Search Results (4,098)

Obesity is increasingly recognized as a complex systemic disorder rather than a simple consequence of excess energy intake and fat accumulation. This review presents a systems biology framework that examines how obesity-driven disruption of inter-organ communication networks contributes to chronic disease susceptibility, with particular emphasis on colorectal cancer (CRC). Disrupted signaling among the brain, adipose tissue, liver, skeletal muscle, gut, and immune system generates maladaptive feedback loops that promote chronic metabolic inflammation (metaflammation), loss of physiological resilience, and progressive metabolic dysfunction. Within this framework, obesity is redefined as a network disease characterized by neuroendocrine dysregulation, adipose tissue remodeling, immune dysfunction, impaired organ crosstalk, and alterations in the gut microbiome. A central feature of this dysregulation is persistent low-grade inflammation driven by immune-metabolic reprogramming and sustained activation of inflammatory pathways. Obesity-associated metaflammation is further linked to accelerated biological aging through mechanisms involving cellular senescence, mitochondrial dysfunction, oxidative stress, and impaired metabolic resilience. These interconnected processes create a tumor-promoting environment by enhancing oncogenic signaling, disrupting intestinal barrier integrity, altering microbial and metabolic signaling, impairing immune surveillance, and promoting epithelial dysfunction, thereby increasing susceptibility to CRC. The review also examines how behavioral, circadian, environmental, and socioeconomic factors influence metabolic health and cancer risk. Finally, emerging translational opportunities, including biomarker-guided risk stratification, precision prevention, metabolic network restoration, and integrative lifestyle and pharmacological interventions, are discussed. Collectively, this review reframes obesity as a whole-body regulatory disorder and provides an integrated conceptual framework linking metabolism, inflammation, aging, and colorectal carcinogenesis to inform future prevention and therapeutic strategies. Full article

The interindividual phenotypic heterogeneity in Alpha-1 Antitrypsin Deficiency (AATD), despite a shared genetic etiology (the Z-allele of SERPINA1), is explained by the interaction of dual pathogenic mechanisms (gain-of-function vs. loss-of-function), additional genetic modifiers, and environmental or metabolic factors. Building on recent evidence suggesting divergent disease trajectories, we investigated whether pulmonary and hepatic impairments represent coupled manifestations or independent clinical dimensions within a large European cohort. Methods: This international multicenter study utilized the European Alpha-1 Research Collaboration (EARCO) registry (n = 1217). Pulmonary and hepatic severities were quantified using concurrent 0.0–10.0 composite indices. Independence was evaluated via partial Spearman correlations, multivariable multinomial regression, and geometric mapping across a continuous phenotypic space. Results: Cross-domain correlations between respiratory metrics and liver stiffness were near zero (r = −0.03), demonstrating statistical independence. Phenotypic dominance classification isolated distinct profiles; the lung-dominant group exhibited a higher age (57.0 vs. 54.0 years; p < 0.001) and tobacco exposure, while the liver-dominant group registered a higher body mass index (25.8 vs. 24.4 kg/m²; p < 0.001). Multivariable models identified age (OR 1.03; 95% CI 1.02–1.05) and smoking as independent predictors of lung dominance, whereas body mass index was independently associated with liver dominance (OR 1.04; 95% CI 1.01–1.07). Geometric mapping revealed advanced disease clusters at orthogonal margins rather than forming a systemic continuum. Conclusions: Hepatic and pulmonary impairments in AATD operate as independent clinical dimensions modulated by distinct metabolic and environmental factors. Risk stratification must transition toward organ-specific prognostic models. Full article

Tomato harvesting still relies heavily on manual labor, while factors such as clustered fruit growth, inconsistent ripening stages, occlusion, and complex cultivation environments pose significant challenges to automated harvesting systems and place higher demands on target detection accuracy. To address these issues, a tomato detection method based on the Mamba state space model was proposed, and an improved model termed YOLO-VCW was developed based on YOLOv8n. Specifically, the original C2f module in the backbone network was replaced with the C2f-VSS module to enhance global contextual feature extraction. A Coordinate Attention mechanism was introduced into the feature fusion stage to improve the model’s ability to focus on tomato target regions under complex background and occlusion conditions. In addition, the WIoUv3 loss function was adopted in the detection head to improve localization accuracy and training stability in overlapping fruit scenarios. Experimental results showed that YOLO-VCW achieved a precision of 91.33%, a recall of 86.79%, and an F1-score of 89.00% on the tomato dataset. Compared with YOLOv8n, the proposed model improved precision, recall, F1-score, and mAP₅₀ by 1.90%, 4.43%, 3.25%, and 4.44%, respectively, with only a slight increase in Parameters to 3.9 M. These results demonstrate that YOLO-VCW provides effective and robust performance for tomato target detection in complex environments. Full article

