Search Results (93)

Background/Objectives: This study is part of an exploratory mixed-methods project investigating how companies and their employees in Germany dealt with adapted working conditions during the COVID-19 pandemic. Here, we identify predictive factors for employees’ attitudes towards the suitability of work-related technical, organisational, and personal SARS-CoV-2 infection control measures. Methods: In July 2021, when there was little evidence to suggest that the risk of work-related exposure to SARS-CoV-2 differed between occupations and workplaces, a standardised online and an optional paper-and-pencil survey were distributed across seven companies in southern Germany. Multivariate linear regression was used for analysis. Results: A total of 821 employees participated (average response rate: 24.5%). Most of the respondents (93%) worked in large companies, in the production industry (82%), with most of them having office jobs (82%). Around 29% reported doing most of their office work remotely during the pandemic. The perceived suitability of workplace infection control measures was rated quite high, with an overall mean score of 4.11 (SD 0.60) out of a possible 5. Workplace characteristics related to the COVID-19 pandemic as well as individual perception of SARS-CoV2 and COVID-19 in general were the most prominent predictors of attitudes towards the suitability of work-related SARS-CoV-2 infection control. For example, a higher COVID-19-specific reactance was negatively associated with attitudes towards technical (ß = −0.16), organisational (ß = −0.14), and personal (ß = −0.17) infection control measures (all p-values < 0.001). Furthermore, a higher rating of the employer’s commitment to occupational safety and health related to SARS-CoV-2, a higher individual disease perception, and a higher individual COVID-19-specific resilience had a positive association with attitudes towards the suitability of infection control measures. Finally, professional activity as well as company affiliation had statistically significant associations with employees’ attitudes towards the suitability of infection control measures. Conclusions: The results provide insight into factors relevant to pandemic prevention and control. In particular, our findings highlight the potential to implement organisational measures alongside compulsory technical occupational health measures. This could inform the development of pandemic preparedness strategies that prioritise adherence to established occupational infection control measures. Full article

The mechanisation of sesame (Sesamum indicum L.) planting remains a significant challenge due to the crop’s small, fragile seeds and non-uniform shape, which hinder the effectiveness of standard seeding systems. Crop emergence and production are adversely affected by poor singulation and uneven seed distribution, which are frequently caused by conventional and general-purpose planting equipment. For sesame, consistency in seed distribution and emergence is very important, necessitating careful consideration of agronomic conditions as well as seed properties. This study was conducted as a systematic review following the PRISMA 2020 guidelines to critically evaluate the existing literature on advanced planting methods that prioritise precision, efficiency, and seed protection. A comprehensive search was conducted across Scopus, Web of Science, and Google Scholar for peer-reviewed studies published from 2000 to 2025. Studies focused on the agronomic parameters of sesame, planting technologies, and/or simulation integration, such as Discrete Element Modelling (DEM), were included in this review, and studies unrelated to sesame planting or not available in full text were excluded. The findings from these studies were analysed to examine the interaction between seed metering mechanisms and seed morphology, specifically seed thickness and shape variability. Agronomic parameters such as optimal seed spacing, sowing depth, and population density are analysed to guide the development of effective planting systems. The review also evaluates limitations in existing mechanised approaches while highlighting innovations in precision planting technology. These include optimised seed plate designs, vacuum-assisted metering systems, and simulation tools such as DEM for performance prediction and system refinement. A total of 22 studies were included and analysed using systematic narrative synthesis, grouped into agronomical, technological, and simulation-based themes. The studies were screened for methodological clarity, and reference list screening was performed to reduce reporting bias. In conclusion, the findings of this research support the development of crop-specific planting strategies tailored to meet the unique requirements of sesame production. Full article

