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24 pages, 13302 KB  
Article
Investigation of the Effects of Ambient Conditions and Injection Strategies on Methanol Spray Characteristics
by Decheng Wang, Wuzhe Zhu, Zhijie Li, Changhui Zhai, Xiaoxiao Zeng, Kui Shi, Yunliang Qi and Zhi Wang
Energies 2026, 19(2), 416; https://doi.org/10.3390/en19020416 - 14 Jan 2026
Viewed by 365
Abstract
To reveal the physical evolution of methanol spray under different environmental conditions and injection strategies, this study focuses on the atomization and evaporation behavior of low-pressure methanol spray. The coupled effects of temperature, pressure, and injection parameters are systematically investigated based on constant-volume [...] Read more.
To reveal the physical evolution of methanol spray under different environmental conditions and injection strategies, this study focuses on the atomization and evaporation behavior of low-pressure methanol spray. The coupled effects of temperature, pressure, and injection parameters are systematically investigated based on constant-volume combustion chamber experiments and three-dimensional CFD simulations. The formation, evolution, and interaction mechanisms of the liquid column core and cooling core are revealed. The results indicate that temperature is the dominant factor influencing methanol spray atomization. When the temperature increases from 255 K to 333 K, the spray penetration distance increases by approximately 70%, accompanied by a pronounced shortening of the liquid-core length and enhanced evaporation and air entrainment. Under low-temperature conditions, a stable liquid-core structure and a strong cooling core are formed, characterized by a high-density, long-axis morphology and an extensive low-temperature region, which suppress fuel–air mixing and ignition. Increasing the ambient pressure improves spray–air mixing but reduces penetration; at 255 K, increasing the ambient pressure from 0.05 MPa to 0.2 MPa increases the spray cone angle by approximately 10% while reducing the penetration distance by about 50%. Furthermore, optimizing the injection pressure or shortening the injection pulse width effectively enhances atomization performance: increasing the injection pressure from 0.4 MPa to 0.6 MPa and reducing the pulse width from 5 ms to 2 ms increases the penetration distance by approximately 30% and reduces the mean droplet diameter by about 20%. Full article
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24 pages, 3847 KB  
Article
Seismic Failure Mechanism Shift in RC Buildings Revealed by NDT-Supported, Field-Calibrated BIM-Based Models
by Mehmet Esen Eren and Cenk Fenerli
Appl. Sci. 2026, 16(1), 455; https://doi.org/10.3390/app16010455 - 1 Jan 2026
Viewed by 495
Abstract
This study proposes a field-calibrated, NDT-integrated BIM modeling framework to improve the reliability of post-earthquake assessment for reinforced concrete (RC) buildings. The approach combines destructive and nondestructive testing (NDT) data—including core drilling, Schmidt hammer, ultrasonic pulse velocity (UPV), and Windsor probe—through a site-specific [...] Read more.
This study proposes a field-calibrated, NDT-integrated BIM modeling framework to improve the reliability of post-earthquake assessment for reinforced concrete (RC) buildings. The approach combines destructive and nondestructive testing (NDT) data—including core drilling, Schmidt hammer, ultrasonic pulse velocity (UPV), and Windsor probe—through a site-specific WinSonReb regression model. The calibrated material properties (average compressive strength ≈ 18.6 MPa, CoV > 20%) were embedded into a Building Information Modeling (BIM) environment, producing an as-is, NDT-calibrated BIM model representing a Level-2 static digital twin of the structure. Nonlinear static pushover analyses performed in accordance with TBDY-2018 and ASCE 41-17 showed that the calibrated model exhibits a fundamental period of 0.85 s—approximately 18% longer than the uncalibrated BIM model. This elongation increased displacement demand and caused a shift in performance classification: while the uncalibrated model indicated Life Safety (LS), the calibrated model predicted behavior approaching Collapse Prevention (CP) in the Y direction. Furthermore, calibration reversed the predicted damage hierarchy, from ductile beam hinging to brittle column- and wall-controlled failure near elevator openings, consistent with post-event observations from the 2023 Kahramanmaraş earthquakes. These results demonstrate that integrating field-calibrated NDT data into BIM-based seismic models fundamentally alters both strength estimation and failure-mechanism prediction, reducing epistemic uncertainty and providing a more conservative basis for retrofit prioritization. Although demonstrated on a single case study, the proposed workflow offers a realistic and scalable pathway for NDT-supported seismic performance assessment of existing RC buildings. Full article
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19 pages, 7079 KB  
Article
A Six-Tap 720 × 488-Pixel Short-Pulse Indirect Time-of-Flight Image Sensor for 100 m Outdoor Measurements
by Koji Itaba, Kamel Mars, Keita Yasutomi, Keiichiro Kagawa and Shoji Kawahito
Sensors 2026, 26(1), 26; https://doi.org/10.3390/s26010026 - 19 Dec 2025
Viewed by 718
Abstract
Long-range, high-resolution distance measurement with high ambient-light tolerance has been achieved using a 720 × 488-resolution short-pulse indirect time-of-flight (SP-iToF) image sensor featuring six-tap, one-drain pixels fabricated by a front-side illumination (FSI) process. The sensor performs 30-phase demodulation through six-tap pixels in each [...] Read more.
