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Keywords = random phased array

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16 pages, 4886 KB  
Article
Fibonacci Tessellation for Optimizing Planar Phased Arrays in Satellite Communications
by Juan L. Valle, Marco A. Panduro, Carlos A. Brizuela, Roberto Conte, Carlos del Río Bocio and David H. Covarrubias
Technologies 2025, 13(10), 478; https://doi.org/10.3390/technologies13100478 - 21 Oct 2025
Viewed by 549
Abstract
This article presents a novel strategy for the design of planar phased arrays using Fibonacci-based partitioning combined with a random multi-objective search. This approach intends to minimize the number of phase shifters used by the system while maintaining the radiation characteristics required for [...] Read more.
This article presents a novel strategy for the design of planar phased arrays using Fibonacci-based partitioning combined with a random multi-objective search. This approach intends to minimize the number of phase shifters used by the system while maintaining the radiation characteristics required for Ku-band user terminals in Low Earth Orbit (LEO) satellite communications. This methodology efficiently tessellates a 16×16 antenna array, reducing the solution search space size and improving algorithmic computational time. From a total of 409,600 possible configurations, an optimal candidate solution was obtained in 2 h. This configuration achieves a balanced trade-off between radiation performance metrics, including side lobe level (SLL), first null beamwidth (FNBW), and the number of phase shifters. This optimal design maintains a value of SLL below 15 dB across all the azimuth scanning angles, with a beam steering capability of θ=40 and 0ϕ360. These results demonstrate the suitability of this novel approach regarding Ku-band satellite communications, providing efficient and practical solutions for high-demand internet services via LEO satellite systems. Full article
(This article belongs to the Special Issue Technologies Based on Antenna Arrays and Applications)
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26 pages, 7979 KB  
Article
Machine Learning-Driven Inspired MTM and Parasitic Ring Optimization for Enhanced Isolation and Gain in 26 GHz MIMO Antenna Arrays
by Linda Chouikhi, Chaker Essid, Bassem Ben Salah, Mongi Ben Moussa and Hedi Sakli
Micromachines 2025, 16(10), 1082; https://doi.org/10.3390/mi16101082 - 25 Sep 2025
Viewed by 653
Abstract
This paper presents an intelligent design framework for a high-performance 26 GHz MIMO antenna array tailored to 5G applications, built upon a compact single-element patch. The 11.5 mm × 11.5 mm × 1.6 mm microstrip patch on FR4 exhibits near-unity electrical length, an [...] Read more.
This paper presents an intelligent design framework for a high-performance 26 GHz MIMO antenna array tailored to 5G applications, built upon a compact single-element patch. The 11.5 mm × 11.5 mm × 1.6 mm microstrip patch on FR4 exhibits near-unity electrical length, an ultra-deep return loss (S11 < −40 dB at 26 GHz), and a wide operational bandwidth from 24.4 to 31.2 GHz (6.8 GHz, ~26.2%). A two-element array, spaced at λ/2, is first augmented with a inspired metamaterial (MTM) unit cell whose dimensions are optimized via a Multi-Layer Perceptron (MLP) model to maximize gain (+2 dB) while preserving S11. In the second phase, a closed-square parasitic ring is introduced between the elements; its side length, thickness, and position are predicted by a Random Forest (RF) model with Bayesian optimization to minimize mutual coupling (S12) from −25 dB to −58 dB at 26 GHz without significantly degrading S11 (remains below −25 dB). Full-wave simulations and anechoic chamber measurements confirm the ML predictions. The close agreement among predicted, simulated, and measured S-parameters validates the efficacy of the proposed AI-assisted optimization methodology, offering a rapid and reliable route to next-generation millimeter-wave MIMO antenna systems. Full article
(This article belongs to the Special Issue Microwave Passive Components, 3rd Edition)
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17 pages, 3374 KB  
Technical Note
A Novel Real-Time Multi-Channel Error Calibration Architecture for DBF-SAR
by Jinsong Qiu, Zhimin Zhang, Yunkai Deng, Heng Zhang, Wei Wang, Zhen Chen, Sixi Hou, Yihang Feng and Nan Wang
Remote Sens. 2025, 17(16), 2890; https://doi.org/10.3390/rs17162890 - 19 Aug 2025
Viewed by 1060
Abstract
Digital Beamforming SAR (DBF-SAR) provides high-resolution wide-swath imaging capability, yet it is affected by inter-channel amplitude, phase and time-delay errors induced by temperature variations and random error factors. Since all elevation channel data are weighted and summed by the DBF module in real [...] Read more.
