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24 pages, 1074 KiB  
Article
Effective BIM Curriculum Development for Construction Management Program Transformation Through a Change Management Lens
by Ki Pyung Kim, Rob Freda and Seoung-Wook Whang
Buildings 2025, 15(15), 2775; https://doi.org/10.3390/buildings15152775 - 6 Aug 2025
Abstract
Integrating BIM curriculum into traditional construction management (CM) programs is essential to meet the increasing industry demand for BIM-ready graduates. However, academia struggles with BIM curriculum integration due to unfamiliar emerging BIM technologies, and the increased workload associated with curriculum transformation. Disciplines including [...] Read more.
Integrating BIM curriculum into traditional construction management (CM) programs is essential to meet the increasing industry demand for BIM-ready graduates. However, academia struggles with BIM curriculum integration due to unfamiliar emerging BIM technologies, and the increased workload associated with curriculum transformation. Disciplines including nursing, health science, and medical overcame the same challenges using the ability-desire-knowledge-ability-reinforcement (ADKAR) change management model, while CM programs have not explored this model for BIM curriculum development. Thus, this research introduces the ADKAR change management lens to BIM curriculum development by proposing a practically modified and replicable ADKAR model for CM programs. Focus group interviews with 14 academics from the UK, USA, Korea, and Australia, revealed establishing a sense of urgency by appointing a BIM champion is the most critical step before the BIM curriculum development. Instant advice demystifying uncertain BIM concepts is recognised the most effective motivation among academia. Well-balanced BIM concept integrations is ‘sine qua non’ since excessively saturating BIM aspects across the program can dilute students’ essential domain knowledge. Students’ evaluation over the BIM curriculum were collected through a six-year longitudinal focus group interviews, revealing that progressive BIM learnings scaffolded from foundational concepts to advanced applications throughout their coursework is the most valuable. Full article
(This article belongs to the Section Construction Management, and Computers & Digitization)
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18 pages, 2678 KiB  
Article
Pre-Conception Maternal Obesity Confers Autism Spectrum Disorder-like Behaviors in Mice Offspring Through Neuroepigenetic Dysregulation
by Nina P. Allan, Amada Torres, Michael J. Corley, Brennan Y. Yamamoto, Chantell Balaan, Yasuhiro Yamauchi, Rafael Peres, Yujia Qin, Vedbar S. Khadka, Youping Deng, Monika A. Ward and Alika K. Maunakea
Cells 2025, 14(15), 1201; https://doi.org/10.3390/cells14151201 - 5 Aug 2025
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with early-life origins. Maternal obesity has been associated with increased ASD risk, yet the mechanisms and timing of susceptibility remain unclear. Using a mouse model combining in vitro fertilization (IVF) and embryo transfer, we [...] Read more.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with early-life origins. Maternal obesity has been associated with increased ASD risk, yet the mechanisms and timing of susceptibility remain unclear. Using a mouse model combining in vitro fertilization (IVF) and embryo transfer, we separated the effects of pre-conception and gestational obesity. We found that maternal high fat diet (HFD) exposure prior to conception alone was sufficient to induce ASD-like behaviors in male offspring—including altered vocalizations, reduced sociability, and increased repetitive grooming—without anxiety-related changes. These phenotypes were absent in female offspring and those exposed only during gestation. Cortical transcriptome analysis revealed dysregulation and isoform shifts in genes implicated in ASD, including Homer1 and Zswim6. Whole-genome bisulfite sequencing of hippocampal tissue showed hypomethylation of an alternative Homer1 promoter, correlating with increased expression of the short isoform Homer1a, which is known to disrupt synaptic scaffolding. This pattern was specific to mice with ASD-like behaviors. Our findings show that pre-conceptional maternal obesity can lead to lasting, isoform-specific transcriptomic and epigenetic changes in the offspring’s brain. These results underscore the importance of maternal health before pregnancy as a critical and modifiable factor in ASD risk. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Autism Spectrum Disorder)
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16 pages, 448 KiB  
Essay
The Application of a Social Identity Approach to Measure and Mechanise the Goals, Practices, and Outcomes of Social Sustainability
by Sarah Vivienne Bentley
Soc. Sci. 2025, 14(8), 480; https://doi.org/10.3390/socsci14080480 - 4 Aug 2025
Viewed by 239
Abstract
Today, ‘social sustainability’ is a key feature of many organisations’ environmental, social, and governance strategies, as well as underpinning sustainable development goals. The term refers to the implementation of targets such as reduced societal inequalities, the promotion of social well-being, and the practice [...] Read more.
