Search Results (593)

Over the years, macromycete fungi have been used as a source of food, part of religious rites and rituals, and as a medicinal remedy. Species with strong health-promoting potential include Hericium erinaceus, Cordyceps militaris, Ganoderma lucidum, Pleurotus ostreatus, Flammulina velutipes, and Inonotus obliquus. These species contain many bioactive compounds, including β-glucans, endo- and exogenous amino acids, polyphenols, terpenoids, sterols, B vitamins, minerals, and lovastatin. The level of some biologically active substances is species-specific, e.g., hericenones and erinacines, which have neuroprotective properties, and supporting the production of nerve growth factor in the brain for Hericium erinaceus. Due to their high health-promoting potential, mushrooms and substances isolated from them have found applications in livestock nutrition, improving their welfare and productivity. This phenomenon may be of particular importance in the nutrition of laying hens and broiler chickens, where an increase in pathogen resistance to antibiotics has been observed in recent years. Gallus gallus domesticus is a key farm animal for meat and egg production, so the search for new compounds to support bird health is important for food safety. Studies conducted to date indicate that feed supplementation with mushrooms has a beneficial effect on, among other things, bird weight gain; bone mineralisation; and meat and egg quality, including the lipid profile and protein content and shell thickness, and promotes the development of beneficial microbiota, thereby increasing immunity. Full article

This study presents the development and optimization of a functional soy sauce fermented with Cordyceps militaris (C. militaris), a medicinal fungus known for its high cordycepin and polysaccharide content. Using C. militaris as the sole starter culture, the process aimed to improve both nutritional and functional properties. Response surface methodology was employed to optimize the entire fermentation process. During the koji stage, temperature, aeration, and inoculum concentration were adjusted to maximize protease activity and cordycepin production. In the fermentation stage, temperature, brine concentration, and water-to-material ratio were optimized to increase amino acid nitrogen and bioactive compound levels. Under optimal conditions (24 °C, 679.60 LPM aeration, 9.6% inoculum for koji; 32 °C, 12% brine, 1.53:1 water-to-material ratio for fermentation), the resulting soy sauce contained 1.14 ± 0.05 g/100 mL amino acid nitrogen and 16.88 ± 0.47 mg/100 mL cordycepin. Compared with traditionally fermented soy sauce, the C. militaris product exhibited a darker color, enhanced umami taste, and a distinct volatile profile featuring linoleic acid, methyl palmitate, and niacinamide. These results demonstrate the feasibility of using C. militaris in soy sauce fermentation and its potential as a novel functional condiment with improved bioactivity and sensory quality. Full article

Wound care in military and combat environments poses distinct challenges that set it apart from conventional medical practice in civilian settings. The nature of injuries sustained on the battlefield—often complex, contaminated, and involving extensive tissue damage—combined with limited access to immediate medical intervention, significantly increases the risk of infection, delayed healing, and adverse outcomes. Traditional wound dressings frequently prove inadequate under such extreme conditions, as they have not been designed to address the specific physiological and logistical constraints present during armed conflicts. This review provides a comprehensive overview of recent progress in the development of advanced wound dressings tailored for use in military scenarios. Special attention has been given to multifunctional dressings that go beyond basic wound coverage by incorporating biologically active macromolecules such as collagen, chitosan, thrombin, alginate, therapeutic peptides, and growth factors. These compounds contribute to properties including moisture balance control, exudate absorption, microbial entrapment, and protection against secondary infection. This review highlights the critical role of advanced wound dressings in improving medical outcomes for injured military personnel. The potential of these technologies to reduce complications, enhance healing rates, and ultimately save lives underscores their growing importance in modern battlefield medicine. Full article