Digital Beamforming SAR (DBF-SAR) provides high-resolution wide-swath imaging capability, yet it is affected by inter-channel amplitude, phase and time-delay errors induced by temperature variations and random error factors. Since all elevation channel data are weighted and summed by the DBF module in real time, conventional record-then-compensate approaches cannot meet real-time processing requirements. To resolve the problem, a real-time calibration architecture for Intermediate Frequency DBF (IFDBF) is presented in this paper. The Field-Programmable Gate Array (FPGA) implementation estimates amplitude errors through simple summation, time-delay errors via a simple counter, and phase errors via single-bin Discrete-Time Fourier Transform (DTFT). The time-delay and phase error information are converted into single-tone frequency components through Dechirp processing. The proposed method deliberately employs a reduced-length DTFT implementation to achieve enhanced delay estimation range adaptability. The method completes calibration within tens of PRIs (under 1 s). The proposed method is analyzed and validated through a spaceborne simulation and X-band 16-channel DBF-SAR experiments. Full article
(This article belongs to the Section Remote Sensing Image Processing)
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14 pages, 1805 KB  
Data Descriptor
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Trial: Genetic Resource for Precision Nutrition
by Yuxi Liu, Hailie Fowler, Dong D. Wang, Lisa L. Barnes and Marilyn C. Cornelis
Nutrients 2025, 17(15), 2548; https://doi.org/10.3390/nu17152548 - 4 Aug 2025
Cited by 2 | Viewed by 4448
Abstract
Background: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) was a 3-year, multicenter, randomized controlled trial to test the effects of the MIND diet on cognitive decline in 604 individuals at risk for Alzheimer’s dementia. Here, we describe the genotyping, imputation, and quality control [...] Read more.
Background: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) was a 3-year, multicenter, randomized controlled trial to test the effects of the MIND diet on cognitive decline in 604 individuals at risk for Alzheimer’s dementia. Here, we describe the genotyping, imputation, and quality control (QC) procedures for the genetic data of trial participants. Methods: DNA was extracted from either whole blood or serum, and genotyping was performed using the Infinium Global Diversity Array. Established sample and SNP QC procedures were applied to the genotyping data, followed by imputation using the 1000 Genomes Phase 3 v5 reference panel. Results: Significant study-site, specimen type, and batch effects were observed. A total of 494 individuals of inferred European ancestry and 58 individuals of inferred African ancestry were included in the final imputed dataset. Evaluation of the imputed APOE genotype against gold-standard sequencing data showed high concordance (98.2%). We replicated several known genetic associations identified from previous genome-wide association studies, including SNPs previously linked to adiponectin (rs16861209, p = 1.5 × 10−5), alpha-linolenic acid (rs174547, p = 1.3 × 10−7), and alpha-tocopherol (rs964184, p = 0.003). Conclusions: This dataset represents the first genetic resource derived from a dietary intervention trial focused on cognitive outcomes. It enables investigation of genetic contributions to variability in cognitive response to the MIND diet and supports integrative analyses with other omics data types to elucidate the biological mechanisms underlying cognitive decline. These efforts may ultimately inform precision nutrition strategies to promote cognitive health. Full article
(This article belongs to the Section Nutrigenetics and Nutrigenomics)
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20 pages, 1811 KB  
Article
Enhancing Direction-of-Arrival Estimation for Single-Channel Reconfigurable Intelligent Surface via Phase Coding Design
by Changcheng Hu, Ruoyu Zhang, Jingqi Wang, Boyu Sima, Yue Ma, Chen Miao and Wei Kang
Remote Sens. 2025, 17(14), 2394; https://doi.org/10.3390/rs17142394 - 11 Jul 2025
Viewed by 1017
Abstract
Traditional antenna arrays for direction-of-arrival (DOA) estimation typically require numerous elements to achieve target performance, increasing system complexity and cost. Reconfigurable intelligent surfaces (RISs) offer a promising alternative, yet their performance critically depends on phase coding design. To address this, we propose a [...] Read more.
