Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (196)

Search Parameters:
Keywords = paper fluidics

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
23 pages, 8212 KiB  
Review
Recent Developments in the Nonlinear Hydroelastic Modeling of Sea Ice Interaction with Marine Structures
by Sarat Chandra Mohapatra, Pouria Amouzadrad and C. Guedes Soares
J. Mar. Sci. Eng. 2025, 13(8), 1410; https://doi.org/10.3390/jmse13081410 - 24 Jul 2025
Viewed by 337
Abstract
This review provides the recent advancements in nonlinear sea ice modeling for hydroelastic analysis of ice-covered channels and their interaction with floating structures. It surveys theoretical, experimental, and numerical methodologies used to analyze complex coupled sea ice–structure interactions. The paper discusses governing fluid [...] Read more.
This review provides the recent advancements in nonlinear sea ice modeling for hydroelastic analysis of ice-covered channels and their interaction with floating structures. It surveys theoretical, experimental, and numerical methodologies used to analyze complex coupled sea ice–structure interactions. The paper discusses governing fluid domain solutions, fluid–ice interaction mechanisms, and ice–structure (ship) contact models, alongside experimental techniques and various numerical models. While significant progress has been made, particularly with coupled approaches validated by experimental data, challenges remain in full-scale validation and accurately representing ice properties and dynamic interactions. Findings highlight the increasing importance of understanding sea ice interactions, particularly in the context of climate change, Arctic transportation, and the development of very large floating structures. This review serves as a crucial resource for advancing safe and sustainable Arctic and offshore engineering. Full article
(This article belongs to the Section Ocean Engineering)
Show Figures

Figure 1

26 pages, 406 KiB  
Article
A Path-Driven Fluid Routing and Scheduling Method for Continuous-Flow Microfluidic Biochips with Delay Time Optimization
by Zhisheng Chen, Bowen Liu, Hongjin Su, Zhen Chen, Genggeng Liu and Xing Huang
Micromachines 2025, 16(6), 625; https://doi.org/10.3390/mi16060625 - 26 May 2025
Viewed by 372
Abstract
Routing and application mapping are critical stages in the design of continuous-flow microfluidic biochips (CFMBs). The routing stage determines the channel network connecting components and ports, while application mapping schedules fluid transportation and wash operations based on the designed biochip architecture. Existing methods [...] Read more.
Routing and application mapping are critical stages in the design of continuous-flow microfluidic biochips (CFMBs). The routing stage determines the channel network connecting components and ports, while application mapping schedules fluid transportation and wash operations based on the designed biochip architecture. Existing methods typically handle these stages separately: routing focuses solely on physical metrics without considering subsequent scheduling requirements, while application mapping adopts one-shot scheduling strategies that can lead to suboptimal solutions. This paper proposes an integrated path-driven methodology that jointly optimizes routing and application mapping. For routing, we develop a hybrid particle swarm optimization algorithm that incorporates conflict awareness and channel utilization strategies. For application mapping, we introduce an iterative approach that leverages historical scheduling information to progressively optimize fluidic-handling and wash operations. Experimental results on both real and synthetic benchmarks demonstrate significant improvements over state-of-the-art methods, achieving reductions of 22.05% in total channel length, 21.79% in intersections, 21.97% in total delay time, and 8.30% in biochemical reaction completion time. The proposed methodology provides an effective solution for the automated design of CFMBs with enhanced physical and operational efficiency. Full article
Show Figures

