Search Results (3,341)

Background/Objectives: Malnutrition is an imbalance of nutrients required for growth, development, and organ function. Its impact on bone development is known, but its effects on cartilage remain unclear. This study aimed to evaluate the femoral cartilage thickness in children with primary malnutrition. Methods: In this cross-sectional observational study, 83 children with primary malnutrition and 62 age- and sex-matched healthy controls were included. Patients with primary malnutrition were classified as mild, moderate and severe. Femoral cartilage thickness measurements of all children were taken by ultrasound from the femoral lateral condyle, femoral medial condyle and intercondylar area for both knees with the patient in a supine position with the knees flexed 90 degrees. Results: The right lateral, right medial, left lateral, and left medial femoral cartilages were significantly thicker in patients with malnutrition compared to those without malnutrition (p = 0.002, 0.004, <0.001, and 0.001, respectively). A significant negative correlation was found between age, weight Z-score, and height Z-score and triceps skinfold thickness. Conclusions: Distal femoral cartilage thickness is significantly greater in children with primary malnutrition. This demonstrates the effect of nutritional factors on cartilage tissue and suggests that children with chronic malnutrition are at risk for both knee joint problems and short stature later in life. Full article

Under conservation tillage in the Huang-Huai-Hai wheat–maize rotation area, the ridge-clearing no-till seeder for strip tillage mitigates the adverse impacts of surface residues on seeding quality by clearing stubble specifically within the seed rows, demonstrating significant potential for application and promotion. However, the inadequate understanding of the seeder’s operational performance and governing mechanisms under varying field conditions hinders its high-quality and efficient implementation. To address this issue, this study selected the stubble height, forward speed, and stubble knife rotational speed (PTO speed) as experimental factors. Employing a three-factor quasi-level orthogonal experimental design, coupled with response surface regression analysis, this research systematically elucidated the interaction mechanisms among these factors concerning the seeding depth consistency and seed spacing uniformity of the seeder. An optimized parameter-matching model was subsequently derived through equation system solving. Field trials demonstrated that a lower forward speed improved the seed spacing uniformity and seeding depth consistency, whereas high speeds increased the missing rates and spacing deviations. An appropriate stubble height enhanced the seed spacing accuracy, but an excessive height compromised depth precision. Higher PTO speeds reduced multiple indices but impaired depth accuracy. Response surface analysis based on the regression models demonstrated that the peak value of the seed spacing qualification index occurred within the forward speed range of 8–9 km/h and the stubble height range of 280–330 mm, with the stubble height being the dominant factor. Similarly, the peak value of the seeding depth qualification index occurred within the stubble height range of 300–350 mm and the forward speed range of 7.5–9 km/h, with the forward speed as the primary factor. Validation confirmed that combining stubble heights of 300−330 mm, forward speeds of 8−9 km/h, and PTO speeds of 540 r/min optimized both metrics. This research reveals nonlinear coupling relationships between operational parameters and seeding quality metrics, establishes a stubble–speed dynamic matching model, and provides a theoretical foundation for the intelligent control of seeders in conservation tillage systems. Full article

To investigate temporal deformation mechanisms of hydraulic asphalt concrete slope flow under evolving temperatures, this study developed a novel temperature-controlled slope flow intelligent test apparatus. Using this apparatus, slope flow tests were conducted at four temperature levels: 20 °C, 35 °C, 50 °C, and 70 °C. By applying nonlinear dynamics theory, the temporal evolution of slope flow deformation and its nonlinear mechanical characteristics under varying temperatures were thoroughly analyzed. Results indicate that the thermal stability of hydraulic asphalt concrete is synergistically governed by the phase-transition behavior between asphalt binder and aggregates. Temporal evolution of slope flow exhibits a distinct three-stage pattern as follows: rapid growth (0~12 h), where sharp temperature rise disrupts the primary skeleton of coarse aggregates; decelerated growth (12~24 h), where an embryonic secondary skeleton forms and progressively resists deformation; stabilization (>24 h), where reorganization of coarse aggregates is completed, establishing structural equilibrium. The thermal stability temperature influence factor (δ) shows a nonlinear concave growth trend with increasing test temperature. Dynamically, this process transitions sequentially through critical stability, nonlinear stability, period-doubling oscillatory stability, and unsteady states. Full article

