Search Results (118)

The acute gouty arthritis (AGA) to chronic gouty arthritis (CGA) transition is a critical phase leading to irreversible joint damage and systemic complications. However, current molecular mechanism investigations have remained limited to single-omics approaches that lack comprehensive multi-omics explorations. We integrate high-depth data-independent acquisition (DIA) proteomics and untargeted metabolomics to analyze serum samples from healthy controls (n =28), AGA (n = 31), and CGA (n = 14) patients to address this gap. Through differential expression analysis, we identified nine persistently dysregulated pivotal proteins with robust discriminative capacity, including the urate excretion regulator ZBTB20 and inflammation/immune-related proteins (GUCY1A2, CNDP1, LYZ, SERPINA5, GSN). Additionally, 11 consistently altered core metabolites with diagnostic potential were detected, indicating perturbations in sex hormones, thyroid hormones, gut microbiota-derived metabolites, environmental exposures, and nutritional factors. Multi-omics KEGG enrichment analysis highlighted thyroid hormone synthesis, AMPK signaling pathway, and taurine and hypotaurine metabolism as central pathways. Correlation network analysis further revealed significant immune dysregulation, illustrating an evolution from acute immune activation to chronic inflammation during AGA-to-CGA progression. Our study establishes that a coordinated disruption of the thyroid hormone–AMPK–taurine metabolic axis and concomitant immune microenvironment remodeling is associated with chronic gout development. These findings provide critical targets for developing early diagnostic indicators and targeted interventions for CGA. Full article

Multi-UAV search missions for prioritized targets under constrained communications suffer from weak communication-decision integration, limited global perception synchronization, and delayed mission response. This paper formulates multi-UAV collaboration search as a multi-objective optimization problem to balance communication overhead and search performance. A Cooperative Hierarchical Target Search under Constrained Communications (CHTS-CC) algorithm is proposed to address the problem. The algorithm incorporates a Cluster-Consistent Information Fusion with Event Trigger (CCIF-ET) method, which enables intra-cluster information fusion. When clusters connect, a single merge that applies joint weighting by cluster scale and uncertainty reduces communication overhead. Furthermore, a Dynamic Preemptive Task Allocation (DPTA) mechanism reallocates UAV resources based on target priority and estimated time of arrival (ETA), enhancing responsiveness to high-priority targets. Simulation results show that when all UAVs and communication links operate normally, CCIF-ET reduces total confirmation time by 8.73% compared to the uncoordinated baseline and maintains a 24.43% advantage during single-UAV failures. In scenarios with obstacles, failures, and dynamic targets, CHTS-CC reduced mission completion steps by 34.78%, 32.35%, and 55.45% compared to the non-allocation baseline. The average detection time for high-priority targets decreased by 28.48%, 29.41%, and 58.82%, respectively, demonstrating the effectiveness of the proposed algorithm. Full article

Accurate fig detection in complex environments is a significant challenge. Small targets, occlusion, and similar backgrounds are considered the main obstacles in intelligent harvesting. To address this, this study proposes Fig-YOLO, an improved YOLOv11n-based detection algorithm with multiple targeted architectural innovations. First, a Spatial–Frequency Selective Convolution (SFSConv) module is introduced into the backbone to replace conventional convolution, enabling joint modeling of spatial structures and frequency-domain texture features for more effective discrimination of figs from visually similar backgrounds. Second, an enhanced bi-branch attention mechanism (EBAM) is incorporated at the network’s terminal stage to strengthen the representation of key regions and improve robustness under severe occlusion. Third, a multi-branch dynamic sampling convolution (MFCV) module replaces the original C3k2 structure in the feature fusion stage, capturing figs of varying sizes through dynamic sampling and residual deep-feature fusion. Experimental results show that Fig-YOLO achieves precision, recall, and mAP@0.5 of 89.2%, 78.4%, and 87.3%, respectively, substantially outperforming the baseline YOLOv11n. Further evaluation confirms that the model maintains stable performance across varying fruit sizes, occlusion levels, lighting conditions, and data sources. Fig-YOLO’s innovations offer solid support for intelligent orchard monitoring and harvesting. Full article

