Search Results (108)

Background/Objectives: Parents of children with Attention Deficit Hyperactivity Disorder (ADHD) present high levels of stress. This population may benefit from Mindfulness-based interventions (MBI) to reduce their stress. This systematic review assesses current literature about the efficacy of MBI for managing stress and stress-related outcomes among those parents. Methods: Studies published up to September 2025 were systematically searched in PubMed, Cochrane Library, Web of Science, and Scopus, and complemented with citation tracking. Both randomized and non-randomized studies were included, provided they quantitatively evaluated parenting stress. Bias assessment was performed using Cochrane ROB-2 and ROBINS-I tools and GRADE analysis was performed. A qualitative synthesis is presented due to the substantial heterogeneity among studies. Results: Nineteen studies including nine Randomized Control Trials (RCTs) and ten non-RCTs met the inclusion criteria. Eight studies used an MBI for parents only, ten studies had a parallel intervention for the child/adolescent, and one study used an MBI for parents and teachers. Overall, the studies showed statistically significant stress reduction, either immediately after the end of the MBI (five RCTs and three non-RCTs) and mostly maintained at follow-up or presenting a delayed therapeutic effect which was only evident at the follow-up analysis (one RCT and four non-RCTs). However, some studies reported only mixed findings or no significant differences (three RCTs and two non-RCTs), and one non-RCT reported worsening of stress. Stress-related outcomes varied among different studies. Conclusions: MBI may have a significant role in reducing the stress of parents of children with ADHD and may improve stress-related outcomes, such as quality of life, psychological well-being, and parenting over-reactivity. Further studies with longer follow-up periods and lower risk of bias are necessary to clarify possible effects of MBI in stress reduction in parents with ADHD. Full article

Objective: Contrary to the traditional notion of risk–return trade-off, prior studies document that financially distressed stocks tend to earn lower future returns than their healthier peers. Extending this strand of literature, this study revisits the distress risk anomaly in UK stocks and further examines whether proximity to the 52-week high and lottery-like characteristics of stocks help explain the financial distress anomaly, if any. Data and methods: In this paper, we analyse the distress risk anomaly using a sample of 4514 UK stocks over the period 2000–2021. The analysis is conducted using both the portfolio-sorting method and Fama–MacBeth cross-sectional regressions. Key findings: The empirical findings confirm the persistence of the financial distress anomaly, showing that high-distress stocks earn lower returns than their low-distress counterparts. Consistent with a mispricing explanation, this inverse distress–return relationship is more pronounced for stocks that are difficult to arbitrage and is stronger following periods of market optimism. Furthermore, the analysis reveals that both the 52-week high effect and lottery-like trading, independently and jointly, contribute to the poor performance of financially distressed stocks. This suggests that underreaction and overreaction interact to shape the observed overvaluation of distressed stocks. These findings remain robust to a battery of robustness checks. The results have several important implications for investors, researchers, and regulators. Full article

The growing prevalence of gaming disorder (GD) in adolescents is a global concern. Despite parents’ critical role in addressing GD, how dysfunctional parenting practices are associated with adolescent GD remains understudied. This study assessed the association between dysfunctional parenting practices and adolescent GD among Japanese male junior high school students. Data were collected in 2024 via web-based, self-administered questionnaires from 300 parents (183 fathers and 117 mothers), each reporting on one male junior high school student. Suspected GD was assessed using a validated parent report measure (i.e., the Gaming Disorder Scale for Parents). Dysfunctional parenting practices were measured using the Parenting Scale, comprising two dimensions: Overreactivity and Laxness. Mean factor scores of Overreactivity and Laxness were compared between the suspected and non-suspected GD groups using a t-test. Logistic regression models assessed the association of Overreactivity and Laxness with suspected GD, controlling for covariates. The mean score of Overreactivity was significantly higher in the suspected GD group than in the non-suspected group, whereas that of Laxness was not. After adjustment, overreactive parenting was significantly associated with suspected GD (adjusted odds ratio: 1.89, 95% CI [1.31, 2.74]). This study showed that overreactive parenting was independently and significantly associated with increased odds of suspected GD. Full article