Today, ‘social sustainability’ is a key feature of many organisations’ environmental, social, and governance strategies, as well as underpinning sustainable development goals. The term refers to the implementation of targets such as reduced societal inequalities, the promotion of social well-being, and the practice of positive community relations. Building a meaningful, accountable, and quantifiable evidence-base from which to translate these high-level concepts into tangible and achievable goals is, however, challenging. The complexities of measuring social capital—often described as a building block of social sustainability—have been documented. The challenge lies in measuring the person, group, or collective in interaction with the context under investigation, whether that be a climate goal, an institution, or a national policy. Social identity theory is a social psychological approach that articulates the processes through which an individual internalises the values, norms, and behaviours of their contexts. Levels of social identification—a concept capturing the state of internalisation—have been shown to be predictive of outcomes as diverse as communication and cognition, trust and citizenship, leadership and compliance, and health and well-being. Applying this perspective to the articulation and measurement of social sustainability provides an opportunity to build an empirical approach with which to reliably translate this high-level concept into achievable outcomes. Full article
(This article belongs to the Section Social Policy and Welfare)
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18 pages, 330 KiB  
Essay
Music and Arts in Early Childhood Education: Paths for Professional Development Towards Social and Human Development
by Helena Rodrigues, Ana Isabel Pereira, Paulo Maria Rodrigues, Paulo Ferreira Rodrigues and Angelita Broock
Educ. Sci. 2025, 15(8), 991; https://doi.org/10.3390/educsci15080991 (registering DOI) - 4 Aug 2025
Viewed by 209
Abstract
This article examines training itineraries for early childhood education professionals in Portugal, focusing on promoting social and human development through music and the arts for infants. The training models discussed are categorized as short-term and long-term, encompassing both theory and practice through a [...] Read more.
This article examines training itineraries for early childhood education professionals in Portugal, focusing on promoting social and human development through music and the arts for infants. The training models discussed are categorized as short-term and long-term, encompassing both theory and practice through a transdisciplinary approach. Based on initiatives promoted by the Companhia de Música Teatral (CMT) and the Education and Human Development Group of the Centre for the Study of Sociology and Musical Aesthetics (CESEM) at NOVA University Lisbon, the article highlights projects such as: (i) Opus Tutti and GermInArte, developed between 2011 and 2018; (ii) the Postgraduate Course Music in Childhood: Intervention and Research, offered at the University since 2020/21, which integrates art, health, and education, promoting collaborative work between professionals; and (iii) Mil Pássaros (Thousand Birds), developed since 2020, which exemplifies the integration of environmental education and artistic practices. The theoretical basis of these training programs combines neuroscientific and educational evidence, emphasizing the importance of the first years of life for integral development. Studies, such as those by Heckman, reinforce the impact of early investment in children’s development. Edwin Gordon’s Music Learning Theory and Malloch and Trevarthen’s concept of ‘communicative musicality’ structure the design of these courses, recognizing music as a catalyst for cognitive, emotional, and social skills. The transformative role of music and the arts in educational and social contexts is emphasized, in line with the Sustainable Development Goals of the 2030 Agenda, by proposing approaches that articulate creation, intervention, and research to promote human development from childhood onwards. Full article
32 pages, 18361 KiB  
Review
Responsive Therapeutic Environments: A Dual-Track Review of the Research Literature and Design Case Studies in Art Therapy for Children with Autism Spectrum Disorder
by Jing Liang, Jingxuan Jiang, Jinghao Hei and Jiaqi Zhang
Buildings 2025, 15(15), 2735; https://doi.org/10.3390/buildings15152735 - 3 Aug 2025
Viewed by 305
Abstract
Art therapy serves as a crucial intervention modality for children with autism spectrum disorder (ASD), demonstrating unique value in emotional expression, sensory integration, and social communication. However, current practice presents critical challenges, including the disconnect between design expertise and clinical needs, unclear mechanisms [...] Read more.
