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Search Results (2,116)

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30 pages, 2190 KiB  
Review
Systematic Review of the State of Knowledge About Açaí-Do-Amazonas (Euterpe precatoria Mart., Arecaceae)
by Sabrina Yasmin Nunes da Rocha, Maria Julia Ferreira, Charles R. Clement and Ricardo Lopes
Plants 2025, 14(15), 2439; https://doi.org/10.3390/plants14152439 - 6 Aug 2025
Abstract
Euterpe precatoria Mart. is an increasingly important palm for subsistence and income generation in central and western Amazonia with growing demand for its fruit pulp, which is an alternative source of açaí juice for domestic and international markets. This study synthesizes current knowledge [...] Read more.
Euterpe precatoria Mart. is an increasingly important palm for subsistence and income generation in central and western Amazonia with growing demand for its fruit pulp, which is an alternative source of açaí juice for domestic and international markets. This study synthesizes current knowledge on its systematics, ecology, fruit production in natural populations, fruit quality, uses, population management, and related areas, identifying critical research gaps. A systematic literature survey was conducted across databases including Web of Science, Scopus, Scielo, CAPES, and Embrapa. Of 1568 studies referencing Euterpe, 273 focused on E. precatoria, with 90 addressing priority themes. Genetic diversity studies suggest the E. precatoria may represent a complex of species. Its population abundance varies across habitats: the highest variability occurs in terra firme, followed by baixios and várzeas. Várzeas exhibit greater productivity potential, with more bunches per plant and higher fruit weight than baixios; no production data exist for terra firme. Additionally, E. precatoria has higher anthocyanin content than E. oleracea, the primary commercial açaí species. Management of natural populations and cultivation practices are essential for sustainable production; however, studies in these fields are still limited. The information is crucial to inform strategies aiming to promote the sustainable production of the species. Full article
(This article belongs to the Section Plant Systematics, Taxonomy, Nomenclature and Classification)
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18 pages, 473 KiB  
Article
Motivation, Urban Pressures, and the Limits of Satisfaction: Insights into Employee Retention in a Changing Workforce
by Rob Kim Marjerison, Jin Young Jun, Jong Min Kim and George Kuan
Systems 2025, 13(8), 661; https://doi.org/10.3390/systems13080661 - 5 Aug 2025
Viewed by 27
Abstract
This study aims to clarify how different types of motivation influence employee retention by identifying the distinct roles of intrinsic and extrinsic factors in shaping job satisfaction, particularly under varying levels of urban stress and generational identity. Drawing on Herzberg’s Two-Factor Theory and [...] Read more.
This study aims to clarify how different types of motivation influence employee retention by identifying the distinct roles of intrinsic and extrinsic factors in shaping job satisfaction, particularly under varying levels of urban stress and generational identity. Drawing on Herzberg’s Two-Factor Theory and Self-Determination Theory, we distinguish between intrinsic drivers (e.g., autonomy, achievement) and extrinsic hygiene factors (e.g., pay, stability). Using survey data from 356 Chinese employees and applying PLS-SEM with a moderated mediation design, we investigate how urbanization and Generation Z moderate these relationships. Results show that intrinsic motivation enhances satisfaction, especially in urban settings, while extrinsic factors negatively affect satisfaction when perceived as insufficient or unfair. Job satisfaction mediates the relationship between motivation and retention, although this effect is weaker among Generation Z employees. These findings refine motivational theories by demonstrating how environmental pressure and generational values jointly shape employee attitudes. The study contributes a context-sensitive framework for understanding retention by integrating individual motivation with macro-level moderators, offering practical implications for managing diverse and urbanizing labor markets. Full article
(This article belongs to the Section Systems Practice in Social Science)
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16 pages, 3158 KiB  
Article
Comparative Metabolomics Analysis of Four Pineapple (Ananas comosus L. Merr) Varieties with Different Fruit Quality
by Ping Zheng, Jiahao Wu, Denglin Li, Shiyu Xie, Xinkai Cai, Qiang Xiao, Jing Wang, Qinglong Yao, Shengzhen Chen, Ruoyu Liu, Yuqin Liang, Yangmei Zhang, Biao Deng, Yuan Qin and Xiaomei Wang
Plants 2025, 14(15), 2400; https://doi.org/10.3390/plants14152400 - 3 Aug 2025
Viewed by 189
Abstract
Understanding the metabolic characteristics of pineapple varieties is crucial for market expansion and diversity. This study performed comparative metabolomic analysis on the “Comte de Paris” (BL) and three Taiwan-introduced varieties: “Tainong No. 11” (XS), “Tainong No. 23” (MG), and “Tainong No. 13” (DM). [...] Read more.
