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Background and Objectives: Cerebrovascular events remain among the most feared complications after transcatheter aortic valve implantation (TAVI). Whether early and post-discharge cerebrovascular events are associated with distinct clinical, echocardiographic, haemodynamic, and procedural predictors remains incompletely clarified. Materials and Methods: This retrospective, observational, two-center cohort study included 556 patients who underwent TAVI for severe symptomatic aortic stenosis between October 2011 and May 2023. The primary outcomes were in-hospital stroke and mid-to-long term stroke occurring after hospital discharge. Stroke diagnoses were established by neurological assessment and confirmed by cranial computed tomography and/or magnetic resonance imaging. Univariable comparisons and Firth penalized multivariable logistic regression analyses were performed to identify predictors of each outcome. Results: In-hospital stroke occurred in 14 patients (2.5%), whereas mid-to-long term stroke occurred in 16 patients (2.9%). In Firth penalized multivariable analysis, baseline mitral regurgitation grade (odds ratio [OR] 2.174, 95% confidence interval [CI] 1.299–3.638; p = 0.003), HbA1c (OR 1.644, 95% CI 1.111–2.433; p = 0.013), and prior cerebrovascular event (OR 4.269, 95% CI 1.150–15.846; p = 0.030) were independently associated with in-hospital stroke. For mid-to-long term stroke, post-dilatation (OR 9.862, 95% CI 2.555–38.067; p < 0.001) and very severe aortic stenosis phenotype (OR 3.649, 95% CI 1.343–9.916; p = 0.011) were independently associated with the outcome. Conclusions: Early and post-discharge cerebrovascular events after TAVI were infrequent but associated with distinct predictor profiles. In-hospital stroke was associated with baseline mitral regurgitation grade, HbA1c, and prior cerebrovascular event, whereas mid-to-long term stroke was associated with post-dilatation and very severe aortic stenosis phenotype. Given the limited number of events, these findings should be interpreted as exploratory and require validation in larger prospective cohorts. Full article

Reversible Solid Oxide Cells (rSOCs) are highly efficient energy conversion systems for power generation in fuel cell mode (SOFC) and energy storage in electrolysis mode (SOEC). These devices are typically manufactured through multi-step processing routes based on conventional functional ceramic fabrication techniques, such as tape-casting, extrusion, screen-printing and spraying. In this work, an alternative mold-casting approach is proposed for the fabrication of planar electrolyte-supported rSOCs. Electrolytes made of 8 mol% yttria-stabilized zirconia (YSZ) were prepared via an aqueous gel-casting process using agarose as the gelling agent. The casting molds were fabricated by 3D printing with polylactic acid (PLA) filament. Dense electrolytes with well-controlled geometries were successfully obtained. Complete cells were produced using porous Ni–YSZ as a fuel electrode and porous lanthanum strontium manganite–YSZ. The cells were microstructurally characterized, and their electrochemical performance was evaluated under both SOFC and SOEC operating conditions at 800–900 °C. At 900 °C, the cell achieved a peak power density of 220 mW cm⁻² in fuel cell mode and an injected current density of 340 mA cm⁻² at 1.3 V in electrolysis mode. Mid-term galvanostatic testing in SOFC mode at 850 °C for 400 h demonstrated good durability and structural stability of the fabricated cells. After the initial stabilization period, the cell exhibited a low degradation rate of 3 mV kh⁻¹. Full article

In this work, scanning microwave microscopy (SMM) is used to monitor the evolution of the local microwave response, in terms of variations in the S₁₁ input reflection coefficient, in two III–V heterostructures relevant to mid-infrared photonics, namely a 150 nm thick heavily doped InGaAs layer on InP and HfO₂ (35 nm)/InGaAs (150 nm)/InP, subjected to Ga⁺ FIB milling over a broad dose range. By correlating raw, uncalibrated two-dimensional S₁₁ maps with atomic force microscopy (AFM) and Raman spectroscopy, we observe a dose-dependent evolution from implantation-dominated behavior to progressive amorphization, layer thinning and surface roughening. In the uncapped InGaAs/InP system, the SMM response varies monotonically with ion dose, consistent with progressive FIB-induced modification of the exposed InGaAs layer and, at larger milling depths, of the underlying InP substrate. In the HfO₂-capped structure, the microwave response is more complex: the oxide initially acts as a partial buffer against ion penetration, delaying damage transfer, but this effect progressively weakens as the cap is thinned and structurally degraded. The resulting S₁₁ contrast may reflect the combined effects of FIB-induced structural modifications, layer removal, local material composition, and surface morphology. Overall, the combined dataset indicates that SMM is a potentially highly sensitive probe of FIB-induced nanoscale modifications in the local microwave response, especially at low doses, provided that suitable on-chip calibration and de-embedding structures are available. Full article

