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Keywords = multimode optical fibers

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18 pages, 1570 KB  
Article
Moisture Content Detection in Mango (Mangifera indica L., cv. Ataulfo) and Papaya (Carica papaya) Slices During Drying Using an MMI-Based Sensor
by Guadalupe López-Morales, Yuliana M. Espinosa-Sánchez, Ariel Flores-Rosas and Héber Vilchis
Sensors 2025, 25(22), 6902; https://doi.org/10.3390/s25226902 - 12 Nov 2025
Abstract
Monitoring moisture content in agricultural products during the drying process is critical for ensuring quality, preserving nutritional value, and optimizing energy consumption. This study presents the design and implementation of an optical fiber sensor based on multimode interference (MMI) for non-destructive detection of [...] Read more.
Monitoring moisture content in agricultural products during the drying process is critical for ensuring quality, preserving nutritional value, and optimizing energy consumption. This study presents the design and implementation of an optical fiber sensor based on multimode interference (MMI) for non-destructive detection of moisture content in mango (Mangifera indica L., cv. Ataulfo) and papaya (Carica papaya) slices during convective drying at 57 °C. Two sensors were designed and fabricated: one operates in the 975 nm range and the other in the 1414.25 nm range. These sensors detect variations in the refractive index caused by moisture loss, which directly affects the MMI spectral response. The sensor output was correlated with reference gravimetric measurements, demonstrating a dependence in tracking the output power as a function of the reduction in humidity over time. The results confirm the feasibility of the MMI-based optical fiber sensor as a reliable tool for in situ monitoring of drying dynamics in tropical fruits, offering potential applications in agri-food processing and quality control. Full article
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11 pages, 2734 KB  
Article
Coaxial LiDAR System Utilizing a Double-Clad Fiber Receiver
by Hao Chen, Zhenquan Su, Zhuolun Li, Hanfeng Ding and Jun Zhang
Photonics 2025, 12(11), 1080; https://doi.org/10.3390/photonics12111080 - 1 Nov 2025
Viewed by 254
Abstract
LiDAR technology has undergone significant advancement in recent years, establishing itself as a technique for long-range, high-precision detection. As its use expands into more intricate scenarios, the need to overcome blind spots in the scanning field and enhance system stability has become increasingly [...] Read more.
LiDAR technology has undergone significant advancement in recent years, establishing itself as a technique for long-range, high-precision detection. As its use expands into more intricate scenarios, the need to overcome blind spots in the scanning field and enhance system stability has become increasingly critical. This paper introduces a novel coaxial LiDAR system featuring a double-clad optical fiber-based receiver which consists of a single-mode fiber core for the emission of the laser beam and a multimode inner cladding for the collection and transmission of the back-reflected beam. The real-time system is specifically engineered to measure distances in both near and far fields, eliminating blind spots. Experimental evaluations demonstrate that our system achieves a detection range of 0.2–70.7 m, with a distance accuracy of 3.4 cm and an angular resolution of 0.018°. Compared with conventional LiDAR systems, our approach eliminates the need for complex optical pathway designs and algorithmic compensation. It offers a simplified structure, enhanced stability, and high accuracy. Full article
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28 pages, 3909 KB  
Article
VCSELs: Influence of Design on Performance and Data Transmission over Multi-Mode and Single-Mode Fibers
by Nikolay N. Ledentsov, Nikolay Ledentsov, Vitaly A. Shchukin, Alexander N. Ledentsov, Oleg Yu. Makarov, Ilya E. Titkov, Markus Lindemann, Thomas de Adelsburg Ettmayer, Nils C. Gerhardt, Martin R. Hofmann, Xin Chen, Jason E. Hurley, Hao Dong and Ming-Jun Li
Photonics 2025, 12(10), 1037; https://doi.org/10.3390/photonics12101037 - 21 Oct 2025
Viewed by 619
Abstract
Substantial improvements in the performance of optical interconnects based on multi-mode fibers are required to support emerging single-channel data transmission rates of 200 Gb/s and 400 Gb/s. Future optical components must combine very high modulation bandwidths—supporting signaling at 100 Gbaud and 200 Gbaud—with [...] Read more.
