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39 pages, 831 KiB  
Article
The Impact of State-Owned Capital Participation on Carbon Emission Reduction in Private Enterprises: Evidence from China
by Runsen Yuan, Yan Li, Chunling Li, Xiaoran Sun and Lingyi Li
Sustainability 2025, 17(16), 7433; https://doi.org/10.3390/su17167433 (registering DOI) - 17 Aug 2025
Abstract
Carbon emission reduction serves as a pivotal strategy for advancing global environmental quality and sustainable socioeconomic development. Private enterprises serve as the primary contributors to industrial carbon emissions. Their low-carbon transition is directly tied to the achievement of China’s Dual Carbon Goals. However, [...] Read more.
Carbon emission reduction serves as a pivotal strategy for advancing global environmental quality and sustainable socioeconomic development. Private enterprises serve as the primary contributors to industrial carbon emissions. Their low-carbon transition is directly tied to the achievement of China’s Dual Carbon Goals. However, constrained by market failures and the profit-driven nature of capital, these enterprises face significant challenges in both motivation and capacity for carbon emission reduction. As a critical link connecting government and market forces, whether state-owned capital can effectively drive private enterprises to reduce emissions and conserve energy still lacks systematic empirical evidence. Leveraging a panel dataset of private industrial listed companies on China’s Shanghai and Shenzhen A-share markets spanning 2008–2022, we examine the impact of state-owned capital participation on carbon emission reduction and the underlying mechanisms. The empirical results demonstrate that state-owned capital participation can significantly drive carbon emission reduction and propel the low-carbon transformation of private enterprises. Mechanism analysis reveals that state-owned capital participation promotes carbon emission reduction through multiple avenues, including enriching the green resource base, strengthening the value recognition of environmental social responsibility, and improving energy efficiency. Further analysis indicates that the emission reduction effect of state-owned capital participation is more pronounced under conditions of weaker government environmental regulation, lower regional marketization, greater industry competition, and tighter green financing constraints. This study enriches the research on mixed-ownership reform and low-carbon transition of enterprises, deepens the theoretical understanding of the internal mechanism of state-owned capital participation affecting carbon emission reduction, and offers empirical evidence for emerging economies to address the dilemma of emission reduction through property rights integration. Full article
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25 pages, 6902 KiB  
Article
Household Waste Disposal Under Structural and Behavioral Constraints: A Multivariate Analysis from Vhembe District, South Africa
by Aifani Confidence Tahulela, Shervin Hashemi and Melanie Elizabeth Lourens
Sustainability 2025, 17(16), 7429; https://doi.org/10.3390/su17167429 (registering DOI) - 17 Aug 2025
Abstract
Both behavioral intentions and structural constraints shape household waste disposal in low-resource settings. This study integrates the Theory of Planned Behavior (TPB) with Environmental Justice (EJ) to examine informal waste disposal in Vhembe District, South Africa, a region marked by infrastructural deficits and [...] Read more.
Both behavioral intentions and structural constraints shape household waste disposal in low-resource settings. This study integrates the Theory of Planned Behavior (TPB) with Environmental Justice (EJ) to examine informal waste disposal in Vhembe District, South Africa, a region marked by infrastructural deficits and uneven municipal services. A cross-sectional survey of 399 households across four municipalities assessed five disposal behaviors, including river dumping and domestic burial. Only 8% of households used formal bins, while over 50% engaged in open or roadside dumping. Although education and income were inversely associated with harmful practices, inadequate service access was the most significant constraint on formal disposal. Logistic regression revealed that rural residents and households in underserved municipalities were significantly more likely to engage in hazardous methods, regardless of socioeconomic status. These findings extend TPB by showing that perceived behavioral control reflects not only psychological agency but also material and institutional limitations. By reframing informal disposal as a structurally conditioned response rather than a behavioral deficit, the study advances EJ theory and provides a transferable TPB–EJ framework for decentralized, justice-oriented waste governance. The results underscore the need for Sustainable Development Goal (SDG)-aligned interventions that integrate equitable infrastructure with context-sensitive behavioral strategies. Full article
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23 pages, 14149 KiB  
Article
Land Use Transition Under a Tense Human–Land Relationship: A GWR Analysis of Conflicts Between Construction Land and Cropland
by Kaichun Zhou, Yulin Li, Zixiang Sun, Junzhu Chen and Binggeng Xie
Land 2025, 14(8), 1660; https://doi.org/10.3390/land14081660 (registering DOI) - 17 Aug 2025
Abstract
The rapid conversion of cropland into construction land in China poses an increasing threat to national food security. Using high-resolution (30 m) land-use data from 2000 to 2020, obtained from the Resource and Environment Science and Data Center, along with spatial analytical methods [...] Read more.