Traditional antenna arrays for direction-of-arrival (DOA) estimation typically require numerous elements to achieve target performance, increasing system complexity and cost. Reconfigurable intelligent surfaces (RISs) offer a promising alternative, yet their performance critically depends on phase coding design. To address this, we propose a phase coding design method for RIS-aided DOA estimation with a single receiving channel. First, we establish a system model where averaged received signals construct a power-based formulation. This transforms DOA estimation into a compressed sensing-based sparse recovery problem, with the RIS far-field power radiation pattern serving as the measurement matrix. Then, we derive the decoupled expression of the measurement matrix, which consists of the phase coding matrix, propagation phase shifts, and array steering matrix. The phase coding design is then formulated as a Frobenius norm minimization problem, approximating the Gram matrix of the equivalent measurement matrix to an identity matrix. Accordingly, the phase coding design problem is reformulated as a Frobenius norm minimization problem, where the Gram matrix of the equivalent measurement matrix is approximated to an identity matrix. The phase coding is deterministically constructed as the product of a unitary matrix and a partial Hadamard matrix. Simulations demonstrate that the proposed phase coding design outperforms random phase coding in terms of angular estimation accuracy, resolution probability, and the requirement of coding sequences. Full article
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23 pages, 5776 KB  
Article
An In-Depth Statistical Analysis of the TARC Parameter to Evaluate the Real Impact of Random Phases in MIMO Antennas
by Angel Perez-Miguel, Hildeberto Jardon-Aguilar, Jose Alfredo Tirado-Mendez, Ricardo Gomez-Villanueva, Ruben Flores-Leal and Erik Fritz-Andrade
Sensors 2025, 25(13), 4171; https://doi.org/10.3390/s25134171 - 4 Jul 2025
Cited by 1 | Viewed by 1013
Abstract
A detailed statistical analysis of the total active reflection coefficient (TARC) is carried out in this paper for three 4-port MIMO antennas featuring different levels of isolation across its ports. This analysis is very useful to determine the most likely performance of a [...] Read more.
A detailed statistical analysis of the total active reflection coefficient (TARC) is carried out in this paper for three 4-port MIMO antennas featuring different levels of isolation across its ports. This analysis is very useful to determine the most likely performance of a MIMO antenna in a real communications scenario. The TARC parameter is commonly evaluated for only several combinations of the random phase with which a signal reaches every input port of a MIMO antenna. By contrast, we have evaluated a million combinations to obtain the probability density function of the TARC, using frequency as its parameter. In this way, an expected value of the TARC is obtained for each frequency, as well as a confidence interval (ΔCITARC) where the TARC values occur with 90% probability. Additionally, we have introduced the term “TARC shadow”, a visual representation of the TARC as a function of the frequency where the probability function is projected into this 2D graphic with different colors to identify the most likely values of the TARC. To demonstrate these concepts, a full TARC evaluation was performed for three 4-port MIMO antennas with increasing isolation of 12.9 dB, 25.4 dB, and 37 dB between elements, and different values of the Snn and Snm parameters, with n and m= 1 to 4. From this study, the importance of the isolation among ports and its comparison with the return losses becomes evident in achieving a MIMO antenna array insensitive to random phase variations occurring in the communication channel. Full article
(This article belongs to the Special Issue Intelligent Massive-MIMO Systems and Wireless Communications)
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13 pages, 2983 KB  
Article
Impact of Reset Pulse Width on Gradual Conductance Programming in Al2O3/TiOx-Based RRAM
by Hyeonseong Lim, Wonbo Shim and Tae-Hyeon Kim
Micromachines 2025, 16(6), 718; https://doi.org/10.3390/mi16060718 - 17 Jun 2025
Cited by 1 | Viewed by 1683
Abstract
This work investigates the impact of reset pulse width on multilevel conductance programming in Al2O3/TiOx-based resistive random access memory. A 32 × 32 cross-point array of Ti (12 nm)/Pt (62 nm)/Al2O3 (3 nm)/TiOx [...] Read more.