Understanding the metabolic characteristics of pineapple varieties is crucial for market expansion and diversity. This study performed comparative metabolomic analysis on the “Comte de Paris” (BL) and three Taiwan-introduced varieties: “Tainong No. 11” (XS), “Tainong No. 23” (MG), and “Tainong No. 13” (DM). A total of 551 metabolites were identified across the four varieties, with 231 metabolites exhibiting no significant differences between all varieties. This included major sugars such as sucrose, glucose, and fructose, as well as key acids like citric, malic, and quinic acids, indicating that the in-season maturing fruits of different pineapple varieties can all achieve good sugar–acid accumulation under suitable conditions. The differentially accumulated metabolites (DAMs) that were identified among the four varieties all primarily belonged to several major subclasses, including phenolic acids, flavonoids, amino acids and derivatives, and alkaloids, but the preferentially accumulated metabolites in each variety varied greatly. Specifically, branched-chain amino acids (L-leucine, L-isoleucine, and L-valine) and many DAMs in the flavonoid, phenolic acid, lignan, and coumarin categories were most abundant in MG, which might contribute to its distinct and enriched flavor and nutritional value. XS, meanwhile, exhibited a notable accumulation of aromatic amino acids (L-phenylalanine, L-tryptophan), various phenolic acids, and many lignans and coumarins, which may be related to its unique flavor profile. In DM, the dominant accumulation of jasmonic acid might contribute to its greater adaptability to low temperatures during autumn and winter, allowing off-season fruits to maintain good quality. The main cultivar BL exhibited the highest accumulation of L-ascorbic acid and many relatively abundant flavonoids, making it a good choice for antioxidant benefits. These findings offer valuable insights for promoting different varieties and advancing metabolome-based pineapple improvement programs. Full article
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25 pages, 384 KiB  
Article
Perception of Corporate Governance Factors in Mitigating Financial Statement Fraud in Emerging Markets: Jordan Experience
by Mohammed Shanikat and Mai Mansour Aldabbas
J. Risk Financial Manag. 2025, 18(8), 430; https://doi.org/10.3390/jrfm18080430 - 1 Aug 2025
Viewed by 347
Abstract
This study investigates the influence of corporate governance on reducing financial statement fraud (FSF) in Jordanian service and industrial companies listed on the Amman Stock Exchange from 2018 to 2022. To achieve this, the study employed the Beneish M-score model to assess the [...] Read more.
This study investigates the influence of corporate governance on reducing financial statement fraud (FSF) in Jordanian service and industrial companies listed on the Amman Stock Exchange from 2018 to 2022. To achieve this, the study employed the Beneish M-score model to assess the likelihood of FSF and logistic regression to examine the influence of corporate governance structure on fraud mitigation. The study identified 13 independent variables, including board size, board director’s independence, board director’s compensation, non-duality of CEO and chairman positions, board diversity, audit committee size, audit committee accounting background, number of annual audit committee meetings, external audit fees, board family business, the presence of women on the board of directors, firm size, and market listing on FSF. The study included 74 companies from both sectors—33 from the industrial sector and 41 from the service sector. Primary data was collected from financial statements and other information published in annual reports between 2018 and 2022. The results of the study revealed a total of 295 cases of fraud during the examined period. Out of the 59 companies analyzed, 21.4% demonstrated a low probability of fraud, while the remaining 78.6% (232 observations) showed a high probability of fraud. The results indicate that the following corporate governance factors significantly impact the mitigation of financial statement fraud (FSF): independent board directors, board diversity, audit committee accounting backgrounds, the number of audit committee meetings, family business involvement on the board, and firm characteristics. The study provides several recommendations, highlighting the importance for companies to diversify their boards of directors by incorporating different perspectives and experiences. Full article
(This article belongs to the Section Business and Entrepreneurship)
48 pages, 3956 KiB  
Article
SEP and Blockchain Adoption in Western Balkans and EU: The Mediating Role of ESG Activities and DEI Initiatives
by Vasiliki Basdekidou and Harry Papapanagos
FinTech 2025, 4(3), 37; https://doi.org/10.3390/fintech4030037 - 1 Aug 2025
Viewed by 137
Abstract
This paper explores the intervening role in SEP performance of corporate environmental, cultural, and ethnic activities (ECEAs) and diversity, equity, inclusion, and social initiatives (DEISIs) on blockchain adoption (BCA) strategy, particularly useful in the Western Balkans (WB), which demands transparency due to extended [...] Read more.
