Search Results (253)

A compact electrochemical sensor module for pH detection was developed for potential integration into specialized devices used for live cell or tissue incubation, for applications in highly parallelized cell culture analysis, by incorporating Organ-on-Chip devices. This research focuses on the deposition, structural and chemical analysis, and functional characterization of different titanium-oxide layers with various compositions as potentially sensitive materials for pH sensing applications. The titanium-oxide layers were deposited using vacuum sputtering and atomic layer deposition at 100 °C and 300 °C, respectively. Transmission electron microscopy and X-ray photoelectron spectroscopy were utilized to determine the specific composition and structure of different titanium-oxide layers. These TiO_x-functionalized electrodes were connected to the application-specific analog front-end chip of the low-power readout circuit for precise evaluation. The pH sensitivity of the differently modified electrodes, employing various TiO_x materials, was evaluated using pH calibration solutions ranging from pH 6 to 8. Among the various deposition solutions, such as sputtering or high-temperature atomic layer deposition, the TiO_x layer deposited using low-temperature atomic layer deposition proved more suitable for pH sensing applications, with a sensitivity of 54.8–56.7 mV/pH, which closely approximates the Nernstian response. Full article

Fast, spark-free detection of hydrogen leaks is indispensable for large-scale hydrogen deployment, yet electronic sensors remain power-intensive and prone to cross-talk. Optical schemes based on surface plasmons enable remote read-out, but single-metal devices offer either weak H2 affinity or poor plasmonic quality. Here we employ full-wave finite-difference time-domain (FDTD) simulations to map the hydrogen response of nanohole arrays (NAs) that can be mass-produced by colloidal lithography. Square lattices of 200 nm holes etched into 100 nm films of Pd, Mg, Ti, V, or Zr expose an intrinsic trade-off: Pd maintains sharp extraordinary optical transmission modes but shifts by only 28 nm upon hydriding, whereas Mg undergoes a large dielectric transition that extinguishes its resonance. Vertical pairing of a hydride-forming layer with a noble metal plasmonic cap overcomes this limitation. A Mg/Pd bilayer preserves all modes and red-shifts by 94 nm, while the predicted optimum Ag (60 nm)/Mg (40 nm) stack delivers a 163 nm shift with an 83 nm linewidth, yielding a figure of merit of 1.96—surpassing the best plasmonic hydrogen sensors reported to date. Continuous-film geometry suppresses mechanical degradation, and the design rules—noble-metal plasmon generator, buried hydride layer, and thickness tuning—are general. This study charts a scalable route to remote, sub-ppm, optical hydrogen sensors compatible with a carbon-neutral energy infrastructure. Full article

A concept towards current measurement in low and medium voltage power distribution networks is presented. The concentric magnetic field around the current-carrying conductor should be measured using a nitrogen-vacancy quantum magnetic field sensor. A bottleneck in current measurement systems is the readout electronics, which are usually based on optically detected magnetic resonance (ODMR). The idea is to have a hardware that tracks up to four resonances simultaneously for the detection of the three-axis magnetic field components and the temperature. Normally, expensive scientific instruments are used for the measurement setup. In this work, we present an electronic device that is based on a Zynq 7010 FPGA (Red Pitaya) with an add-on board, which has been developed to control the excitation laser, the generation of the microwaves, and interfacing the photodiode, and which provides additional fast digital outputs. The T1 measurement was chosen to demonstrate the ability to read out the spin of the system. Full article

The signal-processing architecture of passive surface acoustic wave (SAW) sensors presents significant implementation challenges due to its radar-like operational principle and the inherent complexity of discrete component-based hardware design. While System-in-Package (SiP) has demonstrated remarkable success in miniaturizing electronic systems for smartphones, automotive electronics, and IoT applications, its potential for revolutionizing SAW sensor interrogator design remains underexplored. This paper presents a novel architecture that synergistically combines time-domain ADC design with SiP-based miniaturization to achieve unprecedented simplification of SAW sensor readout systems. The proposed time-domain ADC incorporates an innovative delay chain calibration methodology that integrates physical unclonable function (PUF) principles during time-to-digital converter (TDC) characterization, enabling the simultaneous generation of unique system IDs. The experimental results demonstrate that the integrated security mechanism provides variable-length bit entropy for device authentication, and has a reliability of 97.56 and uniqueness of 49.43, with 53.28 uniformity, effectively addressing vulnerability concerns in distributed sensor networks. The proposed SiP is especially suitable for space-constrained IoT applications requiring robust physical-layer security. This work advances the state-of-the-art wireless sensor interfaces by demonstrating how time-domain signal processing and advanced packaging technologies can be co-optimized to address performance and security challenges in next-generation sensor systems. Full article

