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Search Results (954)

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Keywords = platform economy

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14 pages, 849 KiB  
Article
Autonomous Last-Mile Logistics in Emerging Markets: A Study on Consumer Acceptance
by Emerson Philipe Sinesio, Marcele Elisa Fontana, Júlio César Ferro de Guimarães and Pedro Carmona Marques
Logistics 2025, 9(3), 106; https://doi.org/10.3390/logistics9030106 - 6 Aug 2025
Abstract
Background: Rapid urbanization has intensified the challenges of freight transport, particularly in last-mile (LM) delivery, leading to rising costs and environmental externalities. Autonomous vehicles (AVs) have emerged as a promising innovation to address these issues. While much of the existing literature emphasizes business [...] Read more.
Background: Rapid urbanization has intensified the challenges of freight transport, particularly in last-mile (LM) delivery, leading to rising costs and environmental externalities. Autonomous vehicles (AVs) have emerged as a promising innovation to address these issues. While much of the existing literature emphasizes business and operational perspectives, this study focuses on the acceptance of AVs from the standpoint of e-consumers—individuals who make purchases via digital platforms—in an emerging market context. Methods: Grounded in an extended Unified Theory of Acceptance and Use of Technology 2 (UTAUT2), which is specifically suited to consumer-focused technology adoption research, this study incorporates five constructs tailored to AV adoption. Structural Equation Modeling (SEM) was applied to survey data collected from 304 e-consumers in Northeast Brazil. Results: The findings reveal that performance expectancy, hedonic motivation, and environmental awareness exert significant positive effects on acceptance and intention to use AVs for LM delivery. Social influence shows a weaker, yet still positive, impact. Importantly, price sensitivity exhibits a minimal effect, suggesting that while consumers are generally cost-conscious, perceived value may outweigh price concerns in early adoption stages. Conclusions: These results offer valuable insights for policymakers and logistics providers aiming to implement consumer-oriented, cost-effective AV solutions in LM delivery, particularly in emerging economies. The findings emphasize the need for strategies that highlight the practical, emotional, and environmental benefits of AVs to foster market acceptance. Full article
(This article belongs to the Section Last Mile, E-Commerce and Sales Logistics)
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29 pages, 3400 KiB  
Article
Value-Added Service Pricing Strategies Considering Customer Stickiness: A Freemium Perspective
by Xuwang Liu, Biying Zhou, Wei Qi, Zhiwu Li and Junwei Wang
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 201; https://doi.org/10.3390/jtaer20030201 - 6 Aug 2025
Abstract
Freemium, a popular business model in the digital economy, offers a basic product for free while charging for advanced features or value-added services. This pricing strategy enables platforms to attract a broad user base and then monetize through premium offerings. Customer characteristics and [...] Read more.
Freemium, a popular business model in the digital economy, offers a basic product for free while charging for advanced features or value-added services. This pricing strategy enables platforms to attract a broad user base and then monetize through premium offerings. Customer characteristics and service price are important factors affecting customer choice behavior in such a model. Based on consumption stickiness, we consider a monopoly that provides value-added services by incorporating a multinomial logit model into a two-stage dynamic pricing model. First, we analyze the optimal pricing of value-added services under a normal sales scenario. We then consider optimal pricing during the marketing period under two strategies—level improvement for value-added services and quality reduction for a basic product—and analyze the applicability of each. The results show that increasing the value-added service level has a positive effect on the optimal price of value-added services, whereas reducing the basic product quality has no effect on the optimal price. Furthermore, the numerical simulation shows that when the depth of consumer stickiness is low, the optimal marketing strategy reduces the quality of the basic product, the price of value-added services should be higher than that in the normal sales period but lower than the price under the level-improvement strategy for value-added services; otherwise, improving the level of the value-added services becomes the optimal approach. This study provides a theoretical basis and decision support for product quality design and service pricing that applies to freemium platforms. Full article
(This article belongs to the Topic Digital Marketing Dynamics: From Browsing to Buying)
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24 pages, 1464 KiB  
Review
An Overview of the Italian Roadmap for the Implementation of Circular Economy in the Energy Transition of Buildings
by Marilena De Simone and Daniele Campagna
Buildings 2025, 15(15), 2755; https://doi.org/10.3390/buildings15152755 - 5 Aug 2025
Abstract
An important task for the European Union is to transpose agreements and international standards in regulation and directives that are binding on member states. The resultant European action plans and directives identify priority areas in the building and energy sectors where circular economy [...] Read more.
