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37 pages, 948 KB  
Review
A Review of Socially Assistive Robotics in Supporting Children with Autism Spectrum Disorder
by Muhammad Nadeem, Julien Moussa H. Barakat, Dani Daas and Albert Potams
Multimodal Technol. Interact. 2025, 9(9), 98; https://doi.org/10.3390/mti9090098 - 18 Sep 2025
Viewed by 1436
Abstract
This study aimed to investigate the use of social robots as an interactive learning approach for treating children diagnosed with autism spectrum disorder (ASD). A review was conducted using the meta-analysis technique to compile pertinent research. An analysis was performed on the results [...] Read more.
This study aimed to investigate the use of social robots as an interactive learning approach for treating children diagnosed with autism spectrum disorder (ASD). A review was conducted using the meta-analysis technique to compile pertinent research. An analysis was performed on the results of the online search process, which gathered information on pertinent research published until 31 January 2025, from three publication databases: IEEE Xplore, SCOPUS, and Google Scholar. One hundred and seven papers out of the 591 publications that were retrieved satisfied the previously established inclusion and exclusion criteria. Despite the differences in methodology and heterogeneity, the data were synthesized narratively. This review focuses on the various types of social robots used to treat ASD, as well as their communication mechanisms, development areas, target behaviors, challenges, and future directions. Both practitioners and seasoned researchers looking for a fresh approach to their next project will find this review a useful resource that offers broad summaries of state-of-the-art research in this field. Full article
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32 pages, 38675 KB  
Article
Comparative Study and Multi-Objective Optimization of Electromagnetic Performance of Permanent Magnet Vernier Motors with Rotor Auxiliary Teeth
by Yujun Shi, Wenlei Zhao, Qingqing Liu, Jiwei Wang, Yaogang Liu and Haifeng Lu
Machines 2025, 13(9), 841; https://doi.org/10.3390/machines13090841 - 11 Sep 2025
Viewed by 480
Abstract
Permanent magnet vernier motors (PMVMs) have significant advantages in low-speed direct-drive fields on account of their high torque density, and their performance improvement is still a research hotspot. To enhance the overall electromagnetic performance and provide an alternative solution for low-speed direct-drive applications, [...] Read more.
Permanent magnet vernier motors (PMVMs) have significant advantages in low-speed direct-drive fields on account of their high torque density, and their performance improvement is still a research hotspot. To enhance the overall electromagnetic performance and provide an alternative solution for low-speed direct-drive applications, this paper proposes a permanent magnet vernier motor with rotor auxiliary teeth (denoted as “RAT-PMVM”). Firstly, the structure and working principle of RAT-PMVM are introduced. Then, the two-dimensional (2D) finite element method (FEM) is used to comparatively study the influence of the number, position, and tooth profile of the rotor auxiliary teeth on the electromagnetic performance of the proposed motor. The results show that the RAT-PMVM with trapezoidal teeth (denoted as “TT-PMVM”) achieved improvement in output torque, efficiency, and power factor: the output torque increased from 11.32 Nm to 14.19 Nm, the efficiency increased from 88.5% to 92.2%, and the power factor increased from 0.60 to 0.71. Finally, in order to further reduce the torque ripple and improve the torque, power factor, and efficiency, multi-objective optimization of the TT-PMVM is carried out. The optimization yields a 27.3% increase in torque, a 31.8% reduction in torque ripple ratio, an efficiency improvement from 92.2% to 93%, and a power factor enhancement from 0.73 to 0.81, demonstrating significant potential for low-speed direct-drive applications like industrial robots and wind power generation. Full article
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14 pages, 942 KB  
Article
A Precision Surgery Framework for Lung Resection: Robotic, Video-Assisted, and Open Segmentectomy
by Chiara Catelli, Miriana D’Alessandro, Federico Mathieu, Roberto Corzani, Marco Ghisalberti, Andrea Lloret Madrid, Susanna Guerrini, Piero Paladini and Luca Luzzi
J. Pers. Med. 2025, 15(8), 387; https://doi.org/10.3390/jpm15080387 - 19 Aug 2025
Viewed by 717
Abstract
Objectives: To evaluate outcomes of patients undergoing lung segmentectomy using open thoracotomy, Video-Assisted Thoracoscopic Surgery (VATS), or Robotic-Assisted Thoracoscopic Surgery (RATS) approaches. Methods: A total of 157 patients (mean age: 68.7 years; 58% male) who underwent lung segmentectomy from 2015 to 2024 at [...] Read more.