Art therapy serves as a crucial intervention modality for children with autism spectrum disorder (ASD), demonstrating unique value in emotional expression, sensory integration, and social communication. However, current practice presents critical challenges, including the disconnect between design expertise and clinical needs, unclear mechanisms of environmental factors’ impact on therapeutic outcomes, and insufficient evidence-based support for technology integration. Purpose: This study aimed to construct an evidence-based theoretical framework for art therapy environment design for children with autism, clarifying the relationship between environmental design elements and therapeutic effectiveness. Methodology: Based on the Web of Science database, this study employed a dual-track approach comprising bibliometric analysis and micro-qualitative content analysis to systematically examine the knowledge structure and developmental trends. Research hotspots were identified through keyword co-occurrence network analysis using CiteSpace, while 24 representative design cases were analyzed to gain insights into design concepts, emerging technologies, and implementation principles. Key Findings: Through keyword network visualization analysis, this study identified ten primary research clusters that were systematically categorized into four core design elements: sensory feedback design, behavioral guidance design, emotional resonance design, and therapeutic support design. A responsive therapeutic environment conceptual framework was proposed, encompassing four interconnected components based on the ABC model from positive psychology: emotional, sensory, environmental, and behavioral dimensions. Evidence-based design principles were established emphasizing child-centeredness, the promotion of multisensory expression, the achievement of dynamic feedback, and appropriate technology integration. Research Contribution: This research establishes theoretical connections between environmental design elements and art therapy effectiveness, providing a systematic design guidance framework for interdisciplinary teams, including environmental designers, clinical practitioners, technology developers, and healthcare administrators. The framework positions technology as a therapeutic mediator rather than a driver, ensuring technological integration supports rather than interferes with children’s natural creative impulses. This contributes to creating more effective environmental spaces for art therapy activities for children with autism while aligning with SDG3 goals for promoting mental health and reducing inequalities in therapeutic access. Full article
(This article belongs to the Special Issue Art and Design for Healing and Wellness in the Built Environment)
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17 pages, 524 KiB  
Article
Collaborative Practices in Mental Health Care: A Concept Analysis
by Eslia Pinheiro, Carlos Laranjeira, Camila Harmuch, José Mateus Bezerra Graça, Amira Mohammed Ali, Feten Fekih-Romdhane, Murat Yıldırım, Ana Kalliny Severo and Elisângela Franco
Healthcare 2025, 13(15), 1891; https://doi.org/10.3390/healthcare13151891 - 2 Aug 2025
Viewed by 130
Abstract
Background/Objectives: Collaboration in mental health care is essential for implementing a model oriented towards the psychosocial rehabilitation of people based on multifaceted interventions involving different actors and sectors of society to respond to demands. Despite the benefits presented by the scientific evidence, there [...] Read more.
Background/Objectives: Collaboration in mental health care is essential for implementing a model oriented towards the psychosocial rehabilitation of people based on multifaceted interventions involving different actors and sectors of society to respond to demands. Despite the benefits presented by the scientific evidence, there are still many barriers to collaborative care, and professionals continue to struggle in reorienting their conduct. The current situation demands organization and the framing of well-founded action plans to overcome challenges, which in turn requires a detailed understanding of collaborative practices in mental health care and their conceptual boundaries. A concept analysis was undertaken to propose a working definition of collaborative practices in mental health care (CPMHC). Methods: This paper used the Walker and Avant concept analysis method. This includes identifying the defining concept attributes, antecedents, consequences, and empirical referents. A literature search was carried out from November 2024 to February 2025 in three databases (Medline, CINAHL, and LILACS), considering studies published between 2010 and 2024. Results: The final sample of literature investigated consisted of 30 studies. The key attributes were effective communication, building bonds, co-responsibility for care, hierarchical flexibility, articulation between services, providers and community, monitoring and evaluating of care processes, and attention to the plurality of sociocultural contexts. Conclusions: This comprehensive analysis contributes to guiding future research and policy development of collaborative practices in mental health, considering the individual, relational, institutional, and social levels. Further research is possible to deepen the understanding of the production of collaborative practices in mental health in the face of the complexity of social relations and structural inequities. Full article
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27 pages, 3387 KiB  
Article
Landscape Services from the Perspective of Experts and Their Use by the Local Community: A Comparative Study of Selected Landscape Types in a Region in Central Europe
by Piotr Krajewski, Marek Furmankiewicz, Marta Sylla, Iga Kołodyńska and Monika Lebiedzińska
Sustainability 2025, 17(15), 6998; https://doi.org/10.3390/su17156998 - 1 Aug 2025
Viewed by 192
Abstract
This study investigates the concept of landscape services (LS), which integrate environmental and sociocultural dimensions of sustainable development. Recognizing landscapes as essential to daily life and well-being, the research aims to support sustainable spatial planning by analyzing both their potential and their actual [...] Read more.
