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Automated Radiosynthesis of [18F]FluoFAPI and Its Dosimetry and Single Acute Dose Toxicological Evaluation
- Jason A. Witek,
- Allen F. Brooks,
- Sahil M. Kapila,
- Wade P. Winton,
- Jenelle R. Stauff,
- Peter J. H. Scott and
- Benjamin L. Viglianti
Background: Cancer-associated fibroblasts have become a new target for therapy. Fibroblasts present within malignancies express the fibroblast activation protein (FAP). Inhibitors to FAP (FAPI) are small molecules recently developed as a theranostic...