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Search Results (643)

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20 pages, 1054 KB  
Article
Closed-Form Approximations of Range Mutual Information for Integrated Sensing and Communication Systems
by Zhuoyun Lai, Hao Luo, Yinlu Wang, Yue Zhang and Biao Jin
Sensors 2026, 26(7), 2113; https://doi.org/10.3390/s26072113 (registering DOI) - 28 Mar 2026
Abstract
Sensing mutual information (SMI) is widely adopted as a performance metric for integrated sensing and communication (ISAC) to enhance both sensing and communication capabilities. However, conventional approaches derive SMI from amplitude and phase, whereas an explicit evaluation of range mutual information (RMI) remains [...] Read more.
Sensing mutual information (SMI) is widely adopted as a performance metric for integrated sensing and communication (ISAC) to enhance both sensing and communication capabilities. However, conventional approaches derive SMI from amplitude and phase, whereas an explicit evaluation of range mutual information (RMI) remains absent. In this paper, we investigate a novel closed-form approximation of RMI for ISAC. We first derive an explicit expression for the posterior probability density function (PDF) of the target range, which is formulated as a function of the signal’s autocorrelation and cross-correlation. Furthermore, we show that under high signal-to-noise ratio (SNR), the estimated range PDF approximates a Gaussian distribution in the sensing-unconstrained scenario and a truncated Gaussian distribution in the sensing-constrained scenario. Finally, we derive closed-form approximations of the RMI in both scenarios under high SNR. In the sensing-unconstrained scenario, the RMI is proportional to the delay interval, root-mean-square bandwidth, and SNR. In the constrained scenario, we obtain a closed-form RMI approximation by introducing an entropy correction term that quantifies the impact of boundary constraints. Additionally, we employ a maximum likelihood estimation (MLE) method to assess range estimation performance. Simulation results validate the accuracy of the theoretical results and the effectiveness of the proposed approximations. Full article
(This article belongs to the Section Communications)
24 pages, 1839 KB  
Article
Variational Bayesian-Based Reliability Evaluation of Nonlinear Structures by Active Learning Gaussian Process Modeling
by Wei-Chao Hou, Yu Xin, Ding-Tang Wang, Zuo-Cai Wang and Zong-Zu Liu
Infrastructures 2026, 11(4), 118; https://doi.org/10.3390/infrastructures11040118 - 27 Mar 2026
Abstract
In this study, variational Bayesian inference (VBI) with Gaussian mixture models is applied to update models of nonlinear structures, and then, the calibrated model is employed to estimate the failure probability of structures using a subset simulation (SS) algorithm. To improve the computation [...] Read more.
In this study, variational Bayesian inference (VBI) with Gaussian mixture models is applied to update models of nonlinear structures, and then, the calibrated model is employed to estimate the failure probability of structures using a subset simulation (SS) algorithm. To improve the computation efficiency of probabilistic nonlinear model updating, a Gaussian Process (GP) model is used to construct a surrogate likelihood function in Bayesian inference using an active learning algorithm, and then, Gaussian mixture models (GMMs) are employed to approximate the unknown posterior probabilistic density functions (PDFs) of model parameters. The optimized hyperparameters of GMMs can be obtained by maximizing the evidence lower bound (ELBO), and the stochastic gradient search method is used to solve this optimization problem. Based on the optimized hyperparameters, the posterior distributions of model parameters can be approximated using a combination of multiple Gaussian components. Subsequently, the SS algorithm is used to calculate the earthquake-induced failure probability of structures based on the calibrated nonlinear model. To verify the feasibility and effectiveness of the proposed method, a numerical simulation of a two-span bridge structure subjected to seismic excitations was developed. Moreover, the proposed strategy is further applied to estimate the failure probability of a scaled monolithic column structure subjected to bi-directional earthquake excitations. Both numerical and experimental results indicate that the proposed method is feasible and effective for probabilistic nonlinear model updates, and the updated model can significantly enhance the accuracy of structural failure probability predictions. Full article
(This article belongs to the Section Infrastructures and Structural Engineering)
29 pages, 5347 KB  
Article
Optimized Reinforcement Learning-Driven Model for Remote Sensing Change Detection
by Yan Zhao, Zhiyun Xiao, Tengfei Bao and Yulong Zhou
J. Imaging 2026, 12(3), 139; https://doi.org/10.3390/jimaging12030139 - 19 Mar 2026
Viewed by 152
Abstract
In recent years, deep learning has driven remarkable progress in remote sensing change detection (CD); however, practical deployment is still hindered by two limitations. First, CD results are easily degraded by imaging-induced uncertainties—mixed pixels and blurred boundaries, radiometric inconsistencies (e.g., shadows and seasonal [...] Read more.