Deep marine shale is the primary carrier of shale gas resources in Southwestern China. Because the occurrence and gas content of methane vary with burial conditions, understanding the microscopic mechanism of methane occurrence in deep marine shale is critical for effective shale gas exploitation. The temperature and pressure conditions in deep shale exceed the operating limits of experimental equipment; thus, few studies have discussed the microscopic occurrence mechanism of shale gas in deep marine shale. This study applies molecular simulation technology to reveal the methane’s microscopic occurrence mechanism, particularly the main controlling factor of adsorbed methane in deep marine shale. Two types of simulation models are also proposed. The Grand Canonical Monte Carlo (GCMC) method is used to simulate the adsorption behavior of methane molecules in these two models. The results indicate that the isosteric adsorption heat of methane in both models is below 42 kJ/mol, suggesting that methane adsorption in deep shale is physical adsorption. Adsorbed methane concentrates on the pore wall surface and forms a double-layer adsorption. Furthermore, adsorbed methane can transition to single-layer adsorption if the pore size is less than 1.6 nm. The total adsorption capacity increases with rising pressure, although the growth rate decreases. Excess adsorption capacity is highly sensitive to pressure and can become negative at high pressures. Methane adsorption capacity is determined by pore size and adsorption potential, while accommodation space and adsorption potential are influenced by pore size and mineral type. Under deep marine shale reservoir burial conditions, with burial depth deepening, the effect of temperature on shale gas occurrence is weaker than pressure. Higher temperatures inhibit shale gas occurrence, and high pressure enhances shale gas preservation. Smaller pores facilitate the occurrence of adsorbed methane, and larger pores have larger total methane adsorption capacity. Deep marine shale with high formation pressure and high clay mineral content is conducive to the microscopic accumulation of shale gas in deep marine shale reservoirs. This study discusses the microscopic occurrence state of deep marine shale gas and provides a reference for the exploration and development of deep shale gas. Full article

Fecal microbiota transplantation (FMT) promotes growth performance and intestinal development in yellow-feathered broilers, but whether the virome and metabolites contribute to its growth-promoting effect remains unclear. This study removed the microbiota from FMT filtrate using a 0.45 μm filter membrane, retaining the virome and metabolites to perform fecal virome transplantation (FVT), aiming to investigate its regulatory role in broiler growth. Healthy yellow-feathered broilers with high body weights (top 10% of the population) were used as FVT donors. Ninety-six 8-day-old healthy male yellow-feathered broilers (95.67 ± 3.31 g) served as FVT recipients. Recipient chickens were randomly assigned to a control group and an FVT group. The control group was gavaged with 0.5 mL of normal saline daily, while the FVT group was gavaged with 0.5 mL of FVT solution daily. Growth performance, immune and antioxidant capacity, intestinal development and related gene expression, and microbial diversity were measured. The results showed that FVT improved the feed utilization rate of broilers (the feed conversion ratio decreased by 3%; p < 0.05), significantly increased jejunal length (21%), villus height (69%), and crypt depth (84%) (p < 0.05), and regulated the jejunal barrier: insulin-like growth factor-1 (IGF-1) (2.5 times) and Mucin 2 (MUC2) (63 times) were significantly upregulated (p < 0.05). FVT increased the abundance of beneficial bacteria Lactobacillales. However, negative effects were also observed: Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin M (IgM), Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), and Interferon-gamma (IFN-γ) in broilers were significantly upregulated (p < 0.05), indicating immune system overactivation. Duodenal barrier-related genes Mucin 2 (MUC2), Occludin (OCLN), Claudin (CLDN1), and metabolism-related genes solute carrier family 5 member 1 (SLC5A1) and solute carrier family 7 member 9 (SLC7A9) were significantly downregulated (p < 0.05). The results of this trial demonstrate that, besides the microbiota, the gut virome and metabolites are also functional components contributing to the growth-promoting effect of FMT. The differential responses in the duodenum and jejunum reveal spatial heterogeneity and dual effects of FVT on the intestine. The negative effects limit the application of FMT/FVT. Identifying the primary functional components of FMT/FVT to develop safe and targeted microbial preparations is one potential solution. Full article