Psychosocial stressors are increasingly recognized as critical determinants of workplace safety, yet their mechanisms in construction settings remain poorly understood. This study examines how family–work conflict (FWC) is associated with safety behavior among construction workers, with mental and physical fatigue as parallel mediators and perceived supervisor support (PSS) as a moderator. Drawing on Conservation of Resources (COR) theory, cross-sectional data were gathered from 527 construction workers across three regions of Jordan and analyzed using Hayes’ PROCESS macro. The findings indicate that FWC is negatively associated with safety behavior both directly and through its positive associations with elevated fatigue levels. Supervisor support was found to attenuate the FWC-to-physical-fatigue pathway and buffer safety behavior under high-conflict conditions. These associations should be interpreted as statistical patterns consistent with the proposed theoretical model rather than evidence of causal relationships, given the cross-sectional design. Theoretically, the study extends COR theory into occupational safety by distinguishing two fatigue dimensions and demonstrating a boundary condition for resource loss. Practically, the findings support supervisor-led safety programs and organizational fatigue management as complementary strategies for addressing psychosocial risk factors in high-risk construction environments. Full article

Multi-criteria group decision making (MCGDM) under linguistic uncertainty remains a fundamental challenge in applied mathematics, where decision makers seldom assign crisp numerical evaluations and frequently exhibit heterogeneous risk attitudes shaped by behavioural factors. An integrated mathematical framework, hereafter PLR-3WBC (Probabilistic Linguistic Regret-driven Three-Way Bayesian Consensus), is developed to systematically integrate four methodological components that have each been individually validated in the MCGDM literature: representation of decision information with explicit probability mass on linguistic terms; quantification of decision-maker regret and rejoice psychology under linguistic uncertainty; classification of alternatives into three actionable decision regions rather than a single-valued ranking; and group consensus reaching with credal weight aggregation. Each component has demonstrated its effectiveness in its respective domain; the present framework capitalises on their complementary strengths by embedding them within a single pipeline equipped with formal guarantees, an integration that has not been previously reported. The framework integrates five methodological components: probabilistic linguistic term sets (PLTS) for information representation; the Bayesian best–worst method (BBWM) for credal criterion weighting; a regret–rejoice value function adapted to the linguistic domain for behavioural evaluation; three-way decision (3WD) thresholds derived from a loss-function model for actionable classification; and a distance-based consensus reaching process with feedback mechanism for group convergence. A case study on age-friendliness evaluation of twelve aging urban residential communities under an indicator system of five dimensions and eighteen criteria, with four expert decision makers, demonstrates that PLR-3WBC delivers an actionable three-way classification, recovers a transparent group consensus, and produces rankings broadly consistent with classical TOPSIS, VIKOR, PROMETHEE-II, and BWM-TOPSIS (Spearman rank correlation exceeding 0.97), thereby confirming that the integrated framework preserves the ordinal reliability of these established methods, while additionally delivering three outputs that arise from the methodological integration: an actionable three-way classification enabling discrete budget-aligned decisions, credal weight intervals quantifying the depth of expert agreement on criterion importance, and a behavioural reordering of borderline non-dominated alternatives that reflects the loss-averse psychology of the decision panel and would remain hidden under single-method deployment. Sensitivity analyses with respect to the regret aversion coefficient, the loss function parameters, and the consensus threshold confirm that the qualitative classification is stable across a wide parameter envelope, supporting the practical deployment of PLR-3WBC in age-friendly community renewal programmes. Full article