The rapid conversion of cropland into construction land in China poses an increasing threat to national food security. Using high-resolution (30 m) land-use data from 2000 to 2020, obtained from the Resource and Environment Science and Data Center, along with spatial analytical methods such as land-use transition metrics and centroid-based migration models, this study identifies the spatio-temporal evolution and spatial migration patterns of construction land expansion and cropland loss. Combined with multi-source data, including socioeconomic, environmental, and topographic variables, this study employs a geographically weighted regression (GWR) model to explore the spatially heterogeneous driving mechanisms of two key indicators: the dependency of construction land expansion on cropland (DEP) and the contribution of cropland loss to construction land (CON). The results reveal that cropland has generally increased in the west and decreased in the east, reflecting expansion in underdeveloped areas and shrinkage in wealthier regions. In contrast, construction land expansion shows polycentric and stage-specific characteristics. Both DEP and CON remain high in major grain-producing areas like the North China Plain. Among the influencing factors, the non-grain production rate strongly inhibits DEP, while chemical fertilizer use significantly promotes CON. The urbanization rate shows a southwest-to-northeast increasing inhibitory effect on DEP and a northeast-to-southwest increasing promoting effect on CON. Local fiscal expenditure and land degradation demonstrate spatially heterogeneous effects. These differences highlight the conflict between low-cost land development priorities and cropland protection policies. Full article
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34 pages, 21961 KiB  
Article
Spatial Synergy Between Carbon Storage and Emissions in Coastal China: Insights from PLUS-InVEST and OPGD Models
by Chunlin Li, Jinhong Huang, Yibo Luo and Junjie Wang
Remote Sens. 2025, 17(16), 2859; https://doi.org/10.3390/rs17162859 (registering DOI) - 16 Aug 2025
Abstract
Coastal zones face mounting pressures from rapid urban expansion and ecological degradation, posing significant challenges to achieving synergistic carbon storage and emissions reduction under China’s “dual carbon” goals. Yet, the identification of spatially explicit zones of carbon synergy (high storage–low emissions) and conflict [...] Read more.
Coastal zones face mounting pressures from rapid urban expansion and ecological degradation, posing significant challenges to achieving synergistic carbon storage and emissions reduction under China’s “dual carbon” goals. Yet, the identification of spatially explicit zones of carbon synergy (high storage–low emissions) and conflict (high emissions–low storage) in these regions remains limited. This study integrates the PLUS (Patch-generating Land Use Simulation), InVEST (Integrated Valuation of Ecosystem Services and Trade-offs), and OPGD (optimal parameter-based GeoDetector) models to evaluate the impacts of land-use/cover change (LUCC) on coastal carbon dynamics in China from 2000 to 2030. Four contrasting land-use scenarios (natural development, economic development, ecological protection, and farmland protection) were simulated to project carbon trajectories by 2030. From 2000 to 2020, rapid urbanization resulted in a 29,929 km2 loss of farmland and a 43,711 km2 increase in construction land, leading to a net carbon storage loss of 278.39 Tg. Scenario analysis showed that by 2030, ecological and farmland protection strategies could increase carbon storage by 110.77 Tg and 110.02 Tg, respectively, while economic development may further exacerbate carbon loss. Spatial analysis reveals that carbon conflict zones were concentrated in major urban agglomerations, whereas spatial synergy zones were primarily located in forest-rich regions such as the Zhejiang–Fujian and Guangdong–Guangxi corridors. The OPGD results demonstrate that carbon synergy was driven largely by interactions between socioeconomic factors (e.g., population density and nighttime light index) and natural variables (e.g., mean annual temperature, precipitation, and elevation). These findings