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Article

9 Citations

3,326 Views

27 Pages

Design, Synthesis and Biological Evaluation of Quinazolinamine Derivatives as Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors with Improved Metabolic Stability

Chao-Yun Cai,
Qiu-Xu Teng,
Megumi Murakami,
Suresh V. Ambudkar,
Zhe-Sheng Chen and
Vijaya L. Korlipara

Biomolecules2023, 13(2), 253;https://doi.org/10.3390/biom13020253

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30 January 2023

A series of twenty-two quinazolinamine derivatives showing potent inhibitory activities on breast cancer resistance protein (BCRP) and p-glycoprotein (P-gp) were synthesized. A cyclopropyl-containing quinazolinamine 22 was identified as a dual BCRP a...

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Article

7 Citations

14,675 Views

39 Pages

Structure–Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors

Mathias Elsocht,
Philippe Giron,
Laila Maes,
Wim Versées,
Gustavo J. Gutierrez,
Jacques De Grève and
Steven Ballet

Int. J. Mol. Sci.2021, 22(2), 635;https://doi.org/10.3390/ijms22020635

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10 January 2021

Lung cancer is one of the most frequently diagnosed cancers accounting for the highest number of cancer-related deaths in the world. Despite significant progress including targeted therapies and immunotherapy, the treatment of advanced lung cancer re...

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