Background: Immune checkpoint inhibitors (ICIs) have limited efficacy in proficient mismatch repair (pMMR) and microsatellite stability (MSS) metastatic colorectal cancer (mCRC). Inhibition of vascular endothelial growth factor (VEGF) or cytotoxic chemotherapy can boost immunogenicity and has the potential to upregulate ICI efficacy. Methods: A comprehensive electronic literature search was conducted up to April 2025 to identify randomized controlled trials comparing cytotoxic chemotherapy plus bevacizumab with or without ICI. The primary outcome was progression-free survival (PFS), and secondary outcomes were overall survival (OS), objective response rate (ORR), and severe adverse events (AEs: grade 3 or more). A meta-analysis was performed using random-effects models to calculate hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs). Results: Four studies involving 986 patients (With-ICI group, n = 651; Without-ICI group, n = 335) were included. The meta-analysis demonstrated a significant improvement in PFS in the With-ICI group compared with the Without-ICI group, with an HR of 0.82 (95% CI: 0.70–0.96, p = 0.01) without statistical heterogeneity. No significant improvements were observed between the With- and Without-ICI groups in OS and ORR meta-analyses, but the With-ICI group had a favorable trend in OS. A significant increase in serious AEs was not observed in the With-ICI group. Conclusions: This meta-analysis suggests a potential benefit of adding ICIs to chemotherapy plus bevacizumab in pMMR mCRC; however, the evidence remains preliminary and hypothesis-generating, warranting further investigation in biomarker-driven trials and clarification of long-term outcomes. Full article

This paper presents a preliminary investigation into the aeroelastic behavior of a tailless flying wing equipped with a rotating wingtip. Based on the configuration of Innovative Control Effectors (ICE) aircraft, an aeroelastic model of the tailless flying wing with a rotating wingtip has been developed. Both numerical simulation and wind tunnel tests (WTTs) are employed to study the aeroelastic characteristics of this unique design. The numerical simulation involves the coupling of computational fluid dynamics (CFD) and implicit dynamic approaches (IDAs). Using the CFD/IDA coupling method, aeroelastic response results are obtained under different flow dynamic pressures. The critical flutter dynamic pressure is identified by analyzing the trend of the damping coefficient, with a focus on its transition from negative to positive values. Additionally, the critical flutter velocity and flutter frequency are obtained from the WTT results. The critical flutter parameters, including dynamic pressure, velocity, and flutter frequency, are examined under different wingtip rotation frequencies and angles. These parameters are derived using both the CFD/IDA coupling method and WTT. The results indicate that the rotating wingtip plays a significant role in influencing the flutter behavior of aircraft with such a configuration. Research has shown that the rotation characteristics of the rotating wingtip are the primary factor affecting its aeroelastic behavior, and increasing both the rotation frequency and rotation angle can raise the flutter boundary and effectively suppress flutter onset. Full article

Traps are central to petroleum exploration, where hydrocarbons accumulate during migration. Reservoirs are likewise an essential petroleum system element and serve as the primary medium for hydrocarbon storage. The buried hill is a geological formation highly favorable for reservoir development. However, the factors influencing hydrocarbon accumulation in buried hill reservoirs are highly diverse, especially in areas with complex, active fault systems. Fault systems play a dual role, both in the formation of reservoirs and in the migration of hydrocarbons. Therefore, understanding the impact of complex fault systems helps enhance the exploration success rate of buried hill traps and guide drilling deployment. In the Beibuwan Basin in the South China Sea, buried hill traps are key targets for deep-buried hydrocarbon exploration in this faulted basin. The low level of exploration and research in buried hills globally limits the understanding of hydrocarbon accumulation conditions, thereby hindering large-scale hydrocarbon exploration. By using drilling data, logging data, and seismic data, stress fields and tectonic faults were restored. There are two types of buried hills developed in the Beibuwan Basin, which were formed during the Late Ordovician-Silurian period and Permian-Triassic period, respectively. The tectonic genesis of the Late Ordovician-Silurian period buried hills belongs to magma diapirism activity, while the tectonic genesis of the Permian-Triassic period buried hills belongs to reverse thrust activity. The fault systems formed by two periods of tectonic activity were respectively altered into basement buried hills and limestone buried hills. The negative structural inversion controls the distribution and interior stratigraphic framework of the deformed Carboniferous strata in the limestone buried hill. The faults and derived fractures of the Late Ordovician-Silurian period and Permian-Triassic period promoted the diagenesis and erosion of these buried hills. The faults formed after the Permian-Triassic period are not conducive to calcite cementation, thus facilitating the preservation of the reservoir space formed earlier. The control of hydrocarbon accumulation by the fault system is reflected in two aspects: on the one hand, the early to mid-Eocene extensional faulting activity directly controlled the depositional process of lacustrine source rocks; on the other hand, the Late Eocene-Oligocene, which is closest to the hydrocarbon expulsion period, is the most effective fault activity period for connecting Eocene source rocks and buried hill reservoirs. This study contributes to understanding of the role of complex fault activity in the formation of buried hill traps within hydrocarbon-bearing basins. Full article