Maritime remote sensing ship detection has long been plagued by two major issues: the failure of geometric priors due to the extreme length-to-width ratio of ships; and the sharp drop in edge signal-to-noise ratio caused by the overlapping chromaticity domain between ships and seawater, which leads to unsatisfactory accuracy of existing detectors in such scenarios. Therefore, this paper proposes an optical remote sensing ship detection model combining channel shuffling and bilinear interpolation, named CSBI-YOLO. The core innovations include three aspects: First, a group shuffling feature enhancement module is designed, embedding parallel group bottlenecks and channel shuffling mechanisms into the interface between the YOLOv8 backbone and neck to achieve multi-scale semantic information coupling with a small number of parameters. Second, an edge-gated upsampling unit is constructed, using separable Sobel magnitude as structural prior and a learnable gating mechanism to suppress low-contrast noise on the sea surface. Third, an R-IoU-Focal loss function is proposed, introducing logarithmic curvature penalty and adaptive weights to achieve joint optimization in three dimensions: location, shape, and scale. Dual validation was conducted on the self-built SlewSea-RS dataset and the public DOTA-ship dataset. The results show that on the SlewSea-RS dataset, the mAP₅₀ and mAP_50–95 values of the CSBI-YOLO model increased by 6% and 5.4%, respectively. On the DOTA-ship dataset, comparisons with various models demonstrate that the proposed model outperforms others, proving the excellent performance of the CSBI-YOLO model in detecting maritime ship targets. Full article

To suppress non-stationary main-lobe interference, we utilized the waveform information of the transmitted signal and proposed an interference suppression method based on a multi-polarized array without the need for calculating the target parameters. This method calculates the steering vector of the target through matched filtering. Additionally, for non-stationary interference whose statistical characteristics change over time, we extract high-energy frequency points from the time–frequency joint domain to obtain the time–frequency covariance matrix for subsequent beamforming. Simulation experiments demonstrate that this method leverages the signal polarization information sensed by the multi-polarized array, effectively suppressing non-stationary main-lobe interference in the polarization domain. This method does not require estimation of the target’s polarization parameters and is more suitable for real-world detection scenarios where the waveform is known. Full article

With the advancement of electromagnetic interference and counter-interference technology, complex and unpredictable interference signals greatly reduce radar detection, tracking, and recognition performance. In multi-interference environments, the overlap of interference cross-correlation peaks can mask target signals, weakening radar interference suppression capability. To address this, we propose a joint waveform and filter design method called Multi-Interference Suppression Network (MISNet) for effective interference suppression. First, we develop a design criterion based on suppression coefficients for different interferences, minimizing both cross-correlation energy and interference peak models. Then, for the non-smooth, non-convex optimization problem, we use complex neural networks and gating mechanisms, transforming it into a differentiable problem via end-to-end training to optimize the transmit waveform and receive filter efficiently. Simulation results show that compared to traditional algorithms, MISNet effectively reduces interference cross-correlation peaks and autocorrelation sidelobes in single interference environments; it demonstrates excellent robustness in multi-interference environments, significantly outperforming CNN, PSO, and ANN comparison methods, effectively improving radar interference suppression performance in complex multi-interference scenarios. Full article

Border surveillance, as a critical component of national security, places increasingly stringent demands on the target perception capabilities of video monitoring systems, especially in wide-area and complex environments. To address the limitations of existing systems in low-confidence target detection and multi-camera collaboration, this paper proposes a novel visual enhancement method for cooperative control of multiple PTZ (Pan–Tilt–Zoom) cameras based on hierarchical reinforcement learning. The proposed approach establishes a hierarchical framework composed of a Global Planner Agent (GPA) and multiple Local Executor Agents (LEAs). The GPA is responsible for global target assignment, while the LEAs perform fine-grained visual enhancement operations based on the assigned targets. To effectively model the spatial relationships among multiple targets and the perceptual topology of the cameras, a graph-based joint state space is constructed. Furthermore, a graph neural network is employed to extract high-level features, enabling efficient information sharing and collaborative decision-making among cameras. Experimental results in simulation environments demonstrate the superiority of the proposed method in terms of target coverage and visual enhancement performance. Hardware experiments further validate the feasibility and robustness of the approach in real-world scenarios. This study provides an effective solution for multi-camera cooperative surveillance in complex environments. Full article

In recent years, detection methods for generic object detection have achieved significant progress. However, due to the large number of small objects in aerial images, mainstream detectors struggle to achieve a satisfactory detection performance. The challenges of small object detection in aerial images are primarily twofold: (1) Insufficient feature representation: The limited visual information for small objects makes it difficult for models to learn discriminative feature representations. (2) Background confusion: Abundant background information introduces more noise and interference, causing the features of small objects to easily be confused with the background. To address these issues, we propose a Multi-Level Contextual and Semantic Information Aggregation Network (MCSA-Net). MCSA-Net includes three key components: a Spatial-Aware Feature Selection Module (SAFM), a Multi-Level Joint Feature Pyramid Network (MJFPN), and an Attention-Enhanced Head (AEHead). The SAFM employs a sequence of dilated convolutions to extract multi-scale local context features and combines a spatial selection mechanism to adaptively merge these features, thereby obtaining the critical local context required for the objects, which enriches the feature representation of small objects. The MJFPN introduces multi-level connections and weighted fusion to fully leverage the spatial detail features of small objects in feature fusion and enhances the fused features further through a feature aggregation network. Finally, the AEHead is constructed by incorporating a sparse attention mechanism into the detection head. The sparse attention mechanism efficiently models long-range dependencies by computing the attention between the most relevant regions in the image while suppressing background interference, thereby enhancing the model’s ability to perceive targets and effectively improving the detection performance. Extensive experiments on four datasets, VisDrone, UAVDT, MS COCO, and DOTA, demonstrate that the proposed MCSA-Net achieves an excellent detection performance, particularly in small object detection, surpassing several state-of-the-art methods. Full article