Long-range, high-resolution distance measurement with high ambient-light tolerance has been achieved using a 720 × 488-resolution short-pulse indirect time-of-flight (SP-iToF) image sensor featuring six-tap, one-drain pixels fabricated by a front-side illumination (FSI) process. The sensor performs 30-phase demodulation through six-tap pixels in each subframe, combined with five range-shifted subframe (SF) readouts. The six-tap demodulation pixel, designed with a lateral drift-field pinned photodiode, demonstrates over 90% demodulation contrast for a 20 ns light-pulse width. High-speed column-parallel 12-bit cyclic ADCs enable all six-tap subframe signals to be read within 4.38 ms. This high-speed subframe readout, together with efficient exposure-time allocation across the five subframes, enables a depth-image frame rate of 10 fps. The multi-phase demodulation in SP-iToF measurements, operating with an extremely small duty ratio of 0.2%, effectively suppresses ambient-light charge accumulation and the associated shot noise in the pixel. As a result, distance measurements up to 100 m under 100 klux illumination are achieved, with depth noise maintained below 1%. Full article
(This article belongs to the Collection 3D Imaging and Sensing System)
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11 pages, 1487 KB  
Article
Increasing the Reliability and Versatility of Jellyfish Biohybrid Vehicles via Species Selection and Rhopalia Removal
by Simon R. Anuszczyk, Noa Yoder, John H. Costello, John O. Dabiri, Brad J. Gemmell, Kelsi M. Rutledge and Sean P. Colin
Biomimetics 2025, 10(12), 810; https://doi.org/10.3390/biomimetics10120810 - 3 Dec 2025
Viewed by 645
Abstract
Jellyfish biohybrid robots have been demonstrated to be successfully programmed to perform vertical sampling profiles of the ocean water column. However, the jellyfish’s endogenous swimming behavior can interfere with the controlled swim cycles, decreasing performance. Further, the model animal used to date, Aurelia [...] Read more.
Jellyfish biohybrid robots have been demonstrated to be successfully programmed to perform vertical sampling profiles of the ocean water column. However, the jellyfish’s endogenous swimming behavior can interfere with the controlled swim cycles, decreasing performance. Further, the model animal used to date, Aurelia aurita, is a relatively slow, weakly swimming species. To enhance the performance of the biohybrid vehicles, we tested whether removing the swimming pacemaker of the jellyfish, the rhopalia, eliminated endogenous movements and enhanced responsiveness of the jellyfish to the swim controller. Further, we tested the responsiveness of two fast-swimming jellyfish species, the rhizostome Cassiopea spp. and the cubomedusae Alatina alata. We found in field trials, where the jellyfish swam controlled vertical profiles in the ocean, that removal of rhopalia eliminated all endogenous behaviors and greatly improved the responsiveness of the jellyfish to the swim controller. This was especially true for species with strong endogenous behaviors that prevented the controller from manipulating swim pulses. Further, we found that both Cassiopea spp. and A. alata were highly responsive to the swim controller and that these faster-swimming jellyfish species greatly increased the speed at which the biohybrid vehicle could traverse vertical profiles in the water column. These enhancements greatly increase the reliability and versatility of jellyfish biohybrid robot vehicles. Full article
(This article belongs to the Section Biomimetic Design, Constructions and Devices)
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24 pages, 6546 KB  
Article
Waveform Analysis for Enhancing Airborne LiDAR Bathymetry in Turbid and Shallow Tidal Flats of the Korean West Coast
by Hyejin Kim and Jaebin Lee
Remote Sens. 2025, 17(23), 3883; https://doi.org/10.3390/rs17233883 - 29 Nov 2025
Viewed by 857
Abstract
Tidal flats play a vital role in coastal ecosystems by supporting biodiversity, mitigating natural hazards, and functioning as blue carbon reservoirs. However, monitoring their geomorphological changes remains challenging due to high turbidity, shallow depths, and tidal variability. Conventional approaches—such as satellite remote sensing, [...] Read more.