Substantial improvements in the performance of optical interconnects based on multi-mode fibers are required to support emerging single-channel data transmission rates of 200 Gb/s and 400 Gb/s. Future optical components must combine very high modulation bandwidths—supporting signaling at 100 Gbaud and 200 Gbaud—with reduced spectral width to mitigate chromatic-dispersion-induced pulse broadening and increased brightness to further restrict flux-confining area in multi-mode fibers and thereby increase the effective modal bandwidth (EMB). A particularly promising route to improved performance within standard oxide-confined VCSEL technology is the introduction of multiple isolated or optically coupled oxide-confined apertures, which we refer to collectively as multi-aperture (MA) VCSEL arrays. We show that properly designed MA VCSELs exhibit narrow emission spectra, narrow far-field profiles and extended intrinsic modulation bandwidths, enabling longer-reach data transmission over both multi-mode (MMF) and single-mode fibers (SMF). One approach uses optically isolated apertures with lateral dimensions of approximately 2–3 µm arranged with a pitch of 10–12 µm or less. Such devices demonstrate relaxation oscillation frequencies of around 30 GHz in continuous-wave operation and intrinsic modulation bandwidths approaching 50 GHz. Compared with a conventional single-aperture VCSELs of equivalent oxide-confined area, MA designs can reduce the spectral width (root mean square values < 0.15 nm), lower series resistance (≈50 Ω) and limit junction overheating through more efficient multi-spot heat dissipation at the same total current. As each aperture lases in a single transverse mode, these devices exhibit narrow far-field patterns. In combination with well-defined spacing between emitting spots, they permit tailored restricted launch conditions in MMFs, enhancing effective modal bandwidth. In another MA approach, the apertures are optically coupled such that self-injection locking (SIL) leads to lasing in a single supermode. One may regard one of the supermodes as acting as a master mode controlling the other one. Streak-camera studies reveal post-pulse oscillations in the SIL regime at frequencies up to 100 GHz. MA VCSELs enable a favorable combination of wavelength chirp and chromatic dispersion, extending transmission distances over MMFs beyond those expected for zero-chirp sources and supporting transfer bandwidths up to 60 GHz over kilometer-length SMF links. Full article
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15 pages, 3464 KB  
Article
Multimode Magneto-Optical Fiber Based on Borogermanate Glass Containing Tb3+ for Sensing Applications
by Douglas F. Franco, Steeve Morency, Younès Messaddeq and Marcelo Nalin
Materials 2025, 18(20), 4736; https://doi.org/10.3390/ma18204736 - 16 Oct 2025
Viewed by 413
Abstract
A multimode magneto-optical fiber based on Tb3+-containing borogermanate glass was designed, fabricated, and characterized, aiming at potential sensing applications. There are continuing challenges in the development of single-mode (SMF) or multimode (MMF) optical fibers doped with rare-earth (RE) ions and exhibiting [...] Read more.