The captive breeding and release of threatened small-bodied freshwater fish is a common conservation method, yet many of these fish lack the behavioural profile to survive in the wild. Soft-release sites that provide wild-like experiences with minimal threat to survival can improve post-release outcomes. Here, we investigated whether captive-bred first generation Southern pygmy perch (Nannoperca australis) exposed to six months of soft-release experience develop natural behaviour. In laboratory tests, we compared the behaviour of fish from a hatchery, a soft-release site, or the wild in emergence, exploration, habitat choice, predator response, and novel food tests. As predicted, we found that fish from the soft-release site showed similar behavioural responses to wild-caught fish. However, soft-release fish were significantly larger (14.6 mm, 1.6 g advantage) and made greater use of refuge structures (basket ledges). Also, while trends suggested altered anti-predator responses, statistical support was limited, warranting further investigation. We conclude that soft-release experience enhances growth and shelter-seeking behaviour in this species, though further tests in a more natural environment should be undertaken to confirm ecologically important experience-dependent changes in behaviour. We recommend prioritising soft-release programmes that maximise natural foraging opportunities, reduce competition, and provide complex structures to support shelter use. Finally, the overall similarity in behaviour of fish from different environments suggests that, in this species, behaviour appears mostly inherited. Full article

West Africa is increasingly becoming more vulnerable to extreme heat due to climate change intensification with forecasts predicting hazardous heat days to double by 2060 affecting all societal classes and life sectors. This study examines the relationship between urbanisation, energy-efficient building design, and government guidelines within the Nigerian context. The review of the current national building codes and energy efficiency regulations revealed an alarming gap regarding the abandonment of basic sustainable design practices when addressing the needs of low-income housing. Validated simulations were used to assess the thermal performance of six distinct residential prototypes for low- and middle-income mass housing, which were previously developed by the government and are still used today as development blueprints. The effectiveness of incorporating passive design solutions into the selected prototypes was examined, providing insights into their thermal performance and practical recommendations for improving occupants’ comfort. The findings highlight the value of utilising a combination of passive design methods to achieve occupant thermal comfort, suggesting a reduction of up to 20% in the frequency of thermal discomfort during the hottest period of the year. The study advocates for more comprehensive guidelines to facilitate sustainable housing design that prioritises low-cost passive approaches to enhance indoor comfort and reduce reliance on conventional energy sources, ultimately fostering resilience in the face of climate change. Full article

Peptide therapeutics often fall outside classical small-molecule heuristics, such as Lipinski’s Rule of Five (Ro5), motivating the development of adapted filters and data-driven approaches to early drug-likeness assessment. We curated >300 k drug (small and peptide) and non-drug molecules from PubChem, extracted key molecular descriptors with RDKit, and generated three rule-violation counters for Ro5, the peptide-oriented beyond-Ro5 (bRo5) extension, and Muegge’s criteria. Random Forest (RF) classifier and regressor models (with 10, 20, and 30 trees) were trained and evaluated. Predictions for 26 peptide test molecules were compared with those from SwissADME, Molinspiration, and manual calculations. Model metrics were uniformly high (Ro5 accuracy/precision/recall = 1.0; Muegge ≈ 0.99), indicating effective learning. Ro5 violation counts matched reference values for 23/26 peptides; the remaining cases differed by +1 violation, reflecting larger structures and platform limits. bRo5 predictions showed near-complete agreement with manual values; minor discrepancies occurred in isolated peptides. Muegge’s predictions were internally consistent but tended to underestimate SwissADME by ~1 violation in several molecules. Four peptides (ML13–16) satisfied bRo5 boundaries; three also fully met Ro5. RF models thus provide fast and reliable in silico filters for peptide drug-likeness and can support the prioritisation of orally developable candidates. Full article