In recent years, deep learning has driven remarkable progress in remote sensing change detection (CD); however, practical deployment is still hindered by two limitations. First, CD results are easily degraded by imaging-induced uncertainties—mixed pixels and blurred boundaries, radiometric inconsistencies (e.g., shadows and seasonal illumination changes), and slight residual misregistration—leading to pseudo-changes and fragmented boundaries. Second, prevailing methods follow a static one-pass inference paradigm and lack an explicit feedback mechanism for adaptive error correction, which weakens generalization in complex or unseen scenes. To address these issues, we propose a feedback-driven CD framework that integrates a dual-branch U-Net with deep reinforcement learning (RL) for pixel-level probabilistic iterative refinement of an initial change probability map. The backbone produces a preliminary posterior estimate of change likelihood from multi-scale bi-temporal features, while a PPO-based RL agent formulates refinement as a Markov decision process. The agent leverages a state representation that fuses multi-scale features, prediction confidence/uncertainty, and spatial consistency cues (e.g., neighborhood coherence and edge responses) to apply multi-step corrective actions. From an imaging and interpretation perspective, the RL module can be viewed as a learnable, self-adaptive imaging optimization mechanism: for high-risk regions affected by blurred boundaries, radiometric inconsistencies, and local misalignment, the agent performs feedback-driven multi-step corrections to improve boundary fidelity and spatial coherence while suppressing pseudo-changes caused by shadows and illumination variations. Experiments on four datasets (CDD, SYSU-CD, PVCD, and BRIGHT) verify consistent improvements. Using SiamU-Net as an example, the proposed RL refinement increases mIoU by 3.07, 2.54, 6.13, and 3.1 points on CDD, SYSU-CD, PVCD, and BRIGHT, respectively, with similarly consistent gains observed when the same RL module is integrated into other representative CD backbones. Full article
(This article belongs to the Section AI in Imaging)
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29 pages, 11319 KB  
Article
Confidence-Aware Topology Identification in Low-Voltage Distribution Networks: A Multi-Source Fusion Method Based on Weakly Supervised Learning
by Siliang Liu, Can Deng, Zenan Zheng, Ying Zhu, Hongxin Lu and Wenze Liu
Energies 2026, 19(6), 1503; https://doi.org/10.3390/en19061503 - 18 Mar 2026
Viewed by 192
Abstract
The topology identification (TI) of low-voltage distribution networks (LVDNs) is the foundation for their intelligent operation and lean management. However, the existing identification methods may produce inconsistent results under measurement noise, missing data, and heterogeneous load behaviors. Without principled multiple method fusion and [...] Read more.