This paper explores the intervening role in SEP performance of corporate environmental, cultural, and ethnic activities (ECEAs) and diversity, equity, inclusion, and social initiatives (DEISIs) on blockchain adoption (BCA) strategy, particularly useful in the Western Balkans (WB), which demands transparency due to extended fraud and ethnic complexities. In this domain, a question has been raised: In BCA strategies, is there any correlation between SEP performance and ECEAs and DEISIs in a mediating role? A serial mediation model was tested on a dataset of 630 WB and EU companies, and the research conceptual model was validated by CFA (Confirmation Factor Analysis), and the SEM (Structural Equation Model) fit was assessed. We found a statistically sound (significant, positive) correlation between BCA and ESG success performance, especially in the innovation and integrity ESG performance success indicators, when DEISIs mediate. The findings confirmed the influence of technology, and environmental, cultural, ethnic, and social factors on BCA strategy. The findings revealed some important issues of BCA that are of worth to WB companies’ managers to address BCA for better performance. This study adds to the literature on corporate blockchain transformation, especially for organizations seeking investment opportunities in new international markets to diversify their assets and skill pool. Furthermore, it contributes to a deeper understanding of how DEI initiatives impact the correlation between business transformation and socioeconomic performance, which is referred to as the “social impact”. Full article
(This article belongs to the Special Issue Fintech Innovations: Transforming the Financial Landscape)
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30 pages, 1293 KiB  
Article
Obstacles and Drivers of Sustainable Horizontal Logistics Collaboration: Analysis of Logistics Providers’ Behaviour in Slovenia
by Ines Pentek and Tomislav Letnik
Sustainability 2025, 17(15), 7001; https://doi.org/10.3390/su17157001 - 1 Aug 2025
Viewed by 228
Abstract
The logistics industry faces challenges from evolving consumer expectations, technological advances, sustainability demands, and market disruptions. Logistics collaboration is in theory perceived as one of the most promising solutions to solve these issues, but here are still a lot of challenges that needs [...] Read more.
The logistics industry faces challenges from evolving consumer expectations, technological advances, sustainability demands, and market disruptions. Logistics collaboration is in theory perceived as one of the most promising solutions to solve these issues, but here are still a lot of challenges that needs to be better understood and addressed. While vertical collaboration among supply chain actors is well advanced, horizontal collaboration among competing service providers remains under-explored. This study developed a novel methodology based on the COM-B behaviour-change framework to better understand the main challenges, opportunities, capabilities and drivers that would motivate competing companies to exploit the potential of horizontal logistics collaboration. A survey was designed and conducted among 71 logistics service providers in Slovenia, chosen for its fragmented market and low willingness to collaborate. Statistical analysis reveals cost reduction (M = 4.21/5) and improved vehicle utilization (M = 4.29/5) as the primary motivators. On the other hand, maintaining company reputation (M = 4.64/5), fair resource sharing (M = 4.20/5), and transparency of logistics processes (M = 4.17/5) all persist as key enabling conditions. These findings underscore the pivotal role of behavioural drivers and suggest strategies that combine economic incentives with targeted trust-building measures. Future research should employ experimental designs in diverse national contexts and integrate vertical–horizontal approaches to validate causal pathways and advance theory. Full article
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43 pages, 2466 KiB  
Article
Adaptive Ensemble Learning for Financial Time-Series Forecasting: A Hypernetwork-Enhanced Reservoir Computing Framework with Multi-Scale Temporal Modeling
by Yinuo Sun, Zhaoen Qu, Tingwei Zhang and Xiangyu Li
Axioms 2025, 14(8), 597; https://doi.org/10.3390/axioms14080597 - 1 Aug 2025
Viewed by 209
Abstract
Financial market forecasting remains challenging due to complex nonlinear dynamics and regime-dependent behaviors that traditional models struggle to capture effectively. This research introduces the Adaptive Financial Reservoir Network with Hypernetwork Flow (AFRN–HyperFlow) framework, a novel ensemble architecture integrating Echo State Networks, temporal convolutional [...] Read more.