Objectives: To evaluate outcomes of patients undergoing lung segmentectomy using open thoracotomy, Video-Assisted Thoracoscopic Surgery (VATS), or Robotic-Assisted Thoracoscopic Surgery (RATS) approaches. Methods: A total of 157 patients (mean age: 68.7 years; 58% male) who underwent lung segmentectomy from 2015 to 2024 at the Thoracic Surgery of Siena were retrospectively enrolled and divided into groups based on the surgical approach: thoracotomy (n = 60), VATS (n = 58), and RATS (n = 39). No significant differences were observed between groups in terms of age, gender, or tumor stage. Peri-operative outcomes, and, in patients with non-small cell lung cancer (NSCLC, n = 104), long-term outcomes, were analyzed. Group comparisons were conducted using Kruskal–Wallis, Dunn’s test, Chi-squared, or Fisher’s exact test and Kaplan–Meier analysis with log-rank test. Results: Conversion rate was 13% and 0% for VATS and RATS, respectively (p = 0.005). Pleural effusion on first post-operative day was lower in RATS than VATS (p = 0.0006) and open (p < 0.0001). The maximum Visual Analogue Scale (VAS) value recorded was lower in RATS than open (p = 0.016) and VATS (p = 0.013). Surgery time was longer for RATS than open (p = 0.001) and VATS (p = 0.013). No differences were found in hospital stay and post-operative complications. In patients with NSCLC, the median follow-up was 25 months. The 90-day mortality rate was 9.5% in thoracotomy, 0% in VATS and RATS (p = 0.05). The 1- and 2-year overall survival was higher in VATS and RATS groups than thoracotomy (p = 0.001 and p = 0.040, respectively). The number of harvested lymph nodes was larger in the open group (p = 0.010), while a higher number of stations were harvested in RATS and open than VATS (p = 0.001). No differences were found in local recurrence (p= 0.08). Conclusions: RATS segmentectomy ensures a lower conversion rate, less post-operative pain, reduced daily pleural effusion, and a greater number of harvested lymph node stations compared to VATS, providing comparable peri-operative outcomes. RATS and VATS segmentectomy offer an advantage over the open approach in short- and long-term survival. Full article
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14 pages, 729 KB  
Article
Contralateral Robotic-Assisted Anatomical Resection for Synchronous or Metachronous Lung Cancer: A Retrospective Case Series
by Alessio Campisi, Nabil Khan, Federica Pinna, Dennis Aliev, Raffaella Griffo, Philip Baum, Werner Schmidt, Hauke Winter and Martin Eichhorn
J. Clin. Med. 2025, 14(16), 5786; https://doi.org/10.3390/jcm14165786 - 15 Aug 2025
Viewed by 631
Abstract
Background: Advances in screening programs have led to increased detection of early-stage non-small cell lung cancer (NSCLC), including synchronous or metachronous nodules amenable to surgical resection. Patients requiring contralateral anatomical lung resections present a unique surgical challenge due to potential impairments in [...] Read more.
Background: Advances in screening programs have led to increased detection of early-stage non-small cell lung cancer (NSCLC), including synchronous or metachronous nodules amenable to surgical resection. Patients requiring contralateral anatomical lung resections present a unique surgical challenge due to potential impairments in lung function and the complexities of one-lung ventilation. This study evaluates the feasibility, safety, and perioperative outcomes of robotic-assisted thoracic surgery (RATS) for contralateral anatomical lung resections in patients with NSCLC. Methods: A retrospective analysis was conducted on 20 patients who underwent RATS contralateral anatomical resection between January 2019 and June 2024. Preoperative pulmonary function, perioperative characteristics, and oncological outcomes were assessed. Operative parameters, including conversion rates, intraoperative oxygenation, need for extracorporeal membrane oxygenation (ECMO), and postoperative complications, were recorded. Results: Seventy percent of the patients underwent surgery for metachronous tumors. The median forced expiratory volume in 1 s (FEV1) was 75.94% (66.62–89.24). The most common resection was segmentectomy (65.0%). The median operative time was 148.0 min (108.0–194.75). There were no conversions to open surgery or ECMO requirements. Intraoperative parameters remained stable (median FiO2: 0.8; lowest SaO2: 92.0%). Complications occurred in 25% of the patients, mostly Clavien–Dindo grade 2. No in-hospital, 30-day, or 90-day mortality was observed. Conclusions: Robotic-assisted contralateral anatomical lung resection is a feasible and safe approach for patients with previous contralateral surgery, supporting its role as a minimally invasive alternative for complex surgical cases. Full article
(This article belongs to the Special Issue Robot-Assisted Surgery: Current Trends and Future Perspectives)
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14 pages, 233 KB  
Article
Robotic Surgery Is a Safe Treatment in Very Elderly Patients with Resectable Lung Cancer
by Pierluigi Novellis, Riccardo Di Fonzo, Edoardo Bottoni, Veronica Maria Giudici, Domenico Pontillo, Piergiorgio Muriana, Elisa Dieci, Roberto Ferrara, Alessandra Bulotta, Giuseppe Marulli, Gianluca Perroni and Giulia Veronesi
J. Clin. Med. 2025, 14(12), 4314; https://doi.org/10.3390/jcm14124314 - 17 Jun 2025
Viewed by 761
Abstract
Background: Lung cancer represents a significant health concern, particularly among the elderly population. With global life expectancy increasing, the number of very elderly patients is rising. Robotic-assisted thoracic surgery (RATS) offers potential advantages over both traditional and video-assisted thoracoscopic surgery (VATS). This study [...] Read more.