An important task for the European Union is to transpose agreements and international standards in regulation and directives that are binding on member states. The resultant European action plans and directives identify priority areas in the building and energy sectors where circular economy principles can be applied. Italy records a general circular materials rate of 20.8%, surpassing the mean European value. But low recycling rates are still registered in the construction sector. This paper aims to assess the position of Italy with respect to the European regulatory framework on circularity in the energy transition of buildings. Firstly, the government’s initiatives and technical standards are introduced and commented upon. Secondly, the study illustrates the current Italian platforms, networks, and public and private initiatives highlighting opportunities and obstacles that the energy sector has to overcome in the area of circularity. It emerges that Italian policies still use voluntary tools that are not sufficiently in line with an effective circular economy model. Moreover, data collection plays a crucial role in accelerating the implementation of future actions. Italy should consider the foundation of a National Observatory for the Circular Economy to elaborate European directives, harmonize regional policies, and promote the implementation of effective practices. Full article
(This article belongs to the Special Issue Research on Sustainable Energy Performance of Green Buildings)
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14 pages, 379 KiB  
Essay
Is Platform Capitalism Socially Sustainable?
by Andrea Fumagalli
Sustainability 2025, 17(15), 7071; https://doi.org/10.3390/su17157071 - 4 Aug 2025
Viewed by 158
Abstract
This theoretical essay aims to analyze some of the socio-economic innovations introduced by Platform Capitalism Specifically, it focuses on two main aspects: first, the digital platform as a radical organizational innovation. Digital platforms represent a structural novelty in the market economy, signaling a [...] Read more.
This theoretical essay aims to analyze some of the socio-economic innovations introduced by Platform Capitalism Specifically, it focuses on two main aspects: first, the digital platform as a radical organizational innovation. Digital platforms represent a structural novelty in the market economy, signaling a new organization of production and labor. Second, the essay examines the role of platforms in directly generating value through the concept of “network value”. To this end, it explores the function of “business intelligence” as a strategic and competitive tool. Finally, the paper discusses the key issues associated with platform capitalism, which could threaten its social sustainability and contribute to economic and financial instability. These issues include the increasing commodification of everyday activities, the devaluation of paid labor in favor of free production driven by platform users (the so-called prosumers), and the emergence of proprietary and financial monopolies. Hence, digital platforms do not inherently ensure comprehensive social and environmental sustainability unless supported by targeted economic policy interventions. Conclusively, it is emphasized that defining robust social welfare frameworks—which account for emerging value creation processes—is imperative. Simultaneously, policymakers must incentivize the proliferation of cooperative platforms capable of fostering experimental circular economy models aligned with ecological sustainability. Full article
(This article belongs to the Section Economic and Business Aspects of Sustainability)
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29 pages, 1895 KiB  
Article
How Does Sharing Economy Advance Sustainable Production and Consumption? Evidence from the Policies and Business Practices of Dockless Bike Sharing
by Shouheng Sun, Yiran Wang, Dafei Yang and Qi Wu
Sustainability 2025, 17(15), 7053; https://doi.org/10.3390/su17157053 - 4 Aug 2025
Viewed by 239
Abstract
The sharing economy is considered to be a potentially efficacious approach for promoting sustainable production and consumption (SPC). This study utilizes dockless bike sharing (DBS) in Beijing as a case study to examine how sharing economy policies and business practices advance SPC. It [...] Read more.
