Search Results (1,496)

Mindfulness and body image anxiety are psychological factors associated with disordered eating and may contribute to orthorexia nervosa, yet their combined effects remain underexplored. In this cross-sectional online survey, 382 adults in Greece completed the Mindful Attention Awareness Scale (MAAS-15), the Orthorexia scale (ORTO-6), the Social Physique Anxiety Scale (SPAS-12), and measures of body mass index (BMI) and physical activity (PAVS). Descriptive statistics, correlations, regression analyses, and mediation analysis were conducted to examine the associations among mindfulness, body image anxiety, and orthorexia. Mindfulness correlated negatively with orthorexia and body image anxiety, whereas body image anxiety correlated positively with orthorexia. In multinomial logistic regression, higher body image anxiety increased the odds of low (OR = 1.194, 95% CI 1.114–1.280) and moderate mindfulness (OR = 1.125, 95% CI 1.068–1.185); orthorexia also increased the odds of low (OR = 1.146, 95% CI 1.040–1.264) and moderate mindfulness (OR = 1.099, 95% CI 1.026–1.176). Overall, psychological factors (mindfulness, body image anxiety) appeared more influential than anthropometric or lifestyle factors (BMI, physical activity) in relation to orthorexia. These findings indicate that mindfulness was inversely associated with orthorexia tendencies, while body image anxiety was positively associated with orthorexia and was statistically linked to this association in the mediation analysis. Full article

Tourism development has, in the past decades, brought new opportunities and challenges to residents’ livability in urban destinations, due to mobility, landscape and environmental quality effects. Quality of life may comprise, inter alia, a clean environment, historic atmosphere, cultural identity or a relaxed inner city. In recent years, uncontrolled tourism has led to ‘overcrowding’ and has prompted ‘mixed feelings’ on tourism among residents, despite clear economic benefits. Clearly, tourism takes place in a conflicting domain with different local actors. There is a rising fear in many historic cities that the long-run effects of mass tourism may be detrimental to the locals. This study seeks to examine local tensions among different interest groups in the tourism sector as a result of negative externalities such as decay of local livability, traffic congestion, or quality decline in the supply of tourism attractions. In this paper a novel supply-oriented concept, Local Leisure Resources, is put forward to uncover the externality effects of tourism and tourism mobility on urban livability, as well as the moderating effect of intra-city destination mobility of visitors. This concept will be tested for sustainability challenges in urban areas in China. Our empirical modeling analysis, based on data from 247 Chinese tourist places over the years 2008–2018, shows that local leisure resources have a clear mediating effect on the relationship between tourist visits and quality of life in urban destinations. The internal mobility appears to have a positive moderating effect on the role of diverse local leisure resources in supporting place-based livability of various local groups of actors involved. This research highlights the complex mechanism of tourism development on urban livability and environmental landscapes from the new concept of local leisure resources. It provides a solid basis and reference for sustainable development strategies for local policy actors regarding local destination livability. Full article

The green innovation bubble refers to the phenomenon of a “decoupling between patent quantity and quality” that may arise as firms respond to climate risks, posing a potential threat to the effectiveness of green innovation and sustainable development. Based on data from Chinese A-share listed companies from 2015 to 2023, this study examines the impact of climate risk on corporate green innovation bubbles, as well as the underlying transmission mechanisms and boundary conditions, from the perspective of strategic response. The findings indicate that there is a significant positive association between climate risk and the corporate green innovation bubble. Mechanism tests reveal that this effect operates primarily through three mediating channels: increased attention from green investors, amplified ESG rating divergence, and greater analyst coverage. These factors collectively incentivize firms to engage in “strategic green innovation” in response to external pressures. Heterogeneity analysis shows that the effect of climate risk on the green innovation bubble is more pronounced among small and medium-sized enterprises, firms with relatively optimistic investor sentiment, and firms with stronger ESG performance. Moderation analysis further demonstrates that robust internal controls can effectively mitigate the aggravating effect of climate risk on the green innovation bubble. This study uncovers the formation mechanism underlying the coexistence of “quantity expansion” and “quality lag” in corporate green innovation under climate risk. It provides both theoretical and empirical evidence for identifying and addressing innovation bubbles during the green transition, offering policy insights for improving green innovation incentive mechanisms and reducing greenwashing risks. Full article