Gene inactivation in model organisms has identified numerous genes and signaling pathways involved in mammalian cardiac outflow tract (OFT) development. Human genetics data have implicated the VEGFR3 gene in OFT development, but when and where it is required is unknown. In this study we determined the sensitivity of the developing murine heart to reduced Vegfr3 gene dosage, and we tested whether its requirement is dependent upon TBX1, a known regulator of Vegfr3 expression in cardiac and lymphatic endothelial cells. We found that in the mouse, a single copy of the Vegfr3 gene was sufficient for normal heart development in most cases. Mutation of a single copy of the Tbx1 gene greatly enhanced the sensitivity of heart development to Vegfr3 dosage reduction and led to the formation of cardiac defects. In addition, deletion of Vegfr3 in the Tbx1 expression domain also led to severe cardiac OFT abnormalities. We used RNAscope to reveal the location of Vegfr3 and Tbx1 transcripts in midterm mouse embryos. This revealed co-localization of these transcripts in the endothelium of the aortic sac, caudal pharyngeal arch arteries and proximal OFT, suggesting that these are potential sites of genetic interaction between Vegfr3 and Tbx1 that are critical for murine heart development. Full article

Drought is a natural hazard characterized by gradual onset and prolonged precipitation deficit. With climate change intensifying precipitation variability, accurate drought assessment is critical for effective water resource management and mitigation. Focusing on Maryland in the Mid-Atlantic region of the United States, this study computes and analyzes drought indices to assess both near (2021–2060) and late (2061–2100) drought conditions, in the context of climate variability. We employed three distinct objectives to enhance drought assessment and monitoring capabilities under projected climate scenarios: (1) calculation of the Standardized Precipitation Index (SPI) reflecting meteorological conditions using precipitation data from seven GCMs across three SSPs for two future periods (2021–2060 and 2061–2100); (2) integration of both precipitation and temperature projections in the Palmer Drought Severity Index (PDSI) (implemented here as a simplified PDSI based on a standardized Z-index) to reflect combined hydrological and thermal influences (i.e., Hydrological indices); and (3) a Low Precipitation Duration–Frequency Analysis (LPDF) as indicator of both meteorological and hydrological conditions to quantify and compare the frequency and severity of low precipitation events across different SSPs. These objectives were achieved by fitting a gamma distribution for SPI and an Extreme Value Type I distribution for LPDF, and applying Z-index (i.e., long-term moisture abnormalities) and weighting factors representing the ratio of precipitation to evapotranspiration. Results reveal notable variability in SPI values, with a general trend toward increased extreme wet conditions, especially under high emission scenarios (i.e., SSP585) in the latter half of the century (2061–2100). Meanwhile, PDSI analysis indicated a subtle shift toward drier conditions despite increases in precipitation, particularly under SSP126 and SSP245, suggesting that temperature rises may offset precipitation gains. In addition, LPDF values indicated a reduced frequency of prolonged low-precipitation events under SSP585 compared to SSP126 and SSP245; this reflects higher total precipitation and should not be interpreted as resilience to drought, since the concurrent rise in temperature-driven evaporative demand can still intensify hydrological and agricultural drought stress. These results highlight the importance of incorporating climatic variables in drought assessments to understand future meteorological and hydrological scenarios under climate change projections. The study can help water resource managers and illustrates how such integrations can enhance our understanding of future drought scenarios under different climate change projections. Full article