Thermal mass flow sensors (TMFS) are used to detect the flow rates of gases. TMFS elements are available in different technologies and, depending on the one used, the material choice of substrate, heater, and temperature sensors can limit their performance. In this work, a sensor element based on the Ensinger Microsystems Technology (EMST) is presented that uses PEEK as the substrate, nickel-chromium as the heater, and nickel as the temperature sensor material. The fabrication process of the element is described, the completion to a flow sensor with a control and readout circuit based on discharge time measurement with picosecond resolution is presented, and measurement results are shown, which are compared to sensors with a commercially available element based on thin film technology on ceramic and an element built with discrete components, all using the same electronics. It is shown that the operation of all sensor elements with the proposed readout circuit was successful, flow-dependent signals were achieved, and the performance of TMFS in EMST improved. Its heater shows better results compared to the commercial element due to material choice with a smaller temperature coefficient of resistance. In its current state, the TMFS in EMST is suitable to detect flow rates > 20 SLPM. The performance needs to be improved further, since the temperature sensors still differ too much from another. Full article

Belle II is a particle physics experiment working at an high luminosity collider within a hard irradiation environment. The Time-Of-Propagation detector, aimed at the charged particle identification, surrounds the Belle II tracking detector on the barrel part. This detector is composed by 16 modules, each module contains a finely fused silica bar, coupled to microchannel plate photomultiplier tube (MCP-PMT) photo-detectors and readout by high-speed electronics. The MCP-PMT lifetime at the nominal collider luminosity is about one year, this is due to the high photon background degrading the quantum efficiency of the photocathode. An alternative to these MCP-PMTs is multi-pixel photon counters (MPPC), known as silicon photomultipliers (SiPM). The SiPMs, in comparison to MCP-PMTs, have a lower cost, higher photon detection efficiency and are unaffected by the presence of a magnetic field, but also have a higher dark count rate that rapidly increases with the integrated neutron flux. The dark count rate can be mitigated by annealing the damaged devices and/or operating them at low temperatures. We tested SiPMs, with different dimensions and pixel sizes from different producers, to study their time resolution (the main constraint that has to satisfy the photon detector) and to understand their behavior and tolerance to radiation. For these studies we irradiated the devices to radiation up to $5\times {10}^{11}1$ MeV neutrons equivalent (neq) per cm² fluences; we also started studying the effect of annealing on dark count rates. We performed several measurements on these devices, on top of the dark count rate, at different conditions in terms of overvoltage and temperatures. These measurements are: IV-curves, amplitude spectra, time resolution. For the last two measurements we illuminated the devices with a picosecond pulsed laser at very low intensities (with a number of detected photons up to about twenty). We present results mainly on two types of SiPMs. A new SiPM prototype developed in collaboration with FBK with the aim of improving radiation hardness, is expected to be delivered in September 2025. Full article

A conventional microchannel plate framing camera is typically utilized for inertial confinement fusion diagnosis. However, as a vacuum electronic device, it has inherent limitations, such as a complex structure and the inability to achieve single-line-of-sight imaging. To address these challenges, a CMOS image sensor that can be seamlessly integrated with an electronic pulse broadening system can provide a viable alternative to the microchannel plate detector. This paper introduces the design of an 8 × 8 pixel-array ultrashort shutter-time single-framing CMOS image sensor, which leverages silicon epitaxial processing and a 0.18 μm standard CMOS process. The focus of this study is on the photodiode and the readout pixel-array circuit. The photodiode, designed using the silicon epitaxial process, achieves a quantum efficiency exceeding 30% in the visible light band at a bias voltage of 1.8 V, with a temporal resolution greater than 200 ps for visible light. The readout pixel-array circuit, which is based on the 0.18 μm standard CMOS process, incorporates 5T structure pixel units, voltage-controlled delayers, clock trees, and row-column decoding and scanning circuits. Simulations of the pixel circuit demonstrate an optimal temporal resolution of 60 ps. Under the shutter condition with the best temporal resolution, the maximum output swing of the pixel circuit is 448 mV, and the output noise is 77.47 μV, resulting in a dynamic range of 75.2 dB for the pixel circuit; the small-signal responsivity is 1.93 × 10⁻⁷ V/e⁻, and the full-well capacity is 2.3 Me⁻. The maximum power consumption of the 8 × 8 pixel-array and its control circuits is 0.35 mW. Considering both the photodiode and the pixel circuit, the proposed CMOS image sensor achieves a temporal resolution better than 209 ps. Full article

