions with higher stress concentrations was implemented to address the design limitations of a reverse-engineered dip-moulded polymer valves. The optimized geometry and structure of the polymer valve, which promote smooth, less turbulent blood flow, were evaluated to determine mechanical stresses in the leaflets and the valve’s hemodynamic performance. The study concluded that the systematic increase in the thickness of leaflet regions highly affected by stress concentration significantly reduced stress distribution and improved the valve’s hemodynamic performance. Prototypes were manufactured using a combination of additive manufacturing and compression moulding to ensure precise geometric specifications. It was concluded that computational modelling reduced the need for extensive physical prototyping and testing, which can be time-consuming and costly. Full article

Metamaterials possess unique and desirable multiphysical behaviors derived from deliberately arranging conventional materials into designed structural topologies. Multifunctional mechanical metamaterials that can both carry load and provide in situ state awareness are increasingly needed for applications such as structural health monitoring and soft robotic systems. To address the demand for multifunctional metamaterials, this study reports a scalable fabrication strategy for self-sensing lattice metamaterials by conformally dip-coating 3D-printed flexible cells with a carbon nanotube (CNT)–styrene–ethylene–butylene–styrene (SEBS) nanocomposite. Scanning electron microscopy shows that the coating conforms closely to the printed struts with well-dispersed CNT networks. The electromechanical behavior of coated Octet, Kelvin, and auxetic unit cells was characterized under quasi-static cyclic uniaxial compression (0–40% strain). All the coated structures exhibited highly stable, reversible, and repeatable piezoresistive response, with a near-linear relationship between resistance change and strain. Among the tested geometries, the auxetic unit cell achieved the highest strain sensitivity that was approximately four times that of the Octet cell and six times that of the Kelvin cell. To evaluate scalability, auxetic lattices containing eight scaled auxetic unit cells were shown to retain high sensitivity and remained statistically similar to the unit cell. This study demonstrates that the strain sensing performance of nanocomposites can be engineered through lattice topology using a simple dip-coating functionalization approach, enabling scalable self-sensing metamaterials for large-scale and conformal sensing applications. Full article

Permanent ground deformation caused by fault movement threatens the safe operation of buried pipelines. Accurate fragility assessment of buried pipelines subjected to faulting is essential for pipeline design and risk management. However, buried pipelines exhibit nonlinear mechanical responses due to the coupled effects of multiple factors. Moreover, the effects of key parameters remain insufficiently quantified, limiting the accuracy and engineering applicability of existing fragility assessments. In this study, a three-dimensional finite element model incorporating large deformation and nonlinear pipe–soil interaction is developed and validated against representative experimental data. Using this model, numerical simulations are performed for 352 parameter combinations covering fault type, dip angle, burial depth, soil type, and pipe material. Nonlinear regression of the simulation results yielded predictive models for pipeline peak axial strain under normal-slip and reverse-slip faulting. A fragility framework is then established with fault displacement as the intensity measure, and fragility curves are derived for both faulting modes. The predicted peak axial strains agree with the finite element results: 78.6% (normal-slip) and 72.5% (reverse-slip) of predictions fall within ±20% error. The fragility curves enable quantitative estimation of fault-displacement thresholds. In the case study, the intact-to-damage displacement threshold is approximately 0.6 m for normal-slip faults but approximately 0.2 m for reverse-slip faults, indicating a higher failure likelihood under reverse-slip faulting. Within the investigated parameter ranges, the fault dip angle is the most significant factor affecting the pipeline failure probability for both normal-slip and reverse-slip faulting. Sandy soil and greater burial depth substantially increase the probability of moderate-to-severe damage, whereas higher steel grade increases the displacement threshold for transition from intact to failure. This study provides a rapid quantitative tool and a theoretical basis for pipeline design and risk quantification of buried pipelines in fault zones. Full article

Sliding failure is a common form of instability for reverse rock slopes. The determination of the failure plane for such unstable slopes is currently a key and challenging issue in research. To pinpoint the position of the failure surface with higher accuracy, this paper proposes a key equilibrium model based on the symmetric bidirectional evolutionary structural optimization (BESO) method. This model is based on the basic parameters of the slope, the BESO method, and the limit equilibrium theory. It uses its own algorithm program to search and determine the key failure plane of the slope. At the same time, two rock slope model tests were conducted to verify the effectiveness of this method in slope stability analysis. The calculated results exhibit a good consistency with the experimental outcomes, which confirms the feasibility of using the key equilibrium-bidirectional evolutionary structural optimization (CE-BESO) method for stability evaluation of this type of slopes. Full article

