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Article

895 Views

22 Pages

Immunomodulatory Effects of High-Dose Irradiation Regimens in Renal Cell Carcinoma: Insights from an In Vitro Model with Human Peripheral Blood Mononuclear Cell

Fatima Meniai Merzouki,
Guillaume Paul Grolez,
Clément Bouchez,
Bertrand Leroux,
Jérôme Benoit,
Olivier Morales and
Nadira Delhem

Biomedicines2025, 13(9), 2107;https://doi.org/10.3390/biomedicines13092107

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29 August 2025

Background: Stereotactic ablative radiotherapy (SABR) is increasingly used in the treatment of localized and metastatic renal cell carcinoma (RCC), a malignancy traditionally considered radioresistant. Beyond direct cytotoxicity, SABR may promote imm...

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Article

1 Citations

2,273 Views

18 Pages

Effects of Pre-Calving Body Condition and Different post partum Concentrate Feed Proportions on Immune-Associated and Hematological Parameters in Pluriparous Dairy Cows

Katharina Bünemann,
Jana Frahm,
Susanne Kersten,
Liane Hüther,
Ulrich Meyer,
Helga Sauerwein,
Jürgen Hummel,
Annette Zeyner and
Sven Dänicke

Animals2020, 10(12), 2251;https://doi.org/10.3390/ani10122251

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30 November 2020

The present study aimed at evaluating the influences of different concentrate feed proportions in the ration offered to dairy cows post partum with different body condition scores (BCS) before calving. Therefore, 60 pluriparous cows were divided 42 d...

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Article

17 Citations

3,762 Views

15 Pages

Circulating Neoplastic-Immune Hybrid Cells Predict Metastatic Progression in Uveal Melanoma

Michael S. Parappilly,
Yuki Chin,
Riley M. Whalen,
Ashley N. Anderson,
Trinity S. Robinson,
Luke Strgar,
Thomas L. Sutton,
Patrick Conley,
Christopher Klocke and
Summer L. Gibbs
+ 4 authors

Cancers2022, 14(19), 4617;https://doi.org/10.3390/cancers14194617

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23 September 2022

Background: Uveal melanoma is an aggressive cancer with high metastatic risk. Recently, we identified a circulating cancer cell population that co-expresses neoplastic and leukocyte antigens, termed circulating hybrid cells (CHCs). In other cancers,...

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