This work investigates the impact of reset pulse width on multilevel conductance programming in Al2O3/TiOx-based resistive random access memory. A 32 × 32 cross-point array of Ti (12 nm)/Pt (62 nm)/Al2O3 (3 nm)/TiOx (32 nm)/Ti (14 nm)/Pt (60 nm) devices (2.5 µm × 2.5 µm active area) was fabricated via e-beam evaporation, atomic layer deposition, and reactive sputtering. Following an initial forming step and a stabilization phase of five DC reset–set cycles, devices were programmed using an incremental step pulse programming (ISPP) scheme. Reset pulses of fixed amplitude were applied with widths of 100 µs, 10 µs, 1 µs, and 100 ns, and the programming sequence was terminated when the read current at 0.2 V exceeded a 45 µA target. At a 100 µs reset pulse width, most cycles exhibited abrupt current jumps that exceeded the target current, whereas at a 100 ns width, the programmed current increased gradually in all cycles, enabling precise conductance tuning. Cycle-to-cycle variation decreased by more than 50% as the reset pulse width was reduced, indicating more uniform filament disruption and regrowth. These findings demonstrate that controlling reset pulse width offers a straightforward route to reliable, linear multilevel operation in Al2O3/TiOx-based RRAM. Full article
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14 pages, 8312 KB  
Article
Influence of Reflow Cycles of the Pb–Free/Pb Hybrid Assembly Process on the IMCs Growth Interface of Micro-Solder Joints
by Xinyuan He, Qi Zhang, Qiming Cui, Yifan Bai, Lincheng Fu, Zicong Zhao, Chuanhang Zou and Yong Wang
Crystals 2025, 15(6), 516; https://doi.org/10.3390/cryst15060516 - 28 May 2025
Cited by 1 | Viewed by 820
Abstract
Under the dual impetus of environmental regulations and reliability requirements, the Pb–free/Pb hybrid assembly process in aerospace-grade ball grid array (BGA) components has become an unavoidable industrial imperative. However, constrained process compatibility during single or multiple reflow protocols amplifies structural heterogeneity in solder [...] Read more.
Under the dual impetus of environmental regulations and reliability requirements, the Pb–free/Pb hybrid assembly process in aerospace-grade ball grid array (BGA) components has become an unavoidable industrial imperative. However, constrained process compatibility during single or multiple reflow protocols amplifies structural heterogeneity in solder joints and accelerates dynamic microstructural evolution, thereby elevating interfacial reliability risks at solder joint interfaces. This paper systematically investigated phase composition, grain dimensions, thickness evolution, and crystallographic orientation patterns of interfacial intermetallic compounds (IMCs) in hybrid micro-solder joints under multiple reflows, employing electron backscatter diffraction (EBSD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). The result shows that the first reflow induces prismatic Cu6Sn5 grain formation driven by Pb aggregation zones and elevated Cu concentration gradients. Surface-protruding fine grains significantly increase kernel average misorientation (KAMave) of 0.68° while minimizing crystallographic orientation preference density (PFmax) of 15.5. Higher aspect ratios correlate with elongated grain morphology, consequently elevating grain size of 5.3 μm and IMC thickness of 5.0 μm. Subsequent reflows fundamentally alter material dynamics: Pb redistribution transitions from clustered to randomized spatial configurations, while grains develop pronounced in-plane orientation preferences that reciprocally influence Sn crystal alignment. The second reflow produces scallop-type grains with minimized dimensions of 4.0 μm and a thickness of 2.1 μm, with a KAMave of 0.37° and PFmax of 20.5. The third reflow initiates uniform growth of scalloped grains of 7.0 μm with a stable population density, whereas the fifth reflow triggers a semicircular grain transformation of 9.1 μm through conspicuous coalescence mechanisms. This work elucidates multiple reflow IMC growth mechanisms in Pb–free/Pb hybrid solder joints, providing critical theoretical and practical insights for optimizing hybrid technologies and reliability management strategies in high-reliability aerospace electronics. Full article
(This article belongs to the Special Issue Surface Modification Treatments of Metallic Materials (2nd Edition))
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18 pages, 7863 KB  
Article
Waveform Optimization for Enhancing the Performance of a Scanning Imaging Radar Utilizing a Terahertz Metamaterial Antenna
by Heng Zhang, Hongqiang Wang, Chenggao Luo, Chuanying Liang and Feng Lan
Remote Sens. 2025, 17(9), 1595; https://doi.org/10.3390/rs17091595 - 30 Apr 2025
Viewed by 1480
Abstract
A scanning radar based on terahertz metamaterial phased array (TMPA) is a novel system for forward-looking imaging. In this paper, a waveform optimization method based on random hopping frequency (RHF) and amplitude modulation is proposed to improve the performance of TMPA scanning imaging [...] Read more.