Financial market forecasting remains challenging due to complex nonlinear dynamics and regime-dependent behaviors that traditional models struggle to capture effectively. This research introduces the Adaptive Financial Reservoir Network with Hypernetwork Flow (AFRN–HyperFlow) framework, a novel ensemble architecture integrating Echo State Networks, temporal convolutional networks, mixture density networks, adaptive Hypernetworks, and deep state-space models for enhanced financial time-series prediction. Through comprehensive feature engineering incorporating technical indicators, spectral decomposition, reservoir-based representations, and flow dynamics characteristics, the framework achieves superior forecasting performance across diverse market conditions. Experimental validation on 26,817 balanced samples demonstrates exceptional results with an F1-score of 0.8947, representing a 12.3% improvement over State-of-the-Art baseline methods, while maintaining robust performance across asset classes from equities to cryptocurrencies. The adaptive Hypernetwork mechanism enables real-time regime-change detection with 2.3 days average lag and 95% accuracy, while systematic SHAP analysis provides comprehensive interpretability essential for regulatory compliance. Ablation studies reveal Echo State Networks contribute 9.47% performance improvement, validating the architectural design. The AFRN–HyperFlow framework addresses critical limitations in uncertainty quantification, regime adaptability, and interpretability, offering promising directions for next-generation financial forecasting systems incorporating quantum computing and federated learning approaches. Full article
(This article belongs to the Special Issue Financial Mathematics and Econophysics)
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26 pages, 2036 KiB  
Article
Mission Planning for UAV Swarm with Aircraft Carrier Delivery: A Decoupled Framework
by Hongyun Zhang, Bin Li, Lei Wang, Yujie Cheng, Yu Ding, Chen Lu, Haijun Peng and Xinwei Wang
Aerospace 2025, 12(8), 691; https://doi.org/10.3390/aerospace12080691 - 31 Jul 2025
Viewed by 118
Abstract
Due to the limited endurance of UAVs, especially in scenarios involving large areas and dense target nodes, it is challenging for multiple UAVs to complete diverse tasks while ensuring timely execution. Toward this, we propose a cross-platform system consisting of an aircraft carrier [...] Read more.