Tidal flats play a vital role in coastal ecosystems by supporting biodiversity, mitigating natural hazards, and functioning as blue carbon reservoirs. However, monitoring their geomorphological changes remains challenging due to high turbidity, shallow depths, and tidal variability. Conventional approaches—such as satellite remote sensing, acoustic sounding, and topographic LiDAR—face limitations in resolution, accessibility, or coverage of submerged areas. Airborne bathymetric LiDAR (ABL), which uses green laser pulses to detect reflections from both the water surface and seabed, has emerged as a promising alternative. Unlike traditional discrete-return data, full waveform analysis offers greater accuracy, resolution, and reliability, enabling more flexible point cloud generation and extraction of additional signal parameters. A critical step in ABL processing is waveform decomposition, which separates complex returns into individual components. Conventional methods typically assume fixed models with three returns (water surface, water column, bottom), which perform adequately in clear waters but deteriorate under shallow and turbid conditions. To address these limitations, we propose an adaptive progressive Gaussian decomposition (APGD) tailored to tidal flat environments. APGD introduces adaptive signal range selection and termination criteria to suppress noise, better accommodate asymmetric echoes, and incorporates a water-layer classification module. Validation with datasets from Korea’s west coast tidal flats acquired by the Seahawk ABL system demonstrates that APGD outperforms both the vendor software and the conventional PGD, yielding higher reliability in bottom detection and improved bathymetric completeness. At the two test sites with different turbidity conditions, APGD achieved seabed coverage ratios of 66.7–70.4% and bottom-classification accuracies of 97.3% and 96.7%. Depth accuracy assessments further confirmed that APGD reduced mean depth errors compared with PGD, effectively minimizing systematic bias in bathymetric estimation. These results demonstrate APGD as a practical and effective tool for enhancing tidal flat monitoring and management. Full article
(This article belongs to the Special Issue Remote Sensing of Coastal, Wetland, and Intertidal Zones)
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25 pages, 3960 KB  
Article
Spatial Structure and Temporal Dynamics in Clear Lake, CA: The Role of Wind in Promoting and Sustaining Harmful Cyanobacterial Blooms
by David A. Caron, Alle A. Y. Lie, Brittany Stewart, Amanda Tinoco, Isha Kalra, Stephanie A. Smith, Adam L. Willingham, Shawn Sneddon, Jayme Smith, Eric Webb, Kyra Florea and Meredith D. A. Howard
Water 2025, 17(22), 3265; https://doi.org/10.3390/w17223265 - 15 Nov 2025
Viewed by 888
Abstract
Clear Lake in Lake County, CA, USA has experienced highly toxic cyanobacterial blooms for more than a decade, with multiple cyanobacterial taxa and cyanotoxins appearing sporadically, typically throughout much of the early-spring to late-fall seasons. Recurring blooms have been attributed to high internal [...] Read more.