The wavefront sensor (WFS), equipped with an electron-multiplying charge-coupled device (EMCCD) detector, is a critical component of the Cool Planets Imaging Coronagraph (CPI-C) on the Chinese Space Station Survey Telescope (CSST). Precise calibration of the WFS’s EMCCD detector is essential to meet the stringent requirements for high-contrast exoplanet imaging. This study comprehensively characterizes key performance parameters of the detector to ensure its suitability for astronomical observations. Through a multi-stage screening protocol, we identified an EMCCD chip exhibiting high resolution and low noise. The electron-multiplying gain (EM Gain) of the EMCCD was analyzed to determine its impact on signal amplification and noise characteristics, identifying the optimal operational range. Additionally, noise properties such as readout noise were investigated. Experimental results demonstrate that the optimized detector meets CPI-C’s initial application requirements, achieving high resolution and low noise. This study provides theoretical and experimental foundations for the use of EMCCD-based WFS in adaptive optics and astronomical observations, ensuring their reliability for advanced space-based imaging applications. Full article

In the continuous pursuit of minimally invasive interventions while ensuring a radical excision of lesions, Radio-Guided Surgery (RGS) has been for years the standard for image-guided surgery procedures, such as the Sentinel Lymph Node biopsy (SLN), Radio-guided Seed Localization (RSL), etc. In RGS, the lesion has to be identified precisely, in terms of position and extension. In such a context, going beyond the current one-point probes, introducing portable but high-resolution cameras, handholdable by the surgeon, would be highly beneficial. We developed and tested a novel compact, low-power, handheld gamma camera for radio-guided surgery. This is based on a particular position-sensitive Silicon Photomultiplier (SiPM) technology—the FBK linearly graded SiPM (LG-SiPM). Within the camera, the photodetector is made up of a 3 × 3 array of 10 × 10 mm² SiPM chips having a total area of more than 30 × 30 mm². This is coupled with a pixelated scintillator and a parallel-hole collimator. With the LG-SiPM technology, it is possible to significantly reduce the number of readout channels to just eight, simplifying the complexity and lowering the power consumption of the readout electronics while still preserving a good position resolution. The novel gamma camera is light (weight), and it is made to be a fully stand-alone system, therefore featuring wireless communication, battery power, and wireless recharge capabilities. We designed, simulated (electrically), and tested (functionally) the first prototypes of the novel gamma camera. We characterized the intrinsic position resolution (tested with pulsed light) as being ~200 µm, and the sensitivity and resolution when detecting gamma rays from Tc-99m source measured between 134 and 481 cps/MBq and as good as 1.4–1.9 mm, respectively. Full article

Positron emission tomography (PET) is an imaging modality for non-invasive visualization and quantification of molecular pathways in human diseases, with applications spanning clinical practice and biomedical research. Recent advances in PET system technology target ultra-high spatial resolution (<2 mm) to enhance diagnostic precision for early-stage disease detection and longitudinal monitoring. A key strategy involves organ-specific, or loco-regional, scanner configurations that optimize photon detection efficiency (PDE) while balancing the trade-off between spatial resolution and image signal-to-noise ratio (SNR). This study reviews innovations driving the development of next-generation clinical PET systems, including the following: (1) novel geometries tailored for anatomical regions such as the head/neck and breast, (2) high-performance detector materials and readout electronics, and (3) advanced image reconstruction algorithms. This paper emphasizes progress toward achieving ≤2 mm isotropic spatial resolution in clinical PET systems, and in particular focuses on describing a 1 mm³ resolution system dedicated to head-and-neck or breast cancer imaging that was developed in our laboratory. Full article

We demonstrate a quantum processor based on a 3D linear Paul trap that uses ${}^{171}\mathrm{Yb}^{+}$ ions with eight individually controllable four-level qudits (ququarts), which is computationally equivalent to a sixteen-qubit quantum processor. The design of the developed ion trap provides high secular frequencies and a low heating rate, which, together with individual addressing and readout optical systems, allows executing quantum algorithms. In each of the eight ions, we use four electronic levels coupled by E2 optical transition at 435 nm for qudit encoding. We present the results of single- and two-qubit operations benchmarking and realizing basic quantum algorithms, including the Bernstein–Vazirani and Grover’s search algorithms as well as H₂ and LiH molecular simulations. Our results pave the way to scalable qudit-based quantum processors using trapped ions. Full article