The topology identification (TI) of low-voltage distribution networks (LVDNs) is the foundation for their intelligent operation and lean management. However, the existing identification methods may produce inconsistent results under measurement noise, missing data, and heterogeneous load behaviors. Without principled multiple method fusion and meter-level confidence quantification, the reliability of the identification results is questionable in the absence of ground-truth topology. To address these challenges, a confidence-aware TI (Ca-TI) method for the LVDN based on weakly supervised learning (WSL) and Dempster–Shafer (D-S) evidence theory is proposed, aiming to infer each meter’s latent topology connectivity label and quantify the meter-level confidence without ground truth by fusing different identification methods. Specifically, within the framework of data programming (DP) in WSL, different TI methods were modeled as labeling functions (LFs), and a weakly supervised label model (WSLM) was adopted to learn each method’s error pattern and each meter’s posterior responsibility; within the framework of D-S evidence theory, an uncertainty-aware basic probability assignment (BPA) was constructed from each meter’s posterior responsibility, with posterior uncertainty allocated to ignorance, and was further discounted according to the missing data rate; subsequently, a consensus-calibrated conflict-gated (CCCG)-enhanced D-S fusion rule was proposed to aggregate the TI results of multiple methods, producing the final TI decisions with meter-level confidence. Finally, the test was carried out in both simulated and actual low-voltage distribution transformer areas (LVDTAs), and the robustness of the proposed method under various measurement noise and missing data was tested. The results indicate that the proposed method can effectively integrate the performances of various TI methods, is not adversely affected by extreme bias from any single method, and provides the meter-level confidence for targeted on-site verification. Further, an engineering deployment scheme with cloud–edge collaboration is further discussed to support scalable implementation in utility environments. Full article
(This article belongs to the Special Issue Application of Artificial Intelligence in Electrical Power Systems)
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24 pages, 2763 KB  
Article
Dynamic Hierarchical Fusion for Space Multi-Target Passive Tracking with Limited Field-of-View
by Jizhe Wang, Di Zhou, Runle Du and Jiaqi Liu
Aerospace 2026, 13(3), 282; https://doi.org/10.3390/aerospace13030282 - 17 Mar 2026
Viewed by 160
Abstract
Space-based multi-target passive tracking is critical for space situational awareness, but faces severe challenges due to the limited field-of-view (FoV) and directional ambiguity of onboard sensors. These constraints often lead to target loss, poor observability, and decreased estimation accuracy. To address these issues, [...] Read more.
Space-based multi-target passive tracking is critical for space situational awareness, but faces severe challenges due to the limited field-of-view (FoV) and directional ambiguity of onboard sensors. These constraints often lead to target loss, poor observability, and decreased estimation accuracy. To address these issues, different fusion architectures have been explored. While centralized measurement-level fusion offers superior accuracy for estimating target states, distributed estimation-level fusion provides greater reliability for estimating the number of targets. To adaptively leverage these two complementary strengths, a dynamic hierarchical fusion method through real-time optimization of the fusion topology is proposed. Specifically, at each decision epoch, sensor nodes are dynamically partitioned into local fusion nodes (LFNs) and detection-only nodes (DONs). Each LFN receives measurements from selected DONs and executes an iterated-correction Gaussian-mixture probability hypothesis density filter. Subsequently, LFNs share and fuse their estimates using the intensity-dependent arithmetic average fusion. This dynamic process is achieved by applying a sensor management scheme based on partially observable Markov decision process (POMDP). To ensure accurate cardinality estimation, the reward function in POMDP utilizes the posterior expected number of targets. The resultant optimization is efficiently solved using a binary particle swarm optimization algorithm. Numerical and hardware-in-the-loop simulations demonstrate the effectiveness of the proposed method in balancing the accuracy of target number and state estimation. Full article
(This article belongs to the Section Astronautics & Space Science)
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16 pages, 950 KB  
Article
A CTC-Based Speech Recognition Network Fusing Local Convolution and Global Attention
by Huijuan Hu, Chenyang Tang, Ping Tan and He Xu
Sensors 2026, 26(6), 1865; https://doi.org/10.3390/s26061865 - 16 Mar 2026
Viewed by 281
Abstract
Integrating wav2vec 2.0 with Connectionist Temporal Classification (CTC) for automatic speech recognition (ASR) often involves a trade-off between capturing global semantic consistency and maintaining local feature discriminability. This study proposes DBA-wav2vec 2.0, an architecture designed to manage these modeling requirements by decoupling temporal [...] Read more.