Background: Type 2 diabetes (T2D) is a growing public health concern, particularly in low- and middle-income countries. Although prediabetes is a major risk factor for T2D, it remains largely underdiagnosed and untreated. Structured lifestyle interventions have proven effective in preventing diabetes, but their feasibility within the Brazilian public health system remains unclear. Methods: This multicenter pilot randomized controlled trial assessed the feasibility of a culturally adapted lifestyle intervention (PROVEN-DIA) across the five regions of Brazil. A total of 220 adults at high risk for T2D were randomized to an intervention group or a control group (usual care) and followed for three months. Both groups received similar educational content on healthy eating and physical activity, but the intervention group participated in a structured and personalized lifestyle program with regular follow-up sessions. The primary outcome was adherence to dietary recommendations, assessed using the BALANCE Index—a validated dietary score (range: 0–40) based on the Brazilian Cardioprotective Diet that classifies foods into color-coded groups according to nutritional quality—along with engagement in moderate-to-vigorous physical activity (MVPA). Secondary outcomes included diet quality (DQIR), anthropometric and metabolic parameters. Results: Feasibility was demonstrated by a 93.2% retention rate (n = 205). There was no significant difference in the primary outcome (simultaneous improvement in diet and MVPA). However, the PROVEN-DIA group exhibited significantly greater improvements in diet quality, with a 2.8-point increase in the BALANCE Index (vs. 0.5 in the control, p = 0.03), and a significant improvement in the DQIR (p < 0.001). No significant differences between groups were observed in MVPA, HbA1C, glycaemia, or body weight. Conclusions: The PROVEN-DIA intervention proved feasible within the Brazilian public health context, resulting in significant improvements in dietary quality among individuals at high risk for T2D. A larger trial with longer follow-up is warranted to evaluate its effectiveness in preventing the progression to diabetes. However, to enhance physical activity outcomes, specific adaptations and targeted strategies may be required to better support participant engagement in exercise. Full article

Housing sustainability is a cornerstone element of sustainable economic and social development. This is particularly true for China, where high-rise residential buildings are the primary form of housing. In recent years, China has experienced frequent housing-related accidents, resulting in a significant loss of life and property damage. This study aims to identify the key factors influencing housing sustainability and provide a basis for the prevention and control of housing-related safety risks. This study has developed a housing sustainability evaluation indicator system comprising three primary indicators and 16 secondary indicators. This system is based on an analysis of the causes of over 500 typical housing accidents that occurred in China over the past 10 years, employing research methods such as literature reviews and expert consultations, and drawing on the analytical frameworks of risk management theory and system safety theory. Subsequently, the NK-SNA model, which significantly outperforms traditional models in terms of adaptive learning and optimization, as well as the explicit modeling of complex nonlinear relationships, was used to identify the key risk factors affecting housing sustainability. The empirical results indicate that the risk coupling value is correlated with the number of risk coupling factors; the greater the number of risk coupling factors, the larger the coupling value. Human misconduct is prone to forming two-factor risk coupling with housing, and the physical risk factors are prone to coupling with other factors. The environmental factors easily trigger ‘physical–environmental’ two-factor risk coupling. The key factors influencing housing sustainability are poor supervision, building facilities, the main structure, the housing height, foundation settlement, and natural disasters. On this basis, recommendations are made to make full use of modern information technologies such as the Internet of Things, big data, and artificial intelligence to strengthen the supervision of housing safety and avoid multi-factor coupling, and to improve upon early warnings of natural disasters and the design of emergency response programs to control the coupling between physical and environmental factors. Full article