This paper investigates the degradation law and calculation method for the load-carrying capacity of steel–concrete composite girders under fire exposure based on numerical analysis and mathematical statistics. A finite element model of simply supported box-section steel–concrete composite girders is established using ABAQUS, which is validated against existing scaled test data in terms of temperature field distribution, load-carrying capacity, and mid-span displacement. On this basis, the parametric effects of concrete slab thickness, steel web height, steel plate thickness, and concrete strength on the load-carrying capacity of the girders are systematically analyzed. The results indicate that concrete slab thickness, steel web height, and steel plate thickness exert significant influences on the structural bearing capacity, whereas concrete strength has a negligible effect. Specifically, the load-carrying capacity under fire exposure is substantially improved with the increase in concrete slab thickness, steel web height, and steel plate thickness. Furthermore, a simplified calculation formula for the capacity of box-section steel–concrete composite girders under fire exposure is developed via multiple linear regression analysis, incorporating the three dominant influencing factors of concrete slab thickness, steel web height and steel plate thickness. The proposed formula exhibits satisfactory calculation accuracy and can provide a reliable reference for the fire resistance design and repair decision-making of steel–concrete composite girders. Full article

Background: Body mass index (BMI) is an important consideration in perioperative evaluation. High BMI is correlated with more comorbidities and poorer operative outcomes; however, there is limited literature on the impact of BMI on patient-reported outcome measures (PROMs) after multilevel cervical disc replacement (CDR) surgery. Objective: The objective was to evaluate the relationship between BMI and PROMs in two-level CDR. Methods: A single-surgeon database was retrospectively reviewed for patients who underwent two-level CDR between August 2017 and October 2024. Patients were stratified as non-obese (BMI < 30 kg/m²; n = 44) or obese (BMI ≥ 30 kg/m²; n = 34). The final analytic cohort included 78 patients. Mean follow-up was 7.65 ± 5.53 months. Multivariable linear and logistic regression models adjusted for age, hypertension, diabetes, and Charlson Comorbidity Index. Patient-reported outcome measures (PROMs) and minimal clinically important difference (MCID) were also analyzed. Statistical analysis was conducted using Stata 18.0 (StataCorp LP, College Station, TX, USA). Results: Obese patients had a higher CCI than non-obese patients (0.90 ± 1.06, 1.87 ± 1.31, p = 0.001). Patient-reported outcomes were collected and analyzed after controlling for hypertension, diabetes, CCI scores, and age. At the final postoperative follow-up, only VR12-MCS differed, with the obese cohort having worse scores (60.7 ± 5.0 versus 53.9 ± 10.2, p = 0.040). MCID achievement rates did not differ between groups across PROMs (p > 0.183 for all). Conclusion: Patients with and without obesity demonstrated comparable early-to-midterm PROM trajectories and MCID achievement following two-level CDR. These findings suggest that obesity was not associated with substantially different patient-reported recovery during the observed follow-up period. Full article

Heavy metal fluoride glasses (HMFGs), particularly fluorozirconate glass systems such as ZBLAN have attracted considerable attention due to their unique physical properties, including low phonon energies, wide transparency from the UV to the mid-IR, and high rare-earth ion doping solubility, making them promising materials for photonic applications. This review provides an overview of fluoride glass synthesis methods, structural characteristics, and physical properties of fluorozirconate glasses, with emphasis on glass processing conditions, thermal, mechanical, and optical properties. The structural characteristics are discussed in terms of zirconium–fluorine polyhedral networks and their compositional dependence, while physical properties are analyzed, including glass transition behavior, crystallization tendency, elastic moduli, and infrared transmission. Rare-earth doped Er³⁺, Ho³⁺, and Tm³⁺ ZBLAN glasses are also discussed, which exhibit efficient emissions in the near and mid-IR spectral regions. Although significant progress has been achieved, limitations related to thermal stability, mechanical strength, and incomplete understanding of structure–property relationships persist. Future research should therefore focus on compositional optimization and predictive structural modeling to enable the design of improved fluoride glasses for various applications. Full article