The sharing economy is considered to be a potentially efficacious approach for promoting sustainable production and consumption (SPC). This study utilizes dockless bike sharing (DBS) in Beijing as a case study to examine how sharing economy policies and business practices advance SPC. It also dynamically quantifies the environmental and economic performance of DBS practices from a life cycle perspective. The findings indicate that effective SPC practices can be achieved through the collaborative efforts of multiple stakeholders, including the government, operators, manufacturers, consumers, recycling agencies, and other business partners, supported by regulatory systems and advanced technologies. The SPC practices markedly improved the sustainability of DBS promotion in Beijing. This is evidenced by the increase in greenhouse gas (GHG) emission reduction benefits, which have risen from approximately 35.81 g CO2-eq to 124.40 g CO2-eq per kilometer of DBS travel. Considering changes in private bicycle ownership, this value could reach approximately 150.60 g CO2-eq. Although the economic performance of DBS operators has also improved, it remains challenging to achieve profitability, even when considering the economic value of the emission reduction benefits. In certain scenarios, DBS can maximize profits by optimizing fleet size and efficiency, without compromising the benefits of emission reductions. The framework of stakeholder interaction proposed in this study and the results of empirical analysis not only assist regulators, businesses, and the public in better understanding and promoting sustainable production and consumption practices in the sharing economy but also provide valuable insights for achieving a win-win situation of platform profitability and environmental benefits in the SPC practice process. Full article
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23 pages, 915 KiB  
Article
Understanding Value Propositions and Perceptions of Sharing Economy Platforms Between South Korea and the United States: A Content Analysis and Topic Modeling Approach
by Jing Gu, Da Yeon Kim, Seungwoo Chun and Jin Suk Lee
Sustainability 2025, 17(15), 7028; https://doi.org/10.3390/su17157028 - 2 Aug 2025
Viewed by 198
Abstract
The sharing economy (SE) has rapidly expanded to become a key component of the global economy. However, as SE platforms evolve, a growing disconnect may exist between the value propositions companies emphasize and the values consumers actually perceive. Do the value frames communicated [...] Read more.
The sharing economy (SE) has rapidly expanded to become a key component of the global economy. However, as SE platforms evolve, a growing disconnect may exist between the value propositions companies emphasize and the values consumers actually perceive. Do the value frames communicated by SE companies align with those perceived as important by consumers, and how does this alignment differ across cultural contexts such as South Korea and the U.S.? Drawing on two complementary studies, we examine value alignment between SE companies and consumers in South Korea and the U.S. Study 1 employs content analysis of marketing messages from 246 SE platforms across five sectors, identifying the core value propositions emphasized. Study 2 applied structural topic modeling (STM) to consumer reviews from major SE platforms in both countries, focusing on three sectors: accommodation, service exchanges, and second-hand transactions. The findings reveal that SE companies in both countries primarily emphasize functional and economic values, with U.S. companies placing greater additional emphasis on emotional and social values than their South Korean counterparts. Similarly, consumers in both countries value functional, emotional, and economic aspects, showing general alignment with company marketing communications. However, South Korean consumers tended to emphasize functional and economic values more, while U.S. consumers were relatively more oriented toward emotional and social values. Notably, sustainability, widely regarded as a core principle of the SE, was not strongly emphasized by either companies or consumers. These findings contribute to the theoretical understanding of value dynamics in the SE and offer practical implications for developing culturally informed and value-driven marketing strategies. Full article
(This article belongs to the Section Economic and Business Aspects of Sustainability)
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22 pages, 4300 KiB  
Article
Optimised DNN-Based Agricultural Land Mapping Using Sentinel-2 and Landsat-8 with Google Earth Engine
by Nisha Sharma, Sartajvir Singh and Kawaljit Kaur
Land 2025, 14(8), 1578; https://doi.org/10.3390/land14081578 - 1 Aug 2025
Viewed by 329
Abstract
Agriculture is the backbone of Punjab’s economy, and with much of India’s population dependent on agriculture, the requirement for accurate and timely monitoring of land has become even more crucial. Blending remote sensing with state-of-the-art machine learning algorithms enables the detailed classification of [...] Read more.
