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Search Results (1,373)

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13 pages, 1746 KiB  
Article
Calibration of DEM Parameters and Microscopic Deformation Characteristics During Compression Process of Lateritic Soil with Different Moisture Contents
by Chao Ji, Wanru Liu, Yiguo Deng, Yeqin Wang, Peimin Chen and Bo Yan
Agriculture 2025, 15(14), 1548; https://doi.org/10.3390/agriculture15141548 - 18 Jul 2025
Abstract
Lateritic soils in tropical regions feature cohesive textures and high specific resistance, driving up energy demands for tillage and harvesting machinery. However, current equipment designs lack discrete element models that account for soil moisture variations, and the microscopic effects of water content on [...] Read more.
Lateritic soils in tropical regions feature cohesive textures and high specific resistance, driving up energy demands for tillage and harvesting machinery. However, current equipment designs lack discrete element models that account for soil moisture variations, and the microscopic effects of water content on lateritic soil deformation remain poorly understood. This study aims to calibrate and validate discrete element method (DEM) models of lateritic soil at varying moisture contents of 20.51%, 22.39%, 24.53%, 26.28%, and 28.04% by integrating the Hertz–Mindlin contact mechanics with bonding and JKR cohesion models. Key parameters in the simulations were calibrated through systematic experimentation. Using Plackett–Burman design, critical factors significantly affecting axial compressive force—including surface energy, normal bond stiffness, and tangential bond stiffness—were identified. Subsequently, Box–Behnken response surface methodology was employed to optimize these parameters by minimizing deviations between simulated and experimental maximum axial compressive forces under each moisture condition. The calibrated models demonstrated high fidelity, with average relative errors of 4.53%, 3.36%, 3.05%, 3.32%, and 7.60% for uniaxial compression simulations across the five moisture levels. Stress–strain analysis under axial loading revealed that at a given surface displacement, both fracture dimensions and stress transfer rates decreased progressively with increasing moisture content. These findings elucidate the moisture-dependent micromechanical behavior of lateritic soil and provide critical data support for DEM-based design optimization of soil-engaging agricultural implements in tropical environments. Full article
(This article belongs to the Section Agricultural Technology)
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20 pages, 3567 KiB  
Article
Cycle-Informed Triaxial Sensor for Smart and Sustainable Manufacturing
by Parisa Esmaili, Luca Martiri, Parvaneh Esmaili and Loredana Cristaldi
Sensors 2025, 25(14), 4431; https://doi.org/10.3390/s25144431 - 16 Jul 2025
Viewed by 56
Abstract
Advances in Industry 4.0 and the emergence of Industry 5.0 are driving the development of intelligent, sustainable manufacturing systems, where embedded sensing and real-time health diagnostics play a critical role. However, implementing robust predictive maintenance in production environments remains challenging due to the [...] Read more.
Advances in Industry 4.0 and the emergence of Industry 5.0 are driving the development of intelligent, sustainable manufacturing systems, where embedded sensing and real-time health diagnostics play a critical role. However, implementing robust predictive maintenance in production environments remains challenging due to the variability in machine operations and the lack of access to internal control data. This paper introduces a lightweight, embedded-compatible framework for health status signature extraction based on empirical mode decomposition (EMD), leveraging only data from a single triaxial accelerometer. The core of the proposed method is a cycle-synchronized segmentation strategy that uses accelerometer-derived velocity profiles and cross-correlation to align signals with machining cycles, eliminating the need for controller or encoder access. This ensures process-aware decomposition that preserves the operational context across diverse and dynamic machining conditions to address the inadequate segmentation of unstable process data that often fails to capture the full scope of the process, resulting in misinterpretation. The performance is evaluated on a challenging real-world manufacturing benchmark where the extracted intrinsic mode functions (IMFs) are analyzed in the frequency domain, including quantitative evaluation. As results show, the proposed method shows its effectiveness in detecting subtle degradations, following a low computational footprint, and its suitability for deployment in embedded predictive maintenance systems on brownfield or controller-limited machinery. Full article
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21 pages, 3570 KiB  
Article
Fatigue Life Analysis of Cylindrical Roller Bearings Considering Elastohydrodynamic Lubrications
by Ke Zhang, Zhitao Huang, Qingsong Li and Ruiyu Zhang
Appl. Sci. 2025, 15(14), 7867; https://doi.org/10.3390/app15147867 - 14 Jul 2025
Viewed by 104
Abstract
Cylindrical roller bearings are widely used in industrial machinery, automotive systems, and aerospace applications, where their reliability directly affects the performance and safety of mechanical systems. The fatigue life of cylindrical roller bearings is significantly affected by their elastohydrodynamic lubrication condition, with variations [...] Read more.