Multi-object tracking (MOT) algorithms are a key research direction in the field of computer vision. Among them, the joint detection and embedding (JDE) method, with its excellent speed and accuracy performance, has become the current mainstream solution. However, in complex scenes with dense targets or occlusions, the tracking performance of existing algorithms is often limited, especially in terms of unstable identity assignment and insufficient tracking accuracy. To address these challenges, this paper proposes a new multi-object tracking model—the Reparameterized and Global Context Track (RGTrack). This model is based on the Correlation-Sensitive Track (CSTrack) framework and innovatively introduces multi-branch training and attention mechanisms, combined with reparameterized convolutional networks and global attention modules, significantly enhancing the network’s feature extraction ability in complex scenes, especially in ignoring irrelevant information and focusing on key areas. It adopted a multiple association strategy to better establish the association relationship between targets in consecutive frames. Through this improvement, the Reparameterized and Global Context Track can better handle scenes with dense targets and severe occlusions, providing more accurate target identity matching and continuous tracking. Experimental results show that compared with the Correlation-Sensitive Track, the Reparameterized and Global Context Track has significant improvements in multiple key indicators: multi-object tracking accuracy (MOTA) increased by 1.15%, Identity F1 Score (IDF1) increased by 1.73%, and Mostly Tracked (MT) increased by 6.86%, while ID-switched (ID Sw) decreased by 47.49%. These results indicate that the Reparameterized and Global Context Track not only can stably track targets in more complex scenes but also significantly improves the continuity of target identities. Moreover, the Reparameterized and Global Context Track increased the frames per second (FPS) by 51.48% and reduced the model size by 3.08%, demonstrating its significant advantages in real-time performance and computational efficiency. Therefore, the Reparameterized and Global Context Track model maintains high accuracy while having stronger real-time processing capabilities, making it especially suitable for embedded devices and resource-constrained application environments. Full article

Most electromagnetic invisibility devices are designed while relying on rigid structures, which have limitations in adapting to complex curved surfaces and dynamic deployment. In contrast, flexible invisibility structures have great application value due to their bendable and easy-to-fit characteristics. In this paper, we propose a flexible metasurface suitable for broadband SAR (Synthetic Aperture Radar) imaging invisibility, which realizes multi-domain joint regulation of electromagnetic waves by designing two subwavelength unit structures with differentiated reflection characteristics and combining array inverse optimization methods. The metasurface employs a sponge-like dielectric substrate and integrates resistive ink to construct a resonant structure, which can suppress electromagnetic scattering through joint phase and amplitude modulation, achieving low detectability of targets in UAV (Unmanned Aerial Vehicle) detection scenarios. Indoor microwave anechoic chamber tests and outdoor UAV-borne SAR experiments verify its stable invisibility performance in a wide frequency band, providing theoretical and experimental support for the application of flexible metasurfaces in dynamic electromagnetic detection countermeasures. Full article

Hyperspectral image (HSI) denoising is a crucial step in image preprocessing as its effectiveness has a direct impact on the accuracy of subsequent tasks such as land cover classification, target recognition, and change detection. However, existing methods suffer from limitations in effectively integrating multi-scale features and adaptively modeling complex noise distributions, making it difficult to construct effective spatial–spectral joint representations. This often leads to issues like detail loss and spectral distortion, especially when dealing with complex mixed noise. To address these challenges, this paper proposes a multi-scale differentiated denoising network based on spatial–spectral cooperative attention (MDSSANet). The network first constructs a multi-scale image pyramid using three downsampling operations and independently models the features at each scale to better capture noise characteristics at different levels. Additionally, a spatial–spectral cooperative attention module (SSCA) and a differentiated multi-scale feature fusion module (DMF) are introduced. The SSCA module effectively captures cross-spectral dependencies and spatial feature interactions through parallel spectral channel and spatial attention mechanisms. The DMF module adopts a multi-branch parallel structure with differentiated processing to dynamically fuse multi-scale spatial–spectral features and incorporates a cross-scale feature compensation strategy to improve feature representation and mitigate information loss. The experimental results show that the proposed method outperforms state-of-the-art methods across several public datasets, exhibiting greater robustness and superior visual performance in tasks such as handling complex noise and recovering small targets. Full article