Agriculture is the backbone of Punjab’s economy, and with much of India’s population dependent on agriculture, the requirement for accurate and timely monitoring of land has become even more crucial. Blending remote sensing with state-of-the-art machine learning algorithms enables the detailed classification of agricultural lands through thematic mapping, which is critical for crop monitoring, land management, and sustainable development. Here, a Hyper-tuned Deep Neural Network (Hy-DNN) model was created and used for land use and land cover (LULC) classification into four classes: agricultural land, vegetation, water bodies, and built-up areas. The technique made use of multispectral data from Sentinel-2 and Landsat-8, processed on the Google Earth Engine (GEE) platform. To measure classification performance, Hy-DNN was contrasted with traditional classifiers—Convolutional Neural Network (CNN), Random Forest (RF), Classification and Regression Tree (CART), Minimum Distance Classifier (MDC), and Naive Bayes (NB)—using performance metrics including producer’s and consumer’s accuracy, Kappa coefficient, and overall accuracy. Hy-DNN performed the best, with overall accuracy being 97.60% using Sentinel-2 and 91.10% using Landsat-8, outperforming all base models. These results further highlight the superiority of the optimised Hy-DNN in agricultural land mapping and its potential use in crop health monitoring, disease diagnosis, and strategic agricultural planning. Full article
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21 pages, 5468 KiB  
Article
Simulation Study of Cylinder-to-Cylinder Variation Phenomena and Key Influencing Factors in a Six-Cylinder Natural Gas Engine
by Demin Jia, Qi Cao, Xiaoying Xu, Zhenlin Wang, Dan Wang and Hongqing Wang
Energies 2025, 18(15), 4078; https://doi.org/10.3390/en18154078 - 1 Aug 2025
Viewed by 172
Abstract
Cylinder-to-cylinder variation (CTCV) is a prevalent issue for natural gas (NG) premixed engines with port fuel injection (PFI), which significantly impacts the engine’s power performance, fuel economy, and reliability. Focusing on this issue, this study established a three-dimensional simulation platform based on a [...] Read more.
Cylinder-to-cylinder variation (CTCV) is a prevalent issue for natural gas (NG) premixed engines with port fuel injection (PFI), which significantly impacts the engine’s power performance, fuel economy, and reliability. Focusing on this issue, this study established a three-dimensional simulation platform based on a six-cylinder natural gas premixed engine. Quantitative analysis was conducted to discuss the differences in the main boundaries, combustion process, and engine power between cylinders. Additionally, influencing factors of CTCV were explored in terms of mixture uniformity and distribution uniformity. The results indicate that, for the NG premixed engine, many parameters vary significantly between cylinders even under the economical operating condition of 1200 rpm. For example, the difference rate in the peak cylinder pressure and peak phase between cylinder 3 and cylinder 2 can reach 23.5% and 24.3%, respectively. Through the design of simulation cases, it was found that improving the mixture uniformity had a more significant impact on CTCV than improving the distribution uniformity. For example, the relative standard deviation (RSD) of peak pressure decreased by 2.15% through mixture uniformity improvement, while it only decreased by 0.39% through distribution uniformity improvement. At a high speed of 1800 rpm, the influence of distribution uniformity on CTCV increased notably, but the influence of mixture uniformity still remained greater than that of distribution uniformity. Full article
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23 pages, 849 KiB  
Article
Assessment of the Impact of Solar Power Integration and AI Technologies on Sustainable Local Development: A Case Study from Serbia
by Aco Benović, Miroslav Miškić, Vladan Pantović, Slađana Vujičić, Dejan Vidojević, Mladen Opačić and Filip Jovanović
Sustainability 2025, 17(15), 6977; https://doi.org/10.3390/su17156977 - 31 Jul 2025
Viewed by 172
Abstract
As the global energy transition accelerates, the integration of solar power and artificial intelligence (AI) technologies offers new pathways for sustainable local development. This study examines four Serbian municipalities—Šabac, Sombor, Pirot, and Čačak—to assess how AI-enabled solar power systems can enhance energy resilience, [...] Read more.