emphasize the need to harmonize urban development with ecological conservation through farmland protection, reforestation, and low-emission planning. This study, for the first time, based on the PLUS-Invest-OPGD framework, proposes the concepts of “carbon synergy” and “carbon conflict” regions and their operational procedures. Compared with the single analysis of the spatial distribution and driving mechanisms of carbon stocks or carbon emissions, this method integrates both aspects, providing a transferable approach for assessing the carbon dynamic processes in coastal areas and guiding global sustainable planning. Full article
(This article belongs to the Special Issue Carbon Sink Pattern and Land Spatial Optimization in Coastal Areas)
14 pages, 265 KiB  
Article
Exploring Vulnerable, Ethnic Minority, and Low Socioeconomic Children’s Knowledge, Beliefs, and Attitudes Regarding HPV Vaccination in Romania
by Teodora Achimaș-Cadariu, Andrei Pașca, Delia Nicoară and Dan Lucian Dumitrașcu
Healthcare 2025, 13(16), 2010; https://doi.org/10.3390/healthcare13162010 - 15 Aug 2025
Viewed by 38
Abstract
Background/Objective: To assess vulnerable Romanian children’s knowledge, attitudes, and beliefs regarding the HPV vaccination. Methods: Vulnerable children (ethnic minorities, high social vulnerability index, or low socioeconomic status) from three schools in Cluj County, Romania, were enrolled in a short educational presentation regarding HPV [...] Read more.
Background/Objective: To assess vulnerable Romanian children’s knowledge, attitudes, and beliefs regarding the HPV vaccination. Methods: Vulnerable children (ethnic minorities, high social vulnerability index, or low socioeconomic status) from three schools in Cluj County, Romania, were enrolled in a short educational presentation regarding HPV and were delivered a physical questionnaire consisting of 26 items. Results: 199 vulnerable school students concluded the questionnaire with a mean age of 14.62. Most participants were unaware of the HPV infection or the HPV vaccine. Following the educational program, most participants exhibited a reasonably elevated level of knowledge, which positively correlated with the intention to vaccinate. Fifty-three per cent of respondents would vaccinate in school if the vaccine were available, fifty-four per cent would vaccinate if the product were free of charge or at minimal cost, and over sixty-four per cent would vaccinate at their doctor’s recommendation. Several knowledge items, beliefs, and attitudes towards vaccination were disclosed to influence children’s preference to participate in vaccination campaigns. Conclusions: This analysis unveiled the pivotal role of knowledge about HPV in the immunization uptake within underserved, vulnerable populations of Romanian children. An intricate interplay between vulnerability, knowledge, accessibility, and the willingness to vaccinate was impacted by several beliefs and attitudes towards HPV vaccination. Most children were willing to participate in HPV immunization campaigns, whether school-based, reimbursed, or at the doctor’s recommendation. These findings act as pillars for assembling future educational campaigns in vulnerable Romanian communities of children, aiming to enhance awareness and coverage of HPV vaccination and ensure inclusive health policies. Full article
(This article belongs to the Special Issue HPV Vaccine and Cervical Cancer Prevention)
14 pages, 1021 KiB  
Systematic Review
From the Ocean to the Operating Room: The Role of Fish Skin Grafts in Burn Management—A Systematic Review
by Mohamed Marzouk El Araby, Gianluca Marcaccini, Pietro Susini, Francesco Ruben Giardino, Mirco Pozzi, Vera Pizzo, Luca Grimaldi, Alessandro Innocenti, Roberto Cuomo, Giuseppe Nisi, Cristian Pascone and Antonio Di Lonardo
J. Clin. Med. 2025, 14(16), 5750; https://doi.org/10.3390/jcm14165750 - 14 Aug 2025
Viewed by 179
Abstract
Background: The treatment of burns is a socio-economic challenge for both patients and the National Health Service. Early debridement and skin graft reduces the risk of local and systemic complications. However, when skin autografting is unfeasible or contraindicated, alternative options are required. [...] Read more.