Background: Lung cancer represents a significant health concern, particularly among the elderly population. With global life expectancy increasing, the number of very elderly patients is rising. Robotic-assisted thoracic surgery (RATS) offers potential advantages over both traditional and video-assisted thoracoscopic surgery (VATS). This study aims to evaluate the feasibility and safety of RATS in very elderly patients (VEP) diagnosed with lung cancer. Methods: This retrospective study included patients who underwent major lung resections using RATS between 2015 and 2022 at two specialized centers. Patients were divided into very elderly patients (VEP, ≥80 years) and non-elderly patients (NEP, <80 years). Demographic, clinical, and surgical data were analyzed. Propensity score matching (PSM) at a 1:3 ratio was performed using clinically relevant variables that were significantly different at baseline to balance the two groups. Results: This study included 340 patients: 28 VEP and 312 NEP. Before PSM, VEP had higher ASA scores, more advanced disease stages, and increased comorbidities. Despite these differences, postoperative outcomes were comparable. Complications occurred in 42.9% of VEP and 29.8% of NEP (p = 0.16), but grade III complications were observed in 14.3% of VEP and 6.4% of NEP (p = 0.12), and grade IV complications were observed in 0% of VEP and 0.9% of NEP (p = not estimable). The mean hospital stay was 4 days in both groups (p = 0.99). Even after PSM (26 VEP vs. 71 NEP), complications, hospital stay, and 90-day mortality (3.9% in VEP, 0% in NEP) were similar. Multivariable analysis identified reduced FEV1 as a predictor of complications, while pathological stage I and lobectomy were associated with a decreased risk of complications, both before and after PSM. Conclusions: RATS is a safe and feasible option for selected very elderly patients with lung cancer, yielding outcomes comparable to younger patients. Full article
(This article belongs to the Special Issue Thoracic Surgery: Current Practice and Future Directions)
17 pages, 1891 KB  
Article
Exploring the Impact of Robotic Hand Rehabilitation on Functional Recovery in Parkinson’s Disease: A Randomized Controlled Trial
by Loredana Raciti, Desiree Latella, Gianfranco Raciti, Chiara Sorbera, Mirjam Bonanno, Laura Ciatto, Giuseppe Andronaco, Angelo Quartarone, Giuseppe Di Lorenzo and Rocco Salvatore Calabrò
Brain Sci. 2025, 15(6), 644; https://doi.org/10.3390/brainsci15060644 - 15 Jun 2025
Viewed by 1476
Abstract
Background/Objective: Parkinson’s disease (PD) is characterized by motor and cognitive impairments that significantly affect quality of life. Robotic-assisted therapies, such as the AMADEO® system, have shown potential in rehabilitating upper limb function but are underexplored in PD. This study aimed to assess [...] Read more.