As the global energy transition accelerates, the integration of solar power and artificial intelligence (AI) technologies offers new pathways for sustainable local development. This study examines four Serbian municipalities—Šabac, Sombor, Pirot, and Čačak—to assess how AI-enabled solar power systems can enhance energy resilience, reduce emissions, and support community-level sustainability goals. Using a mixed-method approach combining spatial analysis, predictive modeling, and stakeholder interviews, this research study evaluates the performance and institutional readiness of local governments in terms of implementing intelligent solar infrastructure. Key AI applications included solar potential mapping, demand-side management, and predictive maintenance of photovoltaic (PV) systems. Quantitative results show an improvement >60% in forecasting accuracy, a 64% reduction in system downtime, and a 9.7% increase in energy cost savings. These technical gains were accompanied by positive trends in SDG-aligned indicators, such as improved electricity access and local job creation in the green economy. Despite challenges related to data infrastructure, regulatory gaps, and limited AI literacy, this study finds that institutional coordination and leadership commitment are decisive for successful implementation. The proposed AI–Solar Integration for Local Sustainability (AISILS) framework offers a replicable model for emerging economies. Policy recommendations include investing in foundational digital infrastructure, promoting low-code AI platforms, and aligning AI–solar projects with SDG targets to attract EU and national funding. This study contributes new empirical evidence on the digital–renewable energy nexus in Southeast Europe and underscores the strategic role of AI in accelerating inclusive, data-driven energy transitions at the municipal level. Full article
28 pages, 6962 KiB  
Article
Mapping Drought Incidents in the Mediterranean Region with Remote Sensing: A Step Toward Climate Adaptation
by Aikaterini Stamou, Aikaterini Bakousi, Anna Dosiou, Zoi-Eirini Tsifodimou, Eleni Karachaliou, Ioannis Tavantzis and Efstratios Stylianidis
Land 2025, 14(8), 1564; https://doi.org/10.3390/land14081564 - 30 Jul 2025
Viewed by 482
Abstract
The Mediterranean region, identified by scientists as a ‘climate hot spot’, is experiencing warmer and drier conditions, along with an increase in the intensity and frequency of extreme weather events. One such extreme phenomena is droughts. The recent wildfires in this region are [...] Read more.