Due to the limited endurance of UAVs, especially in scenarios involving large areas and dense target nodes, it is challenging for multiple UAVs to complete diverse tasks while ensuring timely execution. Toward this, we propose a cross-platform system consisting of an aircraft carrier (AC) and multiple UAVs, which makes unified task planning for included heterogeneous platforms to maximize the efficiency of the entire combat system. The carrier-based UAV swarm mission planning problem is formulated to minimize completion time and resource utilization, taking into account large-scale targets, multi-type tasks, and multi-obstacle environments. Since the problem is complex, we design a decoupled framework to simplify the solution by decomposing it into two levels: upper-level AC path planning and bottom-level multi-UAV cooperative mission planning. At the upper level, a drop point determination method and a discrete genetic algorithm incorporating improved A* (DGAIIA) are proposed to plan the AC’s path in the presence of no-fly zones and radar threats. At the bottom level, an improved differential evolution algorithm with a market mechanism (IDEMM) is proposed to minimize task completion time and maximize UAV utilization. Specifically, a dual-switching search strategy and a neighborhood-first buying-and-selling mechanism are developed to improve the search efficiency of the IDEMM. Simulation results validate the effectiveness of both the DGAIIA and IDEMM. An animation of the simulation results is available at simulation section. Full article
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14 pages, 3364 KiB  
Article
Microbial Load and Diversity of Bacteria in Wild Animal Carcasses Sold as Bushmeat in Ghana
by Daniel Oduro, Winnifred Offih-Kyei, Joanita Asirifi Yeboah, Rhoda Yeboah, Caleb Danso-Coffie, Emmanuel Boafo, Vida Yirenkyiwaa Adjei, Isaac Frimpong Aboagye and Gloria Ivy Mensah
Pathogens 2025, 14(8), 754; https://doi.org/10.3390/pathogens14080754 - 31 Jul 2025
Viewed by 215
Abstract
The demand for wild animal meat, popularly called “bushmeat”, serves as a driving force behind the emergence of infectious diseases, potentially transmitting a variety of pathogenic bacteria to humans through handling and consumption. This study investigated the microbial load and bacterial diversity in [...] Read more.
The demand for wild animal meat, popularly called “bushmeat”, serves as a driving force behind the emergence of infectious diseases, potentially transmitting a variety of pathogenic bacteria to humans through handling and consumption. This study investigated the microbial load and bacterial diversity in bushmeat sourced from a prominent bushmeat market in Kumasi, Ghana. Carcasses of 61 wild animals, including rodents (44), antelopes (14), and African civets (3), were sampled for microbiological analysis. These samples encompassed meat, intestines, and anal and oral swabs. The total aerobic bacteria plate count (TPC), Enterobacteriaceae count (EBC), and fungal counts were determined. Bacterial identification was conducted using MALDI-TOF biotyping. Fungal counts were the highest across all animal groups, with African civets having 11.8 ± 0.3 log10 CFU/g and 11.9 ± 0.2 log10 CFU/g in intestinal and meat samples, respectively. The highest total plate count (TPC) was observed in rodents, both in their intestines (10.9 ± 1.0 log10 CFU/g) and meat (10.9 ± 1.9 log10 CFU/g). In contrast, antelopes exhibited the lowest counts across all categories, particularly in EBC from intestinal samples (6.1 ± 1.5 log10 CFU/g) and meat samples (5.6 ± 1.2 log10 CFU/g). A comprehensive analysis yielded 524 bacterial isolates belonging to 20 genera, with Escherichia coli (18.1%) and Klebsiella spp. (15.5%) representing the most prevalent species. Notably, the detection of substantial microbial contamination in bushmeat underscores the imperative for a holistic One Health approach to enhance product quality and mitigate risks associated with its handling and consumption. Full article
(This article belongs to the Section Bacterial Pathogens)
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79 pages, 12542 KiB  
Article
Evolutionary Game-Theoretic Approach to Enhancing User-Grid Cooperation in Peak Shaving: Integrating Whole-Process Democracy (Deliberative Governance) in Renewable Energy Systems
by Kun Wang, Lefeng Cheng and Ruikun Wang
Mathematics 2025, 13(15), 2463; https://doi.org/10.3390/math13152463 - 31 Jul 2025
Viewed by 303
Abstract
The integration of renewable energy into power grids is imperative for reducing carbon emissions and mitigating reliance on depleting fossil fuels. In this paper, we develop symmetric and asymmetric evolutionary game-theoretic models to analyze how user–grid cooperation in peak shaving can be enhanced [...] Read more.