Tire and road wear particles (TRWPs) are major sources of non-exhaust traffic emissions. However, a limited understanding of their generation mechanisms and the lack of efficient collection methods under realistic driving conditions hinder accurate assessment. This study addresses these challenges by developing a vehicle-based methodology for the controlled recovery and characterization of TRWPs in the near-field region, rather than for direct quantification of real-world emissions. An autonomous electric vehicle was employed to ensure stable driving conditions and eliminate exhaust interference. Near-field distribution of TRWPs was visualized using a high-sensitivity optical scattering system. Based on this, a sealed tire enclosure with a high-power on-vehicle vacuum collection system was designed to enhance particle containment and recovery. Controlled circular driving tests were conducted on a dedicated outdoor test track under well-defined and repeatable conditions to enable system-level evaluation of TRWP generation and collection relative to measured tire wear. Particles were analyzed by thermogravimetric analysis, microscopy, scanning electron microscopy–energy-dispersive X-ray spectroscopy, and particle imaging. The results demonstrated stable, reproducible TRWP generation with ~60% collection efficiency relative to tire mass loss. These values are reported as system-dependent recovery indicators rather than precise emission estimates. Additional tests with an expanded recovery protocol indicated that collection efficiency can increase to ~81% (range: 73–91%), highlighting the influence of collection coverage. The collected TRWPs exhibited heterogeneous morphology, bimodal size distribution, and a mixed rubber–mineral composition in the 10–100 μm range. Spatial analysis revealed that TRWPs predominantly accumulated within a narrow zone around the driving lane. While the controlled experimental configuration enables reproducible particle generation and high-efficiency recovery, it represents a simplified driving scenario and may not fully capture the variability of real-world traffic conditions, including straight-line driving and transient maneuvers. Overall, this study demonstrates a technical framework for reproducible and comparative recovery of tire-associated particles under identical, well-defined conditions. The approach is intended to support controlled characterization studies while explicitly acknowledging limitations related to representativeness, particle origin attribution, and quantitative emission relevance, rather than to establish emission factors or mechanistic descriptions of TRWP generation. Full article

Background/Objectives: Natural calcium carbonate materials such as Rügen chalk have a long history of use in balneology and rehabilitation, particularly for musculoskeletal disorders, yet their application remains largely confined to traditional, labour-intensive forms such as powders, suspensions, and packs, which limit usability and broader clinical translation. This study aimed to develop an alginate-based solid foam incorporating Rügen chalk and to evaluate how key formulation components influence its structural, mechanical, and thermal properties relevant for therapeutic use. Methods: Alginate–chalk foams were prepared by mechanical mixing of a sodium alginate–Rügen chalk paste with an amino acid-based surfactant, while in situ CO₂ generation from D–glucono–δ–lactone (GDL) induced calcium-mediated alginate gelation and foam stabilization. A central composite design with response surface methodology was used to assess the effects of alginate, chalk, and Perlastan^®–GDL content on foam pH, overrun, firmness, springiness, pore volume, sphericity, pore density, specific internal surface area, and heat-loss time. Foam microstructure was characterized by optical microscopy and microcomputed tomography (µCT), and the thermal conductivity and cooling behaviour of the selected formulation were compared with therapeutic peat. Results: Stable, elastic solid foams with a three-dimensional porous architecture were obtained across the investigated composition range. Foam overrun (30.8–57.1%) was primarily governed by sodium alginate and Rügen chalk concentrations, while firmness (7.4–15.2 N) increased predominantly with alginate content, and springiness remained high (70–78%), indicating good elastic recovery. Response surface modelling and ANOVA confirmed sodium alginate as the dominant factor influencing both mechanical and structural properties, with statistically significant effects on overrun, firmness, springiness, heat loss, porosity, and specific internal surface. µCT analysis revealed that all foam formulations were predominantly composed of fine, closed-cell pores, with over 96% of pores having volumes below 0.5 mm³ and a consistent median pore volume of 0.02 mm³. Structural differences between formulations were governed primarily by pore number and spatial distribution rather than pore size. Strong correlations were identified between µCT-derived parameters, particularly between specific internal surface, porosity, and pore density, confirming that internal architecture is controlled by pore population rather than individual pore dimensions. Thermal analysis demonstrated that the optimized formulation exhibited thermal conductivity comparable to therapeutic peat and maintained clinically relevant temperatures (35–45 °C) for more than one hour. Based on predefined performance criteria (overrun ≥ 50%, firmness ≤ 10 N, heat loss ≥ 120 s), formulation 7 was identified as optimal, combining favourable mechanical properties, structural uniformity and thermal retention. Conclusions: Alginate-based solid foams incorporating Rügen chalk constitute a feasible and tunable platform that combines efficient mineral loading, elastic porosity, and effective heat retention, offering a practical and modern alternative to conventional mineral-based therapeutic applications in balneology and rehabilitation. Full article