This study investigates the concept of landscape services (LS), which integrate environmental and sociocultural dimensions of sustainable development. Recognizing landscapes as essential to daily life and well-being, the research aims to support sustainable spatial planning by analyzing both their potential and their actual use. The study has three main objectives: (1) to assess the potential of 16 selected landscape types to provide six key LS through expert evaluation; (2) to determine actual LS usage patterns among the local community (residents); and (3) to identify agreements and discrepancies between expert assessments and resident use. The services analyzed include providing space for daily activities; regulating spatial structure through diversity and compositional richness; enhancing physical and mental health; enabling passive and active recreation; supporting personal fulfillment; and fostering social interaction. Expert-based surveys and participatory mapping with residents were used to assess the provision and use of LS. The results indicate consistent evaluations for forest and historical urban landscapes (high potential and use) and mining and transportation landscapes (low potential and use). However, significant differences emerged for mountain LS, rated highly by experts but used minimally by residents. These insights highlight the importance of aligning expert planning with community needs to promote sustainable land use policies and reduce spatial conflicts. Full article
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30 pages, 1583 KiB  
Systematic Review
How Does Outdoor Spatial Design Shape the Microclimate, Comfort, and Behavior in Traditional Chinese Villages? A Systematic Review Across Scales, Contexts, and Users
by Zixi Wan, Huihui Liu, Yan Yu, Yan Wu, Mark Melchior, Pim Martens, Thomas Krafft and David Shaw
Sustainability 2025, 17(15), 6960; https://doi.org/10.3390/su17156960 - 31 Jul 2025
Viewed by 204
Abstract
Traditional Chinese villages, which have long supported villagers’ comfort level of daily activities, are increasingly affected by global climate change and rural reconstruction, prompting growing research interest in their outdoor microclimate design. This systematic review aims to synthesize and evaluate the outdoor microclimate [...] Read more.
Traditional Chinese villages, which have long supported villagers’ comfort level of daily activities, are increasingly affected by global climate change and rural reconstruction, prompting growing research interest in their outdoor microclimate design. This systematic review aims to synthesize and evaluate the outdoor microclimate spatial design mechanism studies in traditional Chinese villages noted for their uniqueness and complexity. Following the PRISMA method, this study was carried out on November 27, 2024, by retrieving studies from the Scopus and CNKI databases and applying predefined inclusion and exclusion criteria; 42 empirical studies were systematically reviewed. It identifies current research trends, summarizes concepts, frameworks, indicators, and methodologies with a focus on the design mechanisms considering scales, contexts, and user groups, and outlines directions for future research. The findings reveal a growing number of publications, with case studies predominantly concentrated on three concepts: physical microclimates, human comfort, and behavioral responses, characterized as distributed in south-east areas. Based on these concepts and their correlations, this study proposes a classification framework based on multiple scales, contexts, and user groups. Within this framework, the study found that relative humidity and PET (physiological equivalent temperature) emerge as the most commonly used indicators, while field measurements, simulations, surveys, and observations are identified as the primary methods. The review further reveals that unique outdoor spatial design characteristics shape physical microclimates, human comfort, and behavior indicators influenced by contexts and users from the macro to the micro scale. Future research should advance existing studies by enriching the current contextual framework and explore more microclimatic factors. This review offers a comprehensive overview and actionable insights for outdoor microclimate design, policymaking, and the promotion of climate adaptation and villagers’ public health in different traditional rural settings. Full article
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20 pages, 1128 KiB  
Article
Evaluating the Role of Food Security in the Context of Quality of Life in Underserved Communities: The ISAC Approach
by Terrence W. Thomas and Murat Cankurt
Nutrients 2025, 17(15), 2521; https://doi.org/10.3390/nu17152521 - 31 Jul 2025
Viewed by 224
Abstract
Background/Objectives: Quality of life (QOL) is a multifaceted concept involving a variety of factors which define the overall well-being of individuals. Food security, which implies a resilient food system, is one factor that is central to the calculus of the QOL status of [...] Read more.
