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2 Results Found

  • Review
  • Open Access
15 Citations
5,412 Views
21 Pages
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Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs

  • Pilar Cercós,
  • Diego A. Peraza,
  • Angela de Benito-Bueno,
  • Paula G. Socuéllamos,
  • Abdoul Aziz-Nignan,
  • Dariel Arrechaga-Estévez,
  • Escarle Beato,
  • Emilio Peña-Acevedo,
  • Armando Albert and
  • Marta Gutiérrez-Rodríguez
  • + 4 authors
Int. J. Mol. Sci.2021, 22(3), 1419;https://doi.org/10.3390/ijms22031419

31 January 2021

Ion channels are macromolecular complexes present in the plasma membrane and intracellular organelles of cells. Dysfunction of ion channels results in a group of disorders named channelopathies, which represent an extraordinary challenge for study an...

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  • Systematic Review
  • Open Access
2 Citations
2,435 Views
30 Pages
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Systematic Review of the Role of Kv4.x Potassium Channels in Neurodegenerative Diseases: Implications for Neuronal Excitability and Therapeutic Modulation

  • Bárbara Teruel-Peña,
  • Piedad Gómez-Torres,
  • Sergio Galarreta-Aperte,
  • Nora Suleiman-Martos,
  • Isabel Prieto,
  • Manuel Ramírez-Sánchez,
  • Carmen M. Fernández-Martos and
  • Germán Domínguez-Vías
Physiologia2025, 5(3), 31;https://doi.org/10.3390/physiologia5030031

10 September 2025

Background/Objectives: The voltage-gated potassium channels of the Kv4 family (Kv4.1, Kv4.2, Kv4.3) regulate neuronal excitability and synaptic integration. The dysregulation of these channels has been linked to neurodegenerative diseases, such as Al...

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