Integrating wav2vec 2.0 with Connectionist Temporal Classification (CTC) for automatic speech recognition (ASR) often involves a trade-off between capturing global semantic consistency and maintaining local feature discriminability. This study proposes DBA-wav2vec 2.0, an architecture designed to manage these modeling requirements by decoupling temporal modeling into parallel local and global streams at the encoder–decoder interface. Depthwise separable convolutions are utilized to capture local acoustic structures, while a self-attention path is retained for long-range dependencies. A task-aware gating mechanism is introduced to integrate these heterogeneous features. By adjusting fusion weights based on acoustic input characteristics, the gate facilitates the refinement of posterior probability distributions, leading to more distinct alignment points. Experimental results on AISHELL-1 and ST-CMDS datasets show relative Character Error Rate (CER) reductions of 6.4% and 7.4%, respectively, compared to a baseline wav2vec 2.0 model. Further evaluations under varying speaking rates demonstrate a 15.3% relative improvement in fast-speech scenarios, suggesting that structural adaptation at the decoding interface can enhance the robustness of CTC-based systems against temporal variations. Full article
(This article belongs to the Section Intelligent Sensors)
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6 pages, 2014 KB  
Communication
First Molecular Verification of the Two-Spot Cotton Leafhopper Amrasca biguttula (Hemiptera: Cicadellidae) in the United States
by Chaoyang Zhao and Kipling S. Balkcom
Insects 2026, 17(3), 313; https://doi.org/10.3390/insects17030313 - 13 Mar 2026
Viewed by 324
Abstract
This report contains the first molecular record of the two-spot cotton leafhopper, Amrasca biguttula (Ishida) (Hemiptera: Cicadellidae), in the United States. Nymphs of multiple instars and adult specimens were collected from a cotton (Gossypium hirsutum) field in Macon County, Alabama, in [...] Read more.
This report contains the first molecular record of the two-spot cotton leafhopper, Amrasca biguttula (Ishida) (Hemiptera: Cicadellidae), in the United States. Nymphs of multiple instars and adult specimens were collected from a cotton (Gossypium hirsutum) field in Macon County, Alabama, in August 2025. While distinct paired dark spots were observed on the forewings of adult specimens, this trait was inconsistently present on nymphal wing pads. Cytochrome oxidase I (COI) DNA barcoding confirmed the specimen identity. The United States sequence shared > 99% identity with Asian A. biguttula references, and phylogenetic analysis placed it within the A. biguttula clade with 100% posterior probability support. Although this pest was previously reported in 2023 from Puerto Rico based solely on morphological traits, our findings provide the first DNA-confirmed evidence of its presence in the United States. Given its well-documented role in damaging cotton across Asia and Africa, this report underscores the urgent need for monitoring and development of management strategies in United States cotton-growing regions. Full article
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13 pages, 535 KB  
Article
Intraoperative Low-Dose Methadone for Pediatric Posterior Spinal Fusion: A Single-Center Retrospective Cohort Study
by Roshni Cheema, Kristina Boyd, Mihaela Visoiu, Hsing-Hua Sylvia Lin, Scott E. Licata, Ruth Ressler, Vishali Veeramreddy, Shraddha Sriram, Selena Rashid, Senthilkumar Sadhasivam and Paul Hoffmann
Children 2026, 13(3), 400; https://doi.org/10.3390/children13030400 - 13 Mar 2026
Viewed by 257
Abstract
Background: Posterior spinal fusion (PSF) for adolescent idiopathic scoliosis causes significant postoperative pain and high opioid requirements. Methadone, with dual μ- and κ-opioid agonism and NMDA antagonism, provides long-acting analgesia and may reduce perioperative opioid use. This study evaluated whether perioperative low-dose methadone [...] Read more.