Cylindrical roller bearings are widely used in industrial machinery, automotive systems, and aerospace applications, where their reliability directly affects the performance and safety of mechanical systems. The fatigue life of cylindrical roller bearings is significantly affected by their elastohydrodynamic lubrication condition, with variations potentially reaching multiple times. However, conventional quasi-static models often neglect lubrication effects. This study establishes a quasi-static analysis model for cylindrical roller bearings that incorporates the effects of elastohydrodynamic lubrication by integrating elastohydrodynamic lubrication theory with the Lundberg–Palmgren life model. The isothermal line contact elastohydrodynamic lubrication equations are solved using the multigrid method, and the contact load distribution is determined through nonlinear iterative techniques to calculate bearing fatigue life. Taking the N324 support bearing on the main shaft of an SFW250-8/850 horizontal hydro-generator as an example, the influences of radial load, inner race speed, and lubricant viscosity on fatigue life are comparatively analyzed. Experimental validation is conducted under both light-load and heavy-load operating conditions. The results demonstrate that elastohydrodynamic lubrication markedly increases contact loads, leading to a reduced predicted fatigue life compared with that of the De Mul model (which ignores lubrication). The proposed lubrication-integrated model achieves an average deviation of 5.3% from the experimental data, representing a 16.1% improvement in prediction accuracy over the De Mul model. Additionally, increased rotational speed and lubricant viscosity accelerate fatigue life degradation. Full article
(This article belongs to the Special Issue Advances and Applications in Mechanical Fatigue and Life Assessment)
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25 pages, 3827 KiB  
Article
Source-Free Domain Adaptation Framework for Rotary Machine Fault Diagnosis
by Hoejun Jeong, Seungha Kim, Donghyun Seo and Jangwoo Kwon
Sensors 2025, 25(14), 4383; https://doi.org/10.3390/s25144383 - 13 Jul 2025
Viewed by 348
Abstract
Intelligent fault diagnosis for rotary machinery often suffers performance degradation under domain shifts between training and deployment environments. To address this, we propose a robust fault diagnosis framework incorporating three key components: (1) an order-frequency-based preprocessing method to normalize rotational variations, (2) a [...] Read more.
Intelligent fault diagnosis for rotary machinery often suffers performance degradation under domain shifts between training and deployment environments. To address this, we propose a robust fault diagnosis framework incorporating three key components: (1) an order-frequency-based preprocessing method to normalize rotational variations, (2) a U-Net variational autoencoder (U-NetVAE) to enhance adaptation through reconstruction learning, and (3) a test-time training (TTT) strategy enabling unsupervised target domain adaptation without access to source data. Since existing works rarely evaluate under true domain shift conditions, we first construct a unified cross-domain benchmark by integrating four public datasets with consistent class and sensor settings. The experimental results show that our method outperforms conventional machine learning and deep learning models in both F1-score and recall across domains. Notably, our approach maintains an F1-score of 0.47 and recall of 0.51 in the target domain, outperforming others under identical conditions. Ablation studies further confirm the contribution of each component to adaptation performance. This study highlights the effectiveness of combining mechanical priors, self-supervised learning, and lightweight adaptation strategies for robust fault diagnosis in the practical domain. Full article
(This article belongs to the Special Issue Sensor Data-Driven Fault Diagnosis Techniques)
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23 pages, 6990 KiB  
Article
Fault Signal Emulation of Marine Turbo-Rotating Systems Based on Rotor-Gear Dynamic Interaction Modeling
by Seong Hyeon Kim, Hyun Min Song, Se Hyeon Jeong, Won Joon Lee and Sun Je Kim
J. Mar. Sci. Eng. 2025, 13(7), 1321; https://doi.org/10.3390/jmse13071321 - 9 Jul 2025
Viewed by 163
Abstract
Rotating machinery is essential in various industrial fields, and growing demands for high performance under harsh operating conditions have heightened interest in fault diagnosis and prognostic technologies. However, a major challenge in fault diagnosis research lies in the scarcity of data, primarily due [...] Read more.