Introduction: Fish skin is the first line of defense against the aquatic environment, acting as a physical, chemical, and immunological barrier. In addition to preventing pathogen entry, the skin and its mucus contribute to osmoregulation, innate immunity, and redox balance. Skin lesions—caused by mechanical damage, parasites, environmental stress, or handling—disrupt this barrier, increasing susceptibility to infections, inflammation, and production losses. Thus, efficient skin regeneration is essential for fish welfare and performance. Nutrition plays a key role in this process by providing substrates for epithelial repair, immune function, and antioxidant defense. Among dietary factors, zinc (Zn) is particularly important due to its involvement in cell proliferation, enzymatic activity, and maintenance of skin integrity. Objective: Our objective is to assess the effectiveness of image-based analysis in quantifying the skin healing process in Atlantic salmon fed diets supplemented with zinc. Methodology: The trial comprised three dietary treatments: a control diet with 42 mg Zn per kg (D1), and two diets supplemented up to 120 mg/kg of zinc, derived from inorganic (D2) or organic (D3) forms. Pit-tagged fish with an initial body weight (78 ± 0.1 g) were fed the diets for 75 days. After 15 days of experimental feeding, a standardized wound lesion (2.5 mm diameter × 0.5 mm depth) was inflicted in deeply anesthetized fish, with a disposable biopsy punch, in the dorsal area. After wound infliction, the fish resumed their normal feeding regime for the rest of the trial days. The progression of skin wound healing was assessed using standardized digital image analysis. High-resolution photographs of individual wounds were collected 8, 16, 24 and 32 days post-wounding. All images were acquired under standardized conditions with the inclusion of ArUco identifiers to enable a subsequent computer-assisted comparison. Morphometric parameters (wound width, diameter, perimeter and area) were used to assess wound contraction and closure over time. In parallel, a semi-quantitative visual scoring system was applied to each wound image to capture qualitative aspects of healing that are not fully described by morphometric data alone. Results: Full data analysis is currently underway, but the first results show beneficial effects of dietary zinc supplementation on the skin regenerative process. Conclusions: The combined use of objective digital measurements and standardized visual scoring enabled a comprehensive evaluation of wound healing progress, bridging quantitative tissue remodeling with biologically relevant phenotypic outcomes. This image-based framework provides a sensitive and reproducible approach for assessing dietary interventions targeting skin regeneration and barrier restoration in Atlantic salmon. Full article

Flexible polyurethane (PUR) foams and latex rubber foams are widely used in furniture and mattress cushioning, yet conventional standardized mechanical tests only partially capture comfort-relevant behavior, particularly in layered constructions where material interactions and sequencing can alter elastic response. This study aimed to compare the mechanical (elastic) properties of selected three-layer composites of approximately 60 mm thickness (composed of conventional PUR, high-resilience PUR, low-resilience PUR, and latex foam) and to preliminarily assess whether combining foam types improves support of such setup and whether changing layer order modifies elasticity and support. Indentation hardness testing of multilayer cushions was conducted by ISO 2439:2008 Method E. Six three-layer systems (Alpha–Zeta) were assembled in two groups. Group X showed nearly identical support factors (2.6–2.7), high recovery (64.3–66.2%), low hysteresis loss (24.3–24.5%), and overlapping force–indentation (IFD) curves, indicating minimal effect of layer order and dominance of the PUR layers. Group Y exhibited higher but more sequence-dependent support (3.1–3.7), markedly reduced, wider range recovery (30.0–45.9%), increased hysteresis (33.0–34.7%), and more dispersed IFD curves. Placing high-resilience foam at the top partially improve recovery, whereas locating low-resilience foam at the surface increase energy loss. The research contributes in part to the body of knowledge about the behavior of the tested materials according to standardized rules. These preliminary results can be compared with other research findings and used in the preparation of testing models for multilayer foam composites, thereby generating new knowledge to improve the design of future experiments, which will result in increased sitting and lying comfort. Full article