Background/Objectives: Traumatic brain injury is one of the leading causes of death and disability. When traumatic brain injury is repeated over time, it can lead to the development of Chronic Traumatic Encephalopathy, a chronic neurodegenerative disease commonly observed in individuals who engage in contact sports or military personnel involved in activities with a high risk of repeated head trauma. At autopsy, the examination of the brain reveals regional atrophy, corresponding to high concentrations of glutamate receptors. Microscopically, the primary findings are the deposition of neurofibrillary tangles and neuropil threads. The aim of this study is to highlight the clinical and histopathological characteristics of Chronic Traumatic Encephalopathy, providing diagnostic support to forensic pathologists. Additionally, it seeks to aid in the differential diagnosis of similar conditions. Methods: A review of literature was conducted following the PRISMA criteria. Of 274 articles, 7 were selected. Results: According to these papers, most patients were male and exhibited neurological symptoms and neuropsychiatric impairments, and a proportion of them committed suicide or had aggressive behavior. Conclusions: Chronic Traumatic Encephalopathy remains largely underdiagnosed during life. The definitive diagnosis of Chronic Traumatic Encephalopathy is established post-mortem through the identification of pathognomonic tauopathy lesions. Early and accurate antemortem recognition, particularly in at-risk individuals, is highly valuable for its differentiation from other neurodegenerative conditions, thereby enabling appropriate clinical management and potential interventions. Full article

Military personnel deployed to Iraq and Afghanistan were exposed to emissions from open-air burn pits, where plastics, metals, and medical waste were incinerated. These exposures have been linked to deployment-related respiratory diseases (DRRD) and may also impact neurological health via the lung–brain axis. To investigate molecular mechanisms, adult male rats were exposed to filtered air, naphthalene (a representative volatile organic compound), or a combination of naphthalene and carbon black (surrogate for particulate matter; CBN) via whole-body inhalation (six hours/day, three consecutive days). Lung, brain, and plasma samples were collected 24 h after the final exposure. Pro-inflammatory biomarkers were assessed using multiplex electrochemiluminescence and western blot. Differentially expressed genes (DEGs) were identified by RNA sequencing, and elastic net modeling was used to define exposure-predictive gene signatures. CBN exposure altered inflammatory biomarkers across tissues, with activation of nuclear factor kappa B (NF-κB) signaling. In the lung, gene set enrichment revealed activated pathways related to proliferation and inflammation, while epithelial–mesenchymal transition (EMT) and oxidative phosphorylation were suppressed. In the brain, EMT, inflammation, and senescence pathways were activated, while ribosomal function and oxidative metabolism were downregulated. Elastic net modeling identified a lung gene signature predictive of CBN exposure, including Kcnq3, Tgfbr1, and Tm4sf19. These findings demonstrate that inhalation of a surrogate burn pit mixture induces inflammatory and metabolic gene expression changes in both lung and brain tissues, supporting the utility of this animal model for understanding systemic effects of airborne military toxicants and for identifying potential biomarkers relevant to DRRD and Veteran health. Full article

Intestinal inflammation involves barrier impairment, immune hyperactivation, and oxidative stress imbalance. Bioactive polysaccharides universally alleviate inflammation via anti-inflammatory, antioxidant, and microbiota-modulating effects, yet exhibit distinct core mechanisms. Elucidating these differences is vital for targeted polysaccharide applications. This research examines distinct regulatory pathways through which diverse bioactive polysaccharides mitigate lipopolysaccharide-triggered intestinal inflammation in male Kunming (KM) mice. This experiment employed Lentinula edodes polysaccharide (LNT), Auricularia auricula polysaccharide (AAP), Cordyceps militaris polysaccharide (CMP), Lycium barbarum polysaccharide (LBP), and Brassica rapa polysaccharide (BRP). The expression levels of biomarkers associated with the TLR4 signaling pathway, oxidative stress, and intestinal barrier function were quantified, along with comprehensive gut microbiota profiling. The results showed that all five polysaccharides alleviated inflammatory responses in mice by inhibiting inflammatory cytokine release, reducing oxidative damage, and modulating gut microbiota, but their modes of action differed: LBP significantly suppressed the TLR-4/MyD88 signaling pathway and its downstream pro-inflammatory cytokine expression, thereby blocking inflammatory signal transduction and reducing oxidative damage; LNT and CMP enhanced the body’s antioxidant capacity by increasing antioxidant enzyme activities and decreasing malondialdehyde (MDA) levels; AAP and BRP enriched Akkermansia (Akk.) within the Verrucomicrobia (Ver.) phylum, upregulating tight junction protein expression to strengthen the intestinal mucosal barrier and indirectly reduce oxidative damage. This research demonstrates that different polysaccharides alleviate inflammation through multi-target synergistic mechanisms: LBP primarily inhibits inflammatory pathways; AAP and BRP focus on intestinal barrier protection and microbiota modulation; and LNT and CMP exert effects via antioxidant enzyme activation. These data support designing polysaccharide blends that leverage complementary inflammatory modulation mechanisms. Full article

