Search Results (18,373)

Cryptocurrency trading platforms operate in highly volatile, technology-intensive, and risk-sensitive environments, yet empirical evaluations of their performance from an information systems perspective remain limited. Prior studies applying the DeLone and McLean Information Systems Success Model (ISSM) have largely focused on traditional e-commerce and e-learning contexts, leaving its applicability to cryptocurrency exchanges underexplored. This study addresses this gap by examining how system quality, information quality, and service quality influence system use, user satisfaction, and net benefits in cryptocurrency trading platforms. This study employs a quantitative research design using survey data collected from 389 active Binance users in Indonesia through purposive sampling. The proposed ISSM-based research model was analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM) and Multi Group Analysis (MGA) to assess the relationships among system quality, information quality, service quality, system use, user satisfaction, and perceived net benefits. The findings indicate that four of the nine hypothesized relationships are statistically supported. System quality emerges as the most influential determinant of both system use and user satisfaction, highlighting the importance of platform reliability, performance, and usability. Information quality also demonstrates a significant effect, whereas service quality exhibits a limited direct influence on user outcomes. Overall, system use and performance-related factors play a more critical role in driving perceived net benefits than service-related attributes. This study extends the DeLone and McLean ISSM to the context of cryptocurrency trading platforms and demonstrates its relevance in high-risk, blockchain-based financial environments. The results offer theoretical insights by refining the relative importance of ISSM constructs in fintech settings and provide practical guidance for developers and platform architects to prioritize system robustness, efficiency, and usability to enhance user satisfaction and engagement. Full article

To achieve the resource utilization of iron tailings sand and improve the skid resistance of asphalt pavement, this study takes asphalt mixtures with different contents of iron tailings sand replacing partial fine aggregates as research objects. Through accelerated wear tests, the skid resistance performance was systematically evaluated under the coupled effects of iron tailings sand content, ambient temperature and wear cycles. The variation laws of the British Pendulum Number (BPN) and Mean Texture Depth (MTD) of the mixtures were investigated, and the mechanism and influence characteristics of various factors on skid resistance were further interpreted in combination with correlation heatmap analysis. The results show that the mixture with 60% iron tailings sand content maintains relatively high initial and final attenuation values of both BPN and MTD, which can effectively delay the degradation of skid resistance under long-term wear, thus representing the preferred content for engineering applications. Temperature is the core environmental factor affecting skid resistance: high temperature accelerates performance degradation, while the mixtures exhibit more stable skid resistance under medium- and low-temperature conditions. The coupling of high iron tailings content and high temperature produces adverse interaction effects, leading to performance differentiation. The relevant quantitative analysis and fitting models enable the long-term prediction of skid resistance, providing support for pavement maintenance decision making. Full article

Thoracic aortopathies, including aneurysm and dissection, are complex vascular disorders characterized by structural alterations of the aortic wall that disrupt normal haemodynamics. Altered shear stress, turbulent flow, and endothelial dysfunction promote thrombus formation and modulate systemic hemostasis via platelet activation and the von Willebrand factor–ADAMTS13 axis. The Total Thrombus-Formation Analysis System (T-TAS) is a microfluidic, flow-dependent assay that quantitatively evaluates thrombus formation under physiological shear conditions. Although studied in various cardiovascular contexts, its application in aortopathies remains largely unexplored, and no prospective studies have validated its clinical utility. Integrating T-TAS with computational haemodynamic approaches, such as two-way fluid–structure interaction simulations, enables assessment of the interplay between blood flow, vessel wall mechanics, pulse wave propagation, and local shear patterns. Patient-specific modelling, including individualized flow profiles, pressure distributions, and wall properties, may enhance mechanistic insights. Genetic variants in Fibrillin-1 gene (FBN1), Transforming Growth Factor Beta Receptor 1/2 (TGFBR1/2), Actin Alpha 2 (ACTA 2), and Myosin Heavy Chain 11 (MYH11) further contribute to structural vascular heterogeneity and diverse systemic haemostatic phenotypes, highlighting the need for personalized assessment. T-TAS should currently be considered an exploratory research tool rather than a validated diagnostic or prognostic method. This narrative review proposes a hypothesis-generating framework integrating structural, haemodynamic, molecular, and functional perspectives. Combining flow-based thrombosis assays with advanced modelling may inform future translational studies, improve mechanistic understanding of thrombus formation, and support personalized risk stratification and management in patients with thoracic aortopathies. Full article