Clear Lake in Lake County, CA, USA has experienced highly toxic cyanobacterial blooms for more than a decade, with multiple cyanobacterial taxa and cyanotoxins appearing sporadically, typically throughout much of the early-spring to late-fall seasons. Recurring blooms have been attributed to high internal nutrient loads within the lake, with hydrography and hydrology playing important but still poorly documented roles in controlling the availability of growth-limiting elements to the phytoplankton community. The lake is approximately 180 km2 in areal extent and composed of three somewhat disjointed lobes, or ‘Arms’. The large size of the lake presents a formidable task for synoptic lakewide surveys and for understanding the specific features that stimulate the development and magnitude of harmful blooms. We conducted a study in August of 2020 that involved the use of an autonomous underwater vehicle and deployment of a hand-held water column profiler to describe the lakewide status of various biological, chemical, and physical features. Discrete water samples were also collected from ten stations located throughout the lake to produce a near-synoptic depiction of lake status. Additionally, a mechanically driven, continuously monitoring water-column profiler was deployed at a central lake location to document short-term temporal (minutes to months) changes in water-column structure and chemistry. Wind was a dominant feature affecting the lake’s chemistry and biology during the study, resulting in massive concentrations and dramatic spatial heterogeneity of phytoplankton biomass and cyanotoxins in the eastern and southeastern Arms of the lake, and confirmed by the analysis of discrete water samples. Unique insight into the processes leading to or prolonging blooms was revealed by the water column profiler, which demonstrated rapid development (within a few hours) of suboxic conditions during periods of calm winds. We speculate that these quiescent periods are fundamental events in the lake’s ecology, resulting in episodic ‘pulses’ of nutrient release from the sediments, which can stimulate or refuel blooms of cyanobacteria in the water column. Full article
(This article belongs to the Section Water Quality and Contamination)
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31 pages, 17070 KB  
Article
WRF Simulations of Passive Tracer Transport from Biomass Burning in South America: Sensitivity to PBL Schemes
by Douglas Lima de Bem, Vagner Anabor, Damaris Kirsch Pinheiro, Luiz Angelo Steffenel, Hassan Bencherif, Gabriela Dornelles Bittencourt, Eduardo Landulfo and Umberto Rizza
Remote Sens. 2025, 17(20), 3483; https://doi.org/10.3390/rs17203483 - 19 Oct 2025
Viewed by 1133
Abstract
This single high-impact case study investigates the impact of planetary boundary layer (PBL) representation on long-range transport of Amazon fire smoke that reached the Metropolitan Area of São Paulo (MASP) from 15 to 20 August 2019, using the WRF model to compare three [...] Read more.
This single high-impact case study investigates the impact of planetary boundary layer (PBL) representation on long-range transport of Amazon fire smoke that reached the Metropolitan Area of São Paulo (MASP) from 15 to 20 August 2019, using the WRF model to compare three PBL schemes (MYNN 2.5, YSU, and BouLac) and three source-tagged tracers. The simulations are evaluated against MODIS-derived aerosol optical depth (AOD), the Light Detection and Ranging (LiDAR) time–height curtain over MASP, and HYSPLIT forward trajectories. Transport is diagnosed along the source-to-MASP pathway using six-hourly cross-sections and two integrative metrics: the projected mean wind in the 700–600 hPa layer and the vertical moment of tracer mass above the boundary layer. Outflow and downwind impact are strongest when a persistent reservoir between 2 and 4 km coexists with projected winds for several hours. In this episode, MYNN maintains an elevated 2–5 km transport layer and matches the observed arrival time and altitude, YSU yields a denser but delayed column, and BouLac produces discontinuous pulses with reduced coherence over the city. A negatively tilted trough, jet coupling, and a nearly stationary front establish a northwest-to-southeast corridor consistent across model fields, trajectories, and satellite signal. Seasonal robustness should be assessed with multi-event, multi-model analyses. Full article
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23 pages, 5280 KB  
Article
Seismic Damage Pattern Analysis of Long-Span CFST Arch Bridges Based on Damper Configuration Strategies
by Bin Zhao, Longhua Zeng, Qingyun Chen, Chao Gan, Lueqin Xu and Guosi Cheng
Buildings 2025, 15(15), 2728; https://doi.org/10.3390/buildings15152728 - 2 Aug 2025
Viewed by 927
Abstract
Variations in damper configuration strategies have a direct impact on the seismic damage patterns of long-span deck-type concrete-filled steel tube (CFST) arch bridges. This study developed an analysis and evaluation framework to identify the damage category, state, and progression sequence of structural components. [...] Read more.
