Search Results (33,377)

The recycling of organic waste is a key element of the circular economy, particularly in response to the increasing generation of biodegradable residues. Composting provides a sustainable solution that supports waste management while improving soil fertility; however, its agronomic value depends on the feedstock origin, composting method, and maturity. This study compares three compost types, two home-produced (C1, C2) and one industrial (C3), to assess their suitability for agricultural application. The chemical characterization included macronutrients and micronutrients, heavy metals, and the humus content, while biological performance was evaluated through seed germination and root growth tests. C1 was nutrient-poor, especially in nitrogen and calcium, indicating the need for supplementation. C2 exhibited high potassium and moisture levels but elevated sodium concentrations, suggesting potential salinity issues. C3 showed high calcium and magnesium contents, moderate nitrogen, and low sodium, making it suitable for calcium-demanding crops. Overall, the home-produced composts demonstrated superior humus quality and more positive effects on plant development than the industrial compost, highlighting their potential as sustainable soil amendments. Full article

Background: Type 1 diabetes (T1D) is associated with metabolic and neuromuscular impairments that may influence fatigue mechanisms and limit exercise tolerance. Although previous investigations have characterized muscle performance in T1D, the peripheral fatigue threshold, defined as the maximal sustainable level of peripheral fatigue, remains poorly understood in this population. This study aimed to compare the amplitude of the maximal peripheral fatigue threshold between individuals with T1D and healthy controls to elucidate the effects of T1D on neuromuscular function. Methods: Twenty-two participants (11 with T1D and 11 healthy controls) completed two randomized experimental sessions. In each session, 60 quadriceps maximal voluntary contractions (MVCs) were completed, performed for 3 s with 2 s of rest between contractions. One session was conducted under a non-fatigued control condition (CTRL), and the other followed a fatiguing neuromuscular electrical stimulation (FNMES) protocol. Central and peripheral fatigue were evaluated from the pre- to post-exercise changes in potentiated twitch force (ΔPtw) and voluntary activation (ΔVA), respectively. Critical torque (CT) was calculated as the average torque produced during the last 12 contractions, whereas the curvature constant of the torque–duration relationship (W′) was quantified as the area above CT. Results: Although both groups exhibited a decline in pre-exercise Ptw following the FNMES condition, no significant within-group differences in ΔPtw were observed between sessions (T1D: p = 0.34; controls: p = 0.23). Nevertheless, the extent of peripheral fatigue was significantly lower in participants with T1D than in controls (ΔPtw = −38 ± 11% vs. −52 ± 17%; p < 0.05). Additionally, W′ values were reduced by 24% in the T1D group relative to controls during the CTRL condition (p = 0.02), and CT was significantly lower in T1D participants (262 ± 49 N) compared to controls (353 ± 71 N; p < 0.01). A significant positive correlation was observed between ΔPtw and W′ across groups (r² = 0.62, p < 0.001), suggesting a mechanistic link between peripheral fatigue tolerance and work capacity. Conclusions: The present results indicate that, although individuals with T1D retain the capacity to develop peripheral fatigue, their fatigue threshold and critical torque are markedly attenuated relative to those of healthy individuals. This reduction reflects impaired neuromuscular efficiency and diminished tolerance to sustained contractile activity. The strong relationship between peripheral fatigue and work capacity underscores the contribution of peripheral mechanisms to exercise intolerance in T1D. These results enhance current understanding of fatigue physiology in diabetes and emphasize the need for tailored exercise and rehabilitation strategies to improve fatigue resistance and functional performance in this population. Full article