Introduction: Intermittent exotropia (IXT) is the most common form of childhood divergent strabismus. Surgery remains the primary approach to control ocular deviation and preserve binocular function. Although previous studies report a success rate of approximately 75%, factors influencing surgical outcomes remain insufficiently explored. This study evaluates the effectiveness of strabismus surgery in children with IXT and identifies predictors of postoperative alignment stability. Methods: This retrospective study included 258 children with basic-type IXT or divergence excess who underwent bilateral lateral rectus recession. Clinical records and surgical data were analyzed to determine the overall success rate and identify associated predictive factors. Results: The sample included 166 females (64.3%) and 92 males (35.7%), with a mean age of 11.19 ± 3.73 years. Surgical success was achieved in 238 patients (92.2%). Success rates were similar across sexes (92.8% in females vs. 91.3% in males). No significant associations were found between surgical success and sex, age, preoperative occlusion therapy, binocular function, or IXT subtype. However, patients with moderate preoperative deviations had higher success rates. A statistically significant difference was observed in the preoperative deviation angle between successful (31 ± 7.08∆) and unsuccessful (42 ± 7.27∆) cases. A lower AC/A ratio was also associated with better outcomes, although it was not the main predictor. Discussion: The high success rate (92.2%) suggests a limited impact of demographic or preoperative variables. The preoperative deviation angle emerged as the strongest predictor of success, with smaller angles correlating with more favorable surgical outcomes. These findings underscore the importance of accurate preoperative assessment in surgical planning for IXT. Full article

This study analyzes the lacustrine hydrocarbon source rocks of the Lower Cretaceous in the Erdengsumu sag of the Erlian Basin, evaluating their characteristics and identifying areas with oil resource potential, while also investigating the ancient lake environment, material source input, and controlling factors, ultimately developing a sedimentary model for lacustrine hydrocarbon source rocks. The findings suggest the following: (1) The lower Tengger Member (K₁bt₁) and the Aershan Formation (K₁ba) are the primary oil-producing strata, with an effective hydrocarbon source rock exhibiting a lower limit of total organic carbon (TOC) at 0.95%. The Ro value typically remains below 0.8%, indicating that high-maturity oil production has not yet been attained. (2) The oil generation threshold depths for the Dalestai and Sayinhutuge sub-sags are 1500 m and 1214 m, respectively. The thickness of the effective hydrocarbon source rock surpasses 200 m, covering areas of 42.48 km² and 88.71 km², respectively. The cumulative hydrocarbon generation intensity of wells Y1 and Y2 is 486 × 10⁴ t/km² and 26 × 10⁴ t/km², respectively, suggesting that the Dalestai sub-sag possesses considerable petroleum potential. The Aershan Formation in the Chagantala sub-sag has a maximum burial depth of merely 1800 m, insufficient to attain the oil generation threshold depth. (3) The research area’s productive hydrocarbon source rocks consist of organic matter types I and II₁. The Pr/Ph range is extensive (0.33–2.07), signifying a reducing to slightly oxidizing sedimentary environment. This aligns with the attributes of small fault lake basins, characterized by shallow water and robust hydrodynamics. (4) The low ratio of ∑nC₂₁₋/∑nC₂₂₊ (0.36–0.81), high CPI values (>1.49), and high C₂₉ sterane concentration suggest a substantial terrestrial contribution, with negligible input from aquatic algae–bacterial organic matter. Moreover, as sedimentation duration extends, the contribution from higher plants progressively increases. (5) The ratio of the width of the deep depression zone to the width of the depression in the Erdengsumu sag is less than 0.25. The boundary fault scale is small, its activity is low, and there is not much input from the ground. Most of the source rocks are in the reducing sedimentary environment of the near-lying gently sloping zone. Full article