Campylobacter jejuni is an important foodborne pathogen. To prevent human infections, special attention should be paid to prevention. Recently, methods involving essential oils have been considered as a means of reducing the number of contaminants in and on foods. This review summarizes the results of studies in which essential oils (EOs) with anti-campylobacter effects were tested. The most widely studied EOs were clove (28%), oregano (24%), thyme (22%), rosemary (8%), lavender (7%), sage (7%), and tea tree (4%), with other EOs studied to a lesser extent. The anti-Campylobacter efficacies of these EOs were demonstrated in vitro using a broad repertoire of methods, such as minimal inhibitory and bactericidal concentrations, agar diffusion, time-kill assays, adhesion and biofilm inhibitory assays, two-dimensional polyacrylamide gel electrophoresis, quantitative reverse-transcription PCR, and liquid chromatography–mass spectrometry. Recent studies have also focused on the practical application of such EOs, with experiments performed on different food matrices, typically chicken, duck, and beef. The most frequent treatment methods were mixing, dipping, and short-time freezing, either in packed or unpacked forms, and storage at different temperatures (typically 4 °C), although experiments were also performed at 25 °C, 32 °C, and 42 °C using different EO concentrations. In summary, these experiments revealed the anti-Campylobacter effects of thyme, cinnamon, coriander, lime, oregano, chrysanthemum, and basil. Full article

Objective: To explore the problems with non-National Immunization Program vaccinations in Hubei Province and to provide the basis for follow-up vaccination and management. Methods: Vaccination data on non-NIP/NIP vaccine doses were extracted from the Hubei Provincial Immunization Planning Information Management System. Descriptive epidemiological analyses were conducted to examine dose administration, vaccine-type composition, regional distribution, and substitution patterns. The trend χ² test was used to assess temporal significance. Multistage regression analysis was performed using Joinpoint software. Results: From 2011 to 2024, a total of 91,009,259 doses (annual average: 6,500,661) with 35 types of non-NIP vaccines were administered in Hubei Province, China. The top five vaccines by doses administered were influenza vaccine, rabies vaccine, Hemophilus influenzae type b conjugate vaccine, varicella attenuated live vaccine, and enterovirus 71 inactivated vaccine. Before 2024 (2011–2023), vaccine utilization showed a long-term upward trend: per 10,000, population usage rose from 657.07 (2011) to a peak of 2393.21 (2023) (Increase: 264.22%, χ² = 138.62, p < 0.05) (AAPC = 10.92%, p < 0.05) and non-NIP’s share of total vaccines increased from 25.52% (2011) to 65.95% (2023), (Increase: 154.33%, χ² = 89.47, p < 0.05) (AAPC = 8.74%, p < 0.05). A notable reversal occurred in 2024. Non-NIP doses dropped from 13,971,544 (2023) to 10,238,861 (2024) with population usage falling from 2393.21 (2023) to 1755.03 (2024) (decrease: 26.66%) per 10,000, with the top three declines being in inactivated polio vaccine (IPV) (decrease: 49.53%), influenza vaccine (decrease: 44.21%), and oral rotavirus attenuated live vaccine (decrease: 43.50%). The total number of substitutive non-National Immunization Program (non-NIP) vaccine doses administered reached 16,618,755, with an overall substitution rate of 10.10%. This rate showed a steady upward trend from 5.57% in 2011 to 24.74% in 2023 (trend χ² = 15.11, p < 0.05), yet it increased to 28.03% in 2024. Conclusions: Non-NIP vaccines and NIP-substitute use grew steadily for over a decade, then contracted sharply in 2024. Decision-makers should investigate the sudden dip, differentiate discretionary from replacement demand, and reallocate funds to sustain equity and prevent further erosion of coverage. Full article

Buildings crossing active faults often suffer severe damage due to fault dislocation during direct-type urban earthquakes. This study employs physical model tests to systematically investigate the dynamic response mechanisms of the integrated “surface rupture zone–overburden–foundation–superstructure” system subjected to bedrock dislocation. A testing apparatus capable of simulating reverse faults with adjustable dip angles (45° and 70°) was developed. Using both sand and clay as representative overburden materials, the experiments simulated the processes of surface rupture evolution, foundation deformation, and structural response under varying fault dislocation magnitudes. Results indicate that the fault rupture pattern is governed by the bedrock dislocation magnitude, soil type, and fault dip angle. The failure process can be categorized into three distinct stages: initial rupture, rupture propagation, and rupture penetration. The severity and progression of structural damage are primarily determined by the building’s location relative to the fault trace. Structures located entirely on the hanging wall exhibited tilting angles that remained below the specified code limit throughout the dislocation process, demonstrating behavior dominated by rigid-body translation. In contrast, buildings crossing the fault exceeded this limit even at low dislocation levels, developing significant tilt and strain concentration due to differential foundation settlement. The most severe damage occurred in high-angle dip sand sites, where the maximum structural tilt reached 5.5°. This research elucidates the phased evolution of seismic damage in straddle-fault structures, providing experimental evidence and theoretical support for the seismic design of buildings in near-fault regions. The principal theoretical and methodological contributions are (1) developing a systematic “fault–soil–structure” testing methodology that reveals the propagation of fault dislocation through the system; (2) clarifying the distinct failure mechanisms between straddle-fault and hanging-wall structures, providing a quantitative basis for targeted seismic design; and (3) quantifying the controlling influence of fault dip angle and soil type combinations on structural damage severity, identifying high-angle dip sand sites as the most critical scenario. Full article