Variations in damper configuration strategies have a direct impact on the seismic damage patterns of long-span deck-type concrete-filled steel tube (CFST) arch bridges. This study developed an analysis and evaluation framework to identify the damage category, state, and progression sequence of structural components. The framework aims to investigate the influence of viscous dampers on the seismic response and damage patterns of long-span deck-type CFST arch bridges under near-fault pulse-like ground motions. The effects of different viscous damper configuration strategies and design parameters on seismic responses of long-span deck-type CFST arch bridges were systematically investigated, and the preferred configuration and parameter set were identified. The influence of preferred viscous damper configurations on seismic damage patterns of long-span deck-type CFST arch bridges was systematically analyzed through the established analysis and evaluation frameworks. The results indicate that a relatively optimal reduction in bridge response can be achieved when viscous dampers are simultaneously installed at both the abutments and the approach piers. Minimum seismic responses were attained at a damping exponent α = 0.2 and damping coefficient C = 6000 kN/(m/s), demonstrating stability in mitigating vibration effects on arch rings and bearings. In the absence of damper implementation, the lower chord arch foot section is most likely to experience in-plane bending failure. The piers, influenced by the coupling effect between the spandrel construction and the main arch ring, are more susceptible to damage as their height decreases. Additionally, the end bearings are more prone to failure compared to the central-span bearings. Implementation of the preferred damper configuration strategy maintains essentially consistent sequences in seismic-induced damage patterns of the bridge, but the peak ground motion intensity causing damage to the main arch and spandrel structure is significantly increased. This strategy enhances the damage-initiation peak ground acceleration (PGA) for critical sections of the main arch, while concurrently reducing transverse and longitudinal bending moments in pier column sections. The proposed integrated analysis and evaluation framework has been validated for its applicability in capturing the seismic damage patterns of long-span deck-type CFST arch bridges. Full article
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14 pages, 3205 KB  
Article
A 209 ps Shutter-Time CMOS Image Sensor for Ultra-Fast Diagnosis
by Houzhi Cai, Zhaoyang Xie, Youlin Ma and Lijuan Xiang
Sensors 2025, 25(12), 3835; https://doi.org/10.3390/s25123835 - 19 Jun 2025
Cited by 1 | Viewed by 1284
Abstract
A conventional microchannel plate framing camera is typically utilized for inertial confinement fusion diagnosis. However, as a vacuum electronic device, it has inherent limitations, such as a complex structure and the inability to achieve single-line-of-sight imaging. To address these challenges, a CMOS image [...] Read more.
A conventional microchannel plate framing camera is typically utilized for inertial confinement fusion diagnosis. However, as a vacuum electronic device, it has inherent limitations, such as a complex structure and the inability to achieve single-line-of-sight imaging. To address these challenges, a CMOS image sensor that can be seamlessly integrated with an electronic pulse broadening system can provide a viable alternative to the microchannel plate detector. This paper introduces the design of an 8 × 8 pixel-array ultrashort shutter-time single-framing CMOS image sensor, which leverages silicon epitaxial processing and a 0.18 μm standard CMOS process. The focus of this study is on the photodiode and the readout pixel-array circuit. The photodiode, designed using the silicon epitaxial process, achieves a quantum efficiency exceeding 30% in the visible light band at a bias voltage of 1.8 V, with a temporal resolution greater than 200 ps for visible light. The readout pixel-array circuit, which is based on the 0.18 μm standard CMOS process, incorporates 5T structure pixel units, voltage-controlled delayers, clock trees, and row-column decoding and scanning circuits. Simulations of the pixel circuit demonstrate an optimal temporal resolution of 60 ps. Under the shutter condition with the best temporal resolution, the maximum output swing of the pixel circuit is 448 mV, and the output noise is 77.47 μV, resulting in a dynamic range of 75.2 dB for the pixel circuit; the small-signal responsivity is 1.93 × 10−7 V/e, and the full-well capacity is 2.3 Me. The maximum power consumption of the 8 × 8 pixel-array and its control circuits is 0.35 mW. Considering both the photodiode and the pixel circuit, the proposed CMOS image sensor achieves a temporal resolution better than 209 ps. Full article
(This article belongs to the Special Issue Ultrafast Optoelectronic Sensing and Imaging)
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21 pages, 2922 KB  
Article
Investigation of the Convective Mass Transfer Characteristics in a Parallel-Plate Channel Flow Disturbed by Using a Selenoid Pulse Generator
by Mehmet Emin Arzutuğ
Processes 2025, 13(6), 1700; https://doi.org/10.3390/pr13061700 - 29 May 2025
Cited by 1 | Viewed by 1006
Abstract
The continuous change in the entrance cross-section of a parallel-plate flow channel generally affects the mass and heat transfer on the walls of the channel. In this paper, an electrochemical parallel-plate flow channel equipped with a selenoid pulse generator has been developed to [...] Read more.