Figure 1

17 pages, 985 KiB  
Article
SlimPort: Port-Driven High-Level Synthesis for Continuous-Flow Microfluidic Biochips
by Youlin Pan, Yanbo Xu, Ziyang Chen, Xing Huang and Genggeng Liu
Micromachines 2025, 16(5), 577; https://doi.org/10.3390/mi16050577 - 14 May 2025
Viewed by 355
Abstract
Continuous-flow microfluidic biochips (CFMBs) automatically execute various bioassays by precisely controlling the transport of fluid samples, which is driven by pressure delivered through fluidic ports. High-level synthesis, as an important stage in the design flow of CFMBs, generates binding and scheduling solutions whose [...] Read more.
Continuous-flow microfluidic biochips (CFMBs) automatically execute various bioassays by precisely controlling the transport of fluid samples, which is driven by pressure delivered through fluidic ports. High-level synthesis, as an important stage in the design flow of CFMBs, generates binding and scheduling solutions whose quality directly affects the efficiency of the execution of bioassays. Existing high-level synthesis methods perform numerous transport tasks concurrently to increase efficiency. However, fluidic ports cannot be shared between concurrently executing transport tasks, resulting in a large number of fluidic ports introduced by existing methods. Increasing the number of fluidic ports undermines the integration, reduces the reliability, and increases the manufacturing cost. In this paper, we propose a port-driven high-level synthesis method based on integer linear programming (ILP) called SlimPort, integrating the optimization of fluidic port number into high-level synthesis, which has never been considered in prior work. Meanwhile, to ensure bioassay correctness, volume management between devices with a non-fixed input/output ratio is realized. Additionally, two acceleration strategies for ILP, scheduling constraint reduction and upper boundary estimation of fluidic port number, are proposed to improve the efficiency of SlimPort. Experimental results from multiple benchmarks demonstrate that SlimPort leads to high assay execution efficiency and a low number of fluidic ports. Full article
(This article belongs to the Special Issue Electronic Design Automation (EDA) for Microfluidic Biochips)
Show Figures

Figure 1

35 pages, 13922 KiB  
Review
Advances on Deflagration to Detonation Transition Methods in Pulse Detonation Engines
by Zhiwu Wang, Weifeng Qin, Lisi Wei, Zixu Zhang and Yuxiang Hui
Energies 2025, 18(8), 2109; https://doi.org/10.3390/en18082109 - 19 Apr 2025
Cited by 4 | Viewed by 1205
Abstract
Pulse detonation engines (PDEs) have become a transformative technology in the field of aerospace propulsion due to the high thermal efficiency of detonation combustion. However, initiating detonation waves within a limited space and time is key to their engineering application. Direct initiation, though [...] Read more.
Pulse detonation engines (PDEs) have become a transformative technology in the field of aerospace propulsion due to the high thermal efficiency of detonation combustion. However, initiating detonation waves within a limited space and time is key to their engineering application. Direct initiation, though theoretically feasible, requires very high critical energy, making it almost impossible to achieve in engineering applications. Therefore, indirect initiation methods are more practical for triggering detonation waves that produce a deflagration wave through a low-energy ignition source and realizing deflagration to detonation transition (DDT) through flame acceleration and the interaction between flames and shock waves. This review systematically summarizes recent advancements in DDT methods in pulse detonation engines, focusing on the basic principles, influencing factors, technical bottlenecks, and optimization paths of the following: hot jet ignition initiation, obstacle-induced detonation, shock wave focusing initiation, and plasma ignition initiation. The results indicate that hot jet ignition enhances turbulent mixing and energy deposition by injecting energy through high-energy jets using high temperature and high pressure; this can reduce the DDT distance of hydrocarbon fuels by 30–50%. However, this approach faces challenges such as significant jet energy dissipation, flow field instability, and the complexity of the energy supply system. Solid obstacle-induced detonation passively generates turbulence and shock wave reflection through geometric structures to accelerate flame propagation, which has the advantages of having a simple structure and high reliability. However, the problem of large pressure loss and thermal fatigue restricts its long-term application. Fluidic obstacle-induced detonation enhances mixing uniformity through dynamic disturbance to reduce pressure loss. However, its engineering application is constrained by high energy consumption requirements and jet–mainstream coupling instability. Shock wave focusing utilizes concave cavities or annular structures to concentrate shock wave energy, which directly triggers detonation under high ignition efficiency and controllability. However, it is extremely sensitive to geometric parameters and incident shock wave conditions, and the structural thermal load issue is prominent. Plasma ignition generates active particles and instantaneous high temperatures through high-energy discharge, which chemically activates fuel and precisely controls the initiation sequence, especially for low-reactivity fuels. However, critical challenges, such as high energy consumption, electrode ablation, and decreased discharge efficiency under high-pressure environments, need to be addressed urgently. In order to overcome the bottlenecks in energy efficiency, thermal management, and dynamic stability, future research should focus on multi-modal synergistic initiation strategies, the development of high-temperature-resistant materials, and intelligent dynamic control technologies. Additionally, establishing a standardized testing system to quantify DDT distance, energy thresholds, and dynamic stability indicators is essential to promote its transition to engineering applications. Furthermore, exploring the DDT mechanisms of low-carbon fuels is imperative to advance carbon neutrality goals. By summarizing the existing DDT methods and technical bottlenecks, this paper provides theoretical support for the engineering design and application of PDEs, contributing to breakthroughs in the fields of hypersonic propulsion, airspace shuttle systems, and other fields. Full article
(This article belongs to the Section I2: Energy and Combustion Science)
Show Figures