Animals with knockout of the dopamine transporter gene (DAT-KO) display hyperdopaminergic phenotypes, including attention-deficit/hyperactivity-like behaviors. A previous behavioral analysis of heterozygous rats with partial knockout (DAT-HET) suggested increased susceptibility to addictive behaviors. The aim of this study was to investigate elements of addictive behaviors and the mechanisms underlying dopamine release in DAT-HET rats. Offspring derived from DAT-knockout breeding underwent genotyping and behavioral assessment using the marble burying test, a manipulative behavior test using nesting material, and a modified version of the Iowa Gambling Task. Feeding behavior was studied using a binge-eating model. Reinforcing properties were investigated using intracranial self-stimulation under fixed-ratio (FR) and variable-ratio (VR) schedules. Dopamine (DA) release and clearance dynamics were assessed using fast-scan cyclic voltammetry (FSCV). DAT-HET rats exhibited moderate hyperactivity, increased impulsive choice, and compulsive responses. Male DAT-HET rats also showed increased compulsive overeating compared with wild-type (WT) rats of both sexes and female DAT-HET rats. In addition, DAT-HET rats demonstrated a preference for VR self-stimulation, which resembles risk- and thrill-seeking behavior in humans. In DAT-KO rats, impaired DA clearance resulted from complete loss of dopamine transporter function. In DAT-HET rats, increased DA release amplitude was observed, and dopamine persisted longer in the extracellular space than in WT rats. These findings underscore the importance of the DAT-HET model for studying impulsivity, compulsivity, and factors underlying the predisposition to addictive behavior. Full article

Lithium niobate on insulator (LNOI) has emerged as a promising platform for compact, low-loss phase modulators. The extant LNOI studies evaluate device performance almost exclusively through the Pockels effect, treating piezoelectric–photoelastic strain and thermo-optic drift as decoupled channels. Crucially, both mechanisms directly perturb the phase bias of a fiber-optic gyroscope (FOG), rendering them indispensable in sensing-oriented design. This work establishes a unified multiphysics model of an X-cut TFLN ridge phase modulator that self-consistently couples the electro-optic, piezoelectric–photoelastic, thermo-optic, and pyroelectric channels. The contributions of the four mechanisms are quantitatively decomposed under realistic FOG operating conditions, and the slab thickness, ridge-top width, and electrode gap are systematically optimized to balance modulation efficiency against environmental robustness. The co-optimization of the ridge geometry and electrode gap design maintains the EO overlap factor near 0.55, while reducing the half-wave voltage requirement. This results in a half-wave voltage length of V_πL = 1.65 V·cm at a 4.4 μm electrode gap. The optimized geometry and electrode gap (4.4 μm) are essentially temperature-independent: extracted from the Pockels modulation slope, V_πL remains stable at ≈1.65 V·cm (push–pull single-pass; within ~0.3%) across 25~85 °C. Furthermore, an externally imposed substrate temperature rise of 60 K (the upper end of the 25~85 °C FOG operating range) induces a mode-field-weighted thermal residual corresponding to approximately 27% of the Pockels modulation depth at an applied voltage of 5 V. The present study demonstrates that the DC-coupled operation of TFLN sensor-grade modulators is viable across the full FOG temperature range, without dedicated active temperature stabilization, and the residual thermal-bias offset is absorbed by the FOG’s standard closed-loop servo electronics. The results of the study provide quantitative design guidelines for high-performance, environmentally stable TFLN phase modulators in compact FOG systems. Full article