The continuous change in the entrance cross-section of a parallel-plate flow channel generally affects the mass and heat transfer on the walls of the channel. In this paper, an electrochemical parallel-plate flow channel equipped with a selenoid pulse generator has been developed to enhance the convective mass transfer on the walls of a mass transfer flow system such as an electrodeposition cell, absorption column, flow reactor, etc. A number of experimental studies have been conducted to determine the distribution of the mass transfer coefficients on the bottom wall of a parallel-plate channel for the flow conditions with/without a pulse in the research. Here, the distribution of the convective mass transfer coefficients has been determined by the electrochemical limiting diffusion current technique (ELDCT) using nickel local cathodes arranged on the bottom surface of the flow channel. The experimental results show the effects of the parameters used, which are the flow Reynolds number, opened/closed (OP/CL) ratio, and pulse number, on the distribution of mass transfer coefficients. The results have revealed that the pulse generator altered the flow structure and increased the turbulent intensity at Re < 2860 flow conditions. Within the range of Reynolds number 950 < Re < 2860, the mass transfer correlation was given as Sh=67.02Re0.897OpCl0.059Sc1/3. According to the research findings, the highest kM values were obtained at Re = 2860 with an (OP/CL) ratio of 1/2. If a parallel-plate flow reactor with a pulse generator is designed using these flow conditions, it will yield a reactor that is both more efficient and more compact than a reactor without a pulse generator. Full article
(This article belongs to the Topic Advanced Heat and Mass Transfer Technologies, 2nd Edition)
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17 pages, 1664 KB  
Article
Joint Optimization of Carrier Frequency and PRF for Frequency Agile Radar Based on Compressed Sensing
by Zhaoxiang Yang, Hao Zheng, Yongliang Zhang, Junkun Yan and Yang Jiang
Remote Sens. 2025, 17(10), 1796; https://doi.org/10.3390/rs17101796 - 21 May 2025
Cited by 2 | Viewed by 1133
Abstract
Frequency agile radar (FAR) exhibits robust anti-jamming capabilities and a superior low probability of intercept performance due to its randomized carrier frequency (CF) and pulse repetition frequency (PRF) hopping sequences. The advent of compressed sensing (CS) theory has effectively addressed the coherent processing [...] Read more.
Frequency agile radar (FAR) exhibits robust anti-jamming capabilities and a superior low probability of intercept performance due to its randomized carrier frequency (CF) and pulse repetition frequency (PRF) hopping sequences. The advent of compressed sensing (CS) theory has effectively addressed the coherent processing challenges of frequency agile signals. Nonetheless, the reconstructed results often suffer from elevated sidelobe levels, which lead to significant sparse recovery errors. The performance of sparse reconstruction is greatly influenced by the correlation between the dictionary matrix columns. Specifically, weaker correlation usually means better target detection performance and lower false alarm probability. Consequently, this paper adopts the maximum coherence coefficient (MCC) between the dictionary matrix columns as the cost function. In addition, in order to reduce the correlation of the dictionary matrix and improve the target detection performance, a genetic algorithm (GA) is employed to jointly optimize the CF hopping coefficients and PRFs of the FAR. The echo of optimized signals is subsequently reconstructed using the alternating direction method of multipliers (ADMM) algorithm. Simulation results demonstrate the effectiveness of the proposal. Full article
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10 pages, 236 KB  
Article
Gender Difference in Orthostatic Vascular Stiffness Increase in Young Subjects
by Victor N. Dorogovtsev, Dmitry S. Yankevich, Valentina M. Tsareva, Denis A. Punin, Ilya V. Borisov, Natalya N. Dekhnich and Andrey V. Grechko
Diagnostics 2025, 15(5), 517; https://doi.org/10.3390/diagnostics15050517 - 20 Feb 2025
Cited by 1 | Viewed by 2254
Abstract
Background/Objectives: Early detection of increased vascular stiffness in young populations may facilitate the development of more effective strategies for the primary prevention of arterial hypertension and other age-related cardiovascular diseases. To examine gender differences in orthostatic increases in vascular stiffness during the head-up [...] Read more.