Background: Posterior spinal fusion (PSF) for adolescent idiopathic scoliosis causes significant postoperative pain and high opioid requirements. Methadone, with dual μ- and κ-opioid agonism and NMDA antagonism, provides long-acting analgesia and may reduce perioperative opioid use. This study evaluated whether perioperative low-dose methadone (0.1 mg/kg) improves postoperative pain and opioid outcomes after pediatric PSF. Methods: In this single-center retrospective cohort study (January 2019–June 2023), pediatric patients <23 years old undergoing PSF were categorized by perioperative methadone exposure (intraoperative and/or postoperative) versus no methadone. The primary outcome was total postoperative opioid consumption (morphine milligram equivalents per kilogram, MME/kg) over postoperative days (POD) 0–3. Secondary outcomes were average daily pain scores and hospital length of stay (LOS). Inverse probability weighting (IPW) adjusted for age, sex, and protocol period. Results: A total of 339 patients (51% no methadone, 49% methadone; mean age 14.6 ± 2.5 years; 76% female) were analyzed. Methadone patients had longer anesthesia (392 vs. 372 min, p = 0.042) and surgery times (287 vs. 266 min, p = 0.01). IPW-adjusted associations show postoperative opioid use was significantly higher in the methadone group on POD 0 (median 2.5 vs. 2.1 MME/kg in no methadone group; p = 0.005). No significant differences were found in postoperative average pain scores (e.g., mean NRS: 2.3 vs. 2.5 on POD 0, p = 0.12) and LOS (3.3 vs. 3.1 days, p = 0.38) between methadone group and no methadone group. Discussion: Perioperative methadone provided similar analgesia for pain management and recovery without prolonging hospitalization, despite higher early opioid use on POD 0. Retrospective design limits causal inference, and residual confounding may persist despite propensity score-based adjustments. Further prospective trials are required to establish safety and dosing. Conclusions: In this retrospective cohort, perioperative low-dose methadone was associated with higher early postoperative opioid use but no significant differences in pain scores or length of stay compared with standard regimens. Methadone did not demonstrate an opioid-sparing effect in this real-world setting. Prospective studies are needed to better define its role and safety in pediatric posterior spinal fusion. Full article
(This article belongs to the Special Issue Anesthesia and Perioperative Management in Pediatrics)
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14 pages, 1031 KB  
Article
Pressure Pain Threshold Cut-Off Points at Trigeminal and Extra-Trigeminal Nervous and Musculoskeletal Structures to Discriminate Patients with Migraine from Episodic Tension-Type Headache: A Diagnostic Accuracy Study
by Leandro H. Caamaño-Barrios, Naiara Benítez-Aramburu, Alberto Nava-Varas, Fernando Galán-del-Río, Mónica López-Redondo, Jorge Buffet-García and Ricardo Ortega-Santiago
Diagnostics 2026, 16(6), 823; https://doi.org/10.3390/diagnostics16060823 - 10 Mar 2026
Viewed by 369
Abstract
Background/Objectives: Pressure pain thresholds (PPTs) are commonly used to quantify mechanical hyperalgesia in migraine and tension-type headache (TTH), but the discriminatory performance of PPTs across neural and muscular sites remains unclear. This study compared nerve- and muscle-related PPTs between migraine and frequent [...] Read more.
Background/Objectives: Pressure pain thresholds (PPTs) are commonly used to quantify mechanical hyperalgesia in migraine and tension-type headache (TTH), but the discriminatory performance of PPTs across neural and muscular sites remains unclear. This study compared nerve- and muscle-related PPTs between migraine and frequent episodic TTH and explored site-specific ROC-derived cut-off values as complementary classification markers. Methods: In this cross-sectional case-group discrimination study, participants with migraine (n = 33) and frequent episodic TTH (n = 31) underwent bilateral PPT assessment (electronic algometry) over the temporalis and tibialis anterior muscles, C5/C6 zygapophyseal joints, peripheral nerves (greater occipital, median, ulnar, radial, posterior tibial, common peroneal), and the second metacarpal region. Results: PPTs were generally lower in the migraine group than in the TTH group. After adjustment for sex and age, the most consistent between-group differences remained at the temporalis muscles bilaterally (left: adjusted mean difference 0.49 kg/cm2, 95% CI 0.10 to 0.89, p = 0.015; right: 0.53 kg/cm2, 95% CI 0.13 to 0.93, p = 0.011) and at the left tibialis anterior muscle (0.90 kg/cm2, 95% CI 0.03 to 1.78, p = 0.044). In the main ROC analysis, the temporalis muscles showed the strongest discriminatory performance (left AUC = 0.733; right AUC = 0.707), whereas tibialis anterior and left posterior tibial nerve sites showed modest, below-threshold discrimination (AUCs < 0.70 despite statistical significance in some cases). Women-only ROC analyses showed a broadly similar pattern, with slightly improved metrics at some sites, particularly the temporalis muscles. Across most sites, likelihood ratios indicated only small-to-moderate shifts in post-test probability. Conclusions: Participants with migraine showed lower PPTs than those with frequent episodic TTH across most assessed sites, with the clearest differences at the temporalis muscles. ROC and PR analyses suggest that PPTs (especially at temporalis sites) may provide complementary, hypothesis-generating discriminatory information, but their overall stand-alone discriminative utility is modest. PPT assessment should therefore be interpreted as an adjunct to clinical evaluation rather than a replacement diagnostic test. Full article
(This article belongs to the Special Issue Clinical Diagnosis and Management in Anesthesia and Pain Medicine)
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26 pages, 4715 KB  
Article
Bayesian Gaussian Mixture Model Classifier for Fault Detection in Induction Motors Using Start-Up Current Analysis
by Kacper Jarzyna, Michał Rad, Paweł Piątek and Jerzy Baranowski
Energies 2026, 19(5), 1328; https://doi.org/10.3390/en19051328 - 6 Mar 2026
Viewed by 211
Abstract
Induction motors constitute a major share of industrial drives, making reliable fault detection essential for maintaining operational continuity. This work develops a Bayesian classifier for identifying rotor-bar damage using start-up current measurements represented in the frequency domain. The spectra are modelled as smooth [...] Read more.