Figure 1

14 pages, 2672 KiB  
Article
A Bio-Inspired Flexible Arm for Subsea Inspection: A Water Hydraulically Actuated Continuum Manipulator
by Emanuele Guglielmino, David Branson and Paolo Silvestri
J. Mar. Sci. Eng. 2025, 13(4), 676; https://doi.org/10.3390/jmse13040676 - 27 Mar 2025
Viewed by 511
Abstract
This paper outlines the outcomes of a multidisciplinary initiative aimed at creating flexible arms that leverage key aspects of soft-bodied sea animal anatomy. We designed and prototyped a flexible arm inspired by nature while focusing on integrating practical engineering technologies from a system [...] Read more.
This paper outlines the outcomes of a multidisciplinary initiative aimed at creating flexible arms that leverage key aspects of soft-bodied sea animal anatomy. We designed and prototyped a flexible arm inspired by nature while focusing on integrating practical engineering technologies from a system perspective. The mechanical structure was developed by studying soft-bodied marine animals from the cephalopod order. Simultaneously, we carefully addressed engineering challenges and limitations, including material flexibility, inherent safety, energy efficiency, cost-effectiveness, and manufacturing feasibility. The design process is demonstrated through two successive generations of prototypes utilizing fluidic actuators. The first one exhibited both radial and longitudinal actuators, the second one only longitudinal actuators, thus trading off between bio-inspiration and engineering constraints. Full article
Show Figures

Figure 1

16 pages, 8330 KiB  
Article
Simulation and Experimental Research on a Fluidic Oscillator with a Deflector Structure
by Jiming Li, Jianming Peng, Dong Ge and Guang Zhang
Energies 2025, 18(6), 1336; https://doi.org/10.3390/en18061336 - 8 Mar 2025
Viewed by 592
Abstract
In the exploitation of deep geothermal energy from hot dry rock (HDR) reservoirs, traditional drilling methodologies exhibit a retarded penetration rate, posing a significant impediment to efficient energy extraction. The fluidic DTH hammer is recognized as a drilling method with potential in hard [...] Read more.
In the exploitation of deep geothermal energy from hot dry rock (HDR) reservoirs, traditional drilling methodologies exhibit a retarded penetration rate, posing a significant impediment to efficient energy extraction. The fluidic DTH hammer is recognized as a drilling method with potential in hard formations. However, a low energy utilization was observed due to the substantial fluid loss in the fluidic oscillator (the control component of a fluidic hammer). In order to reduce the energy loss and improve the performance of fluidic hammers, a fluidic oscillator with a deflector structure is proposed in this paper. Utilizing Computational Fluid Dynamics (CFD) simulations, the optimal structural parameters for the deflector structure have been delineated, with dimensions specified as follows: a = 13.5 mm; b = 2.0 mm; and c = 2.2 mm. Subsequently, the flow field and the performance were observed. The maximum flow recovery of the output channel of the deflector structure increased by 9.1% in the backward stroke and 3.6% in the forward stroke. Moreover, the locking vortex range is expanded upward, which improves the wall attachment stability of the main jet. Finally, to substantiate the numerical findings and evaluate the practical efficacy of the deflector structure, a series of bench tests were conducted. According to the results, compared with the original structure, the average impact frequency can be increased by 5.8%, the single average impact energy increased by 7.5%, and the output power increased by 13.8%. Full article
Show Figures