Background/Objectives: Persistent strength deficits and psychological impairments may compromise return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR). We investigate the relationship between thigh muscle isokinetic strength recovery at six months after ACLR and long-term psychological outcomes related to RTS in competitive male soccer players. Methods: Sixty male soccer players who underwent primary ACLR with bone–patellar tendon–bone autograft were retrospectively analyzed. Isokinetic testing of quadriceps and hamstrings was performed one week before surgery and six months post-surgery at 90°/s and 180°/s. Limb symmetry index (LSI) was calculated both pre- and post-operatively. At long-term follow-up (mean ≈ 4 years after RTS), athletes completed questionnaires assessing RTS status, ACL re-injuries, sport-related perceptions, and kinesiophobia using the Tampa Scale for Kinesiophobia (TSK). Statistical analyses were conducted to explore associations between post-operative LSI and TSK scores and to compare psychological and neuromuscular outcomes between athletes with and without ACL re-injury. Results: Absolute quadriceps and hamstring peak torque values significantly increased from pre- to post-surgery, with quadriceps strength deficits persisting only in the operated limb. However, quadriceps LSI significantly decreased post-operatively, while hamstring LSI remained stable. Pearson correlation analysis revealed a weak positive association between post-operative quadriceps LSI at 90°/s and TSK scores (r = 0.34). Overall, RTS rate was 91.7%, but a second ACL injury occurred in 18.2% of athletes. No significant differences were observed between re-injured and non-re-injured athletes in TSK scores or post-operative LSI values at either angular velocity (all p > 0.29). High kinesiophobia (TSK ≥ 37) was present in 56.7% of the cohort at long-term follow-up. Conclusions: Despite significant strength gains, quadriceps limb symmetry worsened six months after ACLR, with deficits confined to the operated limb, suggesting persistent neuromuscular inhibition. These physical deficits coexist with long-term kinesiophobia despite high RTS rates. The weak associations between strength symmetry and psychological outcomes highlight the multifactorial nature of RTS and support the need for an integrated physical, psychological, and neuro-cognitive approach to rehabilitation and RTS decision-making. Full article

Background: Adolescence is a critical stage for establishing lifelong dietary habits and preventing non-communicable diseases through adequate intake of bioactive compounds. Numerous studies have thoroughly examined the antioxidant profile of traditional diets such as the Mediterranean diet. In contrast, current research provides limited insights into the antioxidant properties of foods typically consumed by Mexican adolescents. Objective: So, this study aimed to quantify the total phenolic compound (TPC) content and antioxidant capacity (AC) of frequently consumed foods and to estimate dietary intake in Mexican adolescents. Methodology: The selected food groups were identified based on their frequency of consumption by 15% or more of the adolescent population, considering those that have demonstrated a sufficient quantity of antioxidants. It was analyzed TPC and ABTS•⁺ and DPPH• to determine the antiradical activity of the analyzed samples. Results: The estimated daily intake of TPC was 1484.01 mg GAE/person, while AC intake was 345.67 mg AAE/person (ABTS•⁺) and 5399.14 µmol TE/person (DPPH•). Cereals and fruits were the major contributors to total antioxidant intake, while the contribution of leafy vegetables and nuts was relatively low. The statistical analysis revealed a significant positive correlation between TPC and AC. The results of the study indicate the antioxidant potential of the adolescent diet. Conclusions: Despite certain limitations, the values obtained from the study are comparable to those of other studies that employed similar methodologies. Consequently, promoting the early consumption of fresh plant-based foods rich in antioxidants, such as polyphenols, which can enhance the dietary profile and contribute to adolescents’ long-term health, constitutes a significant area of research. Full article

Recently, near-net-shape rolling has emerged as a key manufacturing technology for producing high-precision, fatigue-resistant bearing rings with irregular cross-sections, particularly for the production of Wind Turbine Shaft Bearings (WTSBs). The deformation behavior of the material during this rolling process is governed by temperature and rolling speed. Therefore, based on a thermomechanical coupled analysis, a simulation model for the deformation process of GCr15SiMn profiled rings during variable-speed rolling was developed in this study. The model was experimentally validated, confirming a dimensional error of less than 3‰. And then, the distribution of strain and temperature were analyzed during the rolling of the profiled ring. As the initial temperature increased from 1040 °C to 1160 °C, the standard deviation of strain (SDP) decreased from 6.12 to 4.05. Correspondingly, the standard deviation of temperature (SDT) was raised from 4.32 to 4.74. When the drive roll speed was increased from 2.5 rad/s to 4.0 rad/s, the SDP was reduced from 4.24 to 3.42. In addition, the SDT decreased from 4.42 to 3.21. The research indicates that SDP is primarily affected by initial temperature, whereas SDT is significantly influenced by drive roller speed. On the one hand, this study provides a clearly defined optimization framework, parameter ranges for achieving optimal uniformity in GCr15SiMn material (temperature of 1100–1130 °C, speed of 3.0–3.5 rad/s), and their anticipated benefits (an SDP reduction of 32% and an SDT reduction of 15%). On the other hand, it also establishes quantifiable industrial control targets, defining key quality assurance values (SDP ≤ 5.0, SDT ≤ 4.5). The rolling stability and precision can be improved through the selection of optimized rolling temperatures and speeds. This finding provides a theoretical foundation and technical framework for improving the rolling process stability of profiled cross-section bearing rings. Furthermore, this study is of positive significance for reducing the manufacturing costs of high-performance WTSBs. Full article