Impervious surfaces create heterogeneous planting sites for urban trees, but whether crown-scale sealing is associated jointly with leaf economics and reproductive dispersal morphology remains unclear. We aimed to test these associations in mature female Populus tomentosa while treating impervious surface area (ISA) as a composite indicator of site context rather than a direct measure of thermal or hydrological stress. In a single-season, cross-sectional survey of 180 trees in Beijing (60 per low-, mid-, and high-ISA descriptive stratum), we measured crown-scale ISA, short-term midday ground-surface temperature, a pervious-soil access-moisture index (PSAMI), eight leaf traits, and five reproductive traits, and analyzed continuous associations, group contrasts, effect sizes, and multivariate patterns. Greater ISA was associated with lower PSAMI (R² = 0.581) and higher land surface temperature (R² = 0.845). Compared with low-ISA trees, high-ISA trees had lower specific leaf area (117.5 ± 29.1 vs. 90.9 ± 19.0 cm² g⁻¹; Hedges’ g = −1.07, 95% CI [−1.50, −0.71]) and longer seed hairs (0.564 ± 0.067 vs. 0.727 ± 0.078 cm; g = 2.24, 95% CI [1.82, 2.78]), together with greater fuzz biomass and lower seed mass. Multivariate analyses showed coordinated shifts in mean leaf and reproductive phenotype without stronger within-stratum cross-module integration. We conclude that the study’s principal contribution is the joint description of vegetative economics and reproductive dispersal morphology on the same mature urban trees. Because ISA co-varied with land use and management and PSAMI includes structural zeros, the findings are preliminary and do not establish causal stress mechanisms, plant-available water status, airborne exposure, or management effects; multi-year matched-site validation is required. Full article

Coal-bearing tight gas and deep coalbed methane (CBM) widely co-occur in China, and integrated commingled production outperforms separate development. Conventional separated simulation fails to capture coupled reservoir–wellbore gas–water flow. This study develops an integrated geomechanical coupled numerical model with multi-scale fractures and multi-phase wellbore flow: tight gas reservoirs use a stress-sensitive single-porosity model, deep CBM adopts a dual-porosity model for matrix desorption, and EDFM characterizes non-Darcy flow in hydraulic fractures. The Gray gas column and liquid column methods calculate layered bottomhole pressure according to reservoir vertical distribution, and matrix bordering solves the whole coupled system. Validated by field data of Well C-1 in Shanxi, the model yields average relative errors of 8.76% for daily gas output and 2.92% for daily water output. Sensitivity analysis on Well C-2 indicates vertical reservoir stacking controls interlayer pressure difference, and commingled gas curves show dual peaks with shifting dominant gas sources over production stages. A 3.9% rise in deep coalbed methane gas content significantly boosts mid-term peak production and cumulative gas output, making reservoir gas content the dominant geological factor governing commingled production performance. A 120.0% increase in tight gas saturation only delivers a slight uplift in cumulative production under low-porosity conditions. Elevated reservoir stress sensitivity triggers a cumulative gas production reduction of over 50%. Cumulative gas output varies proportionally with hydraulic fracture length, while fracture network width brings mismatched production improvement due to pressure drawdown funnel effects. Therefore, hydraulic fracturing operations should prioritize extending artificial fractures to expand the drainage area of commingled wells. Schemes with constant bottomhole flowing pressure and constant gas rate exert marginal influences on ultimate cumulative production and can be flexibly switched on site. To stabilize daily gas deliverability throughout the early, middle and late production stages, a bottomhole pressure drawdown rate of 0.05 MPa/d or a fixed daily gas rate of 4000 m³/d is recommended. This work provides theoretical support for optimizing commingled development of superimposed tight gas and deep CBM reservoirs. Full article

Acromegaly is almost always caused by a growth hormone-secreting pituitary adenoma, and long-term cure depends on complete surgical resection and accurate detection of residual or recurrent disease on surveillance imaging. This pictorial review focuses on the 3–6-month postoperative interval, when routine surveillance MRI is commonly performed and dynamic contrast-enhanced pituitary imaging can be correlated with IGF-1 and GH trends. We first reviewnormal pituitary anatomy and imaging characteristics, and the typical location and signal characteristics of somatotroph adenomas, as a baseline for postoperative interpretation. Using representative cases of surgically treated acromegaly, we then illustrate the key postoperative MRI appearances on high-resolution T1- and T2-weighted and dynamic contrast-enhanced sequences. Benign patterns include non-enhancing T1-hyperintense packing material, thin rim or septal enhancement around thesurgical cavity, sheet-like floor-based granulation tissue, and simple stalk deviation with nromal rangecaliber, often seen in biochemically cured patients. High-risk imaging patterns comprise nodular or thick enhancing tissue in the resection bed, new or progressive cavernous sinus soft tissue, stalk thickening with avid enhancement, and a spectrum of cavernous carotid abnormalities. For each pattern, we emphasize prevalence, typical signal and enhancement characteristics, and reported correlations with biochemical remission or persistence of disease. Finally, we propose a simple flowchart that integrates biochemical status with these reproducible imaging findings to stratify patients into expected postoperative change, probable residual/recurrent adenoma, vascular complication, or indeterminate category. This pattern-based biochemical–radiologic framework is intended to help radiologists and endocrinologists interpret mid-term postoperative pituitary MRI in acromegaly more confidently and consistently. Full article