Background/Objective: Parkinson’s disease (PD) is characterized by motor and cognitive impairments that significantly affect quality of life. Robotic-assisted therapies, such as the AMADEO® system, have shown potential in rehabilitating upper limb function but are underexplored in PD. This study aimed to assess the effects of Robotic-Assisted Therapy (RAT) compared to Conventional Physical Therapy (CPT) on cognitive, motor, and functional outcomes in PD patients. Methods: A single-blind, randomized controlled trial was conducted with PD patients allocated to RAT or CPT. Participants were assessed at baseline (T0) and post-intervention (T1) using measures including MoCA, FAB, UPDRS-III, 9-Hole Peg Test, FMA-UE, FIM, and PDQ-39. Statistical analyses included ANCOVA and regression models. Results: RAT led to significant improvements in global cognition (MoCA, p < 0.001) and executive functioning (FAB, p = 0.0002) compared to CPT. Motor function improved, particularly in wrist and hand control (FMA-UE), whereas changes in fine motor dexterity (9-Hole Peg Test) were less consistent and did not reach robust significance. No significant improvements were observed in broader quality of life domains, depressive symptoms, or memory-related cognitive measures. However, quality of life improved significantly in the stigma subdomain of the PDQ-39 (p = 0.0075). Regression analyses showed that baseline motor impairment predicted cognitive outcomes. Conclusions: RAT demonstrated superior cognitive and motor benefits in PD patients compared to CPT. These results support the integration of robotic rehabilitation into PD management. Further studies with larger sample sizes and long-term follow-up are needed to validate these findings and assess their sustainability. Full article
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15 pages, 2443 KB  
Article
Optimization of Fuzzy Adaptive Logic Controller for Robot Manipulators Using Modified Greater Cane Rat Algorithm
by Jian Sun, Shuyi Wu, Jinfu Chen, Xingjia Li, Ziyan Wu, Ruiting Xia, Wei Pan and Yan Zhang
Mathematics 2025, 13(10), 1631; https://doi.org/10.3390/math13101631 - 15 May 2025
Viewed by 786
Abstract
In the control of robot manipulators, input torque constraints and system nonlinearities present significant challenges for precise trajectory tracking. However, fuzzy adaptive logic control (FALC) often fails to generate the optimal membership functions or function intervals. This paper proposes a modified greater cane [...] Read more.
In the control of robot manipulators, input torque constraints and system nonlinearities present significant challenges for precise trajectory tracking. However, fuzzy adaptive logic control (FALC) often fails to generate the optimal membership functions or function intervals. This paper proposes a modified greater cane rat algorithm (MGCRA) to optimize a fuzzy adaptive logic controller (FALC) for minimizing input torques during trajectory tracking tasks. The main innovation lies in integrating the improved MGCRA with FALC, which enhances the controller’s adaptability and performance. For benchmarking, several state-of-the-art swarm intelligence algorithms—including particle swarm optimization (PSO), artificial bee colony (ABC), ant colony optimization (ACO), gray wolf optimization (GWO), covariance matrix adaptation evolution strategy (CMA-ES), adaptive guided differential evolution (AGDE), the basic greater cane rat algorithm (GCRA), and a trial-and-error method—are compared under identical conditions. Experimental results show that the MGCRA-tuned FALC achieves lower input torques and improved trajectory tracking accuracy compared to other methods. The findings demonstrate the effectiveness and potential of the proposed MGCRA-FALC framework for advanced robotic manipulator control. Full article
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9 pages, 222 KB  
Article
Next-Day Discharge Is Feasible in Robotic-Assisted Thoracic Surgery Anatomical Lung Resections Irrespective of Patient Characteristics
by Ra’fat Tawalbeh, William Ansley, Obada Alqudah, Ahmad Asqalan, Hammad Hassan, Bartolmiej Szafron, Cristina Viola, Jakub Kadlec, Waldemar Bartosik and Vasileios Kouritas
J. Clin. Med. 2025, 14(9), 3198; https://doi.org/10.3390/jcm14093198 - 5 May 2025
Viewed by 583
Abstract
Background: Next-day discharge post-robotic-assisted thoracic surgery (RATS) anatomical lung resections are shown to be achieved in young and fit patients. This study aims to compare next-day discharge RATS anatomical lung resection patients matched with patients who stayed longer. Methods: A retrospective analysis of [...] Read more.
Background: Next-day discharge post-robotic-assisted thoracic surgery (RATS) anatomical lung resections are shown to be achieved in young and fit patients. This study aims to compare next-day discharge RATS anatomical lung resection patients matched with patients who stayed longer. Methods: A retrospective analysis of patients who underwent RATS anatomical lung resection by a single surgeon was conducted. Based on the variables found to be different, two propensity-matched groups were created: a next-day discharge group and a group of patients with longer stays. Results: This study included 202 patients, 49 (24.3%) of whom were discharged the next day. The mean age was 68.3 ± 9.8 years, and 114 (56.4%) patients were females. Based on the variables found different, two matched groups with 46 patients for age, gender, performance score, American Society of Anesthesiologists score, number of co-morbidities and Forced Expiratory Volume in 1 sec were created. Re-admissions, complications, and death rates were similar, but next-day discharge patients had more sublobar resections (65.2% vs. 37%, p = 0.029), shorter procedures (132 vs. 179 min, p = 0.048), and morning theater slots (71.7% vs. 32.6, p = 0.018). These were shown to be independent predictors of next-day discharge. Major air leak issues also kept patients in the hospital longer (23.9% vs. 6.5%, p = 0.024). Conclusions: Next-day discharge following RATS anatomical lung resection appeared to have no increased risk of re-admissions or complications, irrespective of fitness, age, or other patient characteristics. Patients receiving short-duration surgery and morning sublobar resections without major air leak issues have higher chances of achieving next-day discharge. Full article
16 pages, 290 KB  
Review
Robotic-Assisted Thoracoscopic Surgery Versus Video-Assisted Thoracoscopic Surgery: Which Is the Preferred Approach for Early-Stage NSCLC?