Background: Gestation is a period of significant biological plasticity where the intrauterine environment influences fetal development via “fetal programming”. This study systematically reviews and meta-analyzes the association between genetic determinants—specifically the NR3C1, FKBP5, and CRHR1 genes, chosen for their pivotal role in the functional regulation and feedback sensitivity of the hypothalamic–pituitary–adrenal (HPA) axis—and stress reactivity during pregnancy. Methods: Following PRISMA guidelines, a systematic search was conducted across PubMed, Scopus, and Web of Science, yielding an initial total of 1430 records. After removing duplicates and screening 669 studies, a total of 34 primary observational studies were included in the systematic review and qualitative synthesis. For the quantitative synthesis, 27 articles provided sufficient data, resulting in k = 39 independent effect sizes analyzed via a mixed-effects model to account for tissue-specific and cohort-specific outcomes. Results: Systematic analysis reveals that maternal psychosocial stress significantly correlates with NR3C1 hypermethylation, acting as a biological mediator for neonatal cortisol dysregulation and hippocampal volume reduction. The FKBP5 rs1360780 polymorphism emerged as a key moderator of structural vulnerability, showing a “double-hit” effect when combined with epigenetic alterations. Furthermore, the study identifies sex-specific susceptibility, with divergent placental trajectories for male and female fetuses. Meta-analytic estimates confirmed the robustness of these associations (Rosenthal Fail-Safe N = 431,000), despite a general trend toward statistical significance (p = 0.079) in heterogeneous cohorts. Conclusions: The findings underscore a stable link between genetic determinants and prenatal stress reactivity. The interaction between molecular predisposition and environmental factors defines the health of the mother–infant dyad. These results advocate for a transition toward Precision Prenatal Medicine, integrating polygenic risk scores and epigenetic monitoring to implement early, targeted preventive interventions. Full article

Background and Objectives: Anemia is a frequent complication of chronic kidney disease (CKD), primarily attributed to erythropoietin deficiency. Interstitial fibrosis (IF), which disrupts the renal interstitium where erythropoietin-producing cells reside, may contribute to anemia independent of glomerular filtration rate (GFR). However, data in primary glomerulonephritis (PGN) are limited and conflicting. Materials and Methods: In this nationwide multicenter registry analysis (TSN-GOLD), 2794 adults with biopsy-proven PGN were included. Interstitial fibrosis was graded semi quantitatively (0–3). Anemia was defined according to KDIGO/WHO criteria. Multivariable logistic regression models were constructed to evaluate the independent association between IF severity and anemia, adjusting for age, sex, eGFR, log-transformed proteinuria, hypertension, diabetes mellitus, and biopsy diagnosis. Interaction between IF and eGFR was assessed. A predefined subgroup analysis was performed in patients with preserved renal function (eGFR ≥ 60 mL/min/1.73 m²). Results: Anemia was present in 34.4% of patients. Although moderate-to-severe IF was more frequent among anemic patients (p < 0.001), IF severity was not independently associated with anemia in multivariable analysis (p-trend = 0.72). Female sex and lower eGFR were independently associated with anemia. A statistically significant IF×eGFR interaction was observed (p = 0.0029), indicating effect modification across renal function levels. The model demonstrated moderate discrimination (AUC = 0.705). In patients with preserved renal function, IF severity was not associated with anemia. Conclusions: In this large multicenter cohort of PGN patients, interstitial fibrosis severity was not independently associated with anemia after adjustment for renal function and clinical covariates. These findings suggest that the association between interstitial fibrosis and anemia in PGN appears largely mediated by renal functional status rather than fibrosis severity alone. Full article