Background: Patients with primary angle-closure disease (PACD), those with no history of acute angle-closure glaucoma or laser iridotomy, rarely present with prominent corneal endothelial cell density (CECD) loss. To identify factors associated with decreased CECD in PACD, anterior segment parameters were compared in patients with PACD and normal CECD and patients with PACD and decreased CECD, using anterior segment optical coherence tomography (AS-OCT). Patients and Methods: Ten patients with PACD and CECD of less than 1500/mm² without a history of cataract surgery, acute angle-closure glaucoma, or prior laser glaucoma procedures were identified at the Kyorin Eye Center from January 2018 to July 2023. Patients with an obvious corneal guttata or apparent corneal edema were also excluded. Seventeen patients with PACD and normal CECD (normal CECD group) were used as the control. Simultaneous biometry of all anterior segment structures, including the cornea, anterior chamber, and iris, were assessed using a swept-source AS-OCT system. Results: Corneal curvature radius was significantly larger in the decreased CECD group compared with the corneal refractive power in the normal CECD group (p = 0.022, Mann–Whitney test). However, no significant differences were detected in other anterior segment morphology parameters. Multiple regression analysis with CECD as the dependent variable revealed that a large corneal curvature radius was a significant explanatory variable associated with corneal endothelial loss. Conclusions: Flattened corneal curvature may be a risk factor for corneal endothelial loss in patients with PACD. Full article

Background/Objectives: Latinos, particularly those of Mexican ancestry, experience high rates of type 2 diabetes and sleep disturbances, exacerbating adverse health outcomes. This study aimed to examine the prevalence of excessive daytime sleepiness and its associations with diet, cardiometabolic risk factors, and glycemic control in this population. Methods: This cross-sectional study utilized data from the El Banco por Salud biobank, including 1685 participants (aged 52.6 ± 14.5 years, BMI: 32.4 ± 7.0 kg/m²) recruited from Federally Qualified Community Health Centers. Excessive daytime sleepiness was assessed using the Epworth Sleepiness Scale, while dietary information was obtained via the Brief Dietary Assessment Tool for Hispanics. Primary outcomes included cardiometabolic risk factors and glycated hemoglobin (HbA1c) levels. Results: Excessive daytime sleepiness (Epworth Sleepiness Scale > 10) was present in 22.0% of participants and was associated with higher BMI (p < 0.001), larger waist circumference (p = 0.002), poorer diet quality, increased dyslipidemia (p = 0.036), and elevated HbA1c (p = 0.007). Linear regression analyses confirmed that excessive daytime sleepiness was significantly associated with higher HbA1c levels, both in unadjusted (R² = 0.011; p < 0.001) and adjusted for demographic, anthropometric, and socioeconomic factors (R² = 0.107; p = 0.004) models. Conclusions: Excessive daytime sleepiness among Latinos of Mexican ancestry is associated with unhealthy dietary patterns and poor glycemic control, highlighting the need for targeted interventions addressing sleep and dietary habits in this vulnerable population. Full article

Cannabis sativa L. is a versatile plant with significant medicinal, industrial, and recreational applications. Its therapeutic potential is attributed to cannabinoids like THC and CBD, whose production is influenced by environmental factors, such as radiation, temperature, and humidity. Radiation, for instance, is essential for photosynthetic processes, acting as both a primary energy source and a regulator of plant growth and development. This review covers key factors affecting C. sativa cultivation, including photoperiod, light spectrum, cultivation methods, environmental controls, and plant growth regulators. It highlights how these elements influence flowering, biomass, and cannabinoid production across different growing systems, offering insights for optimizing both medicinal and industrial cannabis cultivation. Studies indicate that photoperiod sensitivity varies among cultivars, with some achieving optimal flowering and cannabinoid production under extended light periods rather than the traditional 12/12 h cycle. Light spectrum adjustments, especially red, far-red, and blue wavelengths, significantly impact photosynthesis, plant morphology, and secondary metabolite accumulation. Advances in LED technology allow precise spectral control, enhancing energy efficiency and cannabinoid profiles compared to conventional lighting. The photoperiod plays a vital role in the cultivation of C. sativa spp., directly impacting the plant’s developmental cycle, biomass production, and the concentration of cannabinoids and terpenes. The response to photoperiod varies among different cannabis cultivars, as demonstrated in studies comparing cultivars of diverse genetic origins. On the other hand, indoor or in vitro cultivation may serve as an excellent alternative for plant breeding programs in C. sativa, given the substantial inter-cultivar variability that hinders the fixation of desirable traits. Full article