by Nikolaos Syrigos, Eleni Fyta, Georgios Goumas, Ioannis P. Trontzas, Ioannis Vathiotis, Emmanouil Panagiotou, Nikolaos I. Nikiteas, Elias Kotteas and Dimitrios Dimitroulis
J. Clin. Med. 2025, 14(9), 3032; https://doi.org/10.3390/jcm14093032 - 28 Apr 2025
Viewed by 1045
Abstract
Lung cancer is the leading cause of cancer-related mortality among both men and women worldwide, underscoring the need for an effective treatment strategy. For early-stage non-small cell lung cancer [NSCLC], surgical resection is the standard treatment. Robotic-assisted thoracic surgery [RATS] and video-assisted thoracic [...] Read more.
Lung cancer is the leading cause of cancer-related mortality among both men and women worldwide, underscoring the need for an effective treatment strategy. For early-stage non-small cell lung cancer [NSCLC], surgical resection is the standard treatment. Robotic-assisted thoracic surgery [RATS] and video-assisted thoracic surgery [VATS] are better than open thoracotomy because they are less invasive. Recent lung cancer screening programs are detecting NSCLC at earlier stages, which is expected to result in an increase in the number of NSCLC surgeries as early-stage cases are diagnosed. A limited number of randomized controlled trials have compared RATS and VATS in operable NSCLC. We conducted a literature review to summarize the available evidence on these two surgical techniques. The purpose of this study is to compare the intraoperative and postoperative outcomes of RATS and VATS in early-stage NSCLC patients. RATS shows lower conversion rates to thoracotomy (6.3% vs. 13.1% p < 0.01) and more thorough lymph node dissection than VATS (e.g., 7.5 vs. 5.6 stations, p < 0.001). However, RATS is linked to considerably higher costs (USD 22,582 vs. USD 17,874, p < 0.05) and longer operative times (median 241.7 vs. 214.4 min, p = 0.06). The two techniques exhibited minimal differences in postoperative complications and pain, while RATS patients experienced shortened hospital stays (4–5 vs. 5–6 days, p < 0.006). While the accuracy of staging and treatment planning is improved by the improved lymph node retrieval in RATS, the long-term survival rate is still uncertain. Full article
(This article belongs to the Special Issue Thoracic Surgery: Current Challenges and Future Perspectives)
14 pages, 636 KB  
Review
Technical Innovations and Complex Cases in Robotic Surgery for Lung Cancer: A Narrative Review
by Giacomo Cusumano, Giuseppe Calabrese, Filippo Tommaso Gallina, Francesco Facciolo, Pierluigi Novellis, Giulia Veronesi, Stefano Viscardi, Filippo Lococo, Elisa Meacci, Alberto Terminella, Gaetano Romano, Cristina Zirafa, Franca Melfi, Stefano Margaritora and Marco Chiappetta
Curr. Oncol. 2025, 32(5), 244; https://doi.org/10.3390/curroncol32050244 - 22 Apr 2025
Viewed by 1605
Abstract
For over two decades, robotic-assisted thoracic surgery (RATS) has revolutionized thoracic oncology. With enhanced visualization, dexterity, and precision, RATS has reduced blood loss, shortened hospital stays, and sped up recovery compared to traditional surgery or video-assisted thoracoscopic surgery (VATS). The use of 3D [...] Read more.
