Objective: The purpose of this article was to use the Random Forest method and nonlinear mixed-effects method to develop a model for determining tree height–diameter at breast height (DBH) for a natural coniferous and broad-leaved mixed forest...
Forest carbon sinks are vital in mitigating climate change, making it crucial to have highly accurate estimates of forest carbon stocks. A method that accounts for the spatial characteristics of inventory samples is necessary for the long-term estima...
Bayesian estimation of nonlinear mixed-effects models typically relies on Markov-Chain Monte Carlo (MCMC) methods due to the intractability of the posterior distribution. While widely used for longitudinal data with missing observations, the performa...
When data on the degradation of a chemical substance have been collected in a number of environmental media (e.g., in different soils), two strategies can be followed for data evaluation. Currently, each individual dataset is evaluated separately, an...
Evaluating the behavior of fruit width and length characters throughout the pepper crop cycle is essential for researchers in decision-making aimed at developing appropriate management techniques and harvesting fruits at proper growth stages. The Non...
The release of the cardiac troponin T (cTnT) in patients with acute myocardial infarction (AMI) has been analyzed through a methodology based on nonlinear mixed-effects (NME) models. The aim of this work concerns the investigation of any possible rel...
Nonlinear mixed-effects models (NLMMs) provide a flexible framework for modeling repeated-measures trajectories. However, how best to forecast future observations, especially at ages well beyond those represented in the data, remains relatively under...
Change-point models are frequently considered when modeling phenomena where a regime shift occurs at an unknown time. In aging research, these models are commonly adopted to estimate of the onset of cognitive decline. Yet these models present several...
While existing mixed-effects models address multivariate outcomes, nonlinearity, or non-normality separately, their joint integration remains limited in medical research. This study proposes a flexible semi-parametric multivariate mixed-effects model...
The stand basal area, closely related to age, site quality, and stand density, is an important factor for predicting forest growth and yield. The accurate estimation of site quality is especially a key component in the stand basal area model. We util...
Tree height is a basic input variable in various forest models, such as growth and yield models, biomass models, and carbon budget models, which serve as very important tools for the informed decision-making in forestry. The height-diameter model is...
The Min pig, a Chinese indigenous breed, is valued for its excellent meat quality and stress tolerance. Nevertheless, its growth rate falls considerably short of commercial pig breeds, a pattern typical of most unselected indigenous populations, and...
We propose a new random change point model that utilizes routinely recorded individual-level HIV viral load data to estimate the timing of antiretroviral therapy (ART) initiation in people living with HIV. The change point distribution is assumed to...
Competition among free branches in the tree canopy is an important factor influencing branch length growth. Therefore, there is a need to quantify this competition and to understand the impact of the regression technique on the predictive accuracy of...
Height to crown base (HCB) is an important variable used as a predictor of forest growth and yield. This study developed a nonlinear, mixed-effects HCB model through inclusion of plot-level random effects using data from 29 sample plots distributed a...
(1) Background: Mongolian oak secondary forest is widely distributed in the northeast of China, and most of these forests are formed after the overcutting of broad-leaved Pinus koraiensis mixed forest. Most of the forest productivity is low and the e...
Height-to-diameter at breast height (DBH) ratio (HDR) is an important tree and stand stability measure. Several factors such as stand dynamics, natural and anthropogenic disturbances, and silvicultural tending significantly affect HDR, and, therefore...
Unmanned aerial vehicle laser scanning (UAVLS) systems present a relatively new means of remote sensing and are increasingly applied in the field of forest ecology and management. However, one of the most essential parameters in forest inventory, tre...
Reliable estimates of forest site productivity are a central element of forest management. The model of height-diameter relationship of dominant trees using algebraic difference approach (ADA) is a commonly used method to measure site productivity of...
Background/Objectives: Pemetrexed–platinum chemotherapy is a key treatment option for non-squamous non-small cell lung cancer (NSCLC); however, its use is often limited by hematologic toxicity, particularly neutropenia. We aimed to develop a mo...
Aim: This study aimed to develop a population pharmacokinetic (PK) model of intravenous fluconazole and, using model-based simulations, propose initial dosing recommendations that optimize efficacy while limiting toxicity. Methods: Therapeutic drug m...
Although posaconazole tablets show relatively low variability in pharmacokinetics (PK), the proportion of patients achieving the PK/PD target at the approved uniform dose for both prophylaxis and therapy is not satisfactory. The aim of this study was...
In oncology, longitudinal biomarkers reflecting the patient’s status and disease evolution can offer reliable predictions of the patient’s response to treatment and prognosis. By leveraging clinical data in patients with advanced non-smal...
Serum albumin binding plays a critical role in determining the pharmacokinetic and pharmacodynamic behavior of many drugs. Despite extensive studies on human and bovine serum albumin, quantitative binding data for rabbit serum albumin remain limited...
The global restriction of antimicrobial growth promoters has intensified the search for alternative strategies to sustain poultry health and productivity. One proposed mechanism underlying the historical efficacy of antibiotic performance enhancers i...