In organizational cyber crises, incident response and official communication form coupled control loops, yet they are usually engineered separately. We present V-CHIMERA (Verified Coupled Human–Information–Machine Incident Response Architecture), a framework for organizational cyber crisis response under misinformation that jointly models cyber state, belief dynamics, trust, and communication governance. The framework combines three elements: an explicit cyber–social coupling architecture, a runtime protocol shield for communication safety, and immune-gated coupling (IGC) that uses danger signaling, tolerance thresholds, and immune memory to regulate when social feedback should affect operational response and how strongly counter-messaging should be targeted. Across three representative scenarios—ransomware rumor, outage rumor, and exfiltration scam—and eight seeds per scenario, all shielded policies achieved zero executed protocol violations. Relative to naive coupled control, IGC reduced cyber-harm area under the curve (AUC) by 57.6% in ransomware rumor and 42.6% in outage rumor while also reducing misbelief. Results were scenario-dependent rather than uniformly dominant: in exfiltration scam, a broadcast-only ablation outperformed targeted messaging, showing that targeting can fail when diffusion rapidly crosses community boundaries. Sensitivity analysis further shows that IGC attenuates the brittleness observed under strong coupling and weak moderation. The results suggest that biomimetic regulation is valuable not because coupling always helps, but because it prevents overreaction, clarifies when targeting should be used, and yields safer organizational defaults for misinformation-aware incident response. Full article

Background/Objectives: Viral respiratory tract infections (VRTIs) in patients with diabetes mellitus (DM) are characterized by a severity gap rather than an infection gap. This review synthesizes evidence from the 2023–2026 respiratory seasons to provide a post-pandemic framework for managing the synergistic metabolic and viral threats in this population. Materials and Methods: A scoping review of literature from PubMed, Scopus, and Embase (2023–2026) was conducted, focusing on clinical outcomes and mechanistic interactions between DM and emerging respiratory pathogens. Results: Recent data identify human Metapneumovirus (hMPV) and adenovirus as significant threats to diabetic hosts, with mortality risks equivalent to seasonal influenza (HR 1.00 for hMPV vs. influenza). The two-hit model combines a baseline of innate immune paralysis, characterized by impaired neutrophil chemo-taxis and mechanical SP-D dysfunction, with a cellular signaling environment primed for cytokine overreaction by epigenetic metabolic memory. The stress hyperglycemia ratio (SHR) has emerged as a promising predictor of mortality compared to absolute glucose or HbA1c, with a proposed threshold of ≥1.14 identifying patients at 3.5-fold increased risk for mechanical ventilation. Precision management should consider the prudent suspension of SGLT2 inhibitors to mitigate euglycemic DKA risks and considering the early use of GLP-1 receptor agonists for their hypothesized pulmonary anti-inflammatory properties. Conclusions: Closing the mortality gap may require a shift from generic viral care to a precision model that treats metabolic susceptibility with high clinical priority alongside the treatment of the viral pathogen. Full article