Background/Objectives: Quality of life (QOL) is a multifaceted concept involving a variety of factors which define the overall well-being of individuals. Food security, which implies a resilient food system, is one factor that is central to the calculus of the QOL status of a community considering that food is a staple of life. Advancing food security as a strategy for attaining sustained improvement in community QOL hinges on recognizing that food security is embedded in a matrix of other factors that work with it to generate the QOL the community experiences. The lived experience of the community defines the community’s QOL value matrix and the relative position of food security in that value matrix. Our thesis is that the role of food security in the lived experience of low-income communities depends on the position food security is accorded relative to other factors in the QOL value matrix of the community. Methods: This study employed a multimethod approach to define the QOL value matrix of low-income Guilford County residents, identifying the relative position of the value components and demographic segments based on priority ranking. First, an in-depth interview was conducted and then a telephone survey (280 sample) was used for collecting data. The ISAC Analysis Procedure and Best–Worst Scaling methods were used to identify and rank components of the QOL value matrix in terms of their relative impact on QOL. Results: The analysis revealed that spiritual well-being is the most important contributor to QOL, with a weight of 0.23, followed by access to health services (0.21) and economic opportunities (0.16), while food security has a moderate impact with 0.07. Conclusions: These findings emphasize the need for targeted policy interventions that consider the specific needs of different demographic segments to effectively improve QOL and inform the design of resilient food systems that reflect the lived experiences of low-income communities. Food security policies must be integrated with broader quality of life interventions, particularly for unemployed, low-educated, and single individuals, to ensure that a resilient food system effectively reduces inequities and address community-specific vulnerabilities. Full article
(This article belongs to the Special Issue Sustainable and Resilient Food Systems)
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14 pages, 365 KiB  
Article
Implementation Strategy for a Mandatory Interprofessional Training Program Using an Instructional Design Model
by Susan Gledhill and Mary Jane McAuliffe
Nurs. Rep. 2025, 15(8), 274; https://doi.org/10.3390/nursrep15080274 - 30 Jul 2025
Viewed by 335
Abstract
This concept paper outlines an implementation strategy for a mandatory training programme using the ADDIE instructional design model for delivery to nurses and other health professionals in an interprofessional education (IPE) environment). Background: Competence in Basic Life Support (BLS) is a lifesaving [...] Read more.