For over two decades, robotic-assisted thoracic surgery (RATS) has revolutionized thoracic oncology. With enhanced visualization, dexterity, and precision, RATS has reduced blood loss, shortened hospital stays, and sped up recovery compared to traditional surgery or video-assisted thoracoscopic surgery (VATS). The use of 3D high-definition imaging and articulated instruments allows for complex resections and advanced lymph node assessment. RATS delivers oncological outcomes similar to open surgery and VATS, with high rates of complete (R0) resections and acceptable complication rates. Its minimally invasive nature promotes quicker recovery. Advances in imaging software and augmented reality further enhance surgical accuracy and reduce intraoperative risks. However, RATS has some limitations, including high costs and a lack of tactile feedback, and certain complex procedures, such as extended resections and intrapericardial interventions, remain challenging. With growing experience and technological advances, RATS shows promise in reducing morbidity, improving quality of life, and expanding access to advanced oncologic care. This article reviews the evolution, benefits, and limitations of RATS in NSCLC treatment, highlighting its emerging role in managing complex cases. Full article
(This article belongs to the Section Thoracic Oncology)
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44 pages, 2395 KB  
Systematic Review
Artificial Intelligence in Thoracic Surgery: A Review Bridging Innovation and Clinical Practice for the Next Generation of Surgical Care
by Vasileios Leivaditis, Andreas Antonios Maniatopoulos, Henning Lausberg, Francesk Mulita, Athanasios Papatriantafyllou, Elias Liolis, Eleftherios Beltsios, Antonis Adamou, Nikolaos Kontodimopoulos and Manfred Dahm
J. Clin. Med. 2025, 14(8), 2729; https://doi.org/10.3390/jcm14082729 - 16 Apr 2025
Cited by 4 | Viewed by 3168
Abstract
Background: Artificial intelligence (AI) is rapidly transforming thoracic surgery by enhancing diagnostic accuracy, surgical precision, intraoperative guidance, and postoperative management. AI-driven technologies, including machine learning (ML), deep learning, computer vision, and robotic-assisted surgery, have the potential to optimize clinical workflows and improve patient [...] Read more.
Background: Artificial intelligence (AI) is rapidly transforming thoracic surgery by enhancing diagnostic accuracy, surgical precision, intraoperative guidance, and postoperative management. AI-driven technologies, including machine learning (ML), deep learning, computer vision, and robotic-assisted surgery, have the potential to optimize clinical workflows and improve patient outcomes. However, challenges such as data integration, ethical concerns, and regulatory barriers must be addressed to ensure AI’s safe and effective implementation. This review aims to analyze the current applications, benefits, limitations, and future directions of AI in thoracic surgery. Methods: This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was performed using PubMed, Scopus, Web of Science, and Cochrane Library for studies published up to January 2025. Relevant articles were selected based on predefined inclusion and exclusion criteria, focusing on AI applications in thoracic surgery, including diagnostics, robotic-assisted surgery, intraoperative guidance, and postoperative care. A risk of bias assessment was conducted using the Cochrane Risk of Bias Tool and ROBINS-I for non-randomized studies. Results: Out of 279 identified studies, 36 met the inclusion criteria for qualitative synthesis, highlighting AI’s growing role in diagnostic accuracy, surgical precision, intraoperative guidance, and postoperative care in thoracic surgery. AI-driven imaging analysis and radiomics have improved pulmonary nodule detection, lung cancer classification, and lymph node metastasis prediction, while robotic-assisted thoracic surgery (RATS) has enhanced surgical accuracy, reduced operative times, and improved recovery rates. Intraoperatively, AI-powered image-guided navigation, augmented reality (AR), and real-time decision-support systems have optimized surgical planning and safety. Postoperatively, AI-driven predictive models and wearable monitoring devices have enabled early complication detection and improved patient follow-up. However, challenges remain, including algorithmic biases, a lack of multicenter validation, high implementation costs, and ethical concerns regarding data security and clinical accountability. Despite these limitations, AI has shown significant potential to enhance surgical outcomes, requiring further research and standardized validation for widespread adoption. Conclusions: AI is poised to revolutionize thoracic surgery by enhancing decision-making, improving patient outcomes, and optimizing surgical workflows. However, widespread adoption requires addressing key limitations through multicenter validation studies, standardized AI frameworks, and ethical AI governance. Future research should focus on digital twin technology, federated learning, and explainable AI (XAI) to improve AI interpretability, reliability, and accessibility. With continued advancements and responsible integration, AI will play a pivotal role in shaping the next generation of precision thoracic surgery. Full article
(This article belongs to the Special Issue New Trends in Minimally Invasive Thoracic Surgery)
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14 pages, 3665 KB  
Article
A Novel Method for the Locomotion Control of a Rat Robot via the Electrical Stimulation of the Ventral Tegmental Area and Nigrostriatal Pathway
by Bo Li, Honghao Liu, Guanghui Li, Yiran Lang, Rongyu Tang and Fengbao Yang
Brain Sci. 2025, 15(4), 348; https://doi.org/10.3390/brainsci15040348 - 27 Mar 2025
Cited by 1 | Viewed by 808
Abstract
Background: A rat robot can be constructed by electrically stimulating specific brain regions to control rat locomotion and behavior. The rat robot makes full use of the rat’s motor function and energy supply and has significant advantages in motor flexibility, environmental adaptability, and [...] Read more.