Rotating machinery is essential in various industrial fields, and growing demands for high performance under harsh operating conditions have heightened interest in fault diagnosis and prognostic technologies. However, a major challenge in fault diagnosis research lies in the scarcity of data, primarily due to the inability to deliberately introduce faults into machines during actual operation. In this study, a physical model is proposed to realistically simulate the system behavior of a ship’s turbo-rotating machinery by coupling the torsional and lateral vibrations of the rotor. While previous studies employed simplified single-shaft models, the proposed model adopted gear mesh interactions to reflect the coupling behavior between shafts. Furthermore, the time-domain response of the system is analyzed through state-space transformation. The proposed model was applied to simulate imbalance and gear teeth damage conditions that may occur in marine turbo-rotating systems and the results were compared with those under normal operating conditions. The analysis confirmed that the model effectively reproduces fault-induced dynamic characteristics. By enabling rapid implementation of various fault conditions and efficient data acquisition data, the proposed model is expected to contribute to enhancing the reliability of fault diagnosis and prognostic research. Full article
(This article belongs to the Section Ocean Engineering)
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31 pages, 5571 KiB  
Article
Resolving Non-Proportional Frequency Components in Rotating Machinery Signals Using Local Entropy Selection Scaling–Reassigning Chirplet Transform
by Dapeng Quan, Yuli Niu, Zeming Zhao, Caiting He, Xiaoze Yang, Mingyang Li, Tianyang Wang, Lili Zhang, Limei Ma, Yong Zhao and Hongtao Wu
Aerospace 2025, 12(7), 616; https://doi.org/10.3390/aerospace12070616 - 8 Jul 2025
Viewed by 211
Abstract
Under complex operating conditions, vibration signals from rotating machinery often exhibit non-stationary characteristics with non-proportional and closely spaced instantaneous frequency (IF) components. Traditional time–frequency analysis (TFA) methods struggle to accurately extract such features due to energy leakage and component mixing. In response to [...] Read more.
Under complex operating conditions, vibration signals from rotating machinery often exhibit non-stationary characteristics with non-proportional and closely spaced instantaneous frequency (IF) components. Traditional time–frequency analysis (TFA) methods struggle to accurately extract such features due to energy leakage and component mixing. In response to these issues, an enhanced time–frequency analysis approach, termed Local Entropy Selection Scaling–Reassigning Chirplet Transform (LESSRCT), has been developed to improve the representation accuracy for complex non-stationary signals. This approach constructs multi-channel time–frequency representations (TFRs) by introducing multiple scales of chirp rates (CRs) and utilizes a Rényi entropy-based criterion to adaptively select multiple optimal CRs at the same time center, enabling accurate characterization of multiple fundamental components. In addition, a frequency reassignment mechanism is incorporated to enhance energy concentration and suppress spectral diffusion. Extensive validation was conducted on a representative synthetic signal and three categories of real-world data—bat echolocation, inner race bearing faults, and wind turbine gearbox vibrations. In each case, the proposed LESSRCT method was compared against SBCT, GLCT, CWT, SET, EMCT, and STFT. On the synthetic signal, LESSRCT achieved the lowest Rényi entropy of 13.53, which was 19.5% lower than that of SET (16.87) and 35% lower than GLCT (18.36). In the bat signal analysis, LESSRCT reached an entropy of 11.53, substantially outperforming CWT (19.91) and SBCT (15.64). For bearing fault diagnosis signals, LESSRCT consistently achieved lower entropy across varying SNR levels compared to all baseline methods, demonstrating strong noise resilience and robustness. The final case on wind turbine signals demonstrated its robustness and computational efficiency, with a runtime of 1.31 s and excellent resolution. These results confirm that LESSRCT delivers robust, high-resolution TFRs with strong noise resilience and broad applicability. It holds strong potential for precise fault detection and condition monitoring in domains such as aerospace and renewable energy systems. Full article
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28 pages, 7407 KiB  
Article
WaveAtten: A Symmetry-Aware Sparse-Attention Framework for Non-Stationary Vibration Signal Processing
by Xingyu Chen and Monan Wang
Symmetry 2025, 17(7), 1078; https://doi.org/10.3390/sym17071078 - 7 Jul 2025
Viewed by 240
Abstract
This study addresses the long-standing difficulty of predicting the remaining useful life (RUL) of rolling bearings from highly non-stationary vibration signals by proposing WaveAtten, a symmetry-aware deep learning framework. First, mirror-symmetric and bi-orthogonal Daubechies wavelet filters are applied to decompose each raw signal [...] Read more.