This study investigates the residual web crippling behavior of pultruded glass fiber-reinforced polymer (P-GFRP) hollow sections after exposure to elevated temperatures. The primary objective is to evaluate the combined influence of temperature and loading configuration on web crippling capacity, failure mechanisms, and structural performance, and to develop practical prediction models for engineering applications. A total of twenty pultruded GFRP hollow section specimens were exposed to temperatures of 24 °C, 200 °C, 250 °C, 300 °C, and 350 °C and tested under four loading configurations: End Ground (EG), Interior Ground (IG), End Two Flange (ETF), and Interior Two Flange (ITF). In addition to web crippling tests, tensile, SEM-EDS, TGA-DSC, DMA, and FT-IR analyses were conducted to investigate the mechanical, thermal, and microstructural degradation mechanisms. The results showed that elevated temperatures significantly reduced the web crippling capacity, with strength losses reaching up to 80% at 350 °C due to matrix degradation, fiber–matrix debonding, and loss of structural integrity. Among the investigated loading configurations, IG exhibited the highest load-carrying performance, whereas ETF experienced the greatest capacity reduction. A temperature-dependent reduction factor and unified empirical prediction equations were developed and demonstrated good agreement with the experimental results, with experimental-to-predicted ratios ranging from 0.97 to 1.15. The findings provide valuable insight into the post-fire behavior of pultruded GFRP hollow sections and offer practical guidance for the design, assessment, and fire safety evaluation of GFRP structural members exposed to elevated-temperature environments. Full article

Background/Objectives: Chronic diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) remain a major source of morbidity, healthcare utilization, and limb loss, despite adherence to established standards of care protocols and the widespread availability of advanced wound technologies. Many advanced modalities only target isolated aspects of wound healing and fail to address the complex, interdependent pathophysiology of chronic wounds, particularly tissue hypoxia, edema, impaired microcirculation, and persistent inflammation. Cyclical Pressurized Topical Wound Oxygen (TWO₂) therapy is a home-based, multimodal intervention that combines humidified topical oxygen delivery with cyclical non-contact compression to address these core drivers simultaneously. Methods: This review synthesizes mechanistic rationale and evidence from randomized controlled trials, long-term venous ulcer studies, and real-world comparative effectiveness analyses. Emphasis is placed on the large cohort study by Yellin et al., which directly compared TWO₂ with other advanced modalities including negative pressure wound therapy (NPWT), skin substitutes, and growth factor therapies. Results: Across these studies, TWO₂ therapy is consistently associated with improved healing durability, reduced recurrence, and substantial reductions in hospitalization and amputation rates compared with both standard care and advanced wound therapies. Conclusions: The convergence of randomized and real-world evidence supports TWO₂ therapy as a clinically meaningful and mechanism-driven adjunctive treatment option for patients with chronic, high-risk lower-extremity wounds. Full article

Target tracking for Unmanned Aerial Vehicles (UAVs) can be significantly impacted by environmental factors such as lighting variations, background clutter, and target occlusion. To address these challenges, we developed a target tracking method that integrates both frequency-domain and spatial perception capabilities in UAV vision (FSTrack). Specifically: (1) we utilized the Swin Transformer as the core network to extract features from both the template and search images; (2) we introduced a Transformer-based module to enhance both frequency and spatial information, improving tracking accuracy under varying illumination conditions; (3) we designed a spatio-temporal feature fusion module with multiple multi-head self-attention mechanisms to precisely model the tracking state, thus increasing reliability in cluttered and occluded environments; and (4) we created a hybrid loss function to boost accuracy in both classification and regression tasks. Our experimental results on the UAV123, DTB70, and UAVDT datasets show that our approach not only surpasses current state-of-the-art methods in success rates and precision but also operates more swiftly. Full article

Soil erosion poses a severe threat to agricultural productivity and ecological security on the Loess Plateau. However, previous studies have rarely integrated physical modeling, elasticity coefficients, and spillover effects into a unified framework at the county level. To address this gap, this study coupled the Revised Universal Soil Loss Equation (RUSLE) with the Spatial Durbin Model (SDM) to systematically investigate the spatiotemporal dynamics, factor elasticity characteristics, and spatial dependence mechanisms of soil erosion on the Loess Plateau from 1990 to 2024. Results show that the annual average erosion rate decreased by 15.5%, with a highly volatile phase before 2001 and a stabilized, low-erosion phase thereafter. The driving factors exhibited marked heterogeneity in direction and strength. The land cover and management factor (C) was the strongest erosion-reducing factor, whereas annual precipitation (PRE) was the primary natural erosion-enhancing factor. County-level erosion also displayed significant positive spatial dependence. PRE had a stable positive indirect effect, whereas C and the support practice factor (P) mainly contained erosion within local jurisdictions. These findings of a unified RUSLE–SDM framework reveal a joint driving mechanism of localized human interventions and climate-driven cross-regional spillovers, providing quantitative support for differentiated soil and water conservation strategies on the Loess Plateau. Full article