Soft-ground-story configurations in high-rise buildings present a critical vulnerability during seismic events, often leading to disproportionate structural damage and collapse. This study focuses on the systematic identification of soft-ground-story high-rise structures in Bucharest, a city located in a high seismic hazard zone influenced by Vrancea intermediate-depth earthquakes. The research employs a multi-step methodology combining field surveys, structural documentation, and analysis of architectural layouts from various sources to detect soft-ground-story irregularities across the urban building stock in Bucharest. The findings reveal that such configurations remain prevalent in mixed-use structures along major boulevards, where open ground floors were historically favoured for commercial purposes. The results provide a database of soft-ground-story high-rise buildings in Bucharest, highlighting their prevalence in distinct urban districts and their potential impact on seismic risk. Quantitative screening indicators, vertical element area ratio and mean axial stress in ground-story columns, are proposed for rapid vulnerability assessment. Dynamic measurements confirm a 33–38% increase in fundamental eigenperiods after the 1977 earthquake, indicating moderate-to-extensive damage states. These findings underscore the urgent need for targeted retrofitting strategies and inform seismic risk mitigation policies. The study provides a foundation for future integration of advanced diagnostic tools, such as image-based deep learning and vibration monitoring, into citywide seismic resilience planning. Full article

Traffic accidents represent a significant threat to individuals, with motorcycles frequently involved. Despite concerted efforts by organizations like the World Health Organization and governments worldwide, reducing accident rates remains a challenge. Notably, Indonesia has witnessed a surge in traffic accidents, with motorcycles being a prominent mode of transport. This study aims to evaluate situational awareness and motorcycle riders’ behavior among Indonesians, with respect to factors such as riding time and age. This study involves laboratory-based research and uses quantitative primary data collected with the Situation Awareness Global Assessment Technique (SAGAT), the Situation Present Assessment Method (SPAM), and the Motorcycle Rider Behavior Questionnaire (MRBQ). The results indicate that overall situation awareness is low, with the lowest level among young riders. Nighttime situational awareness is also lower than during the daytime. Recommendations to improve situation awareness include periodic training with scenario-based sessions for motorcycle riders, strict adherence to driving regulations, the potential integration of motorcycle simulators, and prioritizing the program to enhance young riders’ situation awareness. These recommendations aim to boost rider safety and reduce motorcycle accidents. Full article

Currently, deep mining has become the development trend of underground mines, and the harsh working environment underground seriously affects the efficiency of personnel and equipment operations. The operational efficiency of the human–machine system composed of personnel and equipment is not only affected by the status of personnel and equipment, but also closely related to the interaction between human–machine–environment. How to ensure the efficient operation of human–machine systems has become the key to improving the quality and efficiency of mines. Therefore, in order to analyze the interaction relationship between human–machine–environment in the process of human–machine system operation and explore the variation law of human–machine system efficiency. This paper constructs a deep mining human–machine system efficiency system dynamics model under the multi-factor coupling effect of deep well mining, guided by system dynamics theory, and obtains the variation laws of system efficiency under single-factor changes and multi-factor coupling effects. The research results solve the problem of difficulty in quantitatively describing the logical and quantitative relationships between various elements in the study of human–machine system efficiency, providing new ideas for the study of underground work efficiency. Through mathematical modeling, the temperature threshold for the efficient operation of the human–machine system is determined, and the quantitative relationships among temperature, humidity, and wind speed are elaborated, providing a reference for ensuring the efficient operation of the human–machine system in deep mining. Full article

Background: Vitamin D plays an important role in overall health. This study aimed to conduct a pilot screening of serum vitamin D levels in a Malagasy cohort and to compare vitamin D status groups with selected health indicators. Methods: A cross-sectional observational pilot study was performed in two geographically distinct regions of Madagascar—a coastal area and an inland area. In total, 150 individuals underwent a single health screening, including semi-quantitative assessment of serum 25-hydroxyvitamin D, as well as evaluation of glycemic and cholesterol levels, blood pressure, anthropometric parameters, and a brief personal and lifestyle questionnaire. Results: A total of 148 participants (aged 18–88 years) were analyzed. 45.9% of participants had low serum vitamin D levels (<75 nmol/L). Lower vitamin D levels and higher total cholesterol were observed in the coastal group compared to the inland group (p < 0.05). No significant differences were found for most other examined health indicators. In multivariable analysis, age was identified as an important determinant of several outcomes. Vitamin D status did not remain an independent predictor; however, a trend toward an independent association with hypercholesterolemia was observed (p = 0.07), while the association with hyperglycemia was less pronounced (p = 0.11). Conclusions: A substantial proportion of participants exhibited low vitamin D levels despite favorable geographic conditions. The results suggest a potential relationship between vitamin D status and lipid metabolism, although this association did not reach statistical significance after adjustment. These findings provide initial insight into vitamin D status and its potential associations in this setting and may inform future research and public health monitoring. Full article