In this paper, a complete analysis is presented to study a reaction–diffusion system of general gene expression with two time delays and with Neumann boundary conditions. The global existence of a unique strong solution and the existence of an attractor are established. Using delays as bifurcation parameters, we obtain critical values so that the Hopf bifurcation occurs at a unique equilibrium point. Numerical simulations are provided to illustrate both the stability of the equilibrium point and the emergence of bifurcations. For steady-state solutions, the Maximum Principle is used to obtain the bounds of positive solutions. The conditions for the system to have constant solutions are also investigated. Full article

Background/Objectives: To evaluate the clinical and MRI characteristics of benign solitary schwannomas of the extremities, compare pre- and postoperative neurological symptoms, and identify preoperative and intraoperative risk factors for postoperative complications. Methods: A retrospective review was conducted on 47 patients with histopathologically confirmed benign solitary schwannomas of the extremities who underwent surgical excision. Demographic data, MRI characteristics (tumor volume, perilesional edema, and degenerative changes such as cystic components or intratumoral hemorrhage), fascicular relationship, and use of tru-cut biopsy were recorded. Pre- and postoperative neurological symptoms were compared. Univariate logistic regression analysis was performed to identify factors associated with postoperative complications. Results: The mean age was 38.6 ± 15 years, and the mean follow-up period was 109.8 ± 65.1 months. Lesions were predominantly located in the upper extremity (65.9%), with a mean volume of 9.6 ± 4.8 cm³; perilesional edema and/or degenerative changes were present in 53.1% of cases. Postoperative complications occurred in 19.1% of patients, with intrafascicular involvement being a significant predictor (OR = 5.4, p = 0.037) and a positive preoperative Tinel’s sign showing a trend toward significance (OR = 4.2, p = 0.084). Tumor volume, perilesional edema, degenerative changes, tru-cut biopsy, and anatomical location were not significantly associated with complications. At final follow-up, pain remission was 82.1%, and paresthesia improvement was 63.6%. Conclusions: Intrafascicular involvement was associated with postoperative complications in univariate analysis, whereas preoperative MRI characteristics, biopsy, and Tinel’s sign showed no predictive value for postoperative risk. Full article

This study investigates students’ motivation and engagement when participating as pedagogical partners in co-creating assessment rubrics for English language learning. Grounded in self-determination theory, this research explores how students’ sense of autonomy, competence, and relatedness influence their motivation to engage in co-created assessment practices. Data was collected from 143 undergraduate students at a university in Dubai. Findings showed generally positive perceptions of autonomy, with many students valuing opportunities to contribute ideas to assessment design and reporting that co-creation enhanced their ownership of learning. Students also believed that co-created assessments improved their understanding of learning objectives. Students reported that co-creation clarified expectations, reduced anxiety, and allowed them to develop broader academic and soft skills. Despite these benefits, unfamiliarity with assessment design at times hindered effective participation. These findings suggest that co-created assessment can strengthen motivation by enhancing competence, autonomy, and relatedness, but it is also important for the students to have clear guidelines to support meaningful student involvement. Full article

The anisotropic properties of wood make timber beams prone to developing longitudinal cracks. Notably, cracks occurring at the mid-height position are both highly common and critically detrimental to structural load-bearing capacity. This study focuses on the influence mechanisms of such cracks through four-point bending tests on 860 specimens, finite element simulations, and fracture morphology analyses. By introducing a horizontal crack location parameter called crack eccentricity (e), the influence of cracks at different horizontal positions on timber beam load-bearing capacity was investigated. The experimental results show that the horizontal position of the crack has a “critical eccentricity effect”: when e is below the critical value, cracks will not propagate and will have a minor impact on the load-bearing performance of timber beams; when e exceeds the critical value, cracks will propagate and their harmfulness will increase dramatically. As a special case, specimens with side-opening cracks (e = 1) exhibit “damage saturation” characteristics. That is, when the crack length exceeds the threshold (half of the beam span), regardless of further lengthening, the bearing capacity is unchanged and the damage evolution reaches a saturation plateau. The above analysis results suggest that the influence of cracks on the bearing capacity of timber beams may be counterintuitive. The calculation method for the “crack hazard coefficient” proposed in this study can provide a reference for crack hazard assessments. Full article