Figure 1

18 pages, 1620 KiB  
Review
Applications of 3D Printing in Paper-Based Devices for Biochemical and Environmental Analyses
by Tran Quoc Thang and Joohoon Kim
Chemosensors 2025, 13(3), 89; https://doi.org/10.3390/chemosensors13030089 - 4 Mar 2025
Cited by 1 | Viewed by 1489
Abstract
Paper-based analytical devices (PADs) have received considerable attention due to their affordability, portability, and ease of use, making them suitable for on-site and point-of-care testing. The conventional fabrication of PADs has been explored for years to enhance their performance in sensing applications. Recently, [...] Read more.
Paper-based analytical devices (PADs) have received considerable attention due to their affordability, portability, and ease of use, making them suitable for on-site and point-of-care testing. The conventional fabrication of PADs has been explored for years to enhance their performance in sensing applications. Recently, to facilitate the automated production of PADs and support their practical use, 3D printing technology has been applied to fabricate PADs. Integrating 3D printing with PADs allows for precise fabrication without human intervention, improves fluidic control, and enables the development of complete devices. This technology allows for the printing of 3D parts that can be integrated with smartphones, making portable sensing applications of PADs more feasible. This mini-review highlights recent advancements in the application of 3D printing techniques to PADs. It focuses on their use in detecting biochemical analytes and monitoring environmental pollutants. Additionally, this review discusses the challenges and future possibilities of integrating 3D printing with PADs. Full article
Show Figures

Figure 1

18 pages, 6141 KiB  
Article
Optimizing Solid Rocket Missile Trajectories: A Hybrid Approach Using an Evolutionary Algorithm and Machine Learning
by Carlo Ferro, Matteo Cafaro and Paolo Maggiore
Aerospace 2024, 11(11), 912; https://doi.org/10.3390/aerospace11110912 - 6 Nov 2024
Cited by 1 | Viewed by 2034
Abstract
This paper introduces a novel approach for modeling and optimizing the trajectory and behavior of small solid rocket missiles. The proposed framework integrates a six-degree-of-freedom (6DoF) simulation environment experimentally tuned for accuracy, with a combination of genetic algorithms (GAs) and machine learning (ML) [...] Read more.
This paper introduces a novel approach for modeling and optimizing the trajectory and behavior of small solid rocket missiles. The proposed framework integrates a six-degree-of-freedom (6DoF) simulation environment experimentally tuned for accuracy, with a combination of genetic algorithms (GAs) and machine learning (ML) to enhance the performance of the missile path. In the initial phase, a GA is employed to optimize the missile’s trajectory for efficient target acquisition, defining key launch parameters such as the ramp angle and lateral maneuver force to minimize positional errors and to ensure effective target engagement. Following trajectory optimization, the derived data are used to train an ML model that predicts setup parameters, significantly reducing computational costs and time. This close integration enables real-time adjustments for acquiring moving targets, thereby improving accuracy and minimizing maneuvering costs. This study also explores the application of fluidic thrust vectoring for small rockets, providing an innovative solution to enhance maneuverability and control, especially at low speeds. The proposed framework was validated using experimental launch data from the Icarus Team. The methodology offers a robust and cost-effective solution for precision targeting and improved maneuverability in aerospace and defense contexts. Full article
(This article belongs to the Section Astronautics & Space Science)
Show Figures