Background/Objectives: Early detection of increased vascular stiffness in young populations may facilitate the development of more effective strategies for the primary prevention of arterial hypertension and other age-related cardiovascular diseases. To examine gender differences in orthostatic increases in vascular stiffness during the head-up tilt test (HUTT), standardized by hydrostatic column height. Materials and Methods: A total of 133 healthy adults aged 18–20 years (93 females and 40 males) were evaluated. Blood pressure and pulse wave velocity at the brachial–ankle artery site (baPWV) were measured using an ABI system 100 PWV multichannel sphygmomanometer. Orthostatic changes in arterial stiffness were assessed during a head-up tilt test (HUTT) using the Luanda protocol, which standardizes hydrostatic column height. The functional reserve coefficient (FRC) of orthostatic circulatory regulation was introduced as a measure of adaptive capacity: FRC = ΔbaPWV/baPWVb. This coefficient accounts for both structural (baPWVb) and functional (ΔbaPWV = baPWVt − baPWVb) components influencing cardiovascular system adaptation, which exhibit multidirectional changes with age. Results: Baseline baPWV (baPWVb) values in the horizontal position showed no significant differences between genders and were within normal age ranges. However, baPWV values in the upright HUTT position (baPWVt) were significantly higher in men (p = 0.0007). Dynamic biomarkers of vascular reserve, including ΔbaPWV and FRC, were also significantly elevated in men (p = 0.0009 and p = 0.0064, respectively). Conclusions: While baseline baPWVb values were comparable between genders, dynamic biomarkers of vascular reserve, such as ΔbaPWV and FRC, were significantly higher in men. Prospective studies are needed to establish optimal reference values for these dynamic biomarkers, enabling the assessment of individual trends in vascular aging and evaluating the effects of treatment, lifestyle modifications, and other preventive measures on vascular health. Full article
(This article belongs to the Section Clinical Diagnosis and Prognosis)
19 pages, 8563 KB  
Article
Picosecond Laser Direct Writing of Micro-Nano Structures on Flexible Thin Film for X-Band Transmittance Function
by Jiecai Feng, Jin Zhou, Cuilian Xu, Bingdong Yang, Ze Tian, Hongfei Liu, Yilian Zhang, Zhenghao Sun, Xiaohai Peng and Yingzhong Tian
Materials 2025, 18(2), 403; https://doi.org/10.3390/ma18020403 - 16 Jan 2025
Cited by 1 | Viewed by 1385
Abstract
Recently, ultrafast laser direct writing has become an effective method for preparing flexible films with micro-nano structures. However, effective control of laser parameters to obtain acceptable micro-nano structures and the effect of micro-nano structure sizes on function of the film remain challenges. Additionally, [...] Read more.
Recently, ultrafast laser direct writing has become an effective method for preparing flexible films with micro-nano structures. However, effective control of laser parameters to obtain acceptable micro-nano structures and the effect of micro-nano structure sizes on function of the film remain challenges. Additionally, flexible films with high X-band transmittance are urgently required in aerospace and other fields. In this work, we evaluate the feasibility of applying picosecond laser direct writing for fabricating micro-nano structures on the surface of flexible thin film and the relationship between the size of square columnar micro-nano structures and the transmittance of the flexible thin film. The results show that an array of square columnar micro-nano structures was achieved by picosecond laser direct writing on the surface of flexible thin film (Au-SiO2-PI) with a thickness of 50 µm. Additionally, excellent micro-nano structures morphology of the square columnar arrays without burning through or destroying were obtained by laser direct writing with a pulse power and frequency of 2 W and 100 KHz, respectively. The results also show that the X-band transmittance was effected by the characteristic of the square columnar array on the surface of the flexible thin film. The X-band transmittance was significantly increased by decreasing the length of the square column on the surface of the flexible thin film. The X-band transmittance was slightly increased by decreasing the width of the groove of the square column on the surface of the flexible thin film. Full article
(This article belongs to the Special Issue Recent Advances in Ultrafast Laser Precise Manufacturing)
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18 pages, 3359 KB  
Article
Development of a Dual-Stage CIM® CDI Reactor with Immobilized Glucuronan Lyases and Laccases for Sustainable Synthesis of Antioxidant Phenolized Oligoglucuronan
by Xiaoyang Hou, Pascal Dubessay, Gwendoline Christophe, Nicolas Bridiau, Pierre-Edouard Bodet, Mounir Traikia, Mugilan Damadoran Raja, Thierry Maugard, Aleš Štrancar, Fabrice Audonnet, Philippe Michaud and Guillaume Pierre
Polysaccharides 2024, 5(4), 743-760; https://doi.org/10.3390/polysaccharides5040047 - 15 Nov 2024
Viewed by 1923
Abstract
Immobilized enzyme reactors (IMERs) are critical tools for developing novel oligosaccharides based on the enzymatic catalysis of polysaccharides. In this paper, a novel glucuronan lyase from Peteryoungia rosettiformans was produced, purified, and then immobilized on a CIM® CDI disk for cleaving glucuronan. [...] Read more.
