Search Results (10)

The way in which Aquaporin-4 (AQP4) is localized on the astrocytes’ surface—i.e., with AQP4 channels predominantly located on the endfeet of astrocytes near the blood vessels—represents an important structural element for maintaining brain fluid homeostasis. In addition to this structural function, AQP4 polarity also facilitates glymphatic transport, the maintenance of the blood–brain barrier (BBB) functions, ion buffering, and neurotransmitter removal, and helps regulate neurovascular communications. The growing body of literature suggests that the loss of AQP4 polarity—a loss in the organization of AQP4 channels to the perivascular membrane—is associated with increased vascular, inflammatory, and metabolic disturbances in the context of many neurological diseases. As a result, this review attempts to synthesize both experimental and clinical studies to highlight that AQP4 depolarization often occurs in conjunction with early signs of neurodegeneration and neuroinflammation; however, we are aware that the loss of AQP4 polarity is only one factor in a complex pathophysiological environment. This review examines the molecular structure responsible for maintaining the polarity of AQP4—such as dystrophin–syntrophin complexes, orthogonal particle arrays, lipid microdomains, trafficking pathways, and transcriptional regulators—and describes how the vulnerability of these systems to various types of vascular stress, inflammatory signals, energy deficits, and mechanical injury can lead to a loss of AQP4 polarity. Furthermore, we will explore how a loss of AQP4 polarity can lead to the disruption of perivascular fluid movement, changes in blood–brain barrier morphology, enhanced neuroimmune activity, changes in ionic and metabolic balance, and disruptions in the global neural network synchronization. Importantly, we recognize that each of these disruptions will likely occur in concert with other disease-specific mechanisms. Alterations in AQP4 polarity have been observed in a variety of neurological disorders including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, traumatic brain injury, and glioma; however, we also observe that the same alterations in fluid regulation occur across all of these different diseases, but that no single upstream event accounts for the alteration in polarity. Ultimately, we will outline emerging therapeutic avenues to restore perivascular fluid transport, and will include molecular-based therapeutic agents designed to modify the anchoring of AQP4, methods designed to modulate the state of astrocytes, biomaterials-based drug delivery systems, and therapeutic methods that leverage dynamic modulation of the neurovascular interface. Future advances in multi-omic profiling, spatial proteomics, glymphatic imaging, and artificial intelligence will allow for earlier identification of AQP4 polarity disturbances and potentially allow for the development of more personalized treatment plans. Ultimately, by linking these concepts together, this review aims to frame AQP4 polarity as a modifiable aspect of the “fluidic connectome”, and highlight its importance in maintaining overall brain health across disease states. Full article

Ruled surfaces in Minkowski 3-space play a crucial role in differential geometry and have significant applications in physics and engineering. This study explores the fundamental properties of ruled surfaces via orthogonal modified frame in Minkowski space ${\mathrm{E}}_1^3$, focusing on their minimality, developability, and curvature characteristics. We examine the necessary and sufficient conditions for a ruled surface to be minimal, considering the mean curvature and its implications. Furthermore, we analyze the developability of such surfaces, determining the conditions under which they can be locally unfolded onto a plane without distortion. The Gaussian and mean curvatures of ruled surfaces in Minkowski space are computed and discussed, providing insights into their geometric behavior. Special attention is given to spacelike, timelike, and lightlike rulings, highlighting their unique characteristics. This research contributes to the broader understanding of the geometric properties of ruled surfaces within the framework of Minkowski geometry. Full article

In this study, we explore the sweeping surfaces in Euclidean 3-space, utilizing the modified orthogonal frames with non-zero curvature and torsion, which allows us to consider the spine curves even if their second differentiations vanish. If the curvature of the spine curve of a sweeping surface has discrete zero points, the Frenet frame might undergo a discontinuous change in orientation. Therefore, the conventional parametrization with the Frenet frame of such a surface cannot be given. Thus, we introduce two types of modified sweeping surfaces by considering two types of spine curves; the first one’s curvature is not identically zero and the second one’s torsion is not identically zero. Then, we determine the criteria for classifying the coordinate curves of these two types of modified sweeping surfaces as geodesic, asymptotic, or curvature lines. Additionally, we delve into determining criteria for the modified sweeping surfaces to be minimal, developable, or Weingarten. Through our analysis, we aim to clarify the characteristics defining these surfaces. We present graphical representations of sample modified sweeping surfaces to enhance understanding and provide concrete examples that showcase their properties. Full article

To detect moving weak targets in the dual function radar communication (DFRC) system of an orthogonal frequency division multiplexing (OFDM) waveform, a modified hybrid integration method is addressed in this paper. A high-speed aircraft can cause range walk (RW) and Doppler walk (DW), rendering traditional detection methods ineffective. To overcome RW and DW, this paper proposes an integration approach combining DFRC and OFDM. The proposed approach consists of two primary components: intra-frame coherent integration and hybrid multi-inter-frame integration. After the echo signal is re-fragmented into multiple subfragments, the first step involves integrating energy across fixed situations within intra-frames for each subcarrier. Subsequently, coherent integration is performed across the subfragments, followed by the application of a Radon transform (RT) to generate frames based on the properties derived from the coherent integration output. This paper provides detailed expressions and analyses for various performance metrics of our proposed method, including the communication bit error ratio (BER), responses of coherent and non-coherent outputs, and probability of detection. Simulation results demonstrate the effectiveness of our strategy. Full article