Background/Objectives: Post-intensive care syndrome (PICS) includes new or worsening physical, cognitive, and mental impairments following intensive care unit (ICU) admission. However, its predictors remain poorly defined. This study aimed to identify the predictors of PICS among ICU survivors 30 days after discharge. Methods: This prospective, monocentric, observational study was conducted from September 2023 to March 2024. Adult ICU survivors were assessed using the Healthy Ageing Brain Care Monitor to evaluate their physical, cognitive, and mental dimensions. The predictors included age, sex, coma, sedation, clinical severity (APACHE score), risk of ICU delirium (PREDELIRIC score), infection, hospital length of stay, and mechanical ventilation duration. Multivariate linear regression was used to identify independent predictors (p < 0.05). Results: A total of 90 ICU survivors were enrolled in the study. Higher clinical severity (B = 0.17, p = 0.001) and high delirium risk (PREDELIRIC score: B = 3.11, p = 0.007) were associated with worse cognitive PICS. Functional PICS was predicted by clinical severity (B = 0.36, p = 0.002) and moderate delirium risk (PREDELIRIC score: B = 7.12, p = 0.009). Behavioural PICS was inversely associated with coma (B = −6.74, p = 0.023) but positively associated with sedation (B = 7.64, p = 0.013) and moderate delirium risk (B = 2.24, p = 0.031). Conclusions: Clinical severity, PREDELIRIC score, sedation, and coma were significant predictors of PICS subdomains. Multidisciplinary teams may be more effective by prioritising targeted screening to identify ICU survivors at elevated risk for PICS using validated predictors such as clinical severity and the PREDELIRIC score, and delivering focused interventions to those most likely to benefit. Full article

Background: Pancreatic cystic lesions (PCLs), including intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs), pose a diagnostic challenge due to their variable malignant potential. Current guidelines, such as Fukuoka and American Gastroenterological Association (AGA), have moderate predictive accuracy and may lead to overtreatment or missed malignancies. Artificial intelligence (AI), incorporating machine learning (ML) and deep learning (DL), offers the potential to improve risk stratification, diagnosis, and management of PCLs by integrating clinical, radiological, and molecular data. This is the first systematic review to evaluate the application, performance, and clinical utility of AI models in the diagnosis, classification, prognosis, and management of pancreatic cysts. Methods: A systematic review was conducted in accordance with PRISMA guidelines and registered on PROSPERO (CRD420251008593). Databases searched included PubMed, EMBASE, Scopus, and Cochrane Library up to March 2025. The inclusion criteria encompassed original studies employing AI, ML, or DL in human subjects with pancreatic cysts, evaluating diagnostic, classification, or prognostic outcomes. Data were extracted on the study design, imaging modality, model type, sample size, performance metrics (accuracy, sensitivity, specificity, and area under the curve (AUC)), and validation methods. Study quality and bias were assessed using the PROBAST and adherence to TRIPOD reporting guidelines. Results: From 847 records, 31 studies met the inclusion criteria. Most were retrospective observational (n = 27, 87%) and focused on preoperative diagnostic applications (n = 30, 97%), with only one addressing prognosis. Imaging modalities included Computed Tomography (CT) (48%), endoscopic ultrasound (EUS) (26%), and Magnetic Resonance Imaging (MRI) (9.7%). Neural networks, particularly convolutional neural networks (CNNs), were the most common AI models (n = 16), followed by logistic regression (n = 4) and support vector machines (n = 3). The median reported AUC across studies was 0.912, with 55% of models achieving AUC ≥ 0.80. The models outperformed clinicians or existing guidelines in 11 studies. IPMN stratification and subtype classification were common focuses, with CNN-based EUS models achieving accuracies of up to 99.6%. Only 10 studies (32%) performed external validation. The risk of bias was high in 93.5% of studies, and TRIPOD adherence averaged 48%. Conclusions: AI demonstrates strong potential in improving the diagnosis and risk stratification of pancreatic cysts, with several models outperforming current clinical guidelines and human readers. However, widespread clinical adoption is hindered by high risk of bias, lack of external validation, and limited interpretability of complex models. Future work should prioritise multicentre prospective studies, standardised model reporting, and development of interpretable, externally validated tools to support clinical integration. Full article

