Search Results (1,481)

Thin-film detection technology plays a significant role in particle physics, X-ray imaging and radiation monitoring. In this paper, the detection capability of a Cs₃Cu₂I₅ thin-film scintillator toward α particles is investigated. The flexible thin-film scintillator is fabricated by a facile and cost-effective in situ strategy, exhibiting excellent scintillation properties. Upon α-particle excitation, the light yield of the Cs₃Cu₂I₅ thin-film is 2400 photons/MeV, which greatly benefits its application for single-particle events detection. Moreover, it shows linear energy response within the range of 4.7–5.5 MeV and moderate decay time of 667 ns. We further explored the cryogenic scintillation performance of Cs₃Cu₂I₅@PMMA film. As the temperature decreases from 300 K to 50 K, its light yield gradually increases to 1.3 fold of its original value, while its decay time remains almost unchanged. This scintillator film also shows excellent low-temperature stability and flexible operational stability. This work demonstrates the great potential of the Cs₃Cu₂I₅@PMMA film for the practical utilization in α-particle detection application. Full article

Highly integrable silicon carbide (SiC) has emerged as a promising platform for photonic integrated circuits (PICs), offering a comprehensive set of material and optical properties that are ideal for the integration of nonlinear devices and solid-state quantum defects. However, despite significant progress in nanofabrication technology, the development of SiC on an insulator (SiCOI)-based photonics faces challenges due to fabrication-induced material optical losses and complex processing steps. An alternative approach to mitigate these fabrication challenges is the direct deposition of amorphous SiC on an insulator (a-SiCOI). However, there is a lack of systematic studies aimed at producing high optical quality a-SiC thin films, and correspondingly, on evaluating and determining their optical properties in the telecom range. To this end, we have studied a single-source precursor, 1,3,5-trisilacyclohexane (TSCH, C₃H₁₂Si₃), and chemical vapor deposition (CVD) processes for the deposition of SiC thin films in a low-temperature range (650–800 °C) on a multitude of different substrates. We have successfully demonstrated the fabrication of smooth, uniform, and stoichiometric a-SiCOI thin films of 20 nm to 600 nm with a highly controlled growth rate of ~0.5 Å/s and minimal surface roughness of ~5 Å. Spectroscopic ellipsometry and resonant micro-photoluminescence excitation spectroscopy and mapping reveal a high index of refraction (~2.7) and a minimal absorption coefficient (<200 cm⁻¹) in the telecom C-band, demonstrating the high optical quality of the films. These findings establish a strong foundation for scalable production of high-quality a-SiCOI thin films, enabling their application in advanced chip-scale telecom PIC technologies. Full article

The fast-maturing photonic integration technology is calling for a versatile platform that supports both active and passive functions as well as high scalability through component miniaturization. Indium phosphide (InP) has long been recognized for its ability to deliver a comprehensive suite of photonic components. InP membrane technology has emerged as a next-generation solution that could unite the functional completeness with high scalability. This paper describes recent advancements in the InP-membrane-on-Si (IMOS) platform, which supports high-performance passives, polarization and mode handling, native light sources, amplifiers, modulators and detectors, and novel material integration. Full article

Advances in plaque imaging have transformed cardiovascular diagnostics through detailed characterization of atherosclerotic plaques beyond traditional stenosis assessment. This review outlines the clinical applications of varying modalities, including dual-layer spectral CT, photon-counting CT, dual-energy CT, and CT-derived fractional flow reserve (CT-FFR). These technologies offer improved spatial resolution, tissue differentiation, and functional assessment of coronary lesions. Additionally, artificial intelligence has emerged as a powerful tool to automate plaque detection, quantify burden, and refine risk prediction. Collectively, these innovations provide a more comprehensive approach to coronary artery disease evaluation and support personalized management strategies. Full article

Terahertz (THz) frequencies, spanning from 0.1 to 1 THz, are poised to play a pivotal role in the development of future 6G wireless communication systems. These systems aim to utilize photonic technologies to enable ultra-high data rates—on the order of terabits per second—while maintaining low latency and high efficiency. In this work, we present a novel photonic method for generating sub-THz vector signals within the THz band, employing a semiconductor optical amplifier (SOA) and phase modulator (PM) to create an optical frequency comb, combined with in-phase and quadrature (IQ) modulation techniques. We demonstrate, both through simulation and experimental setup, the generation and successful transmission of a 0.1 THz vector. The process involves driving the PM with a 12.5 GHz radio frequency signal to produce the optical comb; then, heterodyne beating in a uni-traveling carrier photodiode (UTC-PD) generates the 0.1 THz radio frequency signal. This signal is transmitted over distances of up to 30 km using single-mode fiber. The resulting 0.1 THz electrical vector signal, modulated with quadrature phase shift keying (QPSK), achieves a bit error ratio (BER) below the hard-decision forward error correction (HD-FEC) threshold of ${3.8 \times 10}^{-3}$. To the best of our knowledge, this is the first experimental demonstration of a 0.1 THz photonic vector THz wave based on an SOA and a simple PM-driven optical frequency comb. Full article