The integration of renewable energy into power grids is imperative for reducing carbon emissions and mitigating reliance on depleting fossil fuels. In this paper, we develop symmetric and asymmetric evolutionary game-theoretic models to analyze how user–grid cooperation in peak shaving can be enhanced by incorporating whole-process democracy (deliberative governance) into decision-making. Our framework captures excess returns, cooperation-driven profits, energy pricing, participation costs, and benefit-sharing coefficients to identify equilibrium conditions under varied subsidy, cost, and market scenarios. Furthermore, this study integrates the theory, path, and mechanism of deliberative procedures under the perspective of whole-process democracy, exploring how inclusive and participatory decision-making processes can enhance cooperation in renewable energy systems. We simulate seven scenarios that systematically adjust subsidy rates, cost–benefit structures, dynamic pricing, and renewable-versus-conventional competitiveness, revealing that robust cooperation emerges only under well-aligned incentives, equitable profit sharing, and targeted financial policies. These scenarios systematically vary these key parameters to assess the robustness of cooperative equilibria under diverse economic and policy conditions. Our findings indicate that policy efficacy hinges on deliberative stakeholder engagement, fair profit allocation, and adaptive subsidy mechanisms. These results furnish actionable guidelines for regulators and grid operators to foster sustainable, low-carbon energy systems and inform future research on demand response and multi-source integration. Full article
(This article belongs to the Section E2: Control Theory and Mechanics)
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25 pages, 527 KiB  
Article
Do Board Characteristics Influence Leverage and Debt Maturity? Empirical Evidence from a Transitional Economy
by Adja Hamida, Olivier Colot and Rabah Kechad
J. Risk Financial Manag. 2025, 18(8), 418; https://doi.org/10.3390/jrfm18080418 - 28 Jul 2025
Viewed by 310
Abstract
This study examines the impact of board characteristics on capital structure decisions in the context of a transition economy, focusing on Algeria, where governance institutions are underdeveloped and the financial market remains immature. Using the Generalized Method of Moments (GMM) on a panel [...] Read more.
This study examines the impact of board characteristics on capital structure decisions in the context of a transition economy, focusing on Algeria, where governance institutions are underdeveloped and the financial market remains immature. Using the Generalized Method of Moments (GMM) on a panel dataset of 120 firms over the period 2015 to 2019, we identify a U-shaped relationship between board size and leverage, and an inverted U-shaped relationship between board size and debt maturity. Furthermore, increased nationality diversity on boards is found to significantly reduce debt maturity. These findings highlight the critical role of board composition in shaping corporate financing strategies in transition economies and provide novel insights into corporate governance dynamics in a relatively underexplored institutional context. The results are particularly relevant for national entities such as COSOB and Hawkama El Djazaïr and may guide banking sector practices by promoting the integration of board governance criteria into credit evaluation processes. Full article
(This article belongs to the Special Issue Emerging Trends and Innovations in Corporate Finance and Governance)
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25 pages, 1903 KiB  
Article
Pesticide Residues in Fruits and Vegetables from Cape Verde: A Multi-Year Monitoring and Dietary Risk Assessment Study
by Andrea Acosta-Dacal, Ricardo Díaz-Díaz, Pablo Alonso-González, María del Mar Bernal-Suárez, Eva Parga-Dans, Lluis Serra-Majem, Adriana Ortiz-Andrellucchi, Manuel Zumbado, Edson Santos, Verena Furtado, Miriam Livramento, Dalila Silva and Octavio P. Luzardo
Foods 2025, 14(15), 2639; https://doi.org/10.3390/foods14152639 - 28 Jul 2025
Viewed by 329
Abstract
Food safety concerns related to pesticide residues in fruits and vegetables have increased globally, particularly in regions where monitoring programs are scarce or inconsistent. This study provides the first multi-year evaluation of pesticide contamination and associated dietary risks in Cape Verde, an African [...] Read more.