Within the framework of the carbon market mechanism, corporate investments to secure forestry carbon credits play a pivotal role in mobilizing social capital for ecological construction and realizing the value of ecosystem services. This study integrates information decision theory and Bayesian network analysis to simulate corporate investment decision-making for forestry carbon sequestration within China’s carbon market. Through this approach, we explore the decision-making mechanisms behind corporate investments in forestry carbon sequestration and conduct decision simulations. The findings reveal several key insights: (1) External factors, including tax incentives, consumer preference for low-carbon products, and societal environmental awareness, exert a significant impact on the valuation of forestry carbon sequestration investments. Internally, the challenge posed by technological costs in achieving emission reductions significantly influences the evaluation of forestry carbon sequestration investments. (2) Investment value judgments are shaped by the nature of the decision-making problem, which inherently involves a synergistic relationship. (3) Corporations recognize the importance of forestry carbon sequestration in reducing the costs of emission reduction, formulating low-carbon development plans, expanding investment opportunities, and enhancing the quality of forestry carbon sequestration. (4) The collective value judgment of corporates regarding forestry carbon sequestration in terms of cost reduction for emission reduction, low-carbon development planning, investment opportunity expansion, and corporate image enhancement significantly influences their investment decisions in forestry carbon sequestration. (5) Corporate investment decisions exhibit a strong preference for market-based pricing and risk-sharing mechanisms. Consequently, enhancing the carbon information disclosure system and the carbon market trading mechanism, as well as establishing price protection and income stabilization expectations for forestry carbon sequestration, can encourage corporates to make investments in this area. This not only aids in the green, low-carbon transformation of businesses but also addresses the challenge of positive externalities associated with forestry carbon sequestration through market-oriented solutions. Full article

The disparities in accessibility of public charging stations (PCSs) have emerged as a critical bottleneck constraining urban social equity and sustainable development. This study focuses on PCS accessibility within the central urban area of Tianjin. Employing an enhanced Gaussian-based two-step floating catchment area method, spatial autocorrelation analysis, and multi-scale geographically weighted regression, the research investigates spatial configuration, spatial dependence, and influencing factors from three analytical dimensions. The study elaborates on the disparities in PCS accessibility among different income groups and examines the determinants contributing to these variations. Research findings indicate that: (1) PCS accessibility1 in the central urban area exhibits a core-periphery spatial structure, with notable heterogeneity in the spatial distribution patterns of PCS accessibility across different income groups. (2) The MGWR model demonstrates superior performance compared to conventional models, with an increase in R² explanatory power of at least 23.7% and a reduction in AICc values ranging from 3.94% to 47.45%. (3) Housing prices are positively correlated with PCS accessibility across different income groups, while per capita income and education and cultural services differentiated associations with PCS accessibility. From the perspective of different income groups, this study systematically analyzes the disparities in PCS accessibility and their associated factors, providing a theoretical foundation for sustainable urban planning and development. Full article

Conventional mixed-flow pump designs are typically developed under the assumption of uniform inflow. However, due to various operational constraints, these pumps often operate under non-uniform inflow conditions, which can significantly deteriorate hydraulic performance and operational stability. To investigate the influence of inflow conditions on parameter analysis and optimization results of mixed-flow pumps, this study conducted optimization design under both uniform and non-uniform inflow conditions. Four loading control parameters—LE (leading-edge preloading), K (slope of the intermediate linear segment), and NC and ND (first and second loading inflection positions)—were selected as design parameters, while the weighted hydraulic efficiency at 0.8Q_des, 1.0Q_des, and 1.2Q_des served as the optimization objective. Under uniform inflow conditions, the sensitivity ranking of the parameters for efficiency (subscripts s and h denote shroud and hub, respectively) is: LE_s > K_h > LE_h > ND_h > NC_h > K_s > NC_s > ND_s. The corresponding optimal parameter values are −0.2, 0, 0.2, 0.4, 0.25, 1.5, 0.1, and 0.6. Under non-uniform inflow, the ranking changes markedly to: NC_h > LE_s > K_h > K_s > ND_h> LE_h > ND_s > NC_s, with optimal values of 0.4, 0, 1.5, 0, 0.6, −0.2, 0.8, and 0.1, respectively. Compared with the baseline model, the optimized configurations achieve efficiency improvements of 0.61%, 2.94%, and 3.74% under uniform inflow, and 0.23%, 4.42%, and 6.78% under non-uniform inflow. Analysis of the internal flow field indicates that incorporating inflow conditions at the initial design stage significantly enhances the robustness of the optimized blade geometry when subjected to non-uniform inflow. These findings provide important implications for the optimization and practical design of mixed-flow pumps operating under complex inflow environments. Full article