The integration of artificial intelligence (AI) and advanced digital workflows is revolutionising full-arch implant dentistry, particularly for geriatric patients with edentulous and atrophic arches, for whom achieving both prosthetic passivity and optimal aesthetic outcomes is critical. This narrative review evaluates current challenges in intraoral scanning accuracy—such as scan distortion, angular deviation, and cross-arch misalignment—and presents how innovations like the Medit SmartX AI-guided workflow and the Scan Ladder system can significantly enhance precision in implant position registration. These technologies mitigate stitching errors by using real-time scan body recognition and auxiliary geometric references, yielding mean RMS trueness values as low as 11–13 µm, comparable to dedicated photogrammetry systems. AI-driven prosthetic design further aligns implant-supported restorations with facial symmetry and smile aesthetics, prioritising predictable midline and occlusal plane control. Early clinical data indicate that such tools can reduce prosthetic misfits to under 20 µm and lower complication rates related to passive fit, while shortening scan times by up to 30% compared to conventional workflows. This is especially valuable for elderly individuals who may not tolerate multiple lengthy adjustments. Additionally, emerging AI applications in design automation, scan validation, and patient-specific workflow adaptation continue to evolve, supporting more efficient and personalised digital prosthodontics. In summary, AI-enhanced scanning and prosthetic workflows do not merely meet functional demands but also elevate aesthetic standards in complex full-arch rehabilitations. The synergy of AI and digital dentistry presents a transformative opportunity to consistently deliver superior precision, passivity, and facial harmony for edentulous implant patients. Full article

Background: Hemiplegic migraine (HM) is a rare and severe subtype of migraine with a complex genetic basis. Although pathogenic variants in CACNA1A, ATP1A2, and SCN1A explain some familial cases, a significant proportion of patients remain genetically undiagnosed. Increasing evidence points to an overlap between migraine and cerebral small vessel disease (SVD), implicating vascular dysfunction in HM pathophysiology. Objective: This study aimed to identify rare or novel variants in genes associated with SVD in a cohort of patients clinically diagnosed with HM who tested negative for known familial hemiplegic migraine (FHM) pathogenic variants. Methods: We conducted a case-control association analysis of whole exome sequencing (WES) data from 184 unrelated HM patients. A targeted panel of 34 SVD-related genes was assessed. Variants were prioritised based on rarity (MAF ≤ 0.05), location (exonic/splice site), and predicted pathogenicity using in silico tools. Statistical comparisons to gnomAD’s Non-Finnish European population were made using chi-square tests. Results: Significant variants were identified in several SVD-related genes, including LRP1 (p.Thr4077Arg), COL4A1 (p.Pro54Leu), COL4A2 (p.Glu1123Gly), and TGFBR2 (p.Met148Leu and p.Ala51Pro). The LRP1 variant showed the strongest association (p < 0.001). All key variants demonstrated pathogenicity predictions in multiple computational models, implicating them in vascular dysfunction relevant to migraine mechanisms. Conclusions: This study provides new insights into the genetic architecture of hemiplegic migraine, identifying rare and potentially deleterious variants in SVD-related genes. These findings support the hypothesis that vascular and cellular maintenance pathways contribute to migraine susceptibility and may offer new targets for diagnosis and therapy. Full article

Football performance results from the dynamic interaction between physical, tactical, technical, and psychological dimensions—each of which also influences player well-being, recovery, and readiness. However, integrated monitoring approaches remain scarce, particularly in youth and sub-elite contexts. This systematic review screened 341 records from PubMed, Scopus, and Web of Science, with 46 studies meeting the inclusion criteria (n = 1763 players; age range: 13.2–28.7 years). Physical external load was reported in 44 studies using GPS-derived metrics such as total distance and high-speed running, while internal load was examined in 36 studies through session-RPE (rate of perceived exertion × duration), heart rate zones, training impulse (TRIMP), and Player Load (PL). A total of 22 studies included well-being indicators capturing fatigue, sleep quality, stress levels, and muscle soreness, through tools such as the Hooper Index (HI), the Total Quality Recovery (TQR) scale, and various Likert-type or composite wellness scores. Tactical behaviours (n = 15) were derived from positional tracking systems, while technical performance (n = 7) was assessed using metrics like pass accuracy and expected goals, typically obtained from Wyscout^® or TRACAB^® (a multi-camera optical tracking system). Only five studies employed multivariate models to examine interactions between performance domains or to predict well-being outcomes. Most remained observational, relying on descriptive analyses and examining each domain in isolation. These findings reveal a fragmented approach to player monitoring and a lack of conceptual integration between physical, psychological, tactical, and technical indicators. Future research should prioritise multidimensional, standardised monitoring frameworks that combine contextual, psychophysiological, and performance data to improve applied decision-making and support player health, particularly in sub-elite and youth populations. Full article