Background: A rat robot can be constructed by electrically stimulating specific brain regions to control rat locomotion and behavior. The rat robot makes full use of the rat’s motor function and energy supply and has significant advantages in motor flexibility, environmental adaptability, and covertness. It can be widely used in disaster search and rescue, terrain survey, anti-terrorism, and explosion-proof tasks. However, the motor control of existing rat robots mainly relies on the virtual whisker touch produced by the electrical stimulation of the barrel area of the somatosensory cortex and the virtual reward generated by the electrical stimulation of the medial forebrain bundle. The methods requires substantial experimental training to encourage the animals to match the virtual sensation with the motor behavior. However, the conditioned reflexes acquired by the animals will gradually disappear after a period of time at the end of the experiments, which will lead to a decrease in the stability of the motor control system. Methods: In this study, we developed a new method to gain control of inclined movement in rats by the electrical stimulation of the ventral tegmental area (VTA) of the midbrain and motor control of steering in rats by the electrical stimulation of nigrostriatal (NS) pathway. Results: The results showed that the electrical stimulation of the rat VTA could induce stable inclined movement in rats and that the neuromodulatory effect significantly correlated with the electrical stimulation parameters. In addition, the electrical stimulation of the NS pathway was able to directly and stably induce the steering movements of the head and trunk to the contralateral side of the stimulated side of the rat. Conclusions: These findings are of great importance for the motor control of rat robots, especially in the field environment with many slopes. In addition, the rat robot constructed based on this method does not need pre-training while ensuring reliability, which greatly improves the preparation efficiency and has certain practical application value. Full article
(This article belongs to the Section Neural Engineering, Neuroergonomics and Neurorobotics)
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27 pages, 540 KB  
Review
Efficacy of Neurorehabilitation Approaches in Traumatic Brain Injury Patients: A Comprehensive Review
by Diana Andrei, Alexandra Laura Mederle, Laura Andreea Ghenciu, Claudia Borza and Alexandra Corina Faur
Life 2025, 15(3), 503; https://doi.org/10.3390/life15030503 - 20 Mar 2025
Cited by 1 | Viewed by 4558
Abstract
Traumatic brain injury (TBI) represents a significant public health issue, causing long-term disabilities and imposing considerable socioeconomic and healthcare challenges. While advancements in acute care have improved survival rates, the demand for effective neurorehabilitation is increasing. This narrative review explores the evidence on [...] Read more.
Traumatic brain injury (TBI) represents a significant public health issue, causing long-term disabilities and imposing considerable socioeconomic and healthcare challenges. While advancements in acute care have improved survival rates, the demand for effective neurorehabilitation is increasing. This narrative review explores the evidence on neurorehabilitation strategies for TBI, focusing on interventions targeting cognitive, motor, and psychological recovery. A total of 32 studies were included and categorized into six approaches: non-invasive brain stimulation, virtual reality (VR), computer-based training, telerehabilitation, robot-assisted therapy (RAT), and mixed approaches. Non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), showed variable effectiveness in improving cognitive outcomes. VR-based therapies enhanced attention and executive functions, while RAT, such as Lokomat and exoskeletons, improved gait symmetry and functional mobility. Computer-assisted programs demonstrated benefits in rehabilitating social cognition and executive functions. Telerehabilitation and telephone-based treatments provided short-term gains but lacked sustained effects. Overall, cognitive improvements were better described and represented, while several motor improvements lacked consistency. Despite the promising results, significant gaps remain, including heterogeneity in methodologies, small sample sizes, and limited long-term outcome data. Full article
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15 pages, 278 KB  
Review
Video-Assisted vs. Robotic-Assisted Thoracoscopic Surgery in Lung Cancer: A Comprehensive Review of Techniques and Outcomes
by Dina Sbeih, Mayar Idkedek and Firas Abu Akar
J. Clin. Med. 2025, 14(5), 1598; https://doi.org/10.3390/jcm14051598 - 26 Feb 2025
Viewed by 4374
Abstract
Lung cancer is the primary cause of cancer-related mortality globally; hence, several medical and surgical approaches have been developed for its management. This can be easily recognized with the evolution from the traditional open thoracotomy toward minimally invasive procedures—in particular, video-assisted thoracoscopic surgery [...] Read more.