The Mediterranean region, identified by scientists as a ‘climate hot spot’, is experiencing warmer and drier conditions, along with an increase in the intensity and frequency of extreme weather events. One such extreme phenomena is droughts. The recent wildfires in this region are a concerning consequence of this phenomenon, causing severe environmental damage and transforming natural landscapes. However, droughts involve a two-way interaction: On the one hand, climate change and various human activities, such as urbanization and deforestation, influence the development and severity of droughts. On the other hand, droughts have a significant impact on various sectors, including ecology, agriculture, and the local economy. This study investigates drought dynamics in four Mediterranean countries, Greece, France, Italy, and Spain, each of which has experienced severe wildfire events in recent years. Using satellite-based Earth observation data, we monitored drought conditions across these regions over a five-year period that includes the dates of major wildfires. To support this analysis, we derived and assessed key indices: the Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI), and Normalized Difference Drought Index (NDDI). High-resolution satellite imagery processed within the Google Earth Engine (GEE) platform enabled the spatial and temporal analysis of these indicators. Our findings reveal that, in all four study areas, peak drought conditions, as reflected in elevated NDDI values, were observed in the months leading up to wildfire outbreaks. This pattern underscores the potential of satellite-derived indices for identifying regional drought patterns and providing early signals of heightened fire risk. The application of GEE offered significant advantages, as it allows efficient handling of long-term and large-scale datasets and facilitates comprehensive spatial analysis. Our methodological framework contributes to a deeper understanding of regional drought variability and its links to extreme events; thus, it could be a valuable tool for supporting the development of adaptive management strategies. Ultimately, such approaches are vital for enhancing resilience, guiding water resource planning, and implementing early warning systems in fire-prone Mediterranean landscapes. Full article
(This article belongs to the Special Issue Land and Drought: An Environmental Assessment Through Remote Sensing)
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17 pages, 370 KiB  
Article
Social Media Dimensions and Productivity Among Healthcare Workers: Evidence from a Nigerian Tertiary Hospital
by Precious Chisom Uzoeghelu and Mary Agoyi
Healthcare 2025, 13(15), 1836; https://doi.org/10.3390/healthcare13151836 - 28 Jul 2025
Viewed by 183
Abstract
Background: Social media platforms play a crucial role in contemporary healthcare, facilitating patient participation and enabling communication among healthcare workers, as well as serving as a platform for medical awareness and advocacy. Social media use among healthcare workers has increased to 91%, [...] Read more.
Background: Social media platforms play a crucial role in contemporary healthcare, facilitating patient participation and enabling communication among healthcare workers, as well as serving as a platform for medical awareness and advocacy. Social media use among healthcare workers has increased to 91%, with 65% using it for health promotion purposes. Nonetheless, current studies have not properly and empirically explored its dimensions. Objectives: This study therefore examines social media dimensions and the productivity of healthcare workers. Methods: Leveraging the professional productivity theory and digital engagement theory, the study employs SPSS to analyze the gathered data through a partial least squares (PLS-SEM) approach to explore social media dimensions and productivity among healthcare workers in a Nigerian Tertiary Hospital. Based on a cross-sectional descriptive survey design and stratified random sampling method, 344 medical workers were analyzed. Findings: The study found that fear of missing out, information sharing, social influence, trust, and social media usage have a significant impact on the productivity of healthcare professionals. Conclusions: This research adds to the growing academic research on the capabilities of social media within the circular economic systems aimed at advancing healthcare delivery in developing economies. The research offers a method for maximizing the use of social media within healthcare settings to foster enhanced healthcare outcomes, particularly productivity. Full article
(This article belongs to the Section Healthcare Quality and Patient Safety)
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41 pages, 3292 KiB  
Review
Black Soldier Fly: A Keystone Species for the Future of Sustainable Waste Management and Nutritional Resource Development: A Review
by Muhammad Raheel Tariq, Shaojuan Liu, Fei Wang, Hui Wang, Qianyuan Mo, Zhikai Zhuang, Chaozhong Zheng, Yanwen Liang, Youming Liu, Kashif ur Rehman, Murat Helvaci, Jianguang Qin and Chengpeng Li
Insects 2025, 16(8), 750; https://doi.org/10.3390/insects16080750 - 22 Jul 2025
Viewed by 1130
Abstract
The global escalation of organic waste generation, coupled with rising protein demand and environmental pressure, necessitates innovative, circular approaches to resource management. Hermetia illucens (Black Soldier Fly, BSF) has emerged as a leading candidate for integrated waste-to-resource systems. This review examines BSF biological [...] Read more.