Herpes simplex virus type 1 (HSV-1) has a global prevalence of 64%. Established antiviral drugs, such as acyclovir (ACV), have been successfully used over the past decades. However, due to growing viral resistance against approved antivirals and the lack of effective vaccines, new concepts are essential to target HSV-1 infections. Here, we present data on the inhibitory effect of the procaine-based substance ProcCluster^® (PC) in reducing HSV-1 replication in vitro. Non-toxic PC concentrations significantly decreased HSV-1 replication in infected cells. Immunofluorescence microscopy revealed an accumulation of viral proteins in early and recycling endosomes, resulting in reduced viral release. The combination of PC with ACV resulted in an enhanced antiviral effect. Based on these results, PC alone, as well as in combination with ACV, appears to be a promising substance with antiviral potential against HSV-1 infections. Full article

Hierarchical surface structuring is a critical aspect of advanced materials design, impacting fields ranging from optics to biomimetics. Among several laser-based methods for complex structuring of photo-responsive surfaces, the broadband vectorial interferometry proposed here offers unique performances. Such a method leverages a polychromatic laser source, an unconventional choice for holographic encoding, to achieve deterministic multiscale surface structuring through interference light patterning. Azopolymer films are used as photosensitive substrates. By exploring the interaction between optomechanical stress modulations at different spatial periodicities induced within the polymer bulk, we demonstrate the emergence of hierarchical Fourier surfaces composed of multiple deterministic levels. These structures range from sub-micrometer to tens of micrometers scale, exhibiting a high degree of control over their morphology. The experimental findings reveal that the optical encoding scheme significantly influences the resulting topographies. The polarization light patterns lead to more regular and symmetric hierarchical structures compared to those obtained with intensity patterns, underscoring the role of vectorial light properties in controlling surface morphologies. The proposed method is fully scalable, compatible with more complex recording schemes (including multi-beam interference), and it is applicable to a wide range of advanced technological fields. These include optics and photonics (diffractive elements, polarimetric devices), biomimetic surfaces, topographical design, information encoding, and anti-counterfeiting, offering a rapid, reliable, and versatile strategy for high-precision surface structuring at a submicrometric scale. Full article

Liquid biopsy (LB) has gained attention as a valuable approach for cancer diagnostics, providing a minimally invasive option compared to conventional tissue biopsies and helping to overcome issues related to patient discomfort and procedural invasiveness. Recent advances in biosensor technologies, particularly photonic sensors, have improved the accuracy, speed, and real-time capabilities for detecting circulating biomarkers in biological fluids. Incorporating these tools into clinical practice facilitates more informed therapeutic choices and contributes to tailoring treatments to individual patient profiles. This review highlights the clinical potential of LB, examines technological limitations, and outlines future research directions. Departing from traditional biosensor focused reviews, it adopts a reverse-mapping approach grounded in clinically relevant tumor biomarkers. Specifically, biomarkers associated with prevalent cancers, such as breast, prostate, and lung cancers, serve as the starting point for identifying the most suitable photonic sensing platforms. The analysis underscores the need to align sensor design with the physicochemical properties of each biomarker and the operational requirements of the application. No photonic platform is universally optimal; rather, each exhibits specific strengths depending on performance metrics such as sensitivity, limit of detection, and easy system integration. Within this framework, the review provides a comprehensive assessment of emerging photonic biosensors and outlines key priorities to support their effective clinical translation in cancer diagnostics. Full article

Interest in germanium electronic devices is experiencing a comeback thanks to their suitability for a wide range of new applications, like CMOS transistors, quantum technology or infrared photonics. Among these applications, Ge-based thermophotovoltaic converters could become the backbone of thermo-electrical batteries. However, these devices are still far from the efficiency threshold needed for industrial deployment, with surface recombination as the main limiting factor for the material. In this work, we discuss the main passivation techniques developed for germanium photovoltaic and thermophotovoltaic devices, summarizing their main advantages and disadvantages. The analysis reveals that surface recombination velocities as low as 2.7 cm/s and 1.3 cm/s have already been reported for p-type and n-type germanium, respectively, although improving surface recombination velocities below 100 cm/s would result in marginal efficiency gains. Therefore, the main challenge for the material is not reducing this parameter further but developing robust and reliable processes for integrating the current techniques into functional devices. Full article