This study employs advanced numerical simulation to investigate the influence of shelf temperature on the freeze-drying kinetics and product quality of Cordyceps militaris. Emphasis is placed on the glass transition and structural collapse mechanisms during the primary drying stage. A detailed computational model was developed to predict temperature profiles, glass transition temperature, collapse temperature, and moisture distribution under varying process conditions. Simulation results indicate that maintaining the shelf temperature below 10 °C minimizes the risk of structural collapse and volume shrinkage while improving drying efficiency and product stability. Based on the model, an optimal freeze-drying protocol is proposed: shelf heating at 0 °C, condenser plate at −32 °C, and chamber pressure at 35 Pa. Experimental validation confirmed the feasibility of this regime, yielding a shrinkage of 9.52%, a color difference (ΔE) of 4.86, water activity of 0.364 ± 0.018, and a rehydration ratio of 55.14 ± 0.789%. Key bioactive compounds, including adenosine and cordycepin, were well preserved. These findings underscore the critical role of simulation in process design and optimization, contributing to the development of efficient and high-quality freeze-dried functional food products. Full article

Colombia is a megadiverse, multiethnic, and multicultural country with a tremendous socio-ecological systems (SESs) diversity, which faces essential challenges arising from human activities, low levels of sustainable economic development, poverty, and social inequality rates, and the persistence of multiple forms of military, political, and social violence. Understanding the resilience of this complex system is both fundamental and challenging due to the contradictory effects of economic development and regional ecosystem degradation. This research proposes the Socio-Ecological Resilience Integrated Index (SERII) to assess historical changes in socio-ecological resilience in Colombia’s departments (political-administrative units) between 1985–2022. The SERII considers the trade-offs between ecosystems, social systems, and production systems, providing a complete perspective of integrated management with a geographic resolution at the level of general political-administrative units. The results reveal a spatial variation in the SERII, with worse conditions in the Caribbean, the Pacific, and the Colombian Amazon (on the country periphery) and better conditions in departments of the country center. From 1985 to 2022, the SERII experienced a decrease (51.5%), driven by ecosystem degradation, increased extractive activities (illegal and illegal), and the persistence of military, political, and social violence. While the limitations of the proposed indicator are described, the SERII effectively replicates the overall resilience of Colombia’s departments to external shocks and allows for suggesting regional management priorities for the targeted promotion of sustainable development. Full article

College student military training is an organized, high-intensity, short-term militarized activity in China; this study aims to explore the differences in thermal perception between different intensities of military training. Questionnaires and microclimate measurements were conducted during summer military training in cold regions, including the Protective and Rescue Training and Assessment (PRTA), Formation Training (FT), the Shooting and Tactical Training and Assessment (STTA), the Route March (RM), and Dagger Practice (DP). The results indicated that (1) there was no significant correlation between the intensity of the activity and votes on thermal perception. The strongest thermal sensations, the lowest comfort, and the lowest thermal acceptability were experienced during FT, with a lower activity intensity. (2) Air temperature (T_a), globe temperature (T_g), relative humidity (RH), mean radiant temperature (T_mrt), and solar radiation (G) had significant effects on the TSV. (3) FT involved the lowest neutral temperatures (NUTCI/NPET), while DP and RM training had the highest NUTCI and NPET values, respectively. The neutral temperature range during military training was narrower compared to that in other aerobic activities. This study reveals, for the first time, the non-traditional correlation between military training intensity and thermal perception, confirming the specificity of thermal sensations in mandatory training and providing a theoretical basis for optimizing military training arrangements and developing thermal protection strategies. Full article