A scanning radar based on terahertz metamaterial phased array (TMPA) is a novel system for forward-looking imaging. In this paper, a waveform optimization method based on random hopping frequency (RHF) and amplitude modulation is proposed to improve the performance of TMPA scanning imaging radars. The RHF signal waveform is employed to reduce the sidelobes of the range ambiguity function for improving the measurement accuracy in range, while the amplitude modulation is applied to optimize the convolution matrix composed of samples of the antenna pattern, thereby enhancing the azimuth super-resolution. Interestingly, amplitude modulation for waveform design is based on the criterion of minimizing the residual between the real echo and the reconstructed echo with the limited transmission power, without any assumptions about the statistical distribution of target scattering. The effectiveness of the proposed waveform optimization method for enhancing the performance of a TMPA scanning imaging radar is verified through simulations and experiments. Full article
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13 pages, 1171 KB  
Article
Development and Validation of an HPLC-DAD Method to Determine Alkylphenols in Milk
by Serenella Seccia and Irene Dini
Beverages 2025, 11(3), 59; https://doi.org/10.3390/beverages11030059 - 24 Apr 2025
Cited by 2 | Viewed by 2513
Abstract
While providing considerable societal and economic benefits, plastic packaging leads to global pollution and poses health risks. Plastic additives like alkylphenols (APs) can interfere with endocrine functions even at low concentrations. Therefore, developing and validating analytical methods for their routine dosage in foods [...] Read more.
While providing considerable societal and economic benefits, plastic packaging leads to global pollution and poses health risks. Plastic additives like alkylphenols (APs) can interfere with endocrine functions even at low concentrations. Therefore, developing and validating analytical methods for their routine dosage in foods is paramount. The present work validated a chromatographic method to quantify alkylphenols (4-tert-octylphenol, 4-n-octylphenol mono-ethoxylate, 4-n-octylphenol, and 4-n-nonylphenol) in milk. The analytical method uses Chem Elut S a rapid supported liquid extraction (SLE) cartridges to eliminate the matrix effect, and reverse phase chromatography linked to a Diode Array Detector (DAD) to dosage the alkylphenols. The method was validated using the strategy of accuracy profiling, a decision-making instrument that calculates the method’s total error, encompassing bias and standard deviation. The reliability of the test was defined by the lack at the retention times of the APs of interfering peaks, the close linear relationship between the independent and the dependent variables in the regression model, the excellent precision at each concentration level for intra-day and inter-day measurements, and the errors of the procedure (systematic and random) estimated within the pre-established acceptability limits (±10%). The minimal environmental impact and ease of execution suggest its use in routine analyses. Full article
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24 pages, 16264 KB  
Article
Beacon-Based Phased Array Antenna Calibration for Passive Radar
by José P. González-Coma, Rubén Nocelo López, José M. Núñez-Ortuño and Francisco Troncoso-Pastoriza
Remote Sens. 2025, 17(3), 490; https://doi.org/10.3390/rs17030490 - 30 Jan 2025
Cited by 3 | Viewed by 2634
Abstract
Passive radar has drawn a lot of attention due to its applications across military and civilian sectors. Under this working paradigm, the utilization of antenna arrays is instrumental, as it increases the signal quality and enables precise target positioning. These promising features rely, [...] Read more.