Background/Objectives: Mindfulness-based interventions show promise for treating childhood ADHD, yet the mechanisms through which they produce effects remain unclear. This study provides the first direct comparison of treatment mechanisms between a mindfulness-based family intervention (MYmind) and methylphenidate. Methods: Data were drawn from a preregistered trial combining randomized and preference arms, comparing MYmind (2-month parallel parent–child mindfulness training) with 4-month methylphenidate in children aged 8–18 with ADHD (N = 120 children, 224 parents). Families were assessed at baseline, 2, 4 and 10 months. Multilevel mediation analyses tested whether treatment effects on ADHD symptoms were transmitted through 111 treatment-to-mediator-to-outcome pathways across three mechanism categories: child emotion regulation and coping (all children); adolescent self-regulation and mindfulness (ages 11+); and parent-level mechanisms, including mindful parenting, parental mindfulness, parenting style and self-compassion. Results: Direct treatment effects favored methylphenidate for ADHD symptom reduction at 4 months, with mindfulness catching up by 10 months. MYmind produced significantly greater improvements than methylphenidate in adolescent healthy self-regulation, parental self-compassion, mindful parenting and over-reactive parenting. Treatment did not differentially affect the remaining mechanisms. Across model sets, observed emotion regulation, maladaptive coping, parental self-compassion and mindful parenting each predicted ADHD outcomes. Across 111 pathways tested in 18 models, numerous significant individual pathways were consistent with theoretical predictions, yet no complete mediation chains reached statistical significance. Conclusions: MYmind engages distinct psychological and family-level processes compared to methylphenidate that are separately associated with ADHD symptom improvement. The absence of significant mediation effects likely reflects power limitations. These findings support mindfulness-based family intervention as a viable alternative to medication and highlight the need for larger-scale mechanism research. Full article

Political events in major economies generate uncertainty that can propagate through global financial markets, influencing investor behaviour and asset prices. The 2024–2025 U.S. presidential election cycle, including presidential debates, assassination attempts, the election outcome, the inauguration, and major policy announcements, such as liberation day tariffs, provides a unique setting to examine these effects. This study investigates how international stock markets responded to these sequential political events, focusing on abnormal returns (ARs) and cumulative abnormal returns (CARs) across G20 countries. Using both mean-adjusted and market models, complemented by cross-sectional regressions, the analysis captures heterogeneous market reactions while accounting for the role of market fundamentals. The results indicate that markets often anticipate events, react strongly to new information, and gradually adjust as uncertainty dissipates. Emerging markets generally exhibited positive reactions, whereas developed markets responded more cautiously or negatively to political shocks. Cross-sectional regression analysis further shows that market fundamentals have a limited influence on ARs but significantly shape CARs, consistent with overreaction and uncertain information hypotheses. Overall, these findings provide evidence on how global financial markets process political uncertainty and underscore the importance of sequential political events for investors, portfolio managers, and policymakers. Full article

Despite practice models of trauma-informed care (TIC) emphasizing relational engagement and emotional attunement as critical to service delivery, the role of individual dispositions in shaping staff perceptions and behavior remains underexplored. This study examined how rejection sensitivity, a construct grounded in attachment theory, defined as a dispositional tendency to anxiously expect and overreact to perceived rejection, may influence staff perceptions of their roles and client relationships in residential mental health agencies implementing TIC. We further explored whether individual and organizational factors, including job satisfaction, prior trauma training, perceived isolation at work, and trauma-related knowledge, contribute to these associations. Regression analyses were conducted on survey data from 155 frontline staff across three agencies testing the associations between rejection sensitivity and two relational outcomes: perceptions of work and of clients. Higher rejection sensitivity was significantly associated with more disengaged perceptions of work and less empathic views of clients, even after controlling for demographic and contextual organizational variables. Job satisfaction and trauma knowledge emerged as domain-specific protective factors, reducing the negative impact of rejection sensitivity. The findings underscore the importance of addressing staff relational dispositions to sustain effective TIC implementation. Enhancing job satisfaction and trauma knowledge may help support staff engagement in trauma-informed practice. Full article

This study evaluates the applicability and limitations of the International Maritime Organization (IMO)’s maneuvering standards (MSC.137(76)) for large fishing vessels under 100 m in length, which are not currently included in the regulation. Full-scale turning circle, zig-zag, and stopping tests were conducted on three representative vessels—a stern trawler, a purse seiner, and a squid-jigging boat—in accordance with ISO 15016:2015 and ITTC procedures. All the vessels satisfied the IMO criteria for their turning and stopping performance; however, the zig-zag tests revealed distinct differences in directional stability. The stern trawler and purse seiner showed excessive first-overshoot angles, indicating over-reactive yaw responses influenced by the hull form and propulsion–rudder interaction, whereas the squid-jigging boat exhibited very small overshoot angles, reflecting strong yaw damping. These patterns correspond with variations in the block coefficient (C_b), Froude number (F_n), and length-to-breadth ratio L_BP/B. Although all vessels met the IMO stopping requirements, their deceleration behavior differed due to their hull fullness and reverse-thrust efficiency. Overall, the findings clearly demonstrate a mismatch between merchant-vessel-based IMO standards and the maneuvering characteristics of fishing vessels, which require agility and frequent low-speed operations. The results provide a basis for refining maneuvering prediction methods and developing assessment criteria tailored to fishing vessel design and operational profiles. Full article