The long-distance high-voltage transmission tower-line system, frequently traversing active fault zones, is vulnerable to severe symmetry-breaking damage during earthquakes due to asymmetric permanent ground displacements. However, the seismic performance of such systems, particularly concerning symmetry-breaking effects caused by asymmetric fault displacements, remains inadequately studied. This study investigates the symmetry degradation mechanisms in a 1:40 scaled 500 kV tower-line system subjected to cross-fault ground motions via shaking table tests. The testing protocol incorporates representative fault mechanisms—strike-slip and normal/reverse faults—to systematically evaluate their differential impacts on symmetry response. Measurements of acceleration, strain, and displacement reveal that while acceleration responses are spectrally controlled, structural damage is highly fault-type dependent and markedly asymmetric. The acceleration of towers without permanent displacement was 35–50% lower than that of towers with permanent displacement. Under identical permanent displacement conditions, peak displacements caused by normal/reverse motions exceeded those from strike-slip motions by 50–100%. Accordingly, a fault-type-specific amplification factor of 1.5 is proposed for the design of towers in dip-slip fault zones. These results offer novel experimental insights into symmetry violation under fault ruptures, including fault-specific correction factors and asymmetry-resistant design strategies. However, the conclusions are subject to limitations such as scale effects and the exclusion of vertical ground motion components. Full article

On 8 June 2025, the Mw 6.4 Paratebueno earthquake struck the eastern foothills of the Eastern Andes, Colombia. The event occurred near the Guaicáramo fault, along the eastern margin of the Eastern Cordillera fold-and-thrust belt. To investigate its rupture characteristics and tectonic implications, we utilized ALOS-2 and Sentinel-1 SAR data to derive coseismic deformation fields. Source geometry and slip distribution were inverted with the Okada dislocation model, and static Coulomb failure stress change were calculated to assess the triggering relationship with the 2023 Mw 6.2 Meta-Cundinamarca earthquake. The results reveal maximum line-of-sight displacements of 43 cm, 23 cm and 32 cm, respectively, caused by a northwest-dipping blind reverse fault (strike ~213°, dip 58°) with ~5 m maximum slip concentrated at depths of 8–12 km, without surface rupture. Combining geological and stratigraphic evidence, including regional structures and sedimentary cover thickness, this event implies a transition from a normal fault to reverse fault due to ongoing shortening of fold-and-thrust belt, consistent with a thick-skinned tectonic origin. Coulomb stress modeling suggests the 2023 event promoted the 2025 rupture, and the combined effect of the two events further increased stress on the southeastern Guaicáramo fault, implying elevated seismic hazard. Full article

Background: Although there has been an improvement in the survival rates of patients following heart transplantation, many complications, such as hypertension, continue to develop. The aim of the study was to assess the 24-hour blood pressure profile and hypertension treatment among patients after heart transplantation and comparison to the control group. Methods: A retrospective data analysis included 26 male patients post-heart transplantation and 39 male patients in the control group. During a routine visit, the following data were collected: 24-hour blood pressure monitoring, laboratory tests, and medical history. Results: Hypertension was diagnosed in 76.9% of heart transplant recipients (HTXr) and in 56.4% of the control group (Cx). During the night-time rest period, diastolic blood pressure values ≥ 70 mmHg were observed in 76.9% of HTXr (vs. 33.33% Cx, p = 0.001). The average daytime systolic/diastolic blood pressure did not differ significantly between the groups. It was also observed that the groups differed in circadian blood pressure (Chi²ML = 15.87, p < 0.001), as there were significantly more reverse dippers in HTXr than in the control group (30.8% (8) vs. 10.3% (4)). The same proportions were also noted in HTXr and the control group in terms of isolated nocturnal hypertension. Conclusions: Heart transplant recipients require a tailored approach to hypertension management, including a variety of medications and appropriate chronotherapy. Full article