This study addresses the long-standing difficulty of predicting the remaining useful life (RUL) of rolling bearings from highly non-stationary vibration signals by proposing WaveAtten, a symmetry-aware deep learning framework. First, mirror-symmetric and bi-orthogonal Daubechies wavelet filters are applied to decompose each raw signal into multi-scale approximation/detail pairs, explicitly preserving the left–right symmetry that characterizes periodic mechanical responses while isolating asymmetric transient faults. Next, a bidirectional sparse-attention module reinforces this structural symmetry by selecting query–key pairs in a forward/backward balanced fashion, allowing the network to weight homologous spectral patterns and suppress non-symmetric noise. Finally, the symmetry-enhanced features—augmented with temperature and other auxiliary sensor data—are fed into a long short-term memory (LSTM) network that models the symmetric progression of degradation over time. Experiments on the IEEE PHM2012 bearing dataset showed that WaveAtten achieved superior mean squared error, mean absolute error, and R2 scores compared with both classical signal-processing pipelines and state-of-the-art deep models, while ablation revealed a 6–8% performance drop when the symmetry-oriented components were removed. By systematically exploiting the intrinsic symmetry of vibration phenomena, WaveAtten offers a robust and efficient route to RUL prediction, paving the way for intelligent, condition-based maintenance of industrial machinery. Full article
(This article belongs to the Section Computer)
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27 pages, 10447 KiB  
Article
Supervised Learning-Based Fault Classification in Industrial Rotating Equipment Using Multi-Sensor Data
by Aziz Kubilay Ovacıklı, Mert Yagcioglu, Sevgi Demircioglu, Tugberk Kocatekin and Sibel Birtane
Appl. Sci. 2025, 15(13), 7580; https://doi.org/10.3390/app15137580 - 6 Jul 2025
Viewed by 490
Abstract
The reliable operation of rotating machinery is critical in industrial production, necessitating advanced fault diagnosis and maintenance strategies to ensure operational availability. This study employs supervised machine learning algorithms to apply multi-label classification for fault detection in rotating machinery, utilizing a real dataset [...] Read more.
The reliable operation of rotating machinery is critical in industrial production, necessitating advanced fault diagnosis and maintenance strategies to ensure operational availability. This study employs supervised machine learning algorithms to apply multi-label classification for fault detection in rotating machinery, utilizing a real dataset from multi-sensor systems installed on a suction fan in a typical manufacturing industry. The presented system focuses on multi-modal data analysis, such as vibration analysis, temperature monitoring, and ultrasound, for more effective fault diagnosis. The performance of general machine learning algorithms such as kNN, SVM, RF, and some boosting techniques was evaluated, and it was shown that the Random Forest achieved the best classification accuracy. Feature importance analysis has revealed how specific domain characteristics, such as vibration velocity and ultrasound levels, contribute significantly to performance and enabled the detection of multiple faults simultaneously. The results demonstrate the machine learning model’s ability to retrieve valuable information from multi-sensor data integration, improving predictive maintenance strategies. The presented study contributes a practical framework in intelligent fault diagnosis as it presents an example of a real-world implementation while enabling future improvements in industrial condition-based maintenance systems. Full article
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20 pages, 3835 KiB  
Article
Fuzzy PD-Based Control for Excavator Boom Stabilization Using Work Port Pressure Feedback
by Joseph T. Jose, Gyan Wrat, Santosh Kr. Mishra, Prabhat Ranjan and Jayanta Das
Actuators 2025, 14(7), 336; https://doi.org/10.3390/act14070336 - 4 Jul 2025
Viewed by 235
Abstract
Hydraulic excavators operate in harsh environments where direct measurement of actuator chamber pressures and boom displacement is often unreliable or infeasible. This study presents a novel control strategy that estimates actuator chamber pressures from work port pressures using differential equations, eliminating the need [...] Read more.