Background: The treatment of burns is a socio-economic challenge for both patients and the National Health Service. Early debridement and skin graft reduces the risk of local and systemic complications. However, when skin autografting is unfeasible or contraindicated, alternative options are required. Recent research has introduced new potential tools: fish skin grafts (FSGs). This systematic review focuses on FSGs with the aim of improving the management of burn patients. Methods: A systematic search on articles concerning FSG for the treatment of burns was performed by searching PubMed, Web of Science and Embase according to the PRISMA statement. Clinical trials, retrospective studies, case series and case reports were included. Results: A total of 36 studies were identified through the search strategy and imported for screening. After duplicate removal, 26 studies were considered. Based on predetermined criteria, 20 full texts were assessed for eligibility, leaving 18 articles to be included in the systematic review. Conclusions: By virtue of the safety and effectiveness of FSGs, including low risk of zoonosis transmission and valuable outcomes even in austere environments, FSGs could represent a new alternative for the treatment of burns. Full article
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25 pages, 2308 KiB  
Article
Socio-Economic Benefits of Different Indonesian Crops: Opportunities for Sago Starch in Bioplastic Development
by Ida Bagus Gede Sutawijaya, Aritta Suwarno and Lars Hein
Sustainability 2025, 17(16), 7351; https://doi.org/10.3390/su17167351 - 14 Aug 2025
Viewed by 96
Abstract
The growing global demand for bioplastics highlights the need for sustainable starch sources, and Indonesia has considerable potential for cultivating such feedstock. While cassava has been widely promoted, there is limited scientific justification for prioritizing it over alternatives such as sago. An important [...] Read more.
The growing global demand for bioplastics highlights the need for sustainable starch sources, and Indonesia has considerable potential for cultivating such feedstock. While cassava has been widely promoted, there is limited scientific justification for prioritizing it over alternatives such as sago. An important distinction is that cassava is grown on mineral soils, where many alternative crops are viable, whereas sago is cultivated on peatlands, where relatively few crops can be grown sustainably. This study compares the socio-economic benefits of cassava and sago, considering their competitiveness against their main competing crops (i.e., corn on mineral soils and oil palm on peatlands). For new plantations, sago generated lower farm-level benefits than cassava, with net present values of 1534 EUR/ha and 5719 EUR/ha, respectively. However, when integrating starch processing and environmental impacts, sago provided greater benefits than cassava (4166 EUR/ha vs. 3555 EUR/ha). In the long term, sago may become more profitable than cassava due to its low maintenance and lack of replanting needs. Additionally, sago offers broader societal and environmental advantages, as it thrives on undrained peatlands, for which few alternatives exist. This study concludes that sago, as a paludiculture crop, is a sustainable option for bioplastic feedstock and can support peatland restoration. Full article
(This article belongs to the Section Resources and Sustainable Utilization)
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11 pages, 849 KiB  
Article
Prevalence of Preterm Birth in a Marginalized Roma Population—Quantitative Analysis in One of the Most Disadvantaged Regions of Hungary
by Kinga Pauwlik and Anita R. Fedor
Int. J. Environ. Res. Public Health 2025, 22(8), 1270; https://doi.org/10.3390/ijerph22081270 - 14 Aug 2025
Viewed by 220
Abstract
Preterm birth is a leading cause of perinatal morbidity and mortality and is particularly prevalent among socially disadvantaged female populations. This quantitative, cross-sectional study aimed to explore the prevalence of preterm birth in three segregated Roma communities in Hungary and to identify health [...] Read more.