Food safety concerns related to pesticide residues in fruits and vegetables have increased globally, particularly in regions where monitoring programs are scarce or inconsistent. This study provides the first multi-year evaluation of pesticide contamination and associated dietary risks in Cape Verde, an African island nation increasingly reliant on imported produce. A total of 570 samples of fruits and vegetables—both locally produced and imported—were collected from major markets across the country between 2017 and 2020 and analyzed using validated multiresidue methods based on gas chromatography coupled to Ion Trap mass spectrometry (GC-IT-MS/MS), and both gas and liquid chromatography coupled to triple quadrupole tandem mass spectrometry (GC-QqQ-MS/MS and LC-QqQ-MS/MS). Residues were detected in 63.9% of fruits and 13.2% of vegetables, with imported fruits showing the highest contamination levels and diversity of compounds. Although only one sample exceeded the maximum residue limits (MRLs) set by the European Union, 80 different active substances were quantified—many of them not authorized under the current EU pesticide residue legislation. Dietary exposure was estimated using median residue levels and real consumption data from the national nutrition survey (ENCAVE 2019), enabling a refined risk assessment based on actual consumption patterns. The cumulative hazard index for the adult population was 0.416, below the toxicological threshold of concern. However, when adjusted for children aged 6–11 years—taking into account body weight and relative consumption—the cumulative index approached 1.0, suggesting a potential health risk for this vulnerable group. A limited number of compounds, including omethoate, oxamyl, imazalil, and dithiocarbamates, accounted for most of the risk. Many are banned or heavily restricted in the EU, highlighting regulatory asymmetries in global food trade. These findings underscore the urgent need for strengthened residue monitoring in Cape Verde, particularly for imported products, and support the adoption of risk-based food safety policies that consider population-specific vulnerabilities and mixture effects. The methodological framework used here can serve as a model for other low-resource countries seeking to integrate analytical data with dietary exposure in a One Health context. Full article
(This article belongs to the Special Issue Risk Assessment of Hazardous Pollutants in Foods)
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15 pages, 664 KiB  
Article
Real-World Safety of Vedolizumab in Inflammatory Bowel Disease: A Retrospective Cohort Study Supported by FAERS Signal Analysis
by Bojana Milašinović, Sandra Vezmar Kovačević, Srđan Marković, Marija Jovanović, Tamara Knežević Ivanovski, Đorđe Kralj, Petar Svorcan, Branislava Miljković and Katarina Vučićević
Pharmaceuticals 2025, 18(8), 1127; https://doi.org/10.3390/ph18081127 - 28 Jul 2025
Viewed by 410
Abstract
Background/Objectives: Vedolizumab is a gut-selective anti-integrin monoclonal antibody approved for the treatment of inflammatory bowel disease (IBD). While clinical trials have demonstrated a favorable safety profile, real-world studies are essential for identifying rare adverse events (AEs) and evaluating post-marketing safety. This study [...] Read more.
Background/Objectives: Vedolizumab is a gut-selective anti-integrin monoclonal antibody approved for the treatment of inflammatory bowel disease (IBD). While clinical trials have demonstrated a favorable safety profile, real-world studies are essential for identifying rare adverse events (AEs) and evaluating post-marketing safety. This study assessed vedolizumab’s safety in a real-world cohort and supported the detection of potential safety signals. Methods: A retrospective chart review was conducted on adult IBD patients treated with vedolizumab at a tertiary center in the Republic of Serbia between October 2021 and August 2022. Data included demographics, AEs, and newly reported extraintestinal manifestations (EIMs). Exposure-adjusted incidence rates were calculated per 100 patient-years (PYs). Disproportionality analysis using the FDA Adverse Event Reporting System (FAERS) was performed to identify safety signals, employing reporting odds ratios (RORs) and proportional reporting ratios (PRRs) for AEs also observed in the cohort. Prior IBD therapies and reasons for discontinuation were evaluated. Results: A total of 107 patients (42.1% Crohn’s disease, 57.9% ulcerative colitis) were included, with a median vedolizumab exposure of 605 days. There were 92 AEs (56.51/100 PYs), most frequently infections (23.95/100 PYs), gastrointestinal disorders (4.30/100 PYs), and skin disorders (4.30/100 PYs). The most frequently reported preferred terms (PTs) included COVID-19, COVID-19 pneumonia, nephrolithiasis, and nasopharyngitis. Arthralgia (12.90/100 PYs) was the most frequent newly reported EIM. No discontinuations due to vedolizumab AEs occurred. FAERS analysis revealed potential signals for events not listed in prescribing information but observed in the cohort: nephrolithiasis, abdominal pain, diarrhea, malaise, cholangitis, gastrointestinal infection, blood pressure decreased, weight decreased, female genital tract fistula, respiratory symptom, and appendicectomy. Most patients had received three prior therapies, often stopping one due to AEs. Conclusions: Vedolizumab demonstrated a favorable safety profile in the IBD cohort. However, FAERS-identified signals, such as nephrolithiasis, gastrointestinal infections, and decreased blood pressure, warrant further investigation in larger, more diverse populations. Full article
(This article belongs to the Special Issue Therapeutic Drug Monitoring and Adverse Drug Reactions: 2nd Edition)
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20 pages, 3775 KiB  
Article
CIRGNN: Leveraging Cross-Chart Relationships with a Graph Neural Network for Stock Price Prediction
by Shanghui Jia, Han Gao, Jiaming Huang, Yingke Liu and Shangzhe Li
Mathematics 2025, 13(15), 2402; https://doi.org/10.3390/math13152402 - 25 Jul 2025
Viewed by 263
Abstract
Recent years have seen a rise in combining deep learning and technical analysis for stock price prediction. However, technical indicators are often prioritized over technical charts due to quantification challenges. While some studies use closing price charts for predicting stock trends, they overlook [...] Read more.