This paper proposes a novel Global Navigation Satellite System (GNSS)-based remote sensing method for simulating Radar Doppler Map (RDM) features through joint electromagnetic scattering modeling and signal processing, enabling characteristic parameter extraction for both point and ship targets in multi-satellite scenarios. Simulations demonstrate that the B3I signal achieves a significantly enhanced range resolution (tens of meters) compared to the B1I signal (hundreds of meters), attributable to its wider bandwidth. Furthermore, we introduce an Unscented Particle Filter (UPF) algorithm for dynamic target tracking and state estimation. Experimental results show that four-satellite configurations outperform three-satellite setups, achieving <10 m position error for uniform motion and <18 m for maneuvering targets, with velocity errors within ±2 m/s using four satellites. The joint detection framework for multi-satellite, multi-target scenarios demonstrates an improved detection accuracy and robust localization performance. Full article

Traditional collision risk warning methods primarily focus on vehicle-to-vehicle collisions, neglecting conflicts between vehicles and vulnerable road users (VRUs) such as pedestrians, while the difficulty in predicting pedestrian trajectories further limits the accuracy of collision warnings. To address this problem, this study proposes a vehicle-to-everything-based (V2X) multi-fusion vehicle–pedestrian collision warning method, aiming to enhance the traffic safety protection for VRUs. First, Unmanned Aerial Vehicle aerial imagery combined with the YOLOv7 and DeepSort algorithms is utilized to achieve target detection and tracking at unsignalized intersections, thereby constructing a vehicle–pedestrian interaction trajectory dataset. Subsequently, key foundational modules for collision warning are developed, including the vehicle trajectory module, the pedestrian trajectory module, and the risk detection module. The vehicle trajectory module is based on a kinematic model, while the pedestrian trajectory module adopts an Attention-based Social GAN (AS-GAN) model that integrates a generative adversarial network with a soft attention mechanism, enhancing prediction accuracy through a dual-discriminator strategy involving adversarial loss and displacement loss. The risk detection module applies an elliptical buffer zone algorithm to perform dynamic spatial collision determination. Finally, a collision warning framework based on the Monte Carlo (MC) method is developed. Multiple sampled pedestrian trajectories are generated by applying Gaussian perturbations to the predicted mean trajectory and combined with vehicle trajectories and collision determination results to identify potential collision targets. Furthermore, the driver perception–braking time (TTM) is incorporated to estimate the joint collision probability and assist in warning decision-making. Simulation results show that the proposed warning method achieves an accuracy of 94.5% at unsignalized intersections, outperforming traditional Time-to-Collision (TTC) and braking distance models, and effectively reducing missed and false warnings, thereby improving pedestrian traffic safety at unsignalized intersections. Full article

Background/Objectives: Degenerative joint diseases (DJDs) involve intricate molecular disruptions within bone, cartilage, and synovial tissues, often preceding overt radiographic changes. These tissues exhibit complex biomolecular architectures and their degeneration leads to microstructural disorganization and inflammation that are challenging to detect with conventional imaging techniques. This review aims to synthesize recent advances in imaging, computational modeling, and sequencing technologies that enable high-resolution, non-invasive characterization of joint tissue health. Methods: We examined advanced modalities including high-resolution MRI (e.g., T1ρ, sodium MRI), quantitative and dual-energy CT (qCT, DECT), and ultrasound elastography, integrating them with radiomics, deep learning, and multi-scale modeling approaches. We also evaluated RNA-seq, spatial transcriptomics, and mass spectrometry-based proteomics for omics-guided imaging biomarker discovery. Results: Emerging technologies now permit detailed visualization of proteoglycan content, collagen integrity, mineralization patterns, and inflammatory microenvironments. Computational frameworks ranging from convolutional neural networks to finite element and agent-based models enhance diagnostic granularity. Multi-omics integration links imaging phenotypes to gene and protein expression, enabling predictive modeling of tissue remodeling, risk stratification, and personalized therapy planning. Conclusions: The convergence of imaging, AI, and molecular profiling is transforming musculoskeletal diagnostics. These synergistic platforms enable early detection, multi-parametric tissue assessment, and targeted intervention. Widespread clinical integration requires robust data infrastructure, regulatory compliance, and physician education, but offers a pathway toward precision musculoskeletal care. Full article

Azimuth ambiguity caused by spectral aliasing severely degrades the quality of Synthetic Aperture Radar (SAR) images. To suppress azimuth ambiguity while preserving image details as much as possible, this paper proposes an azimuth ambiguity suppression method for SAR based on time-frequency joint analysis. By exploiting the distribution differences of ambiguous signals across different sub-spectra, the method locates azimuth ambiguity in the time domain through multi-sub-spectrum change detection and fusion, followed by ambiguity suppression in the azimuth time-frequency domain. Experimental results demonstrate that the proposed method effectively suppresses azimuth ambiguity while maintaining superior performance in preserving genuine targets. Full article