Passive radar has drawn a lot of attention due to its applications across military and civilian sectors. Under this working paradigm, the utilization of antenna arrays is instrumental, as it increases the signal quality and enables precise target positioning. These promising features rely, however, on the precise calibration of the antenna array, as the different hardware components introduce impairments that compromise the beamforming capabilities of the system. We propose a technique that employs a low-power external beacon signal to produce precise information about the target location, avoiding the angular ambiguities present in other solutions in the literature. The experimental results demonstrate the method’s ability to effectively correct the amplitude and phase inconsistencies while compensating for frequency drifts, enabling beamforming capabilities and direction-of-arrival estimation. Among the tested beacon waveforms, the pseudo-random noise-based signals proved the most robust, especially in low-power scenarios. Additionally, the method was validated in a passive radar setup, where it successfully detected a vessel using opportunistic signals. These findings highlight the method’s potential to enhance passive radar performance while maintaining a low probability of detection, a key aspect in military applications, as well as its applicability to civilian purposes, such as infrastructure monitoring, environmental observation, and traffic management. Full article
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10 pages, 7201 KB  
Article
Array-Patterned Micro-Structures in Spectacle Lenses Designed for Myopia Control via Image Blur
by Huilv Jiang, Zengwei Zhao, Quan Yuan, Yiqian Li, Ke Ma, Yaoyao Fu, Jiaojie Chen, Jun Jiang and Yiyu Li
Photonics 2025, 12(2), 110; https://doi.org/10.3390/photonics12020110 - 26 Jan 2025
Cited by 4 | Viewed by 2592
Abstract
Using micro-structure components in spectacle lenses has enabled myopia progression control in children and teenagers. However, the optical design of these spectacle lenses has never been discussed, leading to a lack of correct understanding of the underlying optical treatment principles. In this work, [...] Read more.
Using micro-structure components in spectacle lenses has enabled myopia progression control in children and teenagers. However, the optical design of these spectacle lenses has never been discussed, leading to a lack of correct understanding of the underlying optical treatment principles. In this work, array-patterned hexagonal lenslets with two powers of opposite signs were proposed to construct a lenslet array-integrated (LARI) spectacle lens developed for an ongoing, randomized, controlled clinical trial and to support the optical approach to myopia control leveraging retinal image blur. We found that the phase modulation induced by the micro-structures of the lenslet array contributes to the increase in RMS wavefront aberrations, leading to image blur, further inspiring the novel array-patterned micro-structure design with high-order phase elements (HOPEs). The optical performance of both LARI and HOPE spectacle lenses was investigated by simulation and experiment. Full article
(This article belongs to the Special Issue Advances in Visual Optics)
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16 pages, 3804 KB  
Article
Ring Oscillators with Additional Phase Detectors as a Random Source in a Random Number Generator
by Łukasz Matuszewski, Mieczysław Jessa and Jakub Nikonowicz
Entropy 2025, 27(1), 15; https://doi.org/10.3390/e27010015 - 28 Dec 2024
Cited by 1 | Viewed by 1974
Abstract
In this paper, we propose a method to enhance the performance of a random number generator (RNG) that exploits ring oscillators (ROs). Our approach employs additional phase detectors to extract more entropy; thus, RNG uses fewer resources to produce bit sequences that pass [...] Read more.
In this paper, we propose a method to enhance the performance of a random number generator (RNG) that exploits ring oscillators (ROs). Our approach employs additional phase detectors to extract more entropy; thus, RNG uses fewer resources to produce bit sequences that pass all statistical tests proposed by National Institute of Standards and Technology (NIST). Generating a specified number of bits is on-demand, eliminating the need for continuous RNG operation. This feature enhances the security of the produced sequences, as eavesdroppers are unable to observe the continuous random bit generation process, such as through monitoring power lines. Furthermore, our research demonstrates that the proposed RNG’s perfect properties remain unaffected by the manufacturer of the field-programmable gate arrays (FPGAs) used for implementation. This independence ensures the RNG’s reliability and consistency across various FPGA manufacturers. Additionally, we highlight that the tests recommended by the NIST may prove insufficient in assessing the randomness of the output bit streams produced by RO-based RNGs. Full article
(This article belongs to the Section Signal and Data Analysis)
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15 pages, 4130 KB  
Article
Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer
by Muhammad Zubair, Imad Uddin, Robert Dickinson and Chris J. Diederich
Bioengineering 2025, 12(1), 14; https://doi.org/10.3390/bioengineering12010014 - 28 Dec 2024
Cited by 2 | Viewed by 1935
Abstract
In exploring adjuvant therapies for head and neck cancer, hyperthermia (40–45 °C) has shown efficacy in enhancing chemotherapy and radiation, as well as the delivery of liposomal drugs. Current hyperthermia treatments, however, struggle to reach large deep tumors uniformly and non-invasively. This study [...] Read more.