Figure 1

22 pages, 15149 KiB  
Article
A Peridynamics-Smoothed Particle Hydrodynamics Coupling Method for Fluid-Structure Interaction
by Chengjie Cao, Chenxu Gu, Chao Wang, Chunhui Wang, Pei Xu and Hui Wang
J. Mar. Sci. Eng. 2024, 12(11), 1968; https://doi.org/10.3390/jmse12111968 - 1 Nov 2024
Cited by 1 | Viewed by 1277
Abstract
Ice–water interaction is a critical issue of engineering studies in polar regions. This paper proposes a methodology to simulate fluid–ice interactions by employing a structure modeled using ordinary state-based peridynamics (OSB-PD) within a smoothed particle hydrodynamics (SPH) framework, effectively representing a deformable moving [...] Read more.
Ice–water interaction is a critical issue of engineering studies in polar regions. This paper proposes a methodology to simulate fluid–ice interactions by employing a structure modeled using ordinary state-based peridynamics (OSB-PD) within a smoothed particle hydrodynamics (SPH) framework, effectively representing a deformable moving boundary. The forces at the fluid–structure interface are delineated by solving the fluid motion equations for normal forces exerted by the fluid on the structure, grounded in the momentum conservation law. Upon validating the PD and SPH methods, a dam break flowing through an elastic gate was simulated. When compared with experimental results, the model exhibited discrepancies of 3.8%, 0.5%, and 4.6% in the maximum horizontal displacement, maximum vertical displacement, and the waterline deviation (W = 0.05 m), respectively. Moreover, the method demonstrated a high degree of accuracy in simulating the fracture of in-situ cantilever ice beams, with deflection closely matching experimental data and a 7.4% error in maximum loading force. The proposed PD-SPH coupling approach demonstrates its effectiveness in capturing the complex fluid–structure interactions and provides a valuable tool for studying the deformation and fracture of structures under the influence of fluid forces. Full article
(This article belongs to the Section Ocean Engineering)
Show Figures

Figure 1

18 pages, 2831 KiB  
Article
Framework for Microdosing Odors in Virtual Reality for Psychophysiological Stress Training
by Daniel Anheuer, Brid Karacan, Lara Herzog, Nora Weigel, Silja Meyer-Nieberg, Thomas Gebhardt, Jessica Freiherr, Martin Richter, Armin Leopold, Monika Eder, Marko Hofmann, Karl-Heinz Renner and Cornelia Küsel
Sensors 2024, 24(21), 7046; https://doi.org/10.3390/s24217046 - 31 Oct 2024
Cited by 2 | Viewed by 3446
Abstract
To better cope with stress in emergencies, emergency personnel undergo virtual reality (VR) stress training. Such training typically includes visual, auditory and sometimes tactile impressions, whereas olfactory stimuli are mostly neglected. This concept paper therefore examines whether odors might be beneficial for further [...] Read more.
To better cope with stress in emergencies, emergency personnel undergo virtual reality (VR) stress training. Such training typically includes visual, auditory and sometimes tactile impressions, whereas olfactory stimuli are mostly neglected. This concept paper therefore examines whether odors might be beneficial for further enhancing the experience of presence and immersion into a simulated environment. The aim is to demonstrate the benefits of VR civilian stress training for emergency personnel and to investigate the role of odors as stressors by manipulating the degree of perceived psychophysiological stress via olfactory impressions. Moreover, the current paper presents the development and validation of a convenient and portable fragrance dosing system that allows personalized odor presentation in VR. The presented system can transport reproducible small quantities of an air-fragrance mixture close to the human nose using piezoelectric stainless steel micropumps. The results of the fluidic system validation indicate that the micropump is suitable for releasing odors close to the nose with constant amounts of odor presentation. Furthermore, the theoretical background and the planned experimental design of VR stress training, including odor presentation via olfactory VR technology, are elucidated. Full article
(This article belongs to the Special Issue Sensing Technology in Virtual Reality)
Show Figures

Figure 1

36 pages, 139423 KiB  
Article
Novel Fluidic Oscillator Evaluation Considering Dimensional Modifications
by Kavoos Karimzadegan and Josep M. Bergada
Appl. Sci. 2024, 14(21), 9912; https://doi.org/10.3390/app14219912 - 29 Oct 2024
Viewed by 1182
Abstract
Although flow mixing and cooling can be greatly enhanced when considering the use of fluidic oscillators (FOs), they are more commonly employed in active flow control (AFC) applications where the injected pulsating flow interacts with the boundary layer, usually in order to delay [...] Read more.
Although flow mixing and cooling can be greatly enhanced when considering the use of fluidic oscillators (FOs), they are more commonly employed in active flow control (AFC) applications where the injected pulsating flow interacts with the boundary layer, usually in order to delay its separation. In fact, prior to any FO implementation in a given application, it is essential to study the range of frequencies and amplitudes it can generate as a function of the incoming mass flow and its dimensions. This is what is being performed in the present manuscript for a rather novel FO configuration. A numerical study of a standard three-dimensional (3D) FO configuration, and also using a two-dimensional (2D) approach, is initially presented. After comparing the 3D and the 2D results and analyzing the main differences, we modified some of the internal dimensions of the FO in order to evaluate the variation in its dynamic performance. The present results clarify which internal dimensional modifications are more effective in generating larger output frequencies and velocity field variations. Care is taken to analyze the origin of self-sustained oscillations. This paper links, for the first time, the origin of the pressure force oscillations at the feedback channel’s outlet, with the interaction of the mixing chamber central jet and the reverse feedback channel flow at the mixing chamber’s converging walls. A novel equation relating the FO outlet mass flow frequency with the time-averaged FC reverse flow is presented and discussed. In fact, the present study needs to be seen as the continuation of a former one, recently published by authors, where the effects of several Reynolds numbers as well as some different internal dimensions were considered. Full article
(This article belongs to the Section Fluid Science and Technology)
Show Figures