Preterm birth is a leading cause of perinatal morbidity and mortality and is particularly prevalent among socially disadvantaged female populations. This quantitative, cross-sectional study aimed to explore the prevalence of preterm birth in three segregated Roma communities in Hungary and to identify health behavior and care factors associated with its occurrence. In our study, preterm birth was defined as delivery before 37 completed weeks of gestation (i.e., <259 days). Data were collected from 231 Roma women living in three municipalities of Szabolcs-Szatmár-Bereg County, one of Hungary’s most disadvantaged regions, using a structured interview questionnaire. The participants were women aged 18–65 years. Of these, 209 had been pregnant at least once in their lifetime. The questionnaire covered socio-demographic characteristics (age, level of education, employment status, housing conditions, marital status), health behaviors (smoking, alcohol consumption, drug use, vitamin supplementation, other substance use), antenatal care attendance, and birth outcomes (preterm birth, gestational age, low birth weight, newborn status). Statistical analyses included descriptive statistics, chi-square tests, and binary logistic regression with significance set at p < 0.05. Preterm birth was significantly more common among women who smoked, consumed alcohol or drugs during pregnancy, or had vaginal infections. Drug use showed the strongest association with a 22-fold increase in risk, followed by alcohol (nearly fivefold), smoking (over threefold), and infections (threefold). Although non-attendance at antenatal care was associated with increased risk, this relationship was not statistically significant. In the multivariate logistic regression model, alcohol consumption (OR = 1.744, p < 0.01), smoking (OR = 2.495, p < 0.01), drug use (OR = 25.500, p < 0.001), and vaginal infections (OR = 4.014, p < 0.01) during pregnancy were independently associated with an increased risk of preterm birth, whereas folic acid supplementation (OR = 0.448, p < 0.05) showed a significant protective effect. These findings highlight that preterm birth is intricately linked to socioeconomic disadvantage and adverse health behaviors. Culture-specific, community-based prevention strategies are essential to reduce perinatal risks in marginalized populations. Full article
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18 pages, 705 KiB  
Article
Vitamin D Supplementation in the Czech Republic: Socioeconomic Determinants and Public Awareness Gaps
by Drahomira Holmannova, Jan Hodac, Lenka Borska, Eva Cermakova and Lenka Hodacova
Nutrients 2025, 17(16), 2623; https://doi.org/10.3390/nu17162623 - 13 Aug 2025
Viewed by 140
Abstract
Background: Vitamin D deficiency is a worldwide health problem associated with various health complications. This study aimed to determine the prevalence of vitamin D supplementation in the Czech Republic, understand reasons for supplementation, and assess participants’ knowledge of vitamin D’s physiological effects. Methods: [...] Read more.
Background: Vitamin D deficiency is a worldwide health problem associated with various health complications. This study aimed to determine the prevalence of vitamin D supplementation in the Czech Republic, understand reasons for supplementation, and assess participants’ knowledge of vitamin D’s physiological effects. Methods: The study included 1812 participants representing the Czech population aged 15+, stratified by gender, age, and regional distribution. Data analysis was performed using SASD 1.5.8, using chi2 independence tests and regression analysis. Results: The results revealed that only 13.5% of the participants maintained regular year-round vitamin D supplementation, while 51.5% never supplemented. A slight increase in supplementation was observed during the pandemic (2020–2021). Supplementation patterns were influenced by socioeconomic factors including age, gender, marital status, income, employment, and education (p > 0.001). Regarding vitamin D knowledge, 67.5% and 65.6% of participants recognized its role in immune system modulation and bone health, respectively. There were minor misconceptions, with 1.4% believing that it aggravates allergies and 1.8% linking it to cancer. Knowledge levels varied with education and residence size. Conclusions: Despite the high prevalence of vitamin D deficiency in the Czech population, regular supplementation remains low, indicating the need for enhanced prevention programs and awareness campaigns. Full article
(This article belongs to the Section Micronutrients and Human Health)
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14 pages, 567 KiB  
Review
An Integrated Strategy for Preventing and Rehabilitating Dust-Induced Occupational Bronchopulmonary Diseases: A Scoping Review
by Alexandr E. Gulyayev, Karlygash S. Absattarova, Sayagul A. Kairgeldina, Raushan S. Dosmagambetova, Kanat K. Tekebayev, Madina B. Baurzhan, Nazym Sagandykova and Gaukhar Sh. Dauletova
Adv. Respir. Med. 2025, 93(4), 30; https://doi.org/10.3390/arm93040030 - 13 Aug 2025
Viewed by 311
Abstract
Background: Occupational bronchopulmonary diseases (OBPDs)—including pneumoconiosis, silicosis, and occupational COPD—remain a pressing public health issue, especially in regions with intensive mining, metallurgy, and construction industries. Caused by chronic inhalation of fibrogenic dusts, these conditions are often diagnosed at late stages, resulting in irreversible [...] Read more.