This concept paper outlines an implementation strategy for a mandatory training programme using the ADDIE instructional design model for delivery to nurses and other health professionals in an interprofessional education (IPE) environment). Background: Competence in Basic Life Support (BLS) is a lifesaving requirement for health professionals in clinical settings to ensure patient safety and accreditation outcomes. It is essential that health professionals are supported in attending mandatory training, including BLS. To inform learning and teaching strategies, it is useful to apply theoretical perspectives to the development of mandatory staff training methods. However, various training models exist, and few are grounded in instructional design theory to the unique environment for BLS in IPE. Method: A theory-based implementation strategy is outlined for a mandatory interprofessional training programme including BLS, using the ADDIE model to enhance patient outcomes. ADDIE is an instructional design framework comprising five elements: Assess, Design, Develop, Implement and Evaluate; describing a learning methodology that can be readily applied to mandatory training in IPE. Results: Through its iterative capability, the ADDIE model promotes learner needs and rapid acquisition of clinical skills that improve training accessibility. The strategy can equip educators with teaching skills based on a robust theoretical model, with potential to promote nursing and health professional attendance for mandatory training. Conclusions: Mandatory health professional training that addresses a theory informed strategy framed by the ADDIE model can support interprofessional collaboration and consistent competency across healthcare teams. This strategy has potential to contribute by demonstrating how instructional design can be operationalised to improve the effectiveness and engaging approach to BLS training and education to the unique dynamics of an interprofessional environment. Full article
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22 pages, 12611 KiB  
Article
Banana Fusarium Wilt Recognition Based on UAV Multi-Spectral Imagery and Automatically Constructed Enhanced Features
by Ye Su, Longlong Zhao, Huichun Ye, Wenjiang Huang, Xiaoli Li, Hongzhong Li, Jinsong Chen, Weiping Kong and Biyao Zhang
Agronomy 2025, 15(8), 1837; https://doi.org/10.3390/agronomy15081837 - 29 Jul 2025
Viewed by 170
Abstract
Banana Fusarium wilt (BFW, also known as Panama disease) is a highly infectious and destructive disease that threatens global banana production, requiring early recognition for timely prevention and control. Current monitoring methods primarily rely on continuous variable features—such as band reflectances (BRs) and [...] Read more.
Banana Fusarium wilt (BFW, also known as Panama disease) is a highly infectious and destructive disease that threatens global banana production, requiring early recognition for timely prevention and control. Current monitoring methods primarily rely on continuous variable features—such as band reflectances (BRs) and vegetation indices (VIs)—collectively referred to as basic features (BFs)—which are prone to noise during the early stages of infection and struggle to capture subtle spectral variations, thus limiting the recognition accuracy. To address this limitation, this study proposes a discretized enhanced feature (EF) construction method, the automated kernel density segmentation-based feature construction algorithm (AutoKDFC). By analyzing the differences in the kernel density distributions between healthy and diseased samples, the AutoKDFC automatically determines the optimal segmentation threshold, converting continuous BFs into binary features with higher discriminative power for early-stage recognition. Using UAV-based multi-spectral imagery, BFW recognition models are developed and tested with the random forest (RF), support vector machine (SVM), and Gaussian naïve Bayes (GNB) algorithms. The results show that EFs exhibit significantly stronger correlations with BFW’s presence than original BFs. Feature importance analysis via RF further confirms that EFs contribute more to the model performance, with VI-derived features outperforming BR-based ones. The integration of EFs results in average performance gains of 0.88%, 2.61%, and 3.07% for RF, SVM, and GNB, respectively, with SVM achieving the best performance, averaging over 90%. Additionally, the generated BFW distribution map closely aligns with ground observations and captures spectral changes linked to disease progression, validating the method’s practical utility. Overall, the proposed AutoKDFC method demonstrates high effectiveness and generalizability for BFW recognition. Its core concept of “automatic feature enhancement” has strong potential for broader applications in crop disease monitoring and supports the development of intelligent early warning systems in plant health management. Full article
(This article belongs to the Section Pest and Disease Management)
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18 pages, 404 KiB  
Article
Long COVID-19: A Concept Analysis
by Sujata Srikanth, Jessica R. Boulos, Diana Ivankovic, Lucia Gonzales, Delphine Dean and Luigi Boccuto
Infect. Dis. Rep. 2025, 17(4), 90; https://doi.org/10.3390/idr17040090 - 29 Jul 2025
Viewed by 268
Abstract
Background/Objectives: In late 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused a pandemic called the ‘coronavirus disease 2019’ (COVID-19). After the acute SARS-CoV-2 infection, many individuals (up to 33%) complained of unexplained symptoms involving multiple organ systems and were diagnosed [...] Read more.