Internet advertising, while enabling unprecedented commercial reach, has become a pervasive vehicle for deceptive practices that inflict measurable harm on consumers. This study empirically investigates the structural relationships between internet advertising falsity and consumer harm by integrating analyses of the mediating role of consumer cognitive processes and the moderating role of consumer vulnerability within a unified structural framework. Survey data were collected from 600 adult consumers with online purchase experience in the Republic of Korea—an advanced digital economy characterized by exceptionally high mobile-commerce penetration, mature e-commerce infrastructure, and evolving digital consumer protection regulation—and analyzed using structural equation modeling (SEM) with AMOS 24.0, supplemented by Hayes’ PROCESS macro Model 59 for conditional process analysis. All 13 hypotheses were supported, although path magnitudes varied substantially across falsity dimensions and mediator pathways—with direct effects ranging from β = 0.156 (false scarcity) to β = 0.224 (performance exaggeration), and indirect effects dominated by the risk assessment distortion pathway. Among the four sub-dimensions of advertising falsity—factual misrepresentation, performance exaggeration, price deception, and false scarcity—performance exaggeration exerted the strongest direct effect on consumer harm. The three cognitive mediators—perceived advertising credibility, risk assessment distortion, and purchase decision pressure—all demonstrated significant partial mediation, with risk assessment distortion emerging as the most powerful indirect pathway. All four consumer vulnerability dimensions—digital literacy level, demographic vulnerability, prior victimization experience, and impulsive buying tendency—significantly moderated the falsity–harm relationship, with low-digital-literacy consumers experiencing approximately 1.7 times the adverse effect of high-literacy counterparts. Moderated mediation analysis revealed that the conditional indirect effect for the high-vulnerability group was approximately 2.3 times that of the low-vulnerability group, confirming that the cognitive harm mechanism intensifies systematically for vulnerable consumers. These findings advance consumer vulnerability theory in the digital context and offer evidence-based implications for consumer protection policy, platform governance, and digital literacy education. Full article

Generation Z (Gen Z) consumers exhibit a distinctive multi-platform purchase behavior: they habitually discover products through social commerce (S-commerce) stimuli—including influencer content and livestream shopping—yet systematically migrate to e-marketplaces to complete their transactions. Despite the strategic importance of this behavioral pattern for platform operators, brand managers, and policymakers, the underlying mechanisms remain poorly understood. This study advances a Consumer Decision Journey framework comprising five stages—Social Commerce Stimuli, Discovery, Risk Evaluation, Marketplace Evaluation, and Purchase Decision—and integrates Stimulus-Organism-Response theory and the Elaboration Likelihood Model to explain how Gen Z consumers navigate cross-platform purchase decisions. Employing a sequential explanatory mixed-methods design, we conducted a large-scale survey (n = 423 Gen Z respondents) analyzed via Partial Least Squares Structural Equation Modeling, complemented by 18 in-depth qualitative interviews. Results confirm that influencer persuasion, livestream engagement, and perceived product authenticity drive product discovery; price comparison mediates, and price sensitivity moderates the discovery-to-risk pathway. Critically, perceived risk in S-commerce paradoxically accelerates cross-platform migration and elevates trust in e-marketplaces. Trust in e-marketplaces and logistics reliability each moderate the risk-to-purchase relationship. Qualitative analysis reveals that cross-platform behavior is a deliberate, internalized strategy among Gen Z—a platform arbitrage norm. These findings have substantial implications for S-commerce platform design, influencer marketing strategy, and e-marketplace positioning in emerging economies. Full article

Background/Objectives: Synthetic stimulants represent the most prevalent subclass on the new psychoactive substances (NPSs) market. However, the toxicokinetic properties of M-ALPHA, a regioisomer of MDMA and N-methyl-cyclazodone a pemoline derivative, are not yet characterized. Methods: Therefore, this study investigated the metabolism of both NPSs in pooled liver S9 fraction and rat urine, characterized cytochrome P450 (CYP) kinetics and plasma protein binding (PPB), and assessed the CYP inhibition potential of M-ALPHA, using high-performance liquid chromatography coupled to high resolution tandem mass spectrometry (HPLC-HRMS/MS). Results: Four metabolites of M-ALPHA were detected including one phase I and three phase II metabolites, resulting from demethylenation followed by subsequent methylation or glucuronidation. For N-methyl-cyclazodone, one phase I metabolite formed via N-demethylation was identified. The primary enzymes involved in M-ALPHA metabolism were CYP2B6 and CYP2D6. Notably, M-ALPHA inhibited these enzymes to a strong or moderate extent, respectively. In contrast, the metabolism of N-methyl-cyclazodone was primarily mediated by CYP2A6. PPB studies indicated low-to-moderate binding for both compounds, suggesting that significant protein-binding interactions are unlikely. Conclusions: As M-ALPHA only formed metabolites that overlapped with those of MDMA, differing only by minor retention time shifts, reliable HPLC-HRMS/MS-based identification may be challenging in clinical and forensic toxicology settings as well as doping analysis. Furthermore, drug–drug interactions following polydrug use cannot be excluded for either NPS, particularly when co-ingested with other CYP substrates metabolized by the same isoforms. Full article