This study quantifies the sustainable development thresholds of marine ecosystems under high-intensity human development by establishing a composite evaluation framework based on the Pressure–State–Response (PSR) model. Taking the Nantong sea area as a typical study region, this research indicates that prior to large-scale development (2006–2010), the comprehensive carrying capacity was higher in the northern region than in the south. The lowest capacity was observed near the Yangtze River Estuary, while the Subei Radial Sand Ridges in the north exhibited the highest capacity. Following the period of intensive coastal development (2016–2020), a significant decline in composite marine carrying capacity occurred in the northern radial sand ridge area, whereas the central waters remained stable. The nearshore areas in the south exhibited the poorest capacity. Despite a substantial increase in anthropogenic pressure, the overall decline of the sea area’s composite marine carrying capacity remains within an acceptable range, with all levels categorized as “Near Carrying Capacity” or above. Quantitative assessment of marine environmental carrying capacity and marine ecological carrying capacity provides an effective pathway for monitoring the specific status of the marine environment and determining whether critical thresholds have been reached under high-intensity human development scenarios. Full article

This study explores the intricate behavioral consumer psychology dynamics of how certain elements—color, price, gender differences, and the concept of the frequency illusion—affect emotions, brand awareness, and consumer decision-making in a digital environment. Going beyond conventional analyses, this study also explores the intersection of sustainable business practices, elucidating the potential for ethical, environmentally conscious, and business-sustainable decision-making. Utilizing a quantitative method and survey data from 207 respondents, this research contributes to a more profound level of understanding of consumer decision-making in the Lebanese retail sector, offering strategic insights for organizations seeking to enhance brand recognition, while aligning with responsible and sustainable practices in today’s dynamic and competitive environment. The study found that psychological cues—color, price, gender differences, and frequency illusion—significantly influence emotions, brand awareness, and consumer decision-making in retail. Future research should examine the tensions in consumer decision-making, where brand awareness and emotional cues can simultaneously facilitate and bias choices, with effects contingent on exposure, demographic characteristics, digital fluency, and cultural context. Full article

Background: Sustainability-oriented higher education research has increasingly foregrounded staff wellbeing, motivational practice, and instructional continuity as central to long-term educational effectiveness. However, empirical evidence remains limited for university English language teaching (ELT) instructors operating within fragile, post-conflict, and regionally uneven systems such as Libya. In particular, little is known about whether job satisfaction is translated into motivational teaching behaviour through teacher self-efficacy, or how such relationships vary across demographic and institutional contexts. Addressing this gap is critical for understanding human-capital sustainability in higher education systems facing structural instability. Methods: A quantitative cross-sectional online survey was conducted using Google Forms and regionally stratified convenience sampling across Libya’s Western, Eastern, Central, and Southern regions. The final sample comprised 385 eligible university ELT instructors, including both full-time and part-time staff. Data were collected using three validated instruments: an adapted Teacher Job Satisfaction Questionnaire (21 items), a teacher self-efficacy scale (12 items), and a motivational teaching strategies scale (18 items). All measures demonstrated satisfactory internal consistency. Data analysis was performed using IBM SPSS Statistics v29, applying descriptive statistics, Pearson correlation analysis, regression-based mediation analysis with bootstrapping, and group comparisons using independent-samples t-tests and one-way ANOVA. Results: The sample included 57.14% male and 42.86% female instructors, with 62.86% employed full-time and the majority reporting 6–10 years of teaching experience (51.95%). Mean scores indicated moderate levels of job satisfaction (M = 3.32, SD = 0.94) and teacher self-efficacy (M = 3.03, SD = 0.68), alongside high levels of motivational teaching strategies (M = 4.15, SD = 0.87). Job satisfaction was positively associated with motivational teaching strategies (r = 0.61, p < 0.001) and teacher self-efficacy (r = 0.49, p < 0.001), while teacher self-efficacy was also positively related to motivational strategies (r = 0.53, p < 0.001). Mediation analysis revealed a significant partial mediating effect of teacher self-efficacy (indirect effect = 0.19, 95% CI [0.12, 0.28]). Significant differences were observed across demographic variables (age, gender, teaching experience) and institutional characteristics (employment status and university region). Conclusions: The findings indicate that sustainable teaching practice in Libyan higher education has been jointly shaped by organisational satisfaction and teachers’ capability beliefs. These results underscore the importance of context-sensitive institutional policies that support both structural working conditions and psychological resources. Future research could extend this evidence through longitudinal and mixed-methods designs to deepen understanding of sustainability-oriented teaching dynamics in fragile higher education systems. Full article