Background: Occupational bronchopulmonary diseases (OBPDs)—including pneumoconiosis, silicosis, and occupational COPD—remain a pressing public health issue, especially in regions with intensive mining, metallurgy, and construction industries. Caused by chronic inhalation of fibrogenic dusts, these conditions are often diagnosed at late stages, resulting in irreversible lung damage and diminished work capacity. Methods: A scoping review was performed using the Arksey and O’Malley framework, with methodological refinements from the Joanna Briggs Institute. Following PRISMA-ScR guidelines, we searched PubMed, Scopus, and gray literature for publications from 2014 to 2024. After screening 1761 records and full-text review, nine studies were included in the final synthesis, comprising two systematic reviews, two narrative literature reviews, and five observational studies. Results: Key risk factors identified included prolonged exposure to silica and coal dust, tobacco use, and genetic susceptibility. Diagnostic delays were attributed to the underuse of high-resolution CT and exhaled nitric oxide analysis. Several studies highlighted the diagnostic value of oxidative stress and inflammatory markers (e.g., IL-6, TNF-α). Nutritional rehabilitation and polyphenol-enriched herbal therapies were associated with improved respiratory function and quality of life. However, these strategies remain underutilized, particularly in low-resource settings. Conclusions: A coordinated, biomarker-driven approach integrating early diagnosis, dust exposure control, and tailored rehabilitation is urgently needed. Multidisciplinary models may reduce the clinical and socioeconomic burden of OBPDs. Full article
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21 pages, 863 KiB  
Article
Examination of the Factors of Multidimensional Energy Poverty in a Hungarian Rural Settlement
by Mónika Rákos, Laura Mihály-Karnai, Dániel Fróna and Csaba Csetneki
Energies 2025, 18(16), 4287; https://doi.org/10.3390/en18164287 - 12 Aug 2025
Viewed by 217
Abstract
Energy poverty is a multidimensional phenomenon that impairs access to basic energy services and threatens social well-being, particularly in disadvantaged rural communities. This study investigates the extent and drivers of household energy poverty in a Hungarian village through a survey-based analysis (N = [...] Read more.
Energy poverty is a multidimensional phenomenon that impairs access to basic energy services and threatens social well-being, particularly in disadvantaged rural communities. This study investigates the extent and drivers of household energy poverty in a Hungarian village through a survey-based analysis (N = 257) conducted in early 2025. The sample is not nationally representative, however, it reflects approximately 20% of the total village population (1331 inhabitants). This study aims to identify vulnerable household profiles, explore correlations between socio-economic and housing factors and perceived thermal comfort, and compare the effectiveness of multiple measurement indicators the 10% rule, low income high cost, 2M, and M/2. We employ descriptive statistics, Pearson correlation, Fuzzy C-Means clustering, and linear regression, revealing that over half of the sample is energy poor according to the 10% rule, while the LIHC method identifies 29%. Our regression results confirm that cluster membership significantly influences perceived comfort levels (R2 = 0.063, p = 0.002). We conclude that single-indicator approaches are insufficient to capture the nuanced realities of rural energy poverty, therefore, we recommend the development of a rural energy poverty index. Such a tool could help identify affected households and support the formulation of context-sensitive, evidence-based energy and social policy interventions. Full article
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37 pages, 3414 KiB  
Review
Targeting Trypanothione Synthetase and Trypanothione Reductase: Development of Common Inhibitors to Tackle Trypanosomatid Disease
by André Augusto, Inês Costa, Jaime Conceição and Maria L. S. Cristiano
Pharmaceuticals 2025, 18(8), 1182; https://doi.org/10.3390/ph18081182 - 11 Aug 2025
Viewed by 401
Abstract
Neglected Tropical Diseases (NTDs) encompass a range of disorders, including infectious diseases caused by viruses, bacteria, parasites, fungi, and toxins, mainly affecting underprivileged individuals in developing countries. Among the NTDs, those caused by parasites belonging to the Trypanosomatidae family are particularly impacting and [...] Read more.