The present study focuses on liquid-precursor-mediated chemical vapor deposition (under ambient pressure and moderate temperature range) of WSe₂ on sapphire using ammonium meta-tungstate and sodium cholate. The investigation provides additional results and information for the WSe₂ cluster formations on sapphire as an extension of our previous study, especially based on structural, chemical and morphological characterization of the observed largest and predominant polygonal WSe₂ domains whose lateral size can reach several hundreds of micrometers. In addition, highly symmetrical shapes were also observed. The Raman spectroscopy and atomic force microscopy identified the formation of both mono- and multilayered WSe₂. Moreover, the Raman spectrum analysis shows a complex peak structure with unusual splitting effects in the second-order modes marking strong activity of excitonic-resonance processes. Full article

Negative plant–soil feedback (NPSF) drives yield decline in monocropping systems, yet how intraspecific competition modulates NPSF across planting densities remains unclear. We conducted a two-stage plant–soil feedback experiment using five crops (Triticum aestivum L., Zea mays L., Solanum lycopersicum L., Cucumis sativus L., and Panax notoginseng (Burkill) F.H. Chen) with contrasting NPSF intensities under four planting densities (30 × 30 to 8 × 8 cm). Crops with stronger NPSF (P. notoginseng) showed pronounced density-dependent biomass reductions, whereas those with moderate (S. lycopersicum, C. sativus) or low (Z. mays, T. aestivum) NPSF were largely density-insensitive. Given its sensitivity, P. notoginseng was used to explore mechanisms. High-density planting (8 × 8 cm) intensified NPSF, reducing seedling survival by 88.54% and biomass by 56.08% compared with low-density controls (30 × 30 cm). Microbiome profiling showed enrichment of pathogenic Fusarium spp. and depletion of beneficial Humicola spp. under high density. Metabolomic analysis identified linoleic acid and oleamide as key root exudates upregulated under high-density stress, which selectively stimulated Fusarium growth as preferred carbon sources. Collectively, these results reveal a density-dependent feedback in which intensified competition reshapes root exudation, promotes pathogen proliferation, and suppresses beneficial taxa, thereby amplifying NPSF. This provides mechanistic insights into microbially mediated NPSF under density stress and highlights the importance of optimizing planting density to sustain crop productivity. Full article

Emotion regulation (ER) is associated with various mental health issues. However, a de-tailed understanding of the underlying processes is important for developing targeted interventions for common mental health problems, such as anxiety and depression. Limited research has focused on these processes among emerging adults, a group that has shown a marked increase in mental health difficulties. The aim of this study was to examine whether rumination and worry, as forms of perseverative thinking, mediate the relationship between ER and symptoms of depression and anxiety in emerging adulthood. A two-wave longitudinal design was employed. The sample included 286 university students (80.4% female; M_age = 20.3, sd = 1.7). Mediation and moderation analyses were conducted in PROCESS. The results indicated a full mediation between ER and anxiety, where only worry emerged as a significant mediator. The relationship between ER and depression was both direct and indirect, mediated only by rumination. However, after controlling for all baseline values, all paths became nonsignificant, suggesting that the results may reflect stable between-person differences rather than within-person change. The moderation analysis revealed that the highest levels of depressive symptoms were observed among participants with simultaneously high levels of ER difficulties, rumination, and worry. The results suggest that preventive programs focusing on reducing perseverative thinking could play a key role in promoting better mental health outcomes in emerging adulthood. Full article