Hydraulic excavators operate in harsh environments where direct measurement of actuator chamber pressures and boom displacement is often unreliable or infeasible. This study presents a novel control strategy that estimates actuator chamber pressures from work port pressures using differential equations, eliminating the need for direct pressure or position sensors. A fuzzy logic-based proportional–derivative (PD) controller is developed to mitigate boom oscillations, particularly under high-inertia load conditions and variable operator inputs. The controller dynamically adjusts gains through fuzzy logic-based gain scheduling, enhancing adaptability across a wide range of operating conditions. The proposed method addresses the limitations of classical PID controllers, which struggle with the nonlinearities, parameter uncertainties, and instability introduced by counterbalance valves and pressure-compensated proportional valves. Experimental data is used to design fuzzy rules and membership functions, ensuring robust performance. Simulation and full-scale experimental validation demonstrate that the fuzzy PD controller significantly reduces pressure overshoot (by 23% during extension and 32% during retraction) and decreases settling time (by 31.23% and 28%, respectively) compared to conventional systems. Frequency-domain stability analysis confirms exponential stability and improved damping characteristics. The proposed control scheme enhances system reliability and safety, making it ideal for excavators operating in remote or rugged terrains where conventional sensor-based systems may fail. This approach is generalizable and does not require modifications to the existing hydraulic circuit, offering a practical and scalable solution for modern hydraulic machinery. Full article
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5 pages, 1345 KiB  
Proceeding Paper
Improving Predictive Maintenance Performance Using Machine Learning and Vibration Analysis Algorithms
by Ibtissam Elharnaf, Khadija Achtaich and Samir Tetouani
Eng. Proc. 2025, 97(1), 45; https://doi.org/10.3390/engproc2025097045 - 2 Jul 2025
Viewed by 284
Abstract
This research examines advanced machine learning techniques utilized for the predictive maintenance of industrial machinery. A hybrid model combining long-term memory networks (LSTM) and gated recurrent unit (GRU) networks alongside a random forest classifier has been created utilizing vibration data collected from sensors [...] Read more.
This research examines advanced machine learning techniques utilized for the predictive maintenance of industrial machinery. A hybrid model combining long-term memory networks (LSTM) and gated recurrent unit (GRU) networks alongside a random forest classifier has been created utilizing vibration data collected from sensors for fault classification purposes. The method includes feature extraction, time series analysis, and classification, utilizing the benefits of these models to efficiently manage sequential data. The results show significant improvements in forecasting accuracy, reduced downtime, and better-aligned maintenance schedules. These advancements demonstrate the capabilitie of integrating AI-driven solutions into industrial systems, consistent with Industry 4.0 principles, to improve operational capabilities. Full article
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28 pages, 1946 KiB  
Review
Understanding Microglia in Mesocorticolimbic Circuits: Implications for the Study of Chronic Stress and Substance Use Disorders
by David B. Nowak, Juan Pablo Taborda-Bejarano, Fernando J. Chaure, John R. Mantsch and Constanza Garcia-Keller
Cells 2025, 14(13), 1014; https://doi.org/10.3390/cells14131014 - 2 Jul 2025
Viewed by 434
Abstract
Exposure to chronic stress creates vulnerability to drug misuse and presents a barrier to sustained recovery for many individuals experiencing substance use disorders (SUDs). Preclinical literature demonstrates that stress modulates psychostimulant intake and seeking, yet there are wide gaps in our understanding of [...] Read more.