Figure 1

18 pages, 4168 KiB  
Article
Enhanced Performance of Fluidic Phononic Crystal Sensors Using Different Quasi-Periodic Crystals
by Ahmed G. Sayed, Ali Hajjiah, Mehdi Tlija, Stefano Bellucci, Mostafa R. Abukhadra, Hussein A. Elsayed and Ahmed Mehaney
Crystals 2024, 14(11), 925; https://doi.org/10.3390/cryst14110925 - 26 Oct 2024
Viewed by 1033
Abstract
In this paper, we introduce a comprehensive theoretical study to obtain an optimal highly sensitive fluidic sensor based on the one-dimensional phononic crystal (PnC). The mainstay of this study strongly depends on the high impedance mismatching due to the irregularity of the considered [...] Read more.
In this paper, we introduce a comprehensive theoretical study to obtain an optimal highly sensitive fluidic sensor based on the one-dimensional phononic crystal (PnC). The mainstay of this study strongly depends on the high impedance mismatching due to the irregularity of the considered quasi-periodic structure, which in turn can provide better performance compared to the periodic PnC designs. In this regard, we performed the detection and monitoring of the different concentrations of lead nitrate (Pb(NO3)2) and identified it as being a dangerous aqueous solution. Here, a defect layer was introduced through the designed structure to be filled with the Pb(NO3)2 solution. Therefore, a resonant mode was formed within the transmittance spectrum of the considered structure, which in turn shifted due to the changes in the concentration of the detected analyte. The numerical findings demonstrate the role of the different sequences such as Fibonacci, Octonacci, Thue–Morse, and double period on the performance of the designed PhC detector. Meanwhile, the findings of this study show that the double-period quasi-periodic sequence provides the best performance with a sensitivity of 502.6 Hz/ppm, a damping rate of 5.9×105, a maximum quality factor of 8463.5, and a detection limit of 2.45. Full article
Show Figures

Figure 1

18 pages, 1854 KiB  
Article
Modeling of Actuation Force, Pressure and Contraction of Fluidic Muscles Based on Machine Learning
by Sandi Baressi Šegota, Mario Ključević, Dario Ogrizović and Zlatan Car
Technologies 2024, 12(9), 161; https://doi.org/10.3390/technologies12090161 - 12 Sep 2024
Viewed by 2362
Abstract
In this paper, the dataset is collected from the fluidic muscle datasheet. This dataset is then used to train models predicting the pressure, force, and contraction length of the fluidic muscle, as three separate outputs. This modeling is performed with four algorithms—extreme gradient [...] Read more.
In this paper, the dataset is collected from the fluidic muscle datasheet. This dataset is then used to train models predicting the pressure, force, and contraction length of the fluidic muscle, as three separate outputs. This modeling is performed with four algorithms—extreme gradient boosted trees (XGB), ElasticNet (ENet), support vector regressor (SVR), and multilayer perceptron (MLP) artificial neural network. Each of the four models of fluidic muscles (5-100N, 10-100N, 20-200N, 40-400N) is modeled separately: First, for a later comparison. Then, the combined dataset consisting of data from all the listed datasets is used for training. The results show that it is possible to achieve quality regression performance with the listed algorithms, especially with the general model, which performs better than individual models. Still, room for improvement exists, due to the high variance of the results across validation sets, possibly caused by non-normal data distributions. Full article
(This article belongs to the Section Manufacturing Technology)
Show Figures