Linear active disturbance rejection control (LADRC) has been extensively used in various areas due to its excellent disturbance suppression capability. When LADRC is applied to a single-phase inverter for tracking a sinusoidal reference signal, there is an inherent tracking inaccuracy problem. The steady-state error can be removed with the synchronous reference frame proportional-integral (SRFPI) control, which generates two orthogonal signals. In this paper, a modified control method based on compound SRFPI and LADRC for an off-grid single-phase inverter is put forward, where both output signals of SRFPI are employed as the reference signals of LADRC. Furthermore, a selective harmonic compensation method is performed by paralleling multiple SRFPI controllers to further reduce the selective harmonic components. Detailed theoretical analyses including system stability, robustness, performance of voltage tracking error and disturbance rejection are presented, which indicate that this organic combination fuses the merits of both SRFPI and LADRC without complicating the control design. Additionally, contrast experiments are conducted to demonstrate its effectiveness and superiority. These findings demonstrate that the system realizes a slight voltage tracking error and steady-state error, rapid dynamic response, and low total harmonic distortion (THD), especially under highly nonlinear load conditions. Full article

Spacetime torsion is known to be highly suppressed at the end of inflation, which is called preheating. This result was recently shown in (EPJ C (2022)) in the frame of Einstein–Cartan–Brans–Dicke inflation. In this paper, it is shown that a torsionful magnetogenesis in QED effective Lagrangean drives a torsion damping in order to be subsequently amplified by the dynamo effect after the generation of these magnetic fields seeds. This damping on amplification would depend upon the so-called torsion chirality. Here, a cosmic factor $gkK$ is present where K is the contortion vector and k is the wave vector which is connected to the inverse of magnetic coherence length. In a second example, we find Higgs inlationary fields in Einstein–Cartan gravity thick domain walls (DWs). Recently, a modified Einstein–Cartan gravity was given by Shaposhnikov et al. [PRL (2020)] to obtain Higgs-like inflatons as a portal to dark energy. In the case of thick DW, we assume that there is a torsion squared influence, since we are in the early universe where torsion is not so weak as in the late universe as shown by Paul and SenGupta [EPJ C (2019)] in a 5D brane-world. A static DW solution is obtained when the inflationary potential vanishes and Higgs potential is a helical function. Recently, in the absence of inflation, domain wall dynamos were obtained in Einstein–Cartan gravity (EC) where the spins of the nucleons were orthogonal to the wall. Full article

A numerical investigation of the seismic behaviour of asymmetrical low-rise reinforced concrete (R/C) frames is performed considering the deformability of the supporting soil. The typical rigid base assumption is adopted by most current seismic design codes for ordinary buildings, implicitly assuming that the “beneficial” influence of the Soil-Structure Interaction (SSI) effects results in a decrease of the internal forces of a structure. However, in recent research works, SSI is found to affect the structural response in not always a beneficial manner and occasionally in a detrimental one. In the current study, the non-linear time-domain seismic analyses of selected 2D and 3D symmetric and asymmetric R/C framed buildings are presented considering initially the fixed base assumption. Subsequently, these R/C building models, subjected to the same seismic excitations, are analysed considering SSI, by applying a set of orthogonal footings with tie beams which interact with the soil medium. In addition, in the 3D models, the case of a foundation mat supporting the frames is examined. Comparisons between the numerical response results obtained for the examined supporting conditions yield useful conclusions regarding the modified elastoplastic estimated behaviour of common low-rise R/C buildings due to SSI, which can be used for the improvement of the seismic design codes. Full article

In this paper, we describe an experimental testbed designed to evaluate indoor visible light communications (VLC) in realistic scenarios. The system is based on a mockup where the location and orientation of the optical receiver can be modified with precision for a static configuration of walls and ceiling lamp arrangements. The system utilizes a timing synchronization method, which is based on evaluating the training sequence periods used for channel response estimation, which enables robust frame synchronization. In addition, an adaptive rate orthogonal frequency-division multiplexing (OFDM) scheme is used to assess the VLC performance throughout the receiver plane emulating a real communication. The preliminary results obtained with this prototype, considering a multiple-input single-output (MISO) scenario, demonstrate that reflection on walls yields a significant increase in data rates, which can be additionally improved if appropriate orientation of the receiver is implemented. However, vertical orientation upward of the optical receiver still constitutes a simple solution but efficient enough. Moreover, a good agreement between simulation and experimental results is observed, which confirms the suitability of the mockup as an experimental testbed for practical evaluation of indoor VLC systems, where system performance for different lamp arrangements and receiver designs, including multi-user communications, can be studied. Full article

The internal structure of composite materials is modified during manufacturing. The formation of woven prepregs or dry preforms changes the angle between the warp and weft yarns. The damage behaviour of the consolidated composite is modified by these changes of angle. It is important when designing a composite part to consider this modification when calculating the damage in order to achieve a correct dimensioning. In this paper, a damage calculation approach of the consolidated textile composite that takes into account the change in orientation of the yarns due to forming is proposed. The angles after forming are determined by a simulation of the draping based on a hypoelastic behaviour of the woven fabric reinforcement. Two orthogonal frames based on the warp and weft directions of the textile reinforcement are used for the objective integration of stresses. Damage analysis of the cured woven composite with non-perpendicular warp and weft directions is achieved by replacing it with two equivalent Unidirectional (UD) plies representing the yarn directions. For each ply, a model based on Continuum Damage Mechanics (CDM) describes the progressive damage. Two examples are presented, a bias extension specimen and the hemispherical forming coupon. In both cases, the angles between the warp and weft yarns are changed. It is shown that the damage calculated by taking into account these angle changes is greatly modified. Full article

In this paper, a new modified roller coaster surface according to a modified orthogonal frame is investigated in Euclidean 3-space. In this method, a new modified roller coaster surface is modeled. Both the Gaussian curvature and mean curvature of roller coaster surfaces are investigated. Subsequently, we obtain several characterizations in Euclidean 3-space. Full article