Generative artificial intelligence (AI) is changing higher education. Understanding students’ perceptions, usage behaviour and ethical concerns is crucial for the responsible and sustainable use of AI in the academic environment. The aim of this study was to explore the perceptions, experiences and challenges of health sciences students in relation to the use of generative AI in their academic learning. A descriptive cross-sectional survey was conducted with 397 students enrolled in four undergraduate health-related degree programmes in Slovenia, including nursing, physiotherapy, dietetics and applied kinesiology. The data was collected using a validated 27-point scale. Students were generally favourable towards AI, especially in terms of its perceived usefulness, integration into their daily study routine and ethical considerations. Regression analyses revealed that frequency of AI use, duration of use, self-reported skill level and confidence in using AI significantly predicted perceived usefulness. Gender differences were found, with male students reporting higher perceived usefulness and fewer concerns. Students recognised the potential of generative AI but emphasised the importance of ethical guidance, digital literacy and equal access. Institutions should prioritise structured training and inclusive strategies to ensure meaningful, sustainable and responsible integration of AI into health education. Full article

Background: Borderline personality disorder (BPD) is a severe psychiatric condition characterised by emotional instability, impulsivity, interpersonal dysfunction, and self-injurious behaviours. Despite growing clinical interest, the neuropsychological mechanisms underlying these symptoms are still not fully understood. This review aims to summarise findings from neuroimaging, psychophysiological, and neurodevelopmental studies in order to clarify the neurobiological and physiological basis of BPD, with a particular focus on emotional dysregulation and implications for the treatment of adolescents. Methods: A narrative review was conducted, integrating results from longitudinal neurodevelopmental studies, functional and structural neuroimaging research (e.g. FMRI and PET), and psychophysiological assessments (e.g., heart rate variability and cortisol reactivity). Studies were selected based on their contribution to understanding the neural correlates of BPD symptom dimensions, particularly emotion dysregulation, impulsivity, interpersonal dysfunction, and self-harm. Results: Findings suggest that early reductions in amygdala volume, as early as age 13 predict later BPD symptoms. Hyperactivity of the amygdala, combined with hypoactivity in the prefrontal cortex, underlies deficits in emotion regulation. Orbitofrontal abnormalities correlate with impulsivity, while disruptions in the default mode network and oxytocin signaling are related to interpersonal dysfunction. Self-injurious behaviour appears to serve a neuropsychological function in regulating emotional pain and trauma-related arousal. This is linked to disruption of the hypothalamic-pituitary-adrenal (HPA) axis and structural brain alterations. The Unified Protocol for Adolescents (UP-A) was more effective to Mentalization-Based Therapy for Adolescents (MBT-A) at reducing emotional dysregulation compared, though challenges in treating identity disturbance and relational difficulties remain. Discussion: The reviewed evidence suggests that BPD has its in early neurodevelopmental vulnerability and is sustained by maladaptive neurophysiological processes. Emotional dysregulation emerges as a central transdiagnostic mechanism. Self-harm may serve as a strategy for regulating emotions in response to trauma-related neural dysregulation. These findings advocate for the integration of neuroscience into psychotherapeutic practice, including the application of neuromodulation techniques and psychophysiological monitoring. Conclusions: A comprehensive understanding of BPD requires a neuropsychologically informed framework. Personalised treatment approaches combining pharmacotherapy, brain-based interventions, and developmentally adapted psychotherapies—particularly DBT, psychodynamic therapy, and trauma-informed care—are essential. Future research should prioritise interdisciplinary, longitudinal studies to further bridge the gap between neurobiological findings and clinical innovation. Full article