A multimode magneto-optical fiber based on Tb3+-containing borogermanate glass was designed, fabricated, and characterized, aiming at potential sensing applications. There are continuing challenges in the development of single-mode (SMF) or multimode (MMF) optical fibers doped with rare-earth (RE) ions and exhibiting high Verdet constants, related to devitrification of the precursor glass. Most RE-doped glass compositions are not suitable as precursors for core-cladding fiber production due to devitrification processes and consequent poor optical quality. Application as Faraday rotators is limited by the intrinsically low Verdet constant of silica (~0.589 rad T−1 m−1 at 1550 nm and 0.876 rad T−1 m−1 at 1310 nm). Borogermanate glasses are good candidates for manufacturing optical fibers due to their excellent potential to solubilize high concentrations of Tb3+ ions as well as satisfactory thermal stability. In this work, a magneto-optical core-cladding borogermanate fiber with a 227 μm diameter was fabricated, with characterization using differential scanning calorimetry (DSC), thermomechanical analysis (TMA), viscosity measurements, M-lines spectroscopy, UV-Vis-NIR absorption spectroscopy, the cut-back technique, and magneto-optical measurements. The measured numerical aperture (NA) was 0.183, with minimum attenuation of 13 dB m−1 at 1270 nm. The Verdet constant (VB) reached −6.74 rad T−1 m−1 at 1330 nm. Full article
(This article belongs to the Special Issue Advanced Rare Earth Doped Functional Materials)
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38 pages, 8603 KB  
Review
Fiber-Optic Pressure Sensors: Recent Advances in Sensing Mechanisms, Fabrication Technologies, and Multidisciplinary Applications
by Yihang Wang, Botong Chen, Guirong Wu, Chenyang Xue and Libo Gao
Sensors 2025, 25(20), 6336; https://doi.org/10.3390/s25206336 - 14 Oct 2025
Viewed by 1393
Abstract
Fiber-optic sensing (FOS) technology has emerged as a cutting-edge research focus in the sensor field due to its miniaturized structure, high sensitivity, and remarkable electromagnetic interference immunity. Compared with conventional sensing technologies, FOS demonstrates superior capabilities in distributed detection and multi-parameter multiplexing, thereby [...] Read more.
Fiber-optic sensing (FOS) technology has emerged as a cutting-edge research focus in the sensor field due to its miniaturized structure, high sensitivity, and remarkable electromagnetic interference immunity. Compared with conventional sensing technologies, FOS demonstrates superior capabilities in distributed detection and multi-parameter multiplexing, thereby accelerating its applications across biomedical, industrial, and aerospace fields. This paper conducts a systematic analysis of the sensing mechanisms in fiber-optic pressure sensors, with a particular focus on the performance optimization effects of fiber structures and materials, while elucidating their application characteristics in different sensing scenarios. This review further examines current manufacturing technologies for fiber-optic pressure sensors, covering key processes including fiber processing and packaging. Regarding practical applications, the multifunctional characteristics of fiber-optic pressure sensors are thoroughly investigated in various fields, including biomedical monitoring, industrial and energy monitoring, and wearable devices, as well as aerospace monitoring. Furthermore, current challenges are discussed regarding performance degradation in extreme environments and multi-parameter cross-sensitivity issues, while future research directions are proposed, encompassing the integration and exploration of novel structures and materials. By synthesizing recent advancements and development trends, this review serves as a critical reference bridging the gap between research and practical applications, accelerating the advancement of fiber-optic pressure sensors. Full article
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14 pages, 3363 KB  
Article
Design for Assembly of a Confocal System Applied to Depth Profiling in Biological Tissue Using Raman Spectroscopy
by Edgar Urrieta Almeida, Lelio de la Cruz May, Olena Benavides, Magdalena Bandala Garces and Aaron Flores Gil
Technologies 2025, 13(10), 440; https://doi.org/10.3390/technologies13100440 - 30 Sep 2025
Viewed by 915
Abstract
This work presents the development of a Z-depth system for Confocal Raman Spectroscopy (CRS), which allows for the acquisition of Raman spectra both at the surface and at depth profile in heterogeneous samples. The proposed CRS system consists of the coupling of a [...] Read more.