Background: Mindful eating strategies have shown promise in addressing obesity and food insecurity among children. However, limited research has examined the acceptability of mindful eating programs among low-socioeconomic families in rural areas. This study evaluated caregivers’ and teachers’ acceptability and satisfaction with a 14-week, school-based mindful eating program for preschoolers to inform future implementation. The program effectively improved home eating environment, household food insecurity, and child body mass index. Methods: A convergent parallel mixed methods study design was used to evaluate the 14-week mindful eating intervention among 200 preschoolers from 26 Head Start classrooms in rural Michigan, United States. After intervention completion, acceptability and satisfaction data were collected and assessed from 192 caregivers and 23 classroom teachers via (1) quantitative online survey data analyzed using descriptive statistics, and (2) qualitative data from individual interviews completed with a subset of parents and teachers that were analyzed with thematic analysis. Results: Both quantitative and qualitative data showed high acceptability and satisfaction. Caregivers (survey: 88.9%, interview: 94.1%) and teachers (survey: 87.0%, interview: 100%) were satisfied with the program. Teachers (survey: 82.6%, interview: 87.5%) agreed the program improved children’s eating behaviors. Most surveyed caregivers (81.0%) agreed the completion of child letters sent home after the program session helped caregiver–child communication. Several barriers and suggestions for implementation were also identified by interviewed teachers and caregivers, including the limited availability of specific fruits and vegetables in local areas, concerns about preschoolers’ comprehension of curriculum, and recommendations on improving recruitment strategies. Conclusions: This study highlighted the high acceptability and satisfaction of a mindful eating program among caregivers and classroom teachers. The findings offered implications for future interventions to integrate mindful eating programs into early childcare organizations to help address child obesity and food insecurity. Future research exploring nutrition-related policies to sustain implementation of mindful eating programs is needed. Clinical Trial Registration: The clinical trial was registered at ClinicalTrials.gov (NCT05780008) on 27 February 2023. Full article

The prevalence of osteoporosis, a skeletal disorder characterized by reduced bone mass, microarchitectural deterioration, and increased fracture risk, poses a substantial global healthcare burden. Although animal models and two-dimensional cell cultures have been used to advance bone research, they do not completely replicate the multicellular interactions, extracellular matrix organization, and biomechanical environment of human bone, limiting their translational relevance. This review provides a critical synthesis of recent advances in bone organoid technology, emphasizing biological complexity, technical innovation, and relevance to osteoporosis modeling. Beyond summarizing progress, we distinguish validated capabilities from aspirational claims and identify the methodological gaps that must be addressed before bone organoids can reliably support drug screening, regenerative medicine, and precision approaches. Advances in stem cell biology, tissue engineering, and three-dimensional culture systems have enabled the use of self-organizing, multicellular organoids that reproduce key physiological and pathological features of bone. These systems model estrogen-deficiency-induced bone loss, glucocorticoid-associated osteoporosis, aging-related degeneration, and genetic susceptibility. By integrating osteogenic and endothelial components within biomimetic matrices, bone organoids can support mechanistic studies and pharmacological testing. However, their incomplete vascularization, limited mechanical fidelity, instability, and lack of standardized benchmarks restrict their translational readiness. Overcoming these barriers requires technological refinement, quantitative metrics, and regulatory alignment. Full article