Background/Objectives: Childhood obesity represents a growing public health concern. It is closely associated with obstructive sleep apnoea (OSA), which impairs nocturnal breathing and significantly affects neurocognitive and cardiovascular health. This review aims to analyse differences in fat distribution, anthropometric parameters, and instrumental assessments of paediatric OSA compared to adult OSA to improve the diagnostic characterisation of obese children. Methods: narrative review. Results: While adenotonsillar hypertrophy (ATH) remains a primary cause of paediatric OSA, the increasing prevalence of obesity has introduced distinct pathophysiological mechanisms, including fat accumulation around the pharynx, reduced respiratory muscle tone, and systemic inflammation. Children exhibit different fat distribution patterns compared to adults, with a greater proportion of subcutaneous fat relative to visceral fat. Nevertheless, cervical and abdominal adiposity are crucial in increasing upper airway collapsibility. Recent evidence highlights the predictive value of anthropometric and body composition indicators such as neck circumference (NC), neck-to-height ratio (NHR), neck-to-waist ratio (NWR), fat-to-muscle ratio (FMR), and the neck-to-abdominal-fat percentage ratio (NAF%). In addition, ultrasound assessment of lateral pharyngeal wall (LPW) thickness and abdominal fat distribution provides clinically relevant information regarding anatomical contributions to OSA severity. Among imaging modalities, dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and air displacement plethysmography (ADP) have proven valuable tools for evaluating body fat distribution. Conclusions: Despite advances in the topic, a validated predictive model that integrates these parameters is still lacking in clinical practice. Polysomnography (PSG) remains the gold standard for diagnosis; however, its limited accessibility underscores the need for complementary tools to prioritise the identification of children at high risk. A multimodal approach integrating clinical, anthropometric, and imaging data could support the early identification and personalised management of paediatric OSA in obesity. Full article

This study investigates the relationship between CEO characteristics and firm performance across emerging and developed economies using both panel regression and machine learning techniques. Drawing on Upper Echelons Theory, we examine whether CEO age, tenure, gender, founder status, and appointment origin influence Return on Assets (ROA), Return on Equity (ROE), and market-to-book ratio. We apply the fixed and random effects models for inference and deploy random forest and XGBoost models to determine the feature importance of each CEO trait. Our findings show that CEO tenure consistently predicts improved ROE and ROA, while CEO age and founder status negatively affect firm performance. Female CEOs, though not consistently significant in the baseline models, positively influence market valuation in emerging markets according to interaction models. Firm-level characteristics such as size and leverage dominate CEO traits in explaining performance outcomes, especially in machine learning rankings. By integrating machine learning feature importance, this study contributes an original approach to CEO evaluation, enabling firms and policymakers to prioritise leadership traits that matter most. The findings have practical implications for succession planning, diversity policy, and performance-based executive appointments. Full article

This study evaluates the potential of IoT-enabled adaptive traffic management systems for mitigating urban congestion, enhancing mobility, and reducing environmental impacts in densely populated cities. Using London as a case study, the research develops a multiagent simulation framework to assess the effectiveness of advanced traffic management strategies—including adaptive signal control and dynamic rerouting—under varied traffic scenarios. Unlike conventional models that rely on static or reactive approaches, this framework integrates real-time data from IoT-enabled sensors with predictive analytics to enable proactive adjustments to traffic flows. Distinctively, the study couples this integration with a multiagent simulation environment that models the traffic actors—private vehicles, buses, cyclists, and emergency services—as autonomous, behaviourally dynamic agents responding to real-time conditions. This enables a more nuanced, realistic, and scalable evaluation of urban mobility strategies. The simulation results indicate substantial performance gains, including a 30% reduction in average travel times, a 50% decrease in congestion at major intersections, and a 28% decline in CO₂ emissions. These findings underscore the transformative potential of sensor-driven adaptive systems for advancing sustainable urban mobility. The study addresses critical gaps in the existing literature by focusing on scalability, equity, and multimodal inclusivity, particularly through the prioritisation of high-occupancy and essential traffic. Furthermore, it highlights the pivotal role of IoT sensor networks in real-time traffic monitoring, control, and optimisation. By demonstrating a novel and practical application of sensor technologies to traffic systems, the proposed framework makes a significant and timely contribution to the field and offers actionable insights for smart city planning and transportation policy. Full article