This work presents the development of a Z-depth system for Confocal Raman Spectroscopy (CRS), which allows for the acquisition of Raman spectra both at the surface and at depth profile in heterogeneous samples. The proposed CRS system consists of the coupling of a commercial 785 nm Raman Probe Bifurcated (RPB) with a 20x/0.40 infinity plan achromatic polarizing microscope objective, a Long Working Distance (LWD) of 1.2 cm, and a 50 μm core-multimode optical fiber used as a pinhole filter. With this implementation, it is possible to achieve both a high spatial resolution of approximately 16.2 μm and a spectral resolution of ∼14 cm−1, which is determined by the FWHM of the thin 1004 cm−1 Raman profile band. The system is configured to operate within 400–1800 cm−1 spectral windows. The implementation of a system of this nature offers a favorable cost–benefit ratio, as commercial CRS is typically found in high-cost environments such as cosmetics, pharmaceutical, and biological laboratories. The proposed system is low-cost and employs a minimal set of optical components to achieve functionality comparable to that of a confocal Raman microscope. High signal-to-noise ratio (SNR) Raman spectra (∼660.05 at 1447 cm−1) can be obtained with short integration times (∼25 s) and low laser power (30–35 mW) when analyzing biological samples such as in vivo human fingernails and fingertips. This power level is significantly lower than the exposure limits established by the American National Standards Institute (ANSI) for human laser experiments. Raman spectra were recorded from the surface of both the nails and fingertips of three volunteers, in order to characterize their biological samples at different depths. The measurements were performed in 50 μm steps to obtain molecular structural information from both surface and subsurface tissue layers. The proposed CRS enables the identification of differences between two closely spaced, centered, and narrow Raman bands. Additionally, broad Raman bands observed at the skin surface can be deconvolved into at least three sub-bands, which can be quantitatively characterized in terms of intensity, peak position, and bandwidth, as the confocal plane advances in depth. Moreover, the CRS system enables the detection of subtle, low-intensity features that appear at the surface but disappear beyond specific depth layers. Full article
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17 pages, 4501 KB  
Article
Highly Sensitive SNS Structure Fiber Liquid-Sealed Temperature Sensor with PVA-Based Cladding for Large Range
by Si Cheng, Chuan Tian, Xiaolei Bai and Zhiyu Zhang
Photonics 2025, 12(9), 887; https://doi.org/10.3390/photonics12090887 - 3 Sep 2025
Viewed by 657
Abstract
A liquid-sealed single-mode–no-core–single-mode (SNS) structure fiber temperature sensor based on polyvinyl alcohol (PVA) partial replacement coating is proposed. Using a liquid-sealed glass capillary structure, the PVA solution is introduced into the SNS structure and avoids its influence by environmental humidity. Temperature can be [...] Read more.
A liquid-sealed single-mode–no-core–single-mode (SNS) structure fiber temperature sensor based on polyvinyl alcohol (PVA) partial replacement coating is proposed. Using a liquid-sealed glass capillary structure, the PVA solution is introduced into the SNS structure and avoids its influence by environmental humidity. Temperature can be obtained by measuring the shift of the multimode interference spectrum, which is affected by the thermal optical effect of the PVA solution. Through theoretical simulation of the sensor, the optimal NCF fiber length and coating stripped length are obtained by comprehensively considering the transmitted loss and output spectrum signal-to-noise ratio (SNR). The optimal PVA solution concentration is selected by measuring the thermo-optic coefficient (TOC) and refractive index (RI). Based on the theoretical optimization results, a PVA solution-coated SNS fiber optic temperature sensor is experimentally fabricated, and temperature-sensing characteristics are measured within −3.6 to 73.2 °C. The experimental results show that the sensor has a high sensitivity (nm/°C, maximum is 21.713 nm/°C) and has a resolution of 10−3 °C. λdip has a stable negative linear relationship with temperature, and the correlation coefficient of the fitting curve exceeds 95%. The temperature cycling experiment and long-term stability test show that the temperature sensor has good repeatability and stability. The experimental results also show the nonlinear relationship between the temperature measurement range and sensitivity, clarify the important factors affecting the response performance of fiber temperature sensors, and provide important reference values for optical fiber temperature sensors. Full article
(This article belongs to the Section Lasers, Light Sources and Sensors)
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10 pages, 3663 KB  
Article
Compact All-Fiber SERS Probe Sensor Based on the MMF-NCF Structure with Self-Assembled Gold Nanoparticles
by Peng Cai, Tiantian Xu, Hangan Wei, Huili He and Fu Li
Sensors 2025, 25(17), 5221; https://doi.org/10.3390/s25175221 - 22 Aug 2025
Viewed by 952
Abstract
Brain natriuretic peptide (BNP) is an important biomarker for the diagnosis and prediction of chronic heart failure (CHF). Aiming at the problems of the low sensitivity and poor portability of traditional BNP detection methods, this study proposes a Surface-enhanced Raman-scattering (SERS) fiber-optic sensor [...] Read more.