Vegetable intake among military Service Members (SMs) is well below public health guidelines, with only 12.9% meeting the Dietary Guidelines for Americans (DGAs). Low vegetable consumption negatively impacts diet quality as measured by the Healthy Eating Index (HEI), and poses risks to health and performance. Given the high physical and mental demands of military life, improving diet quality, including through increased vegetable intake, is crucial for optimizing health and readiness. Providing meal kits may help improve vegetable intake by reducing access-related barriers for SMs living or working on a military base. Furthermore, the addition of spices and herbs is a readily modifiable accompanying approach to address taste-related barriers and increase intake that has shown promise in other populations with poor diet quality. Background/Objectives: This study aimed to evaluate whether heat-and-serve meal kits with spices and herbs could increase vegetable intake and liking among active-duty SM by simultaneously targeting barriers to healthy eating and modifiable sensory factors. Methods: Conducted at Naval Support Activity Bethesda, the study randomly distributed heat-and-serve meal kits (n = 400) featuring either spiced (n = 200) or plain versions (n = 200) of four vegetables (broccoli, carrots, cauliflower, and kale). Each kit contained a quick response (QR) code for participants to upload post-consumption photos and rate vegetable liking on a nine-point Likert scale. Food photography (SmartIntake^®) was used to estimate vegetable consumption. Paired t-tests were used to determine differences between the intake of plain and spiced vegetables. Results: Intake of the heat-and-serve vegetables was very high for both the spiced and plain preparations (1.73 out of 2 cups, 87%). There was minimal difference (p = 0.87) between the consumption of spiced (1.75 cups) and plain (1.725 cups) vegetables, suggesting that both were well accepted. Overall, convenient and accessible meal options, alongside sensory-driven strategies, appear to improve some barriers to vegetable consumption in SM populations. Conclusions: Future studies should explore long-term outcomes and adaptability across different military environments, while considering additional factors, including convenience and time constraints, that influence dietary choices in the military. Full article

Nowadays, many various types of drive and transmission mechanisms characterized by various parameters and characteristics for different types of vehicles have been designed, developed and optimized with regard to the featured applications. Our research is focused on the creation of a complex simulation model of the drive and transmission mechanism of the vehicle Iveco LMV 4 × 4 M65. The correctness of the simulation model was verified using an analytical approach. The created numerical simulation model will serve as a basis for the further optimization of dynamic, operational and economical parameters of the vehicle. As the modification or replacement of the particular components of the drive and transmission mechanism is very complicated regarding the vehicles used in military operations, our research is focused on the enhancement of the control processes. More specifically, the main goal of the presented research activities is the modification of the gearshift logic and the adjustment of the gearshift map in order to improve the dynamic properties of the vehicle and, at the same time, reduce the fuel consumption. In spite of its complexity, the proposed simulation model can serve as a basis for the optimization of not only the gearshift control under specific input or output quantities and operational or environmental conditions but also for the simulation of the system behavior with modified or replaced components of the drive and transmission mechanism of this type of truck vehicle. Full article

Background: Headache disorders, particularly migraine, are a leading cause of disability among active-duty military personnel, significantly affecting operational readiness and fitness for duty. Despite their high prevalence, limited data exist on how headache disorders are managed within military primary care systems. This study aimed to evaluate diagnostic confidence, treatment strategies, and structural challenges in the management of headache disorders from the perspective of military primary care physicians. Methods: A prospective, nationwide cross-sectional survey was conducted between May and July 2023 among all active-duty military physicians in primary care roles. An anonymous 15-item questionnaire assessed diagnostic practices, therapeutic approaches, referral pathways, perceived knowledge gaps, and suggestions for system improvements. The survey was distributed across military medical centers and outpatient clinics in Germany. Results: Ninety military physicians participated. Migraine and tension-type headache were commonly encountered, with 70% having treated at least one headache patient in the week prior to the survey. Diagnostic confidence was high for migraine (83.4%) and tension-type headache (77.8%) but lower for medication-overuse headache (65.5%) and cluster headache (47.8%). Acute treatment was widely implemented, but only 27.8% of respondents regularly initiated preventive therapies. Awareness of clinical guidelines was limited: only 23.3% were familiar with the ICHD-3, and just 58.9% with national headache treatment guidelines. Respondents expressed strong demand for targeted education, practical diagnostic tools, and improved interdisciplinary coordination. Conclusions: Headache disorders are a prevalent and clinically significant issue in military primary care. While military physicians show high engagement, important gaps exist in preventive treatment, guideline familiarity, and access to specialist care. Structured training, standardized treatment protocols, and system-level improvements are essential to optimize headache care and maintain operational readiness. Full article