Neglected Tropical Diseases (NTDs) encompass a range of disorders, including infectious diseases caused by viruses, bacteria, parasites, fungi, and toxins, mainly affecting underprivileged individuals in developing countries. Among the NTDs, those caused by parasites belonging to the Trypanosomatidae family are particularly impacting and require attention, since the lack of financial incentives has led to constraints on the development of novel drugs to tackle them effectively. To circumvent the minor advances in drug discovery in this area, academic research emerges as a crucial player, namely through the identification and validation of new drug targets, thereby contributing to the development of more efficient, safe, and less expensive therapies against Trypanosomatidae infections. Noteworthy, this is a matter of utmost urgency since these diseases are endemic in countries with low socioeconomic standards. This review provides a comprehensive understanding of the current paradigm of NTDs caused by parasites belonging to the Trypanosomatidae family, addressing the ongoing limitations and challenges associated to the current chemotherapy solutions for these diseases and discussing the opportunities unravelled by recent research that led to the identification of new biomolecular targets that are common to Trypanosomatidae parasites. Among these, the unique properties of Trypanothione Synthetase (TryS) and Trypanothione Reductase (TryR), two key protozoan enzymes that are essential for the survival of Trypanosoma and Leishmania parasites, will be emphasised. In addition to a critical analysis of the latest advances in the discovery of novel molecules capable of inhibiting TryS and TryR, the possibility of dual targeting through a combination of TryS and TryR inhibitors will be addressed Full article
(This article belongs to the Collection Feature Review Collection in Medicinal Chemistry)
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34 pages, 8025 KiB  
Article
Impact of Urban Green Space Patterns on Carbon Emissions: A Gray BP Neural Network and Geo-Detector Analysis
by Yao Xiong, Yiyan Sun and Yunfeng Yang
Sustainability 2025, 17(16), 7245; https://doi.org/10.3390/su17167245 - 11 Aug 2025
Viewed by 362
Abstract
Rapid urbanization has altered the land use pattern, reducing urban green space and increasing carbon emissions, and it is critical to scientifically examine the interaction mechanism between green space and carbon emissions in order to drive low-carbon urban development. Using Nanjing as an [...] Read more.
Rapid urbanization has altered the land use pattern, reducing urban green space and increasing carbon emissions, and it is critical to scientifically examine the interaction mechanism between green space and carbon emissions in order to drive low-carbon urban development. Using Nanjing as an example, this study examined the spatiotemporal evolution characteristics of urban green space patterns and carbon emissions between 2000 and 2020. Carbon emissions at the city and county levels were estimated with great precision using a gray BP neural network model and a downscaling decomposition method. Using urban green space landscape pattern indices and geographic detectors, significant driving factors were discovered and their impact on carbon emissions examined. The results show the following: (1) Carbon emissions are mostly influenced by socioeconomic factors, and the gray BP neural network model (R2 = 0.9619, MAPE = 1.68%) can predict outcomes accurately. (2) Between 2000 and 2020, Nanjing’s overall carbon emissions increased by 118.9%, demonstrating a “core–periphery” pattern of spatial divergence, with significant emissions from industrial districts and emission reductions in the central urban region. (3) The urban green space exhibits “quantity decreasing and quality increasing” characteristics, with the total area falling by 4.84% but the structure optimized to form a networked pattern with huge ecological patches as the backbone. (4) The primary drivers are the LPI, COHESION, and AI. This study reveals the complex relationship mechanism between the spatial configuration of urban green space and carbon emissions and, based on the results, proposes a green space optimization framework with three dimensions, protection of core ecological patches, enhancement of connectivity through ecological corridors, and implementation of low-carbon maintenance measures, which will provide a scientific basis for the planning of urban green space and the construction of low-carbon cities in the Yangtze River Delta region. Full article
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14 pages, 2299 KiB  
Article
Spatiotemporal Dynamics of Dengue in the State of Pará and the Socio-Environmental Determinants in Eastern Brazilian Amazon
by Brenda Caroline Sampaio da Silva, Ricardo José de Paula Souza e Guimarães, Bruno Spacek Godoy, Andressa Tavares Parente, Bergson Cavalcanti de Moraes, Marcia Aparecida da Silva Pimentel, Douglas Batista da Silva Ferreira, Emilene Monteiro Furtado Serra, João de Athaydes Silva Junior, Luciano Jorge Serejo dos Anjos and Everaldo Barreiros de Souza
Infect. Dis. Rep. 2025, 17(4), 99; https://doi.org/10.3390/idr17040099 - 11 Aug 2025
Viewed by 298
Abstract
Background: The Amazon biome exhibits complex arboviral transmission dynamics influenced by accelerating deforestation, climate change, and socioeconomic inequities. Objectives/Methods: This study integrates official epidemiological records with socioeconomic, environmental, and climate variables by applying advanced geostatistical methods (Moran’s I, SaTScan, kernel density estimation) combined [...] Read more.