This study aims to compare the carbon footprints associated with the fabrication of two types of alumina-based tubular ceramic membranes used in microfiltration (MF): a multichannel membrane produced by extrusion and dip-coating, and an asymmetric hollow fiber membrane fabricated via phase inversion. The multichannel process involves two sintering steps but uses no organic solvents, whereas the phase-inversion method simplifies production through single-step shaping and sintering but requires organic solvents that increase environmental burdens. Using a functional unit of 1 m² effective membrane area, carbon emissions were quantified from raw material extraction to waste disposal. The results showed total emissions of 8.57 kg CO₂-eq/m² for the multichannel membrane and 10.67 kg CO₂-eq/m² for the hollow fiber membrane. Although the hollow fiber process consumed less energy, its extensive use of solvents, particularly NMP, led to significantly higher emissions. This study provides the first quantitative comparison of these two common ceramic membrane fabrication routes and underscores the importance of considering both energy use and solvent impacts when evaluating the environmental sustainability of membrane production. A sensitivity analysis further evaluated the influence of key parameters, including alumina emission factor, regional electricity carbon intensity, alumina recycling, and solvent substitution or NMP recycling. The analysis demonstrated that each factor could significantly influence the total carbon footprint and, under favorable conditions, narrow or even reverse the gap between the two fabrication routes. This study provides the first quantitative comparison of these two common ceramic membrane fabrication methods and highlights the importance of considering energy use, solvent impacts, and potential mitigation strategies when assessing the environmental sustainability of ceramic membrane production. Full article

Background: The association between blood pressure (BP) dipping profiles and kidney function among chronic kidney disease (CKD) patients has been well established within the literature, but studies conducted on kidney transplant (KT) patients remain limited. Individual KT studies have small sample sizes and conflicting results. Meta-analysis overcomes these limitations by pooling data to increase statistical power and provide robust clinical guidance. This meta-analysis systematically assesses the impact of BP patterns on KT and CKD populations, aiming to highlight improved BP management strategies in these populations. Materials and methods: A comprehensive search was conducted up to September 9th, 2024, using multiple electronic databases. Results: The current study included 7 studies with a total of 788 patients. KT recipients showed a higher prevalence of non-dipper blood pressure profile than CKD patients. Also, those with a dipper profile had a significantly higher estimated glomerular filtration rate (eGFR) compared to non-dippers and reverse dippers, implying better graft function. No significant differences were observed in acute rejection risk, proteinuria, renal resistive index, cholesterol, or triglycerides across blood pressure profiles. Conclusions: These findings reveal a high prevalence of non-dipping blood pressure profiles in KT and CKD patients, linked to worse renal and cardiovascular outcomes, while also highlighting the need for ambulatory blood pressure monitoring and tailored BP management strategies in these high-risk populations to potentially improve outcomes. However, the observational nature of available studies limits causal inference, and further prospective research is required to establish definitive therapeutic recommendations. Full article

Every year, diarrhoea is responsible for >1 million deaths in children with ages from 0 to 5 years, with rotavirus as the leading cause. The regions most affected lack routine rotavirus diagnosis due to high cost, lack of necessary equipment and shortage of trained-personnel for Enzyme-Link-Immunosorbent-Assay (ELISA) and molecular methods. We report the development and evaluation of a cheap, nanoparticle-based immunoassay for routine machine-free rotavirus diagnosis. In this work, optimal conditions for oxidation of cotton swabs and aldehyde production for kit development was confirmed by Fourier-Transform Infrared Spectroscopy (FTIR). Lactoferrin (LF) needed to bind the virus to the cotton swab was immobilised on activated cotton swabs, followed by the capture of commercial rotavirus antigen on LF-immobilised swabs. This was dipped in coloured nanobeads covalently coupled to rotavirus-group-specific monoclonal antibody for visual rotavirus detection. Subsequently, rotavirus detection by nanoassay, commercial ELISA and quantitative reverse transcription PCR were compared using same set of 186 stool samples and subjected to statistical analyses. Optimal oxidisation condition was observed using 48 mg/mL NaIO₄ in 0.1 M sodium acetate buffer at 35 °C for 9 h. Rotavirus detection was confirmed visually by blue colour retention on swabs after several washings. Sensitivity, specificity, positive-predictive-value and negative-predictive-value of ELISA in rotavirus detection were 60%, 84%, 53% and 88%, respectively, while our immunoassay showed performance at 88%, 94%, 82% and 96%. This immunoassay will provide effective rotavirus public health interventions in low-and-middle-income countries with high morbidity/mortality. Full article