The design and investigation of electrochromic devices have advanced significantly, including distinct applications such as self-charged smart windows, aerospace interactive windows, low power flexible and ecofriendly displays, automatic dimming rearview, wearable smart textiles, military and civilian camouflage systems, electrochromic sensors, among others. Although significant progress has been made in related fields, achieving the full potential of electrochromic devices to meet the standards of maturity and practical applications remains a persistent challenge. Electrochromic devices are typically multilayered structures that can be designed as either rigid or flexible systems, depending on the type of substrate employed. Conventional electrochromic devices comprise layered structures that include transparent electrodes, electrochromic materials, ionic conductors, and ion storage materials. On the other hand, multifunctional systems integrate bifunctional materials or distinct functional layers to simultaneously achieve optical modulation and additional capabilities such as energy storage. The development of advanced materials, comprehensive electrochemical kinetic analysis, the optimization and advancement of process techniques and deposition methods, and innovative device designs are active areas of extensive global research. This review focuses on the recent advances in multifunctional electrochromic materials and devices with particular emphasis on the integration of electrochromic technology with other functional technologies. It further identifies current challenges, proposes potential solutions, and outlines future research directions focused on advancing this technology in both niche and scalable applications. Full article

A previously buried paleosol was found on the continental shelf during a study of sea floor scour, nucleated by large artificial reef structures such as vessel hulks, barges, train cars, military vehicles, etc., called “scour nuclei”. It is a relic paleo-land surface of sapling-sized tree stumps, root systems, and fossil animal bone exhumed by scour processes active adjacent to the artificial reef structure. Over the span of five research cruises to the site in 2022–2024, soil samples were taken using hand excavation, PONAR grab samplers, split spoon, hollow tube auger, and a modified Shelby-style push box. High-definition (HD) video was taken using a Remotely Operated Vehicle (ROV) and diver-held cameras. Radiocarbon dating of wood samples returned ages of 42,015–43,417 calibrated years before present (cal yrBP). Pollen studies, together with the recovered macrobotanical remains, support our interpretation of the site as a freshwater forested wetland whose keystone tree species was Taxodium distichum—bald cypress. The paleosol was identified as an Aquult, a sub-order of Ultisols where water tables are at or near the surface year-round. A deep (0.25 m+) argillic horizon comprised the bulk of the preserved soil. Comparable Ultisols found in Georgia wetlands include Typic Paleaquult (Grady and Bayboro series) soils. Full article

The present work proposes a novel fractional-order multifunction filter topology in current-mode (CM), which is designed based on the Modified Current Feedback Operational Amplifier (MCFOA). The proposed design simultaneously generates fractional-order low-pass (FO-LPF), high-pass (FO-HPF), and band-pass (FO-BPF) outputs while utilizing an optimized set of essential active and passive elements, thereby ensuring simplicity, cost efficiency, and compatibility with integrated circuits (ICs). The fractional-order feature allows precise control over the transition slope between the passband and the stopband, enhancing design flexibility. PSpice simulations validated the filter’s theoretical performance, confirming a 1 kHz cut-off frequency, making it suitable for VLF applications such as military communication and submarine navigation. Monte Carlo analyses demonstrate robustness against parameter variations, while a low THD, a wide dynamic range, and low power consumption highlight its efficiency for high-precision, low-power applications. This work offers a practical and adaptable approach to fractional-order circuit design, with significant potential in communication, control, and biomedical systems. Full article