Brain natriuretic peptide (BNP) is an important biomarker for the diagnosis and prediction of chronic heart failure (CHF). Aiming at the problems of the low sensitivity and poor portability of traditional BNP detection methods, this study proposes a Surface-enhanced Raman-scattering (SERS) fiber-optic sensor based on a multimode fiber (MMF)–no core fiber (NCF) structure. The sensor achieves BNP detection by significantly amplifying the Raman signal of the toluidine blue (TB) marker through the synergistic effect of NCF’s unique optical transmission modes and localized surface plasmon resonance (LSPR). To optimize the sensor performance, we first investigated the effect of the NCF length on the Raman signal, using Rhodamine 6G (R6G), and determined the optimal structural parameters. Combined with the microfluidic chip integration technology, the antibody–BNP–antibody sandwich structure was adopted, and TB was used as the Raman label to realize the quantitative detection of BNP. Experimental results demonstrate that the detection limit of the sensor is lower than the clinical diagnostic threshold and exhibits stability. The sensor sensitivity can be adjusted by regulating the laser power. With its stability and high portability, this sensor provides a new solution for the early diagnosis of heart failure and demonstrates broad application prospects in biomarker detection. Full article
(This article belongs to the Special Issue Novel Optical Sensors for Biomedical Applications—2nd Edition)
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22 pages, 6689 KB  
Article
Design and Implementation of a Sun Outage Simulation System with High Uniformity and Stray Light Suppression Capability
by Zhen Mao, Zhaohui Li, Yong Liu, Limin Gao and Jianke Zhao
Sensors 2025, 25(15), 4655; https://doi.org/10.3390/s25154655 - 27 Jul 2025
Viewed by 720
Abstract
To enable accurate evaluation of satellite laser communication terminals under solar outage interference, this paper presents the design and implementation of a solar radiation simulation system targeting the 1540–1560 nm communication band. The system reconstructs co-propagating interference conditions through standardized and continuously tunable [...] Read more.
To enable accurate evaluation of satellite laser communication terminals under solar outage interference, this paper presents the design and implementation of a solar radiation simulation system targeting the 1540–1560 nm communication band. The system reconstructs co-propagating interference conditions through standardized and continuously tunable output, based on high irradiance and spectral uniformity. A compound beam homogenization structure—combining a multimode fiber and an apodizator—achieves 85.8% far-field uniformity over a 200 mm aperture. A power–spectrum co-optimization strategy is introduced for filter design, achieving a spectral matching degree of 78%. The system supports a tunable output from 2.5 to 130 mW with a 50× dynamic range and maintains power control accuracy within ±0.9%. To suppress internal background interference, a BRDF-based optical scattering model is established to trace primary and secondary stray light paths. Simulation results show that by maintaining the surface roughness of key mirrors below 2 nm and incorporating a U-shaped reflective light trap, stray light levels can be reduced to 5.13 × 10−12 W, ensuring stable detection of a 10−10 W signal at a 10:1 signal-to-background ratio. Experimental validation confirms that the system can faithfully reproduce solar outage conditions within a ±3° field of view, achieving consistent performance in spectrum shaping, irradiance uniformity, and background suppression. The proposed platform provides a standardized and practical testbed for ground-based anti-interference assessment of optical communication terminals. Full article
(This article belongs to the Section Communications)
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14 pages, 3295 KB  
Article
Characterization of Chirp Properties of an 850 nm Single-Mode Multi-Aperture Vertical-Cavity Surface-Emitting Laser and Analysis of Transmission Performance over Multimode and Single-Mode Fibers
by Xin Chen, Nikolay Ledentsov, Abdullah S. Karar, Jason E. Hurley, Oleg Yu. Makarov, Hao Dong, Ahmad Atieh, Ming-Jun Li and Nikolay Ledentsov
Photonics 2025, 12(7), 703; https://doi.org/10.3390/photonics12070703 - 11 Jul 2025
Cited by 1 | Viewed by 809
Abstract
By measuring the transfer function of the single-mode multi-aperture vertical-cavity surface-emitting laser (SM MA VCSEL) transmitting over a long single-mode fiber at 850 nm, we confirm that the chirp of the SM MA VCSEL under study is dominated by transient chirp with an [...] Read more.