Efficient container stacking is a critical factor for the performance of intermodal terminals. This study evaluates how classical, hybrid, and LLM-assisted heuristic stacking strategies perform when terminals operate under incomplete or uncertain schedule information. A simulation model of a 4 × 5 × 3 yard was developed, comparing three strategies: a layer-based rule (LAY), a hybrid heuristic (SVD), and an adaptive heuristic supported by a large language model (ChatGPT-4), rather than a full ML/RL model. Each scenario (0%, 25%, 50%, and 100% schedule visibility) was repeated 10 times with controlled random seeds. Results show that under full schedule information, the LLM-assisted strategy reduced relocations by up to 35% and crane operating time by 28% compared to deterministic methods. However, its performance degraded with partial visibility, sometimes falling behind the hybrid strategy, which remained more stable across scenarios. Standard deviations confirmed that differences between methods were statistically significant. The findings highlight both the potential and the limitations of LLM-assisted heuristics: they can outperform classical approaches in data-rich environments but may overreact to incomplete inputs without explicit data quality assessment. This study should therefore be regarded as a simulation-based proof-of-concept, with further validation on real operational data required to confirm its applicability. Full article

A modular strategy for the molecular design of silicone-based antifoaming agents was developed by precisely controlling the architecture of poly (methylhydrosiloxane) (PMHS). Sixteen PMHS variants were synthesized by systematically varying the siloxane chain length (L1–L4), backbone composition (D₃T₁ vs. D₃₀T₁), and terminal group chemistry (H- vs. M-type). These structural modifications resulted in a broad range of Si-H functionalities, which were quantitatively analyzed and correlated with defoaming performance. The PMHS matrices were integrated with high-viscosity PDMS, a nonionic surfactant, and covalently grafted fumed silica—which was chemically matched to each PMHS backbone—to construct formulation-specific defoaming systems with enhanced interfacial compatibility and colloidal stability. Comprehensive physicochemical characterization via FT-IR, ¹H NMR, GPC, TGA, and surface tension analysis revealed a nonmonotonic relationship between Si-H content and defoaming efficiency. Formulations containing 0.1–0.3 wt% Si-H achieved peak performance, with suppression efficiencies up to 96.6% and surface tensions as low as 18.9 mN/m. Deviations from this optimal range impaired performance due to interfacial over-reactivity or reduced mobility. Furthermore, thermal stability and molecular weight distribution were found to be governed by repeat unit architecture and terminal group selection. Compared with conventional EO/PO-modified commercial defoamers, the PMHS-based systems exhibited markedly improved suppression durability and formulation stability in high-viscosity environments. These results establish a predictive structure–property framework for tailoring antifoaming agents and highlight PMHS-based formulations as advanced foam suppressors with improved functionality. This study provides actionable design criteria for high-performance silicone materials with strong potential for application in thermally and mechanically demanding environments such as coating, bioprocessing, and polymer manufacturing. Full article