Objectives: To quantitatively evaluate the inhibitory effects of commercially available probiotic formulations (Probien, Enterogermina, Reflor) applied as intracanal medicaments against mature dual-species biofilms of Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans) using a qPCR-based in vitro root canal model, with calcium hydroxide included as the reference intracanal medicament for comparison. Materials and Methods: Root canal specimens containing mature dual-species biofilms were medicated with probiotic–poloxamer gel formulations (Probien, Enterogermina, or Reflor) or calcium hydroxide (reference inhibitory control); infected but untreated canals served as the non-inhibitory control, and sterile non-inoculated specimens were included to confirm procedural sterility. After a 7-day intracanal application period, microbial loads were quantified at baseline and post-treatment by qPCR, and results were expressed as delta cycle threshold (ΔCt), colony-forming equivalents (CFE/mL), and percentage reduction values. Results: A total of 78 specimens (n = 13 per group) were analyzed. No significant intergroup differences were found in E. faecalis ΔCt or reduction percentages (p > 0.05), indicating its persistence despite intracanal medication. For C. albicans, differences among groups were significant (p < 0.001). Calcium hydroxide showed the strongest antifungal effect, producing marked ΔCt and CFE reductions versus probiotic and positive control groups, whereas probiotic formulations displayed only limited antifungal activity and no measurable inhibition against E. faecalis. Conclusions: Under the conditions of this in vitro model, the tested commercially available probiotic formulations—originally developed for gastrointestinal use—did not demonstrate significant antimicrobial effects against mature E. faecalis–C. albicans biofilms. These findings should be interpreted in the context of the absence of probiotic formulations specifically designed for intracanal use and the distinct ecological characteristics of the root canal system, which represents a closed, low-oxygen environment dominated by hard-tissue surfaces. Rather than excluding the potential of probiotics in endodontics, the present results highlight the need for root canal–adapted probiotic strains and delivery strategies tailored to intracanal conditions. Clinical Relevance: This in vitro study provides experimental insight into the limitations of directly applying commercially available gastrointestinal probiotic formulations within the root canal system. The findings highlight the importance of developing root canal–specific probiotic strains and delivery strategies tailored to the unique ecological conditions of the intracanal environment, thereby informing future translational and experimental research in biological endodontics. Full article

Rapid urbanization-induced extreme rainstorms severely disrupt social functions. Previous research often focused on “de-densification” strategies, which are difficult to adapt to high-density Sponge City Stormwater Management Units (SMUs) that carry core development functions. This study uses Shenzhen as a case study, utilizing Keep movement big data as a “social sensor” for system function perception and introducing the Socio-Ecological-Technological Systems (SETS) theory to construct a “recovery (RCN)–resistance (MI)” binary assessment framework. Through systematic clustering and hierarchical regression models, the driving mechanisms of blue landscape patterns, topography, road networks, and the built environment on social behavioral resilience are systematically parsed. The results show: (1) Road network morphology dominates resistance, while multi-dimensional elements collaborate for recovery. Resistance (MI) is primarily dominated by macro road network detour resistance (TPD2000, β = 0.956), while recovery depends on the synergistic support of blue space interspersion (Blue_IJI), topography, and micro-circulation road networks. (2) Green infrastructure fails in the model due to efficiency bottlenecks, empirical evidence of weakened regulation caused by green space fragmentation in ultra-high-density environments. (3) Low-density, eco-centric built environments provide dual synergistic gains for resilience. Based on this, a “Bidirectional Socio-Ecological Resilience Needs Pyramid” model is constructed, identifying four governance types such as the “Synergistic Balanced Type”. This study provides a quantitative basis for the transition from administrative control to precise morphological governance in high-density cities. Full article

In the 21st century, rapid urban development during global urbanization has led to high-density environments. These settings have become a significant cause of stress-related health problems for residents. Healing street design plays an important role in helping address mental health challenges caused by this process. Current research often focuses on healing elements and methods from only a single field. As a result, it lacks the integration of multidisciplinary and multi-stakeholder perspectives. To address this gap, this paper formed a Delphi expert panel with multidisciplinary scholars, urban managers, and practicing designers. The panel developed a quantitative evaluation model. This model covers four core dimensions: Safety (0.3210), Attractiveness (0.1080), Friendliness (0.2155), and Comfort (0.3553). It also includes eleven healing elements, such as Pedestrian Right-of-Way (0.4131), Night Lighting (0.3209), Visual Landscape (0.759), Street Furniture (0.4000), and Street Scale (0.3274). Using this model, the healing potential of Jingliu Road in Zhengzhou was assessed. The analysis identified the overall healing potential, core healing dimensions, and shortcomings of the street. This finding provides a clear direction for future healing-oriented street design. This paper builds a healing system for pedestrian spaces in high-density urban streets in China. It thus offers an evidence-based scientific tool for environmental design. Healing environments have expanded from less accessible spaces, such as squares and parks, to interactive and accessible streets. This transition enhances urban spaces’ capacity to address residents’ mental health concerns and promotes public health. Additionally, this paper offers specific recommendations for planners and policymakers to prioritize healing elements in urban renewal projects. Full article