Against the backdrop of climate change and compounded by human activities, increasing water scarcity has triggered a series of drought disasters, which have already severely impacted both ecological environments and socioeconomic production. The SWAT model, recognized for its strong portability and superior spatial heterogeneity, has gained widespread acceptance in fields such as hydrology and environmental science, and is extensively applied in hydrological simulation studies across large-scale river basins. Hydrological models of the study area can be constructed in the SWAT model to simulate changes in hydrological variables by conducting spatial discretization, parameter specification, and boundary condition definition. Standardized drought index can effectively reflect the spatiotemporal variations in drought disasters, holding significant importance for clarifying and predicting drought characteristics. This study took the Luanhe River Basin as the research area, constructed a watershed hydrological model based on SWAT, and projected changes in the basin’s hydrological processes for the period 2030–2060. Based on the model’s projected data, we calculated drought indices and extracted drought events for the basin. The results indicate the following: (1) During the simulation period, only 30% of the years in the Luanhe River basin had annual runoff above the long-term average, with a range of 228.18 mm. The range of mean annual runoff across sub-basins was 173.32 mm. Drought and uneven water resource allocation over both spatial and temporal scales coexisted, and this issue is expected to intensify under future climate warming and drying. (2) The mid-reaches of the Luanhe River are more prone to drought compared to the upper reaches for its higher water demand. However, due to a stronger capacity for ecological restoration, droughts there are mostly of low intensity in the mid-reaches. In contrast, the upper reaches experience more periods classified as severe or extreme drought, and the drought events encountered are generally more intense than those in the mid-reaches. (3) The method proposed in this study can screen extreme drought events based on outliers in the characteristic values of drought events. Taking the simulation from this study as an illustration, anomalies in drought event characteristic values suggest a potential basin-scale, prolonged extreme drought event in the Luanhe River Basin from June 2038 to July 2042. Proactive drought prevention policies should be formulated for this period. The findings of this study provide guiding significance and practical value for drought assessment, risk management, and policy application in the Luanhe River Basin. This study methodologically combines hydrological model predictions with drought event responses, providing a novel method for predicting basin-scale drought conditions and issuing early warnings for extreme drought events. Full article

Sandy littorals are highly dynamic coastal ecosystems but remain poorly studied as wintering habitats for waterbirds in Mediterranean regions. We analysed mid-winter International Waterbird Census data collected along the 100 km sandy littoral of the province of Venice, northern Adriatic Sea (Italy), between 1994 and 2022. The dataset included 28 winter censuses, 70 species, and 150,083 individuals. The assemblage was rich but highly uneven: the Yellow-legged Gull Larus michahellis, Dunlin Calidris alpina, Black-headed Gull Chroicocephalus ridibundus, and Great Cormorant Phalacrocorax carbo accounted for most individuals. Total abundance was stable, despite strong interannual variability, whereas species richness increased significantly. Eco-functional guilds showed contrasting trends: benthic feeders and diving piscivores increased moderately, omnivores declined moderately, whereas the trends of the remaining four guilds were classified as uncertain. The Community Temperature Index did not show a significant directional trend, either for the whole assemblage or after excluding dominant species, suggesting that the observed changes cannot be interpreted as progressive thermophilisation. Overall, the Venetian sandy littoral supports a diverse and functionally heterogeneous wintering bird assemblage, whose long-term changes reflect shifts in community structure and the changing use of open-coast, nearshore, and artificial roosting habitats. The results provide a long-term evidence base for identifying conservation-relevant shoreline sectors, protecting feeding and high-tide roosting habitats, regulating disturbance and beach-management practices, and maintaining continued IWC monitoring of open-coast waterbird assemblages. Full article