This study examines stock market reactions to female board appointments among 34 publicly listed companies in Saudi Arabia between 2021 and 2024. We employ a multi-method approach covering 36 announcements. Our primary methodology is an event study, which we complement with two distinct robustness checks: the Local Projections (LP) method to capture the evolving nature of market responses and the Quantile-on-Quantile analysis to investigate how market conditions interact with the three phases surrounding the event—the anticipation period before the appointment, the appointment event itself, and the post-appointment adjustment period. This comprehensive methodological framework allows us to capture the immediate market response to appointment announcements and the longer-term implications for firm performance while accounting for various econometric challenges inherent in financial market data. Our findings reveal a negative market reaction that gradually intensifies, becoming marginally significant by the tenth trading day. This pattern suggests that investors in the Saudi market may initially view female board appointments with skepticism, potentially reflecting uncertainty about the impact of gender diversity in a traditionally male-dominated business environment. Furthermore, the evolution from 2021 to 2024 suggests a market that is progressively developing more sophisticated frameworks for evaluating female board appointments. Rather than exhibiting a monotonic trend toward either increasingly positive or negative reactions, the market appears to be engaging in a learning process characterized by periodic reassessments. Moreover, our results indicate that while the immediate event and anticipation phases yield mixed impacts across the return distribution, the adjustment period exhibits a robust and significantly negative interaction with market returns. These findings suggest that market overreactions, particularly during bullish periods, contribute to a pronounced correction effect following female board appointments. Full article

Infections by influenza A virus (IAV) are a significant cause of global mortality. The pathogenesis of the infection is usually studied in terms of direct viral-induced damage or the overreactive immune response that continues after the virus is cleared. However, factors such as the initial infectious dose, the early response after infection in different cell types, and the presence of autoantibodies for relevant antiviral cytokines like type I IFNs seem to influence the course of the infection and lead to fatal outcomes. In this article, we address the current knowledge about the early events during influenza virus infection, which are important for their participation in influenza-derived pathogenesis. Full article

Background/Objectives: The current study aims to explore the subjective ego types and characteristics of obese female adolescents in South Korea, providing insights into their self-perception and psychosocial challenges. Methods: Utilizing Q-methodology, a total of 49 Q-statements were derived from a comprehensive Q-population. From these, 20 adolescents diagnosed with obesity were selected as the P-Sample. Q-sorting was conducted, and the data collected were analyzed using the PQ Method software version 2.35, employing centroid factor analysis and varimax rotation. Results: The results revealed five distinct types, accounting for a cumulative explanatory variance of 63%. Type 1 (N = 5) was characterized as “obsession with weight loss”. Type 2 (N = 3) was identified as “overreacting to peer gaze”. Type 3 (N = 6) was labeled “lack of confidence in daily life”. Type 4 (N = 4) was described as “difficulty adapting to school life”. Finally, Type 5 (N = 2) was characterized as “passivity in physical activity”. Furthermore, the consensus statements among each type were examined in Q4 and Q7. Conclusions: These findings provide insights into the self-perception of obese female adolescents, emphasizing the need for tailored psychological interventions to improve their self-image and well-being. Full article

The recognition of cytosolic nucleic acids is a critical step in the host immune response against danger signals, such as molecular patterns from pathogens or tissue damage. Nonetheless, over-reactivity to self-nucleic acids leads to the sustained production of type I interferon (IFN), mediated either by cGAS or RLR, contributing to the pathogenesis of certain autoimmune diseases, such as Aicardi–Goutières syndrome (AGS). Therefore, inhibiting excessive IFN production represents a potential therapeutic strategy for such autoimmune conditions. In this study, we discovered that petroselinic acid (PA), a natural compound isolated from Apiaceae family plants, effectively suppresses type I IFN production induced by cytosolic nucleic acids. Mechanistic investigations revealed that PA inhibits the phosphorylation of TBK1 and IRF3, which are key nodal proteins within the type I interferon pathway. Notably, molecular docking suggests potential binding between PA and cytosolic nucleic acid sensors, such as cGAS and RIG-I. Moreover, we found that PA effectively attenuates the expression of type I IFN and their downstream interferon-stimulated genes (ISGs) in models of AGS autoimmune disease characterized by excessive nucleic acid accumulation. Thus, our research identifies a natural compound that offers a promising strategy for treating autoimmune diseases resulting from aberrant self-nucleic acid recognition and the hyperactivation of type I interferon. Full article