By measuring the transfer function of the single-mode multi-aperture vertical-cavity surface-emitting laser (SM MA VCSEL) transmitting over a long single-mode fiber at 850 nm, we confirm that the chirp of the SM MA VCSEL under study is dominated by transient chirp with an alpha value of −3.81 enabling a 19 GHz bandwidth over 10 km of single-mode fiber. The detailed measurement of the VCSEL with different bias currents also allows us to recover other key characteristics of the VCSEL, thereby enabling us to practically construct the optical eye diagrams that closely match the experimentally measured ones. The link-level transfer function can be obtained using an analytical equation including effects of modal dispersion and laser chirp–chromatic dispersion (CD) interaction for an MMF of a given length and bandwidth grade. The narrow linewidth and chirp characteristics of the SM MA VCSEL enable transmission performance that surpasses that of conventional MM VCSELs, achieving comparable transmission distances at moderate modal bandwidths for OM3 and OM4 fibers and significantly longer reaches when the modal bandwidth is higher. The transmission performance was also confirmed with the modeled eye diagrams using extracted VCSEL parameters. The chirp properties also provide sufficient bandwidth for SM MA VCSEL transmission over kilometer-scale lengths of single-mode fibers at a high data rate of 100G or above with sufficient optical power coupled into the fibers. Advanced transmission distances are possible over multimode and single-mode fibers versus chirp-free devices. Full article
(This article belongs to the Special Issue Advances in Multimode Optical Fibers and Related Technologies)
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15 pages, 1993 KB  
Article
Compact Dual-Wavelength Optical Fiber Sensor for the Simultaneous Measurement of the Refractive Index and Temperature of Liquid Samples
by Karla Ivonne Serrano-Arévalo, Erika Rodríguez-Sevilla, Monserrat Alonso-Murias, Héctor Pérez-Aguilar and David Monzón-Hernández
Chemosensors 2025, 13(6), 198; https://doi.org/10.3390/chemosensors13060198 - 28 May 2025
Viewed by 1534
Abstract
This study proposes the development of a dual-wavelength optical fiber sensor (DWOFS) that integrates two optical fiber structures in a multimode transmission line to measure the refractive index and temperature of a liquid concurrently. One structure is based on a refractive index sensor [...] Read more.
This study proposes the development of a dual-wavelength optical fiber sensor (DWOFS) that integrates two optical fiber structures in a multimode transmission line to measure the refractive index and temperature of a liquid concurrently. One structure is based on a refractive index sensor that utilizes surface plasmon resonance, comprising a 5 mm long single-mode fiber (SMF) section coated with chromium/gold (Cr/Au) films. The secondary structure employs a multimode interferometer with a 29 mm long no-core fiber (NCF) section covered with a thick layer of polydimethylsiloxane (PDMS) to measure temperature. The measurements obtained reveal two distinct drops in the transmission spectrum at approximately 600 nm and 1550 nm, respectively, enabling precise measurement of the two parameters. The sensor demonstrates a high degree of sensitivity to both refractive index and temperature, spanning the visible (2770.30 nm/RIU) and infrared (0.178 nm/°C) regions of the spectra, respectively. Furthermore, the thermo-optical coefficient for water (0.9928×104 RIU/°C) was estimated. The proposed sensor offers a compact solution for the simultaneous measurement of refractive index and temperature in liquid samples for a variety of applications, including biological, environmental, and healthcare research. Full article
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26 pages, 5185 KB  
Article
Seamless Integration of UOWC/MMF/FSO Systems Using Orbital Angular Momentum Beams for Enhanced Data Transmission
by Mehtab Singh, Somia A. Abd El-Mottaleb, Hassan Yousif Ahmed, Medien Zeghid and Abu Sufian A. Osman
Photonics 2025, 12(5), 499; https://doi.org/10.3390/photonics12050499 - 16 May 2025
Cited by 2 | Viewed by 668
Abstract
This work presents a high-speed hybrid communication system integrating Underwater Optical Wireless Communication (UOWC), Multimode Fiber (MMF), and Free-Space Optics (FSO) channels, leveraging Orbital Angular Momentum (OAM) beams for enhanced data transmission. A Photodetector, Remodulate, and Forward Relay (PRFR) is employed to enable [...] Read more.
