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Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease
- Satoshi Okuyama,
- Tomoki Semba,
- Nobuki Toyoda,
- Francesco Epifano,
- Salvatore Genovese,
- Serena Fiorito,
- Vito Alessandro Taddeo,
- Atsushi Sawamoto,
- Mitsunari Nakajima and
- Yoshiko Furukawa
In patients with Parkinson’s disease (PD), hyperactivated inflammation in the brain, particularly microglial hyperactivation in the substantia nigra (SN), is reported to be one of the triggers for the delayed loss of dopaminergic neurons and sequenti...