Background/Objectives: In late 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused a pandemic called the ‘coronavirus disease 2019’ (COVID-19). After the acute SARS-CoV-2 infection, many individuals (up to 33%) complained of unexplained symptoms involving multiple organ systems and were diagnosed as having Long COVID-19 (LC-19). Currently, LC-19 is inadequately defined, requiring the formation of consistent diagnostic parameters to provide a foundation for ongoing and future studies of epidemiology, risk factors, clinical characteristics, and therapy. LC-19 represents a significant burden on multiple levels. The reduced ability of workers to return to work or compromised work efficiency has led to consequences at national, economic, and societal levels by increasing dependence on community services. On a personal scale, the isolation and helplessness caused by the disease and its subsequent impact on the patient’s mental health and quality of life are incalculable. Methods: In this paper, we used Walker and Avants’ eight-step approach to perform a concept analysis of the term “Long COVID-19” and define its impact across these parameters. Results: Using this methodology, we provide an improved definition of LC-19 by connecting the clinical symptomology with previously under-addressed factors, such as mental, psychological, economic, and social effects. This definition of LC-19 features can help improve diagnostic procedures and help plan relevant healthcare services. Conclusions: LC-19 represents a complex and pressing public health challenge with diverse symptomology, an unpredictable timeline, and complex pathophysiology. This concept analysis serves as a tool for improving LC-19 definition, but it remains a dynamic disease with evolving diagnostic and therapeutic approaches, requiring deeper investigation and understanding of its long-term effects. Full article
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18 pages, 1641 KiB  
Article
Evaluating the Impact of Clinical Mastitis on Ovarian Morphometry and the Effectiveness of the Synchronisation Protocol in Dairy Cows
by Gabija Lembovičiūtė, Greta Šertvytytė, Ramūnas Antanaitis, Vytuolis Žilaitis, Walter Baumgartner and Arūnas Rutkauskas
Animals 2025, 15(15), 2215; https://doi.org/10.3390/ani15152215 - 28 Jul 2025
Viewed by 438
Abstract
Inflammatory processes within the body have been hypothesised to be causative agents of various health complications, including reproductive issues. This study investigates the effects of mastitis on ovarian morphometry and fertility outcomes while also comparing the effectiveness of different synchronisation protocols in affected [...] Read more.
Inflammatory processes within the body have been hypothesised to be causative agents of various health complications, including reproductive issues. This study investigates the effects of mastitis on ovarian morphometry and fertility outcomes while also comparing the effectiveness of different synchronisation protocols in affected cows. Healthy multiparous Holstein dairy cows, in their second to fifth lactations and with an average milk yield of approximately 12,000 kg in the preceding lactation, were selected for this study. The average milk yield per lactation was approximately 12,000 kg, with an average daily milk yield of 30 kg. The aim of this study was to determine the impact of mastitis on the reproductive cycle, ovarian morphometry, and function in dairy cows, as well as its effect on synchronisation efficiency. This study focused on both clinically healthy cows and those diagnosed with clinical mastitis postpartum. Three different synchronisation protocols—OvSynch, G7G, and Presynch—were evaluated at 60 days in milk (DIM). A total of 110 cows were included in this study, with 53 being clinically healthy and 57 affected by mastitis. The results indicated that inflammation affects ovarian morphometric parameters such as the area and the number of functional structures. In addition, the G7G protocol was observed to result in higher conception rates in cows suffering from mastitis following the second insemination. This study demonstrated that cows that developed mastitis within the first 30 DIM exhibited higher conception rates after the first insemination compared to those in cows that developed mastitis later in lactation. Full article
(This article belongs to the Section Cattle)
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26 pages, 3167 KiB  
Article
Global Population, Carrying Capacity, and High-Quality, High-Pressure Processed Foods in the Industrial Revolution Era
by Agata Angelika Sojecka, Aleksandra Drozd-Rzoska and Sylwester J. Rzoska
Sustainability 2025, 17(15), 6827; https://doi.org/10.3390/su17156827 - 27 Jul 2025
Viewed by 259
Abstract
The report examines food availability and demand in the Anthropocene era, exploring the connections between global population growth and carrying capacity through an extended version of Cohen’s Condorcet concept. It recalls the super-Malthus and Verhulst-type scalings, matched with the recently introduced analytic relative [...] Read more.