The proteasome is an enzyme that sequentially degrades peptides into small fragments, so the ability to make electrical measurements of its conformational fluctuations could lead to an electronic readout of the sequence of single peptide molecules. Here, we report scanning tunneling microscope (STM) measurements of the conductance of the T. acidophilum 20S proteasome core particle (CP). The wild-type CP did not change conductance significantly as a 4 amino acid peptide substrate was added. Larger peptides were digested by a mutant, CP-Δ12, in which 12 residues were deleted from the N terminus of the alpha chains (opening the central pore). The conductance of this molecule decreased significantly in the presence of a denatured pleiotrophin substrate. Control experiments showed that strong bonding of the protein, both to the substrate electrode and the STM probe, was required for conductivity to be observed. It also appears that substantial penetration of the probe into the protein film is required, a problematic constraint on incorporating the CP into a fixed-gap device for technological applications. Full article

Pixellated scintillation detectors have the potential to overcome several limitations of conventional microchannel-plate-based detectors employed in time-of-flight mass spectrometry (ToF-MS), such as extending detector lifetime, reducing vacuum requirements, or increasing the ion throughput. We have developed a prototype comprising a fast organic scintillator (Exalite 404) coupled to an array of 16 silicon photomultipliers (SiPMs), with read-out electronics based on the FastIC application-specific integrated circuit (ASIC). Each SiPM signal processed by FastIC is fed into its own time-to-digital converter (TDC). The dead time of a single channel can be as short as ∼20 ns. As a result, our system have the potential to process ion rates above ${10}^9$ cm⁻² s⁻¹. We have evaluated the performance of our prototype using a velocity-map imaging ToF-MS instrument, recording the time-of-flight mass spectra of C₃H₆ and CF₃I samples. We achieved time resolutions of ($3.3\pm 0.1$) and ($2.5\pm 0.2$) ns FWHM for ions of mass-to-charge ratio ($m/z$) values of 196 and 18, respectively. This corresponds to a mass resolution of ∼1000 for $m/z<200$, which we found to be dominated by the spread in ion arrival times. Full article

Optical Beam-Loss Monitors (oBLMs) allow for cost-efficient and spatially continuous measurements of beam losses at accelerator facilities. A standard oBLM consists of several tens of metres of optical fibre aligned parallel to a beamline, coupled to photosensors at either or both ends. Using the timing information from loss signals, the loss positions can be reconstructed. This paper presents a novel oBLM system recently deployed at the CERN Linear Electron Accelerator for Research (CLEAR). Multiple methods of extracting timing and position information from measured waveforms with silicon photomultipliers (SiPM) and photomultiplier tubes (PMT) are investigated. For this installation, the optimal approach is determined to be applying a constant fraction discrimination (CFD) on the upstream readout. The position resolution is found to be similar for the tested SiPM and PMT. This work has resulted in the development of a user interface to aid operations by visualising the beam losses and their positions in real time. Full article

Biosensing shows promise in detecting cancer, renal disease, and other illnesses. Depending on their transducing processes, varieties of biosensors can be divided into electrochemical, optical, piezoelectric, and thermal biosensors. Advancements in material production techniques, enzyme/protein designing, and immobilization/conjugation approaches can yield novel nanoparticles with further developed functionality. Research in cutting-edge biosensing with multifunctional nanomaterials, and the advancement of practical biochip plans utilizing nano-based sensing material, are of current interest. The miniaturization of electronic devices has enabled the growth of ultracompact, compassionate, rapid, and low-cost sensing technologies. Some sensors can recognize analytes at the molecule, particle, and single biological cell levels. Nanomaterial-based sensors, which can be used for biosensing quickly and precisely, can replace toxic materials in real-time diagnostics. Many metal-based NPs and nanocomposites are favorable for biosensing. Through direct and indirect labeling, metal-oxide NPs are extensively employed in detecting metabolic disorders, such as cancer, diabetes, and kidney-disease biomarkers based on electrochemical, optical, and magnetic readouts. The present review focused on recent developments across multiple biosensing modalities using metal/metal-oxide-based NPs; in particular, we highlighted the specific advancements of biosensing of key nanomaterials like ZnO, CeO₂, and TiO₂ and their applications in disease diagnostics and environmental monitoring. For example, ZnO-based biosensors recognize uric acid, glucose, cholesterol, dopamine, and DNA; TiO₂ is utilized for SARS-CoV-19; and CeO₂ for glucose detection. Full article