Induction motors constitute a major share of industrial drives, making reliable fault detection essential for maintaining operational continuity. This work develops a Bayesian classifier for identifying rotor-bar damage using start-up current measurements represented in the frequency domain. The spectra are modelled as smooth functional curves using a hierarchical B-spline formulation, and posterior sampling provides a generative mechanism for augmenting scarce labelled data. Classification is performed using a Bayesian Gaussian mixture model, where each prediction is obtained by averaging over thousands of posterior samples, yielding stable and interpretable probability estimates. In experimental evaluation, the proposed approach achieves consistent separation between healthy and faulty motors across repeated training runs, correctly identifying all test cases in the binary classification setting and exhibiting more stable probability estimates than logistic and soft-max regression under limited labelled data. The model additionally signals atypical responses for unmodelled faults, indicating potential for anomaly detection. These findings highlight the suitability of Bayesian functional modelling as a reliable tool for induction motor condition monitoring. Full article
(This article belongs to the Section D: Energy Storage and Application)
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29 pages, 3905 KB  
Article
CS-MLAkNN: A Cost-Sensitive Adaptive k-Nearest Neighbors Algorithm for Imbalanced Multi-Label Learning
by Zhengyao Shen, Jicong Duan, Ying Wang and Hualong Yu
Symmetry 2026, 18(3), 448; https://doi.org/10.3390/sym18030448 - 5 Mar 2026
Viewed by 249
Abstract
Multi-label data usually carries a complex structural class imbalance, which significantly affects the overall predictive performance of multi-label learning models. Although many studies have investigated this problem, most existing methods rely on resampling, static cost weighting, or ensemble learning. Few studies simultaneously consider [...] Read more.
Multi-label data usually carries a complex structural class imbalance, which significantly affects the overall predictive performance of multi-label learning models. Although many studies have investigated this problem, most existing methods rely on resampling, static cost weighting, or ensemble learning. Few studies simultaneously consider cost information and neighborhood size within the local statistical model of ML-kNN. To address this issue, this paper proposes a cost-sensitive adaptive k-nearest neighbors algorithm, named CS-MLAkNN, for imbalanced multi-label learning. The algorithm implements a dual cost-sensitive strategy at both the feature and label levels within the ML-kNN framework. Specifically, feature-level cost sensitivity is achieved through distance weighting during the training phase. In the prediction phase, label distribution information is incorporated into the posterior probability calculation to achieve label-level cost sensitivity. Moreover, the optimal number of neighbors (k) is determined adaptively through cross-validation. CS-MLAkNN maintains the simplicity and interpretability of the original ML-kNN, and meanwhile it explicitly introduces cost sensitivity and adaptiveness into three key steps: distance metric, posterior decision, and neighbor determination. Experimental results on 14 benchmark datasets demonstrate that the proposed method achieves optimal or near-optimal performance across various evaluation metrics. It also shows significant advantages over other state-of-the-art imbalanced multi-label learning algorithms. Full article
(This article belongs to the Special Issue Advances in Machine Learning and Symmetry/Asymmetry)
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25 pages, 1609 KB  
Article
Forensic Validation of the 95K SNP Panel and the Parabon Fx Forensic Analysis Platform for Identification of US Military Unknowns Using Extended Kinship Inference
by Jacqueline Tyler Thomas, Courtney L. Cavagnino, Kimberly Sturk-Andreaggi, Ellen M. Greytak, Julie A. Demarest, Suzanne M. Barritt-Ross, Timothy P. McMahon and Charla Marshall
Genes 2026, 17(3), 306; https://doi.org/10.3390/genes17030306 - 3 Mar 2026
Viewed by 1338
Abstract
Background/Objectives: To identify US military unknowns, the Armed Forces Medical Examiner System’s Armed Forces DNA Identification Laboratory has historically relied upon mitochondrial DNA and Y-chromosomal short tandem repeat testing. Where no appropriate family reference sample (FRS) is available or skeletal samples are degraded, [...] Read more.