The report examines food availability and demand in the Anthropocene era, exploring the connections between global population growth and carrying capacity through an extended version of Cohen’s Condorcet concept. It recalls the super-Malthus and Verhulst-type scalings, matched with the recently introduced analytic relative growth rate. It focuses particularly on the ongoing Fifth Industrial Revolution (IR) and its interaction with the concept of a sustainable civilization. In this context, the significance of innovative food preservation technologies that can yield high-quality foods with health-promoting features, while simultaneously increasing food quantities and reducing adverse environmental impacts, is discussed. To achieve this, high-pressure preservation and processing (HPP) can play a dominant role. High-pressure ‘cold pasteurization’, related to room-temperature processing, has already achieved a global scale. Its superior features are notable and are fairly correlated with social expectations of a sustainable society and the technological tasks of the Fifth Industrial Revolution. The discussion is based on the authors’ experiences in HPP-related research and applications. The next breakthrough could be HPP-related sterilization. The innovative HPP path, supported by the colossal barocaloric effect, is presented. The mass implementation of pressure-related sterilization could lead to milestone societal, pro-health, environmental, and economic benefits. Full article
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42 pages, 914 KiB  
Review
Western Diet and Cognitive Decline: A Hungarian Perspective—Implications for the Design of the Semmelweis Study
by Andrea Lehoczki, Tamás Csípő, Ágnes Lipécz, Dávid Major, Vince Fazekas-Pongor, Boglárka Csík, Noémi Mózes, Ágnes Fehér, Norbert Dósa, Dorottya Árva, Kata Pártos, Csilla Kaposvári, Krisztián Horváth, Péter Varga and Mónika Fekete
Nutrients 2025, 17(15), 2446; https://doi.org/10.3390/nu17152446 - 27 Jul 2025
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Abstract
Background: Accelerated demographic aging in Hungary and across Europe presents significant public health and socioeconomic challenges, particularly in preserving cognitive function and preventing neurodegenerative diseases. Modifiable lifestyle factors—especially dietary habits—play a critical role in brain aging and cognitive decline. Objective: This narrative review [...] Read more.
Background: Accelerated demographic aging in Hungary and across Europe presents significant public health and socioeconomic challenges, particularly in preserving cognitive function and preventing neurodegenerative diseases. Modifiable lifestyle factors—especially dietary habits—play a critical role in brain aging and cognitive decline. Objective: This narrative review explores the mechanisms by which Western dietary patterns contribute to cognitive impairment and neurovascular aging, with specific attention to their relevance in the Hungarian context. It also outlines the rationale and design of the Semmelweis Study and its workplace-based health promotion program targeting lifestyle-related risk factors. Methods: A review of peer-reviewed literature was conducted focusing on Western diet, cognitive decline, cerebrovascular health, and dietary interventions. Emphasis was placed on mechanistic pathways involving systemic inflammation, oxidative stress, endothelial dysfunction, and decreased neurotrophic support. Key findings: Western dietary patterns—characterized by high intakes of saturated fats, refined sugars, ultra-processed foods, and linoleic acid—are associated with elevated levels of 4-hydroxynonenal (4-HNE), a lipid peroxidation product linked to neuronal injury and accelerated cognitive aging. In contrast, adherence to Mediterranean dietary patterns—particularly those rich in polyphenols from extra virgin olive oil and moderate red wine consumption—supports neurovascular integrity and promotes brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) activity. The concept of “cognitive frailty” is introduced as a modifiable, intermediate state between healthy aging and dementia. Application: The Semmelweis Study is a prospective cohort study involving employees of Semmelweis University aged ≥25 years, collecting longitudinal data on dietary, psychosocial, and metabolic determinants of aging. The Semmelweis–EUniWell Workplace Health Promotion Model translates these findings into practical interventions targeting diet, physical activity, and cardiovascular risk factors in the workplace setting. Conclusions: Improving our understanding of the diet–brain health relationship through population-specific longitudinal research is crucial for developing culturally tailored preventive strategies. The Semmelweis Study offers a scalable, evidence-based model for reducing cognitive decline and supporting healthy aging across diverse populations. Full article
(This article belongs to the Section Nutrition and Public Health)
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