In exploring adjuvant therapies for head and neck cancer, hyperthermia (40–45 °C) has shown efficacy in enhancing chemotherapy and radiation, as well as the delivery of liposomal drugs. Current hyperthermia treatments, however, struggle to reach large deep tumors uniformly and non-invasively. This study investigates the feasibility of delivering targeted uniform hyperthermia deep into the tissue using a non-invasive ultrasound spherical random phased array transducer. Simulations in 3D patient-specific models for thyroid and oropharyngeal cancers assessed the transducer’s proficiency. The transducer consisting of 256 elements randomly positioned on a spherical shell, operated at a frequency of 1 MHz with various phasing schemes and power modulations to analyze 40, 41, and 43 °C isothermal volumes and the penetration depth of the heating volume, along with temperature uniformity within the target area using T10, T50, and T90 temperatures, across different tumor models. Intensity distributions and volumetric temperature contours were calculated to define moderate hyperthermia boundaries. The results indicated the array’s ability to produce controlled heating volumes from 1 to 48 cm3 at 40 °C, 0.35 to 27 cm3 at 41 °C, and 0.1 to 8 cm3 at 43 °C. The heating depths ranged from 7 to 39 mm minimum and 52 to 59 mm maximum, measured from the skin’s inner surface. The transducer, with optimal phasing and water-cooled bolus, confined the heating to the targeted regions effectively. Multifocal sonications also improved the heating homogeneity, reducing the length-to-diameter ratio by 38% when using eight foci versus a single one. This approach shows potential for treating a range of tumors, notably deep-seated and challenging oropharyngeal cancers. Full article
(This article belongs to the Section Biomedical Engineering and Biomaterials)
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19 pages, 9326 KB  
Article
U-Net Driven High-Resolution Complex Field Information Prediction in Single-Shot Four-Step Phase-Shifted Digital Holography Using Polarization Camera
by Askari Mehdi, Yongjun Lim, Kwan-Jung Oh and Jae-Hyeung Park
Photonics 2024, 11(12), 1172; https://doi.org/10.3390/photonics11121172 - 12 Dec 2024
Viewed by 1955
Abstract
We present a novel high-resolution complex field extraction technique utilizing U-Net-based architecture to effectively overcome the inherent resolution limitations of polarization cameras with micro-polarized arrays. Our method extracts high-resolution complex field information, achieving a resolution comparable to that of the original polarization camera. [...] Read more.
We present a novel high-resolution complex field extraction technique utilizing U-Net-based architecture to effectively overcome the inherent resolution limitations of polarization cameras with micro-polarized arrays. Our method extracts high-resolution complex field information, achieving a resolution comparable to that of the original polarization camera. Utilizing the parallel phase-shifting digital holography technique, we extracted high-resolution complex field information from four high-resolution phase-shifted interference patterns predicted by our network directly at the hologram plane. Extracting the object’s complex field directly at the hologram plane rather than the object’s plane, our method eliminates the dependency on numerical propagation during dataset acquisition, enabling reconstruction of objects at various depths without DC and conjugate noise. By training the network with real-valued interference patterns and using only a single pair of low- and high-resolution input and ground truth interference patterns, we simplify computational complexity and improve efficiency. Our simulations demonstrate the network’s robustness to variations in random phase distributions and transverse shifts in the input patterns. The effectiveness of the proposed method is demonstrated through numerical simulations, showing an average improvement of over 4 dB in peak-signal-to-noise ratio and 25% in intensity normalized cross-correlation metrics for object reconstruction quality. Full article
(This article belongs to the Special Issue Holographic Information Processing)
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