Immobilized enzyme reactors (IMERs) are critical tools for developing novel oligosaccharides based on the enzymatic catalysis of polysaccharides. In this paper, a novel glucuronan lyase from Peteryoungia rosettiformans was produced, purified, and then immobilized on a CIM® CDI disk for cleaving glucuronan. The results showed that around 63.6% of glycuronan lyases (800.9 μg) were immobilized on the disk. The Vmax values of immobilized glucuronan lyases did not significantly change (56.9 ± 4.7 μM∙min−1), while the Km values (0.310 ± 0.075 g∙L−1) increased by 2.5 times. It is worth noting that immobilized glucuronan lyases overcame the catalytic inhibition of free enzymes observed under high glucuronan concentrations (0.5–2 g∙L−1). circumscribed central composite design (CCCD) and response surface methodology (RSM) showed that glucuronan concentration, flow rate, and reaction time significantly affected the yield of oligoglucuronans. The degree of polymerization (DP) of degraded glucuronan ranged from DP 2–8 according to the results obtained by high performance anion exchange chromatography coupled with a pulsed amperometric detector (HPAEC-PAD). The IMER retained 50.9% activity after running 2373 column volumes of glucuronan. Finally, this glucuronan lyase reactor was tentatively connected to an immobilized laccase reactor to depolymerize, and gallic acid (GA) was added to glucuronan. Approximately 8.5 mg of GA was added onto 1 g of initial glucuronan, and the GA–oligoglucuronan conjugates showed notable antioxidant activity. Full article
(This article belongs to the Collection Bioactive Polysaccharides)
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11 pages, 571 KB  
Article
The Importance of Orthostatic Increase in Pulse Wave Velocity in the Diagnosis of Early Vascular Aging
by Victor Dorogovtsev, Dmitry Yankevich, Andrey Martyushev-Poklad, Ilya Borisov and Andrey V. Grechko
J. Clin. Med. 2024, 13(19), 5713; https://doi.org/10.3390/jcm13195713 - 25 Sep 2024
Cited by 3 | Viewed by 2207
Abstract
Background/Objectives: Vascular aging can be assessed by arterial stiffness measured through pulse wave velocity (PWV). Increased PWV predicts arterial hypertension, cardiovascular events and all-cause mortality. Detection of early signs of vascular aging remains an unmet problem. To search for the most sensitive [...] Read more.
Background/Objectives: Vascular aging can be assessed by arterial stiffness measured through pulse wave velocity (PWV). Increased PWV predicts arterial hypertension, cardiovascular events and all-cause mortality. Detection of early signs of vascular aging remains an unmet problem. To search for the most sensitive markers for the early increase in vascular stiffness in a healthy population. Methods: One-hundred and twenty healthy subjects were divided in three equal age groups: <30 years, 30–45 years and >45 years. Head-up tilt test (HUTT) protocol was applied, providing a standardized hydrostatic column height. PWV at the brachial–ankle artery site (baPWV) was measured using a multichannel sphygmomanometer ABI System 100 PWV in three positions: in the baseline horizontal (supine) position—baPWVb; during the head tilt-up with an individual angle of inclination—baPWVt; and when returning to supine. Results: The most sensitive marker of early stiffness increase in a healthy population is the relative orthostatic increase in baPWV, ΔbaPWV/baPWVb, where ΔbaPWV = baPWVt − baPWVb. The significance of differences in this parameter between the young and elderly groups reached p = 0.000075 and p = 0.000006, respectively. Conclusions: The proposed index ΔbaPWV/baPWVb can be considered as a promising sensitive early biomarker of vascular aging and as a potential effective indicator in cardiovascular prevention. A longitudinal cohort study is needed to confirm this assumption. Full article
(This article belongs to the Special Issue Advances in Vascular Aging)
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