Background/Objectives: Radotinib is a second-generation tyrosine kinase inhibitor (TKI) that has been used for treatment of chronic myeloid leukemia (CML). This study was performed for the first time to characterize the pharmacokinetics of radotinib,...
Global change in the climate is affecting tree/forest growth. There have been many studies that analyzed climate effects on tree growth. Results presented in these studies showed that the climate had both positive and negative effects on tree growth....
Considering its very short elimination half-life, the approved oxacillin dosage might not be sufficient to maintain the pharmacokinetic/pharmacodynamics (PK/PD) target of time-dependent antibiotics. This study aimed to describe the population pharmac...
The objectives of this study were to develop a population pharmacokinetic model of prophylactically administered cefazolin in patients undergoing cardiac surgery with and without the use of the cardiopulmonary bypass of both existing types—stan...
Seedling growth is an essential stage for the future growth of trees, and Paulownia is treated as a rapidly growing hardwood tree species with wide industrial application. There is a knowledge gap in the modeling and analysis of the seedling growth p...
An approach based on the nearest neighbors techniques is presented for producing thematic maps of forest cover (forest/non-forest) and total stand volume for the Terai region in southern Nepal. To create the forest cover map, we used a combination of...
Accurate estimates of tree bole volume are fundamental to sustainable forest management. Total inside and outside bark and merchantable volume equations were developed for 25 major commercial tree species grown in natural stands in eastern and centra...
We investigated the relationship of stem diameter to tree, site and stand characteristics for six major tree species (trembling aspen, white birch, balsam fir, lodgepole pine, black spruce, and white spruce) in Alberta (Canada) with data from Alberta...
Localized climate is sensitive to terrain, underlying surface material, building distribution, green coverage and CO2 emissions. The Regional Climate Model (RegCM) was used to make a statistical detailed analysis of the climate change data in a speci...
Crown architecture has long been evaluated for its impact on taper modeling. However, most of the research has focused on a limited number of crown dimensions. This study examined the effect of adding several crown dimensions in improving the diamete...
Tree height–diameter relationship is very important in forest investigation, describing forest structure and estimating carbon storage. Climate change may modify the relationship. However, our understanding of the effects of climate change on t...
Multivariate nonlinear mixed-effects models (MNLMM) have received increasing use due to their flexibility for analyzing multi-outcome longitudinal data following possibly nonlinear profiles. This paper presents and compares five different iterative a...
Crown size estimations are of vital importance in forest management practice. This paper presents nonlinear models that were developed for crown width prediction of Black pine (Pinus nigra Arn.) natural, pure, even-aged stands in Olympus Mountain, ce...
The main goal of this paper is to propose a two-step method for the estimation of parameters in non-linear mixed-effects models. A first-step estimate
As the dominant height of the stand at the baseline age, the site index is an important index to evaluate site quality. However, due to the variability of environmental factors, the growth process of the dominant height of the same tree species was v...
Nonlinear mixed effects models have become a standard platform for analysis when data is in the form of continuous and repeated measurements of subjects from a population of interest, while temporal profiles of subjects commonly follow a nonlinear te...
L-4-[(10B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron capture therapy. In this study, a Bayesian predictive platform of blood boron concentration based on a B...
In the current study, a novel approach combining quantile regression with nonlinear mixed-effects (QR-NLME) modeling was applied to predict the maximum crown width (cwmax) of three economically important forest species—the European beech (Fagus...
Rapidly advancing airborne laser scanning technology has become greatly useful to estimate tree- and stand-level variables at a large scale using high spatial resolution data. Compared with that of ground measurements, the accuracy of the inferred in...
Accurate estimates of tree height (H) are critical for forest productivity and carbon stock assessments. Based on an extensive dataset, we developed a set of generalized mixed-effects height–DBH (H–D) models in a typical natural mixed for...
Allometric models of internodes are an important component of Functional-Structural Plant Models (FSPMs), which represent the shape of internodes in tree architecture and help our understanding of resource allocation in organisms. Constant allometr...
Background: Patient-perceived seasonality of psoriasis is frequently reported, yet the independent contribution of objectively quantified, individualized ultraviolet (UV) exposure remains insufficiently characterized. We evaluated seasonal variation...
An accurate estimate of the site index is essential for informing decision-making in forestry. In this study, we developed site index (SI) models using stem analysis data to estimate the site index and the dominant height growth for Larix gmelinii va...
Background/Objectives: Palbociclib, an oral CDK 4/6 inhibitor, was evaluated in a Pediatric Brain Tumor Consortium (PBTC) phase 1 (NCT02255461; PBTC-042) study to treat children and young adults with recurrent, progressive, or refractory brain tumors...
Maintaining permanent forest canopy cover and eventually harvesting timber by predetermined target diameter are often considered as a prototype for future management of the oak natural forest. However, target diameters and harvest age based on averag...
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