THz communication stands as a pivotal technology for 6G networks, designed to address the critical challenge of data demands surpassing current microwave and millimeter-wave (mmWave) capabilities. However, realizing Tbps and kilometer-range transmission confronts the “dual attenuation dilemma” comprising severe free-space path loss (FSPL) (>120 dB/km) and atmospheric absorption. This review comprehensively summarizes our group′s advancements in overcoming fundamental challenges of long-distance THz communication. Through systematic photonic–electronic co-optimization, we report key enabling technologies including photonically assisted THz signal generation, polarization-multiplexed multiple-input multiple-output (MIMO) systems with maximal ratio combining (MRC), high-gain antenna–lens configurations, and InP amplifier systems for complex weather resilience. Critical experimental milestones encompass record-breaking 1.0488 Tbps throughput using probabilistically shaped 64QAM (PS-64QAM) in the 330–500 GHz band; 30.2 km D-band transmission (18 Gbps with 543.6 Gbps·km capacity–distance product); a 3 km fog-penetrating link at 312 GHz; and high-sensitivity SIMO-validated 100 Gbps satellite-terrestrial communication beyond 36,000 km. These findings demonstrate THz communication′s viability for 6G networks requiring extreme-capacity backhaul and ultra-long-haul connectivity. Full article

This study explores the impact of graphene integration on lithium niobate (LiNbO₃, LN) ridge waveguides and directional couplers, focusing on coupling efficiency, polarization-dependent light absorption, and temperature sensitivity. Experimental and simulation results reveal that graphene loading significantly alters the effective mode refractive index and enhances waveguide coupling, enabling precise control over light transmission and power distribution. The temperature-dependent behavior of graphene–LN structures demonstrates strong thermal sensitivity, with notable changes in output power ratios between cross and through ports under varying temperatures. These findings highlight the potential of graphene–LN hybrid devices for compact, high-performance photonic circuits and temperature sensing applications. This study provides valuable insights into the design of advanced integrated photonic systems, paving the way for innovations in optical communication, sensing, and quantum technologies. Full article

Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor stroma, whose dynamic alterations significantly impact tumor progression and therapeutic responses. Conventional methods for TAM detection, such as biopsy, are invasive and incapable of whole-body dynamic monitoring. In contrast, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) offer a non-invasive imaging approach by targeting TAM-specific biomarkers like CD206, TSPO, and CCR2. This review comprehensively summarizes the advancements in TAM-targeted imaging probes, including cell surface markers, metabolic/functional markers, and multifunctional nanoprobe, while assessing their potential in tumor immune surveillance and tumor targeting therapeutic applications. While current probes, including ⁶⁸Ga-NOTA-anti-CD206 and ⁶⁴Cu-Macrin, have exhibited high specificity and theragnostic potential in preclinical and early clinical trials, challenges such as target heterogeneity, off-target effects, and clinical translation persist. Moving forward, the advancement of multi-target probes, optimization of pharmacokinetics, and incorporation of multimodal imaging technologies are anticipated to further enhance the impact of TAM-targeted imaging in precision medicine and tumor immunotherapy, fostering the refinement of personalized treatment strategies and improving patient outcomes. Full article

The exponential growth of plastic production in the healthcare sector and the limited capacity of conventional recycling systems have created a global environmental challenge. Latest 3D printing technologies have the potential to solve this problem by enabling on-demand, localized manufacturing. This study aimed to investigate the mechanical properties of 3D-printed ABS composites with Bi₂O₃ fillers after multiple recycling and irradiation cycles to assess their suitability for creating robust, reusable supporting devices for radiotherapy. Filaments of PLA, ABS, and ABS composites enriched with 5 wt% and 10 wt% Bi₂O₃ were extruded, repeatedly recycled through shredding and re-extrusion up to ten times and irradiated to 70 Gy using a 6 MeV photon beam to simulate clinical radiotherapy conditions. In contrast to PLA, ABS demonstrated better recyclability; however, after ten recycling cycles, its tensile strength declined from 25.1 MPa to 20.9 MPa, and its Young’s modulus decreased from 2503.5 MPa to 1410.4 MPa. Incorporation of 5 wt% Bi₂O₃ into ABS significantly improved recyclability and mechanical retention. After ten recycling rounds, an ABS composite containing 5 wt% Bi₂O₃ retained tensile strength of 22.2 MPa, modulus of 1553.9 MPa, and strain at break of 14.4%. In contrast, the composite enforced with 10 wt% Bi₂O₃ showed slightly lower performance, likely due to filler agglomeration. Under irradiation, the ABS–5 wt% Bi₂O₃ composite exhibited minimal additional degradation, maintaining mechanical integrity superior to other materials. These results indicate that ABS–5 wt% Bi₂O₃ is a promising, recyclable material for durable, patient-specific devices in radiotherapy, supporting sustainability in medical manufacturing. Full article