Figure 1

12 pages, 14542 KiB  
Communication
Offsetting Dense Particle Sedimentation in Microfluidic Systems
by Tochukwu Dubem Anyaduba and Jesus Rodriguez-Manzano
Micromachines 2024, 15(9), 1063; https://doi.org/10.3390/mi15091063 - 23 Aug 2024
Viewed by 4586
Abstract
Sedimentation is an undesirable phenomenon that complicates the design of microsystems that exploit dense microparticles as delivery tools, especially in biotechnological applications. It often informs the integration of continuous mixing modules, consequently impacting the system footprint, cost, and complexity. The impact of sedimentation [...] Read more.
Sedimentation is an undesirable phenomenon that complicates the design of microsystems that exploit dense microparticles as delivery tools, especially in biotechnological applications. It often informs the integration of continuous mixing modules, consequently impacting the system footprint, cost, and complexity. The impact of sedimentation is significantly worse in systems designed with the intent of particle metering or binary encapsulation in droplets. Circumventing this problem involves the unsatisfactory adoption of gel microparticles as an alternative. This paper presents two solutions—a hydrodynamic solution that changes the particle sedimentation trajectory relative to a flow-rate dependent resultant force, and induced hindered settling (i-HS), which exploits Richardson–Zaki (RZ) corrections of Stokes’ law. The hydrodynamic solution was validated using a multi-well fluidic multiplexing and particle metering manifold. Computational image analysis of multiplex metering efficiency using this method showed an average reduction in well-to-well variation in particle concentration from 45% (Q = 1 mL/min, n = 32 total wells) to 17% (Q = 10 mL/min, n = 48 total wells). By exploiting a physical property (cloud point) of surfactants in the bead suspension in vials, the i-HS achieved a 58% reduction in the sedimentation rate. This effect results from the surfactant phase change, which increases the turbidity (transient increase in particle concentration), thereby exploiting the RZ theories. Both methods can be used independently or synergistically to eliminate bead settling in microsystems or to minimize particle sedimentation Full article
Show Figures

Figure 1

11 pages, 7955 KiB  
Article
Grating Bio-Microelectromechanical Platform Architecture for Multiple Biomarker Detection
by Fahimeh Marvi, Kian Jafari and Mohamad Sawan
Biosensors 2024, 14(8), 385; https://doi.org/10.3390/bios14080385 - 9 Aug 2024
Cited by 1 | Viewed by 2117
Abstract
A label-free biosensor based on a tunable MEMS metamaterial structure is proposed in this paper. The adopted structure is a one-dimensional array of metamaterial gratings with movable and fixed fingers. The moving unit of the optical detection system is a component of the [...] Read more.
A label-free biosensor based on a tunable MEMS metamaterial structure is proposed in this paper. The adopted structure is a one-dimensional array of metamaterial gratings with movable and fixed fingers. The moving unit of the optical detection system is a component of the MEMS structure, driven by the surface stress effect. Thus, these suspended optical nanoribbons can be moved and change the grating pattern by the biological bonds that happened on the modified cantilever surface. Such structural variations lead to significant changes in the optical response of the metamaterial system under illuminating angled light and subsequently shift its resonance wavelength spectrum. As a result, the proposed biosensor shows appropriate analytical characteristics, including the mechanical sensitivity of Sm = 11.55 μm/Nm−1, the optical sensitivity of So = Δλ/Δd = 0.7 translated to So = Δλ/Δσ = 8.08 μm/Nm−1, and the quality factor of Q = 102.7. Also, considering the importance of multi-biomarker detection, a specific design of the proposed topology has been introduced as an array for identifying different biomolecules. Based on the conducted modeling and analyses, the presented device poses the capability of detecting multiple biomarkers of disease at very low concentrations with proper precision in fluidic environments, offering a suitable bio-platform for lab-on-chip structures. Full article
(This article belongs to the Special Issue Micro-nano Optic-Based Biosensing Technology and Strategy)
Show Figures

Figure 1

Back to TopTop