Background/Objectives: Urinary incontinence after radical prostatectomy remains a significant concern affecting postoperative quality of life. This study aimed to investigate whether the early postoperative International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) score is associated with mid-term urinary continence outcomes, using a patient-reported outcome approach. Methods: We retrospectively analyzed patients who underwent robot-assisted radical prostatectomy between May 2020 and July 2023 at the International University of Health and Welfare Narita Hospital and completed follow-up at one and six months postoperatively. Urinary incontinence severity was assessed using the ICIQ-SF (range 0–21, with higher scores indicating more severe symptoms). The primary outcome was incontinence at 6 months, defined as any pad use. Multivariable logistic regression and exploratory receiver operating characteristic (ROC) analyses were performed. Results: A total of 74 patients with complete follow-up data at both time points were included in the analysis. The ICIQ-SF score at one month was significantly associated with urinary incontinence at six months in both univariable and multivariable analyses. In the adjusted model, a higher one-month ICIQ-SF score independently predicted urinary incontinence at six months (odds ratio 1.15; 95% confidence interval 1.04–1.27; p = 0.005). Age, body mass index, and nerve-sparing status were not significantly associated with incontinence at six months. Exploratory ROC analysis demonstrated acceptable discriminative ability (area under the curve (AUC) 0.74, 95% confidence interval (CI) 0.61–0.87). A cut-off value of 13 yielded a sensitivity of 76.9% and a specificity of 59.1%. Conclusions: The ICIQ-SF score assessed one month after radical prostatectomy significantly predicts persistent urinary incontinence at six months. Early postoperative ICIQ-SF assessment may help identify patients at higher risk of persistent urinary incontinence. Further prospective studies are warranted to determine whether risk-stratified postoperative management based on early ICIQ-SF assessment improves clinical outcomes. Full article

Mountain glaciers constitute sensitive indicators of climate variability and represent essential freshwater reservoirs for downstream ecosystems and societies. Although glacier change in the Greater Caucasus has been extensively investigated at regional scales, detailed long-term reconstructions of individual glacier systems remain comparatively scarce. In this study, we reconstruct two centuries of evolution of Georgia’s largest Lekhziri Glacier and document the recent formation of its proglacial lake. The Little Ice Age glacier extent (AD ~1820) was reconstructed from moraine complexes, whereas later glacier outlines were derived from historical topographic maps, Landsat, SPOT, PlanetScope, and unmanned aerial vehicle (UAV) data spanning 1890–2025. Glacier terminus elevation was analysed using the Copernicus Digital Elevation Model, whereas long-term climatic variability was evaluated from summer air temperature and winter precipitation records obtained from the local meteorological station. The results demonstrate that Lekhziri Glacier experienced substantial and accelerating retreat during the past two centuries. Glacier area decreased from 46.67 ± 2.53 km² in ~1820 to 28.31 ± 0.62 km² in 2025, representing a net reduction of −18.36 km² (−39.34%) with an average annual decrease of −0.19% yr⁻¹. Area loss accelerated markedly after 2000, reaching −0.66% yr⁻¹ during 2000–2014 and −0.87% yr⁻¹ during 2014–2025. Over the last two centuries, the glacier terminus retreated by approximately −4.78 km, equivalent to an average retreat rate of −32.4 m yr⁻¹, while the terminus elevation migrated upward by nearly 600 m, from ~1718 to ~2317 m a.s.l. The glacier also underwent pronounced structural fragmentation after 2014, fundamentally altering its geometry and flow configuration. Concurrently, a proglacial lake first identified in 2019 with an area of 10,805 m² expanded rapidly to 28,947 m² in 2022 and 38,260 m² in 2025, with its continued existence confirmed by UAV observations in 2026. Meteorological records indicate a persistent increase in summer air temperature since the mid-twentieth century, accompanied by a decline in winter precipitation, consistent with the observed acceleration of glacier recession. This study provides one of the most comprehensive reconstructions of glacier evolution to date for an individual glacier in the Greater Caucasus and contributes new insights into the changing dynamics of glacierized mountain landscapes under continued climate warming. Full article