This work presents a high-speed hybrid communication system integrating Underwater Optical Wireless Communication (UOWC), Multimode Fiber (MMF), and Free-Space Optics (FSO) channels, leveraging Orbital Angular Momentum (OAM) beams for enhanced data transmission. A Photodetector, Remodulate, and Forward Relay (PRFR) is employed to enable wavelength conversion from 532 nm for UOWC to 1550 nm for MMF and FSO links. Four distinct OAM beams, each supporting a 5 Gbps data rate, are utilized to evaluate the system’s performance under two scenarios. The first scenario investigates the effects of absorption and scattering in five water types on underwater transmission range, while maintaining fixed MMF length and FSO link. The second scenario examines varying FSO propagation distances under different fog conditions, with a consistent underwater link length. Results demonstrate that water and atmospheric attenuation significantly impact transmission range and received optical power. The proposed hybrid system ensures reliable data transmission with a maximum overall transmission distance of 1125 m (comprising a 25 m UOWC link in Pure Sea (PS) water, a 100 m MMF span, and a 1000 m FSO range in clear weather) in the first scenario. In the second scenario, under Light Fog (LF) conditions, the system achieves a longer reach of up to 2020 m (20 m UOWC link + 100 m MMF span + 1900 m FSO range), maintaining a BER ≤ 10−4 and a Q-factor around 4. This hybrid design is well suited for applications such as oceanographic research, offshore monitoring, and the Internet of Underwater Things (IoUT), enabling efficient data transfer between underwater nodes and surface stations. Full article
(This article belongs to the Special Issue Optical Wireless Communication in 5G and Beyond)
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21 pages, 616 KB  
Review
Biomarkers of Progression Independent of Relapse Activity—Can We Actually Measure It Yet?
by Gabriel Bsteh, Assunta Dal-Bianco, Nik Krajnc and Thomas Berger
Int. J. Mol. Sci. 2025, 26(10), 4704; https://doi.org/10.3390/ijms26104704 - 14 May 2025
Cited by 3 | Viewed by 2828
Abstract
Progression independent of relapse activity (PIRA) is increasingly recognized as a key driver of disability in multiple sclerosis (MS). However, the concept of PIRA remains elusive, with uncertainty surrounding its definition, underlying mechanisms, and methods of quantification. This review examines the current landscape [...] Read more.