Background and Objectives: Axillary lymph node (ALN) status is one of the most important prognostic factors in breast cancer. Numerous studies have evaluated less invasive methods for accurate staging. To investigate the diagnostic performance of ultrasound (US), mammography, and ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in predicting axillary lymph node metastasis in breast cancer patients. Materials and Methods: Axillary involvement detected by US, mammography, and ¹⁸F-FDG PET/CT was analyzed in patients who underwent axillary dissection. Preoperatively, 365, 318, and 85 of 557 patients were evaluated with US, mammography, and PET/CT, respectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of each imaging modality were calculated. Results: The sensitivity, specificity, PPV, NPV, and accuracy of US were 33.3%, 97.5%, 94.4%, 51.0%, and 57.8%, respectively. False-negative US findings were more frequent in T1 (84.6%) and N1 (76.3%) tumors (p < 0.001 for both). For mammography, these values were 12.9%, 97.74%, 88.89%, 44.67%, and 52.9%, while for ¹⁸F-FDG PET/CT they were 72.5%, 100%, 100%, 67.65%, and 82.5%, respectively. Conclusions: Ultrasound remains useful for evaluating axillary lymph node involvement in advanced breast cancer but is insufficient for early-stage disease. Full article

With the increasing emergence of multidrug-resistant (MDR) bacteria, there is an urgent need to discover new antibiotics. In this study, genome mining coupled with anti-bacterial assay guided the targeted isolation of two new heptapeptides nobilamide Q3 (1) and R3 (2). These compounds were identified as new stereoisomers of the known scaffold A-3302-B (3). The structures of these compounds were elucidated through a combination of MS, NMR spectroscopy and Marfey’s analysis. Anti-MDR bacterial assays showed that compounds 2 and 3 exhibited effective growth inhibition against the Gram-positive MDR bacterial strain Staphylococcus aureus CCARM 3090 with MIC values of 3.25–6.5 μg/mL. Notably, our study reveals stereochemistry-dependent differences in their antibacterial activities, providing new insights into the structure–activity relationship of this class of peptides. Finally, an analysis of the biosynthetic gene cluster responsible for their production was conducted. This study underscores the significance of exploring cold-seep environments as a reservoir for discovering new antibiotics and provides a structural starting point for the future optimization of antimicrobial peptides. Full article

Introduction: The serum apelin level in patients with heart failure with reduced ejection fraction (HFrEF) and its relationship with ventricular tachycardia (VT) are not clearly known. This study aimed to investigate changes in serum apelin levels in patients with HFrEF and their relationship with VT. Method: This retrospective pilot study included 90 patients with 30 patients in each group: Group I: HFrEF with documented VT; Group II: HFrEF without VT; Group III: control group without HFrEF. In addition to routine parameters, apelin levels were measured. All parameters were compared between Group I–II–III. Parameters associated with VT were identified. Result: Apelin levels were found to be significantly lower in Group I–II than in Group III. Serum glucose, creatinine, and left atrial diameter were shown to be significantly higher in Group I–II than in Group III. HDL cholesterol and left ventricular ejection fraction (LVEF) levels were significantly lower in Group I–II compared with Group III. A positive and negative correlation was found between plasma apelin levels and LVEF and age, respectively. In logistic regression analysis, apelin levels and LVEF were found to independently determine VT (OR = 0.313, 95%CI: 0.124–0.788, p = 0.014 and OR = 0.912, 95%CI: 0.877–0.968, p < 0.001). In the ROC analysis, the cut-off value for apelin was determined to be 0.80 ng/mL, and it distinguished VT status in this sample with acceptable sensitivity and specificity. Discussion: According to the results of our study, apelin levels are significantly reduced in patients with HFrEF, and reduced apelin levels are associated with the presence of VT in these patients. Full article