Background/Objectives: To identify US military unknowns, the Armed Forces Medical Examiner System’s Armed Forces DNA Identification Laboratory has historically relied upon mitochondrial DNA and Y-chromosomal short tandem repeat testing. Where no appropriate family reference sample (FRS) is available or skeletal samples are degraded, autosomal single nucleotide polymorphism (SNP) testing with next-generation sequencing could assist. Methods: A method utilizing hybridization capture enrichment of a 95,000 (95K) SNP panel, amenable to FRS and extremely challenging samples, was validated. The Parabon Fx Forensic Analysis Platform was used for analysis and extended kinship inference. Skeletal samples (n = 65) and associated FRS (n = 64) were selected for a performance evaluation and case-type sample study. Results: Considering FRS with ≥7 ng DNA input into library preparation, 94% yielded ≥66,320 SNPs at ≥5X coverage. SNP recovery for skeletal samples at ≥1X coverage ranged from 5 to 94,197 SNPs, averaging 40,770 SNPs. When skeletal samples resulted in ≥13,000 SNPs, the most likely relationship category was consistent with the expected relationship. A log10 likelihood ratio of ≥4 and a posterior probability of ≥99.99% were established as thresholds for strong statistical support, and 87% of inferences met these thresholds while 13% were considered inconclusive. Pairwise kinship inference between unrelated individuals yielded an unrelated result in 85% of comparisons, 66% with strong statistical support. There were 170 instances of false positive 4th degree relationship inferences with strong statistical support. All false positives involved skeletal samples from individuals of admixed ancestry. Conclusions: With this approach, autosomal SNP testing can result in reliable kinship inferences between related individuals out to 3rd, and in some cases 4th, degree relationships, increasing the scope of eligible FRS to aid in identifications. Full article
(This article belongs to the Special Issue Advances and Challenges in Forensic Genetics)
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18 pages, 2929 KB  
Article
A Novel Belief Propagation-Based Probabilistic Multiple Hypothesis Tracking Algorithm for Multiple Resolvable Group Targets
by Tianli Ma, Peiling Shi, Sai Liu and Peng Wang
Entropy 2026, 28(3), 273; https://doi.org/10.3390/e28030273 - 28 Feb 2026
Viewed by 211
Abstract
A key challenge in multiple group target tracking is to maintain consistent data association in the presence of dynamic evolutions, i.e., splitting and merging. This paper proposes a Belief Propagation-based Multiple Hypothesis Tracking framework. The measurements are partitioned by using the Minimum Spanning [...] Read more.
A key challenge in multiple group target tracking is to maintain consistent data association in the presence of dynamic evolutions, i.e., splitting and merging. This paper proposes a Belief Propagation-based Multiple Hypothesis Tracking framework. The measurements are partitioned by using the Minimum Spanning Tree divisive clustering algorithm. A factor graph model is then constructed for the association hypotheses between group targets and measurements, followed by the inference of marginal posterior association probabilities via the Belief Propagation. These probabilities are finally integrated into an Expectation-Maximization framework, and the group states are updated by maximizing the expected log-likelihood function. Simulation results demonstrate that the proposed algorithm achieves significantly higher accuracy in the joint estimation of kinematic states and target cardinality compared to the PMHT-based, PHD-based, and JPDA-based algorithms. Full article
(This article belongs to the Special Issue Bayesian Networks and Causal Discovery)
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13 pages, 11096 KB  
Article
Weibull-Based Reliability of Full-Arch Zirconia Prostheses in a Mandibular All-on-4 Model: Monolithic Versus Titanium-Bar-Supported Designs
by Mesut Tuzlali, Nagehan Baki, Güler Yildirim Avcu and Erkan Bahçe
Appl. Sci. 2026, 16(5), 2181; https://doi.org/10.3390/app16052181 - 24 Feb 2026
Viewed by 298
Abstract
Full-arch zirconia prostheses for mandibular All-on-4 rehabilitations are provided as screw-retained monolithic zirconia (Zr-Mono) or as a zirconia suprastructure luted to a CAD/CAM titanium bar (Zr-TiBar). Because zirconia is a brittle and flaw-sensitive ceramic, design assessment should incorporate stress-field-weighted fracture risk. This in [...] Read more.