The global escalation of organic waste generation, coupled with rising protein demand and environmental pressure, necessitates innovative, circular approaches to resource management. Hermetia illucens (Black Soldier Fly, BSF) has emerged as a leading candidate for integrated waste-to-resource systems. This review examines BSF biological and genomic adaptations underpinning waste conversion efficiency, comparative performance of BSF bioconversion versus traditional treatments, nutritional and functional attributes, techno-economic, regulatory, and safety barriers to industrial scale-up. Peer-reviewed studies were screened for methodological rigor, and data on life cycle traits, conversion metrics, and product compositions were synthesized. BSF larvae achieve high waste reductions, feed-conversion efficiencies and redirect substrate carbon into biomass, yielding net CO2 emissions as low as 12–17 kg CO2 eq ton−1, an order of magnitude below composting or vermicomposting. Larval biomass offers protein, lipids (notably lauric acid), micronutrients, chitin, and antimicrobial peptides, with frass serving as a nutrient-rich fertilizer. Pathogen and antibiotic resistance gene loads decrease during bioconversion. Key constraints include substrate heterogeneity, heavy metal accumulation, fragmented regulatory landscapes, and high energy and capital demands. BSF systems demonstrate superior environmental and nutritional performance compared to conventional waste treatments. Harmonized safety standards, feedstock pretreatment, automation, and green extraction methods are critical to overcoming scale-up barriers. Interdisciplinary innovation and policy alignment will enable BSF platforms to realize their full potential within circular bio-economies. Full article
(This article belongs to the Section Role of Insects in Human Society)
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35 pages, 4837 KiB  
Review
MicroRNA-Based Delivery Systems for Chronic Neuropathic Pain Treatment in Dorsal Root Ganglion
by Stefan Jackson, Maria Rosa Gigliobianco, Cristina Casadidio, Piera Di Martino and Roberta Censi
Pharmaceutics 2025, 17(7), 930; https://doi.org/10.3390/pharmaceutics17070930 - 18 Jul 2025
Viewed by 787
Abstract
Neuropathic pain is a significant global clinical issue that poses substantial challenges to both public health and the economy due to its complex underlying mechanisms. It has emerged as a serious health concern worldwide. Recent studies involving dorsal root ganglion (DRG) stimulation have [...] Read more.
Neuropathic pain is a significant global clinical issue that poses substantial challenges to both public health and the economy due to its complex underlying mechanisms. It has emerged as a serious health concern worldwide. Recent studies involving dorsal root ganglion (DRG) stimulation have provided strong evidence supporting its effectiveness in alleviating chronic pain and its potential for sustaining long-term pain relief. In addition to that, there has been ongoing research with clinical evidence relating to the role of small non-coding ribonucleic acids known as microRNAs in regulating gene expressions affecting pain signals. The signal pathway involves alterations in neuronal excitation, synaptic transmission, dysregulated signaling, and subsequent pro-inflammatory response activation and pain development. When microRNAs are dysregulated in the dorsal root ganglia neurons, they polarize macrophages from anti-inflammatory M2 to inflammatory M1 macrophages causing pain signal generation. By reversing this polarization, a therapeutic activity can be induced. However, the direct delivery of these nucleotides has been challenging due to limitations such as rapid clearance, degradation, and reduction in half-life. Therefore, safe and efficient carrier vehicles are fundamental for microRNA delivery. Here, we present a comprehensive analysis of miRNA-based nano-systems for chronic neuropathic pain, focusing on their impact in dorsal root ganglia. This review provides a critical evaluation of various delivery platforms, including viral, polymeric, lipid-based, and inorganic nanocarriers, emphasizing their therapeutic potential as well as their limitations in the treatment of chronic neuropathic pain. Innovative strategies such as hybrid nanocarriers and stimulus-responsive systems are also proposed to enhance the prospects for clinical translation. Serving as a roadmap for future research, this review aims to guide the development and optimization of miRNA-based therapies for effective and sustained neuropathic pain management. Full article
(This article belongs to the Section Nanomedicine and Nanotechnology)
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15 pages, 1006 KiB  
Review
Multifunctional Applications of Biofloc Technology (BFT) in Sustainable Aquaculture: A Review
by Changwei Li and Limin Dai
Fishes 2025, 10(7), 353; https://doi.org/10.3390/fishes10070353 - 17 Jul 2025
Viewed by 403
Abstract
Biofloc technology (BFT), traditionally centered on feed supplementation and water purification in aquaculture, harbors untapped multifunctional potential as a sustainable resource management platform. This review systematically explores beyond conventional applications. BFT leverages microbial consortia to drive resource recovery, yielding bioactive compounds with antibacterial/antioxidant [...] Read more.