Recent years have seen a rise in combining deep learning and technical analysis for stock price prediction. However, technical indicators are often prioritized over technical charts due to quantification challenges. While some studies use closing price charts for predicting stock trends, they overlook charts from other indicators and their relationships, resulting in underutilized information for predicting stock. Therefore, we design a novel framework to address the underutilized information limitations within technical charts generated by different indicators. Specifically, different sequences of stock indicators are used to generate various technical charts, and an adaptive relationship graph learning layer is employed to learn the relationships among technical charts generated by different indicators. Finally, by applying a GNN model combined with the relationship graphs of diverse technical charts, temporal patterns of stock indicator sequences are captured, fully utilizing the information between various technical charts to achieve accurate stock price predictions. Additionally, we further tested our framework with real-world stock data, showing superior performance over advanced baselines in predicting stock prices, achieving the highest net value in trading simulations. Our research results not only complement the existing applications of non-singular technical charts in deep learning but also offer backing for investment applications in financial market decision-making. Full article
(This article belongs to the Special Issue Mathematical Modelling in Financial Economics)
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17 pages, 3667 KiB  
Article
Improving the Recognition of Bamboo Color and Spots Using a Novel YOLO Model
by Yunlong Zhang, Tangjie Nie, Qingping Zeng, Lijie Chen, Wei Liu, Wei Zhang and Long Tong
Plants 2025, 14(15), 2287; https://doi.org/10.3390/plants14152287 - 24 Jul 2025
Viewed by 275
Abstract
The sheaths of bamboo shoots, characterized by distinct colors and spotting patterns, are key phenotypic markers influencing species classification, market value, and genetic studies. This study introduces YOLOv8-BS, a deep learning model optimized for detecting these traits in Chimonobambusa utilis using a dataset [...] Read more.
The sheaths of bamboo shoots, characterized by distinct colors and spotting patterns, are key phenotypic markers influencing species classification, market value, and genetic studies. This study introduces YOLOv8-BS, a deep learning model optimized for detecting these traits in Chimonobambusa utilis using a dataset from Jinfo Mountain, China. Enhanced by data augmentation techniques, including translation, flipping, and contrast adjustment, YOLOv8-BS outperformed benchmark models (YOLOv7, YOLOv5, YOLOX, and Faster R-CNN) in color and spot detection. For color detection, it achieved a precision of 85.9%, a recall of 83.4%, an F1-score of 84.6%, and an average precision (AP) of 86.8%. For spot detection, it recorded a precision of 90.1%, a recall of 92.5%, an F1-score of 91.1%, and an AP of 96.1%. These results demonstrate superior accuracy and robustness, enabling precise phenotypic analysis for bamboo germplasm evaluation and genetic diversity studies. YOLOv8-BS supports precision agriculture by providing a scalable tool for sustainable bamboo-based industries. Future improvements could enhance model adaptability for fine-grained varietal differences and real-time applications. Full article
(This article belongs to the Special Issue Advances in Artificial Intelligence for Plant Research)
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