Background: The Amazon biome exhibits complex arboviral transmission dynamics influenced by accelerating deforestation, climate change, and socioeconomic inequities. Objectives/Methods: This study integrates official epidemiological records with socioeconomic, environmental, and climate variables by applying advanced geostatistical methods (Moran’s I, SaTScan, kernel density estimation) combined with principal component analysis and negative binomial regression to assess the spatiotemporal dynamics of dengue incidence and its association with socio-environmental determinants across municipalities in Pará state (eastern Brazilian Amazon) from 2010 to 2024. Results: Dengue incidence showed an overall decline but with marked epidemic peaks in 2010–2012, 2016, and 2024. The spatial analysis revealed significant clustering (Moran’s I = 0.221, p < 0.01), with persistent high-risk hotspots across most of Pará. Of 144 municipalities, 104 exhibited significant dengue risk, while 58 maintained sustained transmission. Negative binomial regression model identified key determinants: illiteracy, low urbanization, reduced GDP, and climate variables. Conclusions: Dengue transmission in the Amazon is driven by synergistic socio-environmental disruptions, necessitating intersectoral policies that bridge public health surveillance, sustainable land-use governance, and poverty alleviation. Priority actions include targeted vector control in high-risk clusters, coupled with integrated deforestation and climate monitoring to predict outbreak risks. The findings emphasize the urgency of implementing multisectoral interventions tailored to the territorial and socio-environmental complexities of vulnerable Amazonian regions for effective dengue control. Full article
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20 pages, 543 KiB  
Article
More than a Feeling: Self-Esteem as a Predictor of Life Satisfaction in Adolescents: A Cross-Sectional Analysis in Saudi Arabia
by Hawa Alabdulaziz
Children 2025, 12(8), 1046; https://doi.org/10.3390/children12081046 - 9 Aug 2025
Viewed by 280
Abstract
Introduction: Prior research underscores self-esteem as a core determinant of life satisfaction and overall well-being. However, few studies have examined this relationship within the unique sociocultural context of Saudi Arabia. This study assesses the relationship between self-esteem and life satisfaction in adolescents, as [...] Read more.
Introduction: Prior research underscores self-esteem as a core determinant of life satisfaction and overall well-being. However, few studies have examined this relationship within the unique sociocultural context of Saudi Arabia. This study assesses the relationship between self-esteem and life satisfaction in adolescents, as well as the potential moderating effects of demographic factors. Methods: A cross-sectional study was conducted involving 502 adolescents aged 13–18, selected from urban and rural regions of Saudi Arabia. Participants completed the Rosenberg Self-Esteem Scale and the Satisfaction with Life Scale. Data were collected via online survey platforms. Descriptive statistics, correlation analyses, chi-square tests, and multivariate logistic regressions were performed using SPSS version 26. Ethical approval was obtained, and informed consent was secured from all participants. Results: A significant positive correlation was found between life satisfaction and self-esteem scores (r = 0.37, p < 0.001). Adolescents reporting dissatisfaction with life had over seven times greater odds of low self-esteem (OR = 7.2; 95% CI: 3.75–13.83). Higher life satisfaction was associated with being in secondary education, having a family income of 10,000 Saudi Riyal (SR) or more, and living with both parents. Additionally, prior contact with a psychologist was linked to lower self-esteem and reduced life satisfaction. Conclusions: Findings confirm self-esteem as a strong predictor of life satisfaction among Saudi adolescents. Socioeconomic status, family structure, and previous psychological consultation also influenced outcomes. These results emphasize the critical need for culturally sensitive mental health interventions tailored to the Saudi context. Furthermore, they highlight the importance of implementing early mental health screening and support programs within schools to provide accessible and preventive care for youth. Full article
(This article belongs to the Section Pediatric Mental Health)
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