Teachers’ readiness in bilingual early childhood education is increasingly recognized as a multidimensional construct shaped by both professional and language-related factors. However, existing research has typically examined these factors separately, with limited evidence on how they combine across teacher groups, particularly in minority-language contexts. This study examined teachers’ readiness to deliver state-language instruction to dual language learners (DLLs) in Hungarian-medium kindergartens in Slovakia. A total of 313 kindergarten teachers participated in the study. Data were collected through a survey assessing multiple dimensions of readiness. Principal component analysis and confirmatory factor analysis supported a six-factor model comprising professional preparation, teacher competencies, challenge management, instructional aids use, professional needs, and Slovak language use outside kindergarten. Latent profile analysis identified three readiness profiles (low, moderate, and high), reflecting differences in overall preparedness. Background characteristics, particularly age, teaching experience, and language-related factors, were significantly associated with higher readiness. Teachers who used Slovak more frequently in everyday contexts showed higher readiness. Mediation analysis indicated that language proficiency and preferred language use did not mediate the relationship between teaching experience and teachers’ readiness, but functioned as independent predictors. These findings highlight the joint importance of professional and language-related factors in shaping teachers’ readiness and offer implications for teacher education and policy in bilingual early childhood settings. Full article

Soil health is critical for the sustainability of tropical plantation ecosystems, However, the ecological factors driving productivity gradients remain inadequately understood. This study investigated rubber plantations on Hainan Island with varying yield levels to assess soil health and its underlying ecological mechanisms using a minimum data set (MDS) approach. Twenty-seven soil physical, chemical, and biological indicators were analyzed at two depths (0–20 cm and 20–40 cm). Principal component analysis identified seven key indicators for the MDS: soil organic matter (OM), alkaline-hydrolyzable nitrogen (AN), cation exchange capacity (CEC), dissolved organic carbon (DOC), microbial biomass phosphorus (MBP), acid phosphatase activity (ACP), and microbial diversity (Shannon-Wiener index, SHDI). The soil health indices derived from the MDS showed strong correlations with those generated from the total data set (TDS) (p < 0.001), confirming the reliability of the MDS framework. Overall, soil health levels were rated low to moderate with no significant differences across low-yield plantations (≤900 kg·ha⁻¹), medium-yield plantations (900–1200 kg·ha⁻¹), and high-yield plantations (≥1200 kg·ha⁻¹)., suggesting a decoupling of soil health and rubber productivity under uniform management practices. Random forest analysis identified microbial-driven phosphorus cycling, particularly MBP and ACP, as the primary determinant of soil health across soil layers, with DOC and SHDI also contributing significantly. These findings highlight the critical role of microbial-mediated nutrient cycling in maintaining soil health in rubber plantations and suggest that current management practices prioritize short-term yields over long-term soil ecological stability. Enhancing microbial activity and increasing organic matter inputs may be essential for improving soil health and ensuring the sustainability of rubber production in tropical agroecosystems. Full article

In this study, the relationship between land-finance intensity and female educational attainment is examined. A provincial panel dataset for China from 2002 to 2023 is constructed. Two-way fixed effects and mediation models are estimated to identify the underlying mechanisms, and panel threshold models are adopted to test the conditional constraints imposed by government intervention and urbanization. A clear tradeoff is revealed by the findings. On average, land-finance intensity is positively associated with female educational attainment. A dual transmission pathway is identified by mediation analysis: local public education expenditure is significantly increased by land finance, which directly promotes female education, while the urban–rural income gap is simultaneously widened, thus restricting further educational progress. Nonlinear effects are also detected. The positive link between land finance and education is weakened in regions with strong government intervention or high urbanization. Regional heterogeneity is demonstrated by estimation results: the positive effect is strongest in western China, moderate but significant in eastern China, and insignificant in central China. Accordingly, a differentiated spatial governance strategy should be implemented by policymakers. Land revenues should be allocated to basic educational infrastructure in less urbanized regions, and the reduction in urban–rural opportunity gaps should be prioritized in developed regions. Full article

Promoting farmers’ adoption of low-carbon technologies constitutes a vital pathway for achieving agricultural sustainability and a key measure for implementing the national dual-carbon strategy. Drawing upon field survey data from 602 wheat farmers in Heze City, Shandong Province, this study employs an ordered probit model to empirically examine the influence mechanism of data capital on farmers’ low-carbon technology adoption behaviour. The results show that (1) data capital significantly promotes farmers’ adoption of low-carbon technologies; (2) ecological cognition plays a significant mediating role, while economic incentives and human capital serve as positive moderators; (3) heterogeneity analysis indicates that the promoting effect of data capital is more pronounced among large-scale farmers. Based on these findings, recommendations are proposed to consolidate rural digital infrastructure, establish agricultural data service platforms, and enhance farmers’ ecological cognition, thereby fully unleashing the potential of data capital in driving agricultural sustainability. Full article