Full-arch zirconia prostheses for mandibular All-on-4 rehabilitations are provided as screw-retained monolithic zirconia (Zr-Mono) or as a zirconia suprastructure luted to a CAD/CAM titanium bar (Zr-TiBar). Because zirconia is a brittle and flaw-sensitive ceramic, design assessment should incorporate stress-field-weighted fracture risk. This in silico study compared zirconia tensile stress, deformation, and Weibull-based reliability between Zr-Mono and Zr-TiBar designs in a standardized edentulous mandibular All-on-4 model (posterior implants tilted 30°) using linear static finite element analysis. Accordingly, 300 N posterior unilateral loads were applied at the first molar (axial; 45° oblique). Outcomes were maximum principal tensile stress in zirconia (S1max), total prosthesis deformation, and Weibull-predicted fracture probability (Pf) derived from the tensile S1 field. Under axial loading, S1max was essentially identical between designs (~277 MPa). Under oblique loading, S1max was modestly lower for Zr-TiBar (~227 MPa) than for Zr-Mono (~234 MPa), and deformation was slightly lower for Zr-TiBar (<0.07 mm in all cases). Pf remained very low for both designs (10−6–10−7 range) and differed only slightly between them. Under the modeled single 300 N posterior load case, the titanium-bar support reduced deformation and modestly reduced oblique-load peak tensile stress but did not materially reduce the predicted zirconia Pf compared with monolithic zirconia. Full article
(This article belongs to the Section Applied Dentistry and Oral Sciences)
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18 pages, 1444 KB  
Article
Molecular Modelling of Anti-Inflammatory Activity: Application of the ToSS-MoDE Approach to Synthetic and Natural Compounds
by Manuel Londa Vueba, Ana Figueiras and Luis Alberto Torres Goméz
Biophysica 2026, 6(2), 16; https://doi.org/10.3390/biophysica6020016 - 24 Feb 2026
Viewed by 285
Abstract
Traditional drug design methods based on trial and error are costly and inefficient. The computational approach ToSS-MoDE (Topological Substructural Molecular Design) offers an alternative by linking molecular descriptors to biological activity. To develop a QSAR model to predict the anti-inflammatory activity of synthetic [...] Read more.
Traditional drug design methods based on trial and error are costly and inefficient. The computational approach ToSS-MoDE (Topological Substructural Molecular Design) offers an alternative by linking molecular descriptors to biological activity. To develop a QSAR model to predict the anti-inflammatory activity of synthetic and natural compounds using weighted spectral moments. Spectral moments (µk) were calculated from the adjacency matrix between bonds for 410 compounds (180 active and 230 inactive). MODESLAB software (MICROSOFT OFFICE 365) was used to generate descriptors, and Linear Discriminant Analysis (LDA) was applied to classify activity. The model was validated with an external series of 62 compounds. Results. The model showed an overall classification of 91.59% in the training series and 90.2% in validation. The spectral moments µ0, µ3, µ4, and µ5 were the most significant. Diosgenin, a natural metabolite, showed potential anti-inflammatory activity (classification probability: 81%). The model showed strong training performance (91.7% accuracy) and promising external performance for confidently classified compounds. All datasets, descriptor-generation settings, coefficients, and posterior probabilities are fully described in the main text to ensure full reproducibility. Full article
(This article belongs to the Collection Feature Papers in Biophysics)
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