Progression independent of relapse activity (PIRA) is increasingly recognized as a key driver of disability in multiple sclerosis (MS). However, the concept of PIRA remains elusive, with uncertainty surrounding its definition, underlying mechanisms, and methods of quantification. This review examines the current landscape of biomarkers used to predict and measure PIRA, focusing on clinical, imaging, and body fluid biomarkers. Clinical disability scores such as the Expanded Disability Status Scale (EDSS) are widely used, but may lack sensitivity in capturing subtle relapse-independent progression. Imaging biomarkers, including MRI-derived metrics (brain and spinal cord volume loss, chronic active lesions) and optical coherence tomography (OCT) parameters (retinal nerve fiber layer and ganglion cell-inner plexiform layer thinning), offer valuable insights, but often reflect both inflammatory and neurodegenerative processes. Body fluid biomarkers, such as neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP), are promising indicators of axonal damage and glial activation, but their specificity for PIRA remains limited. This review emphasizes the distinction between predicting PIRA—identifying individuals at risk of future progression—and measuring ongoing PIRA-related disability in real time. We highlight the limitations of current biomarkers in differentiating PIRA from relapse-associated activity and call for a clearer conceptual framework to guide future research. Advancing the precision and utility of PIRA biomarkers will require multimodal approaches, longitudinal studies, and standardized protocols to enable their clinical integration and to improve personalized MS management. Full article
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23 pages, 2425 KB  
Systematic Review
Emerging Image-Guided Navigation Techniques for Cardiovascular Interventions: A Scoping Review
by Majid Roshanfar, Mohammadhossein Salimi, Sun-Joo Jang, Albert J. Sinusas, Jiwon Kim and Bobak Mosadegh
Bioengineering 2025, 12(5), 488; https://doi.org/10.3390/bioengineering12050488 - 2 May 2025
Cited by 1 | Viewed by 1945
Abstract
Background: Image-guided navigation has revolutionized precision cardiac interventions, yet current technologies face critical limitations in real-time guidance and procedural accuracy. Method: Here, we comprehensively evaluate state-of-the-art imaging modalities, from conventional fluoroscopy to emerging hybrid systems, analyzing their applications across coronary, structural, and electrophysiological [...] Read more.
Background: Image-guided navigation has revolutionized precision cardiac interventions, yet current technologies face critical limitations in real-time guidance and procedural accuracy. Method: Here, we comprehensively evaluate state-of-the-art imaging modalities, from conventional fluoroscopy to emerging hybrid systems, analyzing their applications across coronary, structural, and electrophysiological interventions. Results: We demonstrate that novel approaches combining optical coherence tomography with near-infrared spectroscopy or fluorescence achieve unprecedented plaque characterization and procedural guidance through simultaneous structural and molecular imaging. Our analysis reveals key challenges, including imaging artifacts and resolution constraints, while highlighting recent technological solutions incorporating artificial intelligence and robotics. We show that non-imaging alternatives, such as fiber optic real-shape sensing and electromagnetic tracking, complement traditional techniques by providing real-time navigation without radiation exposure. This paper also discusses the integration of image-guided navigation techniques into augmented reality systems and patient-specific modeling, highlighting initial clinical studies that demonstrate their significant promise in reducing procedural times and improving accuracy. These findings establish a framework for next-generation cardiac interventions, emphasizing the critical role of multimodal imaging platforms enhanced by AI-driven decision support. Conclusions: We conclude that continued innovation in hybrid imaging systems, coupled with advances in automation, will be essential for optimizing procedural outcomes and expanding access to complex cardiac interventions. Full article
(This article belongs to the Special Issue Advancements in Medical Imaging Technology)
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12 pages, 2523 KB  
Article
Image Reconstruction Through Multimode Polymer Optical Fiber for Potential Optical Recording of Neural Activity
by Fengling Chen, Siyu Chen, Changjian Zhao, Yanan Zou, Kun Xiao, Zhuo Wang, Arnaldo Leal-Junior and Rui Min
Photonics 2025, 12(5), 434; https://doi.org/10.3390/photonics12050434 - 30 Apr 2025
Cited by 1 | Viewed by 845
Abstract
Despite the growing demand for high-resolution imaging techniques in neuroscience, traditional methods are limited in terms of flexibility and spatial resolution. We explored an approach using multimode polymer optical fiber (POF) and employing a neural network for image reconstruction and studied the ability [...] Read more.
Despite the growing demand for high-resolution imaging techniques in neuroscience, traditional methods are limited in terms of flexibility and spatial resolution. We explored an approach using multimode polymer optical fiber (POF) and employing a neural network for image reconstruction and studied the ability of multimode POF to effectively capture and reconstruct high-quality images. Here, a conventional U-Net model within the framework of convolutional neural networks (CNNs) is applied to the reconstruction of speckle images obtained via POF. The model was trained on an experimental dataset consisting of MNIST graphs and successfully reconstructed high-quality images that closely resemble the original undistorted scene. This study not only highlights the potential of POF in biomedical imaging but also paves the way for more sophisticated optical recording techniques. Full article
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