Lung cancer is the primary cause of cancer-related mortality globally; hence, several medical and surgical approaches have been developed for its management. This can be easily recognized with the evolution from the traditional open thoracotomy toward minimally invasive procedures—in particular, video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracoscopic surgery (RATS)—in treating lung cancer. There has been a lot of controversy around the advantages and limitations of these procedures. VATS has been proven to be beneficial in treating early-stage lung cancer. Yet, the restricted mobility of its instruments, as well as the lack of a three-dimensional visualization of anatomical components, make the new RATS desired. RATS uses advanced technology, which has resulted in an exceptional high-definition, three-dimensional image of the working field. This has also led to fine dissection with great precision and accuracy, better lymph node removal, reduced postoperative recovery time, and better outcomes. Compared to VATS, there is less blood loss, shorter hospital stays, and less pleural effusion drainage. Despite its higher cost due to the expensive surgical systems, training and maintenance fees, and longer operative time, RATS has started to gain more use, potentially enhancing patient outcomes as experience and technological improvements progress. Full article
16 pages, 811 KB  
Article
Surgical and Neurological Outcomes in Robotic Thymectomy for Myasthenic Patients with Thymoma
by Khrystyna Kuzmych, Dania Nachira, Amelia Evoli, Raffaele Iorio, Carolina Sassorossi, Maria Teresa Congedo, Gregorio Spagni, Alessia Senatore, Giuseppe Calabrese, Stefano Margaritora and Elisa Meacci
Life 2025, 15(3), 371; https://doi.org/10.3390/life15030371 - 26 Feb 2025
Cited by 1 | Viewed by 1245
Abstract
Background: While the safety and feasibility of robotic thymectomy have been well documented through several studies, the surgical and long-term neurological outcomes in patients with thymomatous myasthenia gravis (MG), particularly in advanced stages, remain scarce. This study aims to evaluate the surgical outcomes [...] Read more.
Background: While the safety and feasibility of robotic thymectomy have been well documented through several studies, the surgical and long-term neurological outcomes in patients with thymomatous myasthenia gravis (MG), particularly in advanced stages, remain scarce. This study aims to evaluate the surgical outcomes in patients undergoing robotic-assisted thymectomy (RATS) for thymoma and to analyze neurological outcomes in patients with myasthenia. Material and Methods: Out of 128 robotic thymectomies performed at our institution between October 2013 and January 2022, clinical and pathological data from 55 patients diagnosed with thymoma were reviewed. Of these, thirty (54.5%) patients had concomitant acetylcholine-receptor-antibody-associated MG. Neurological outcomes were assessed using the Myasthenia Gravis Foundation of America post-intervention score (MGFA-PIS). Results: Thirty-nine (70.9%) procedures were performed using the left-sided approach. The mean operative time was 196.9 ± 79.9 min in patients with MG compared to 175.8 ± 61.6 min in non-MG patients (p = 0.285). Additionally, patients with MG had a longer in-hospital stay (4.8 ± 2.6 vs. 3.3 ± 2.2 days, p = 0.01) and a significantly higher need for intensive care unit admission (p < 0.01). No deaths were reported. The rates of conversions (3.3% vs. 4.0%, p = 0.895) and complications (p = 0.813) were comparable between the myasthenic and non-myasthenic thymomas. A multivariable analysis identified lung involvement (p = 0.023), vascular involvement (p = 0.04), and extended resection (p = 0.019) as significant risk factors for conversion and complications. The mean age of surgery for patients with MG was 54.5 ± 15.9 years. After a mean follow-up period of 35.6 ± 25.7 months, 18 (60%) patients with myasthenia showed clinical improvement of their condition. Specifically, 2 patients (6.6%) achieved complete stable remission (CSR), 2 (6.6%) experienced pharmacological remission (PR), 12 (40.0%) demonstrated minimal manifestation (MM), and 4 (13.3%) exhibited a combination of PR and MM. Twelve patients (40%) exhibited no changes, maintaining a stable clinical condition. No clinical worsening was observed. The overall improvement rates at 2 years and 5 years were 38% and 83%, respectively. Conclusions: RATS thymectomy is a safe and feasible approach for patients with thymoma. Patients with coexisting MG may benefit through a good rate of neurological improvement. Full article
(This article belongs to the Special Issue Feature Paper in Physiology and Pathology: 2nd Edition)
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