Exposure to chronic stress creates vulnerability to drug misuse and presents a barrier to sustained recovery for many individuals experiencing substance use disorders (SUDs). Preclinical literature demonstrates that stress modulates psychostimulant intake and seeking, yet there are wide gaps in our understanding of the specific mechanisms by which stress promotes brain changes that may govern addiction-related behaviors. Recent data suggest that microglia, innate immune cells in the central nervous system, are highly responsive to chronic stressors, and several mechanistic links have been explored highlighting the critical role microglia play in stress-related brain adaptation. Importantly, psychostimulants may engage similar microglial machinery, which opens the door for investigation into how microglia may be involved in shaping motivation for psychostimulants, especially in the context of stress exposure. The aims of this review are threefold: 1. Offer a brief overview of microglial biology in the adult brain. 2. Review current methods of interrogating microglial function with a focus on morphometric analyses. 3. Highlight preclinical research describing how microglia contribute to brain changes following chronic stress and/or psychostimulant exposure. Ultimately, this review serves to prime investigators studying the intersection of stress and SUDs to consider the relevant impacts of microglial actions. Full article
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23 pages, 9135 KiB  
Article
Stone Detection on Agricultural Land Using Thermal Imagery from Unmanned Aerial Systems
by Florian Thürkow, Mike Teucher, Detlef Thürkow and Milena Mohri
AgriEngineering 2025, 7(7), 203; https://doi.org/10.3390/agriengineering7070203 - 1 Jul 2025
Viewed by 375
Abstract
Stones in agricultural fields pose a recurring challenge, particularly due to their potential to damage agricultural machinery and disrupt field operations. As modern agriculture moves toward automation and precision farming, efficient stone detection has become a critical concern. This study explores the potential [...] Read more.
Stones in agricultural fields pose a recurring challenge, particularly due to their potential to damage agricultural machinery and disrupt field operations. As modern agriculture moves toward automation and precision farming, efficient stone detection has become a critical concern. This study explores the potential of thermal imaging as a non-invasive method for detecting stones under varying environmental conditions. A series of controlled laboratory experiments and field investigations confirmed the assumption that stones exhibit higher surface temperatures than the surrounding soil, especially when soil moisture is high and air temperatures are cooling rapidly. This temperature difference is attributed to the higher thermal inertia of stones, which allows them to absorb and retain heat longer than soil, as well as to the evaporative cooling from moist soil. These findings demonstrate the viability of thermal cameras as a tool for stone detection in precision farming. Incorporating this technology with GPS mapping enables the generation of accurate location data, facilitating targeted stone removal and reducing equipment damage. This approach aligns with the goals of sustainable agricultural engineering by supporting field automation, minimizing mechanical inefficiencies, and promoting data-driven decisions. Thermal imaging thereby contributes to the evolution of next-generation agricultural systems. Full article
(This article belongs to the Special Issue Recent Trends and Advances in Agricultural Engineering)
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17 pages, 784 KiB  
Article
A Survey-Based Emission Inventory of Greenhouse Gases Released from Rice Production on Consolidated Land in the Red River Delta of Vietnam
by Dinh Thi Hai Van, Nguyen Thi Kim Oanh and Nguyen Thi Bich Yen
Atmosphere 2025, 16(7), 794; https://doi.org/10.3390/atmos16070794 - 30 Jun 2025
Viewed by 318
Abstract
In this study, relevant rice cultivation data were collected through a local survey, and the life cycle assessment (LCA) method was employed to quantify greenhouse gas (GHG) emissions from rice production on consolidated land in the Red River Delta (RRD). Systematic sampling was [...] Read more.
In this study, relevant rice cultivation data were collected through a local survey, and the life cycle assessment (LCA) method was employed to quantify greenhouse gas (GHG) emissions from rice production on consolidated land in the Red River Delta (RRD). Systematic sampling was used in face-to-face interviews with 45 rice farming households in a representative commune of Hai Duong province. Specific GHG emissions were significantly higher in the summer crop (averaged at 11.4 t CO2-eq/ha or 2.2 t CO2-eq/t grain) than in the spring crop (6.8 t CO2-eq/ha or 1.2 t CO2-eq/t grain). Methane was a dominant GHG emitted from paddy fields, contributing 84% of the total emissions of CO2-eq in the summer crop and 73% in the spring crop. Fertilizer use and N2O emissions accounted for 9% of emissions in the summer crop and 16% in the spring crop. Energy consumption for machinery and irrigation added a further 4% and 8%, respectively. Annually, as of 2023, the rice production activities in the RRD release 7.3 Tg of CO2-eq (100 years), a significant contribution to the national GHG emissions. GHG emissions under alternative scenarios of rice straw management were assessed. This study highlights the role of land consolidation in improving water management, which contributes to lowering emissions. Based on the findings, several mitigation measures could be identified, including improved irrigation practices, optimized fertilizer use, and the promotion of sustainable rice straw management practices. Full article
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15 pages, 1700 KiB  
Article
PROM1 and EFTUD2 Expression in High-Grade Clear Cell Renal Cell Carcinoma as a Molecular Marker for Survival Rate
by Michał Kasperczak, Iga Kołodziejczak-Guglas, Filip Kasperczak, Maciej Wiznerowicz and Andrzej Antczak
Int. J. Mol. Sci. 2025, 26(13), 6296; https://doi.org/10.3390/ijms26136296 - 30 Jun 2025
Viewed by 237
Abstract
Clear cell renal cell carcinoma (ccRCC) is a significant global cancer, particularly impacting individuals in Western countries. Despite that, the molecular mechanisms driving renal cell carcinoma progression remain poorly understood, highlighting the need to investigate these mechanisms and identify novel therapeutic targets. Literature [...] Read more.