Biofloc technology (BFT), traditionally centered on feed supplementation and water purification in aquaculture, harbors untapped multifunctional potential as a sustainable resource management platform. This review systematically explores beyond conventional applications. BFT leverages microbial consortia to drive resource recovery, yielding bioactive compounds with antibacterial/antioxidant properties, microbial proteins for efficient feed production, and algae biomass for nutrient recycling and bioenergy. In environmental remediation, its porous microbial aggregates remove microplastics and heavy metals through integrated physical, chemical, and biological mechanisms, addressing critical aquatic pollution challenges. Agri-aquatic integration systems create symbiotic loops where nutrient-rich aquaculture effluents fertilize plant cultures, while plants act as natural filters to stabilize water quality, reducing freshwater dependence and enhancing resource efficiency. Emerging applications, including pigment extraction for ornamental fish and the anaerobic fermentation of biofloc waste into organic amendments, further demonstrate its alignment with circular economy principles. While technical advancements highlight its capacity to balance productivity and ecological stewardship, challenges in large-scale optimization, long-term system stability, and economic viability necessitate interdisciplinary research. By shifting focus to its underexplored functionalities, this review positions BFT as a transformative technology capable of addressing interconnected global challenges in food security, pollution mitigation, and sustainable resource use, offering a scalable framework for the future of aquaculture and beyond. Full article
(This article belongs to the Section Sustainable Aquaculture)
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31 pages, 1708 KiB  
Systematic Review
Circular Economy and Water Sustainability: Systematic Review of Water Management Technologies and Strategies (2018–2024)
by Gary Christiam Farfán Chilicaus, Luis Edgardo Cruz Salinas, Pedro Manuel Silva León, Danny Alonso Lizarzaburu Aguinaga, Persi Vera Zelada, Luis Alberto Vera Zelada, Elmer Ovidio Luque Luque, Rolando Licapa Redolfo and Emma Verónica Ramos Farroñán
Sustainability 2025, 17(14), 6544; https://doi.org/10.3390/su17146544 - 17 Jul 2025
Viewed by 441
Abstract
The transition toward a circular water economy addresses accelerating water scarcity and pollution. A PRISMA-2020 systematic review of 50 peer-reviewed articles (January 2018–April 2024) mapped current technologies and management strategies, seeking patterns, barriers, and critical bottlenecks. Bibliometric analysis revealed the following three dominant [...] Read more.
The transition toward a circular water economy addresses accelerating water scarcity and pollution. A PRISMA-2020 systematic review of 50 peer-reviewed articles (January 2018–April 2024) mapped current technologies and management strategies, seeking patterns, barriers, and critical bottlenecks. Bibliometric analysis revealed the following three dominant patterns: (i) rapid diffusion of membrane bioreactors, constructed wetlands, and advanced oxidation processes; (ii) research geographically concentrated in Asia and the European Union; (iii) industry’s marked preference for by-product valorization. Key barriers—high energy costs, fragmented regulatory frameworks, and low social acceptance—converge as critical constraints during scale-up. The following three practical action lines emerge: (1) adopt progressive tariffs and targeted tax credits that internalize environmental externalities; (2) harmonize water-reuse regulations with comparable circularity metrics; (3) create multi-actor platforms that co-design projects, boosting local legitimacy. These findings provide policymakers and water-sector practitioners with a clear roadmap for accelerating Sustainable Development Goals 6, 9, and 12 through circular, inclusive, low-carbon water systems. Full article
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