Clear cell renal cell carcinoma (ccRCC) is a significant global cancer, particularly impacting individuals in Western countries. Despite that, the molecular mechanisms driving renal cell carcinoma progression remain poorly understood, highlighting the need to investigate these mechanisms and identify novel therapeutic targets. Literature evidence suggests that elongation factor Tu GTP binding domain containing 2 (EFTUD2) and prominin (PROM1) gene expression have significant diagnostic potential in early tumor detection, potentially reflecting the trends in progression, and may become a novel therapeutic target. Therefore, this study aimed to evaluate EFTUD2 and PROM1 protein expression on clinical characteristics of ccRCC patients, especially overall and progression-free survival. To achieve that goal, we have combined publicly available liquid chromatography–mass spectrometry (LC-MS/MS) protein expression data with a comprehensive literature review to identify key protein markers for further study and immunohistochemical (IHC) analysis. Our findings highlight the importance of considering protein expression heterogeneity within tumors. The significant variation in EFTUD2 expression, its association with PFS, and its intricate connections with the mRNA splicing machinery underscore the need for a more nuanced understanding of its role in ccRCC. Similarly, the downregulation of PROM1 and its potential effects on cell surface interactions warrant further exploration. Future studies should focus on elucidating the mechanisms underlying these observations, exploring their potential as therapeutic targets, and investigating the specific pathways affected by their dysregulation. Full article
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18 pages, 16108 KiB  
Article
Development of roCaGo for Forest Observation and Forestry Support
by Yoshinori Kiga, Yuzuki Sugasawa, Takumi Sakai, Takuma Nemoto and Masami Iwase
Forests 2025, 16(7), 1067; https://doi.org/10.3390/f16071067 - 26 Jun 2025
Viewed by 241
Abstract
This study addresses the ’last-mile’ transportation challenges that arise in steep and narrow forest terrain by proposing a novel robotic palanquin system called roCaGo. It is inspired by the mechanical principles of two-wheel-steering and two-wheel-drive (2WS/2WD) bicycles. The roCaGo system integrates front- and [...] Read more.
This study addresses the ’last-mile’ transportation challenges that arise in steep and narrow forest terrain by proposing a novel robotic palanquin system called roCaGo. It is inspired by the mechanical principles of two-wheel-steering and two-wheel-drive (2WS/2WD) bicycles. The roCaGo system integrates front- and rear-wheel-drive mechanisms, as well as a central suspension structure for carrying loads. Unlike conventional forestry machinery, which requires wide, well-maintained roads or permanent rail systems, the roCaGo system enables flexible, operator-assisted transport along narrow, unprepared mountain paths. A dynamic model of the system was developed to design a stabilization control strategy, enabling roCaGo to maintain transport stability and assist the operator during navigation. Numerical simulations and preliminary physical experiments demonstrate its effectiveness in challenging forest environments. Furthermore, the applicability of roCaGo has been extended to include use as a mobile third-person viewpoint platform to support the remote operation of existing forestry equipment; specifically the LV800crawler vehicle equipped with a front-mounted mulcher. Field tests involving LiDAR sensors mounted on roCaGo were conducted to verify its ability to capture the environmental data necessary for non-line-of-sight teleoperation. The results show that roCaGo is a promising solution for improving labor efficiency and ensuring operator safety in forest logistics and remote-controlled forestry operations. Full article
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