Search Results (14,982)

The persistence and hazardous potential of polycyclic aromatic hydrocarbons (PAHs), with compounds such as anthracene and phenanthrene, raise significant concerns about human health and environmental safety. PAHs are ubiquitous environmental pollutants originating from natural processes and anthropogenic activities, notably fossil fuel combustion. Due to their stability, they tend to accumulate in ecosystems, posing risks to wildlife and human health through bioaccumulation and potential carcinogenicity. Conventional remediation techniques, such as physical adsorption and biological treatment, often fall short in their efficiency and long-term sustainability. Thus, there is an urgent need for innovative methods that can effectively degrade these persistent organic pollutants. Here, we reviewed recent advancements in the photocatalytic degradation of anthracene and phenanthrene, with a focus on metal oxide-based nanocomposites. The major points were: (1) Metal oxides such as TiO₂, ZnO, and CuO, recognized for their photocatalytic properties (they show significantly enhanced efficiency when utilized as a part of nanocomposites, primarily due to the improved charge separation, increased surface area, and numerous active sites); (2) The review of the photocatalytic mechanisms involved in PAH degradation, particularly through the generation of reactive oxygen species that can break down anthracene and phenanthrene into less harmful compounds; and (3) The insights into the formed intermediates and reaction pathways, which can help to deepen the understanding of PAH breakdown and support the design of more efficient catalytic systems for future environmental remediation applications. Full article

Flood risk assessment is essential for flood control and disaster mitigation in arid and semi-arid river basins, where conventional univariate and bivariate frequency analyses struggle to capture nonlinear dependence among flood variables and often underestimate extreme synergistic risks. This study focuses on the Wulanmulun River Basin in Inner Mongolia and employs long-term observations from the Zuanlongwan and Wangdaohengta hydrological stations. A trivariate D-vine Copula model was constructed to jointly characterize peak discharge, total flood volume, and water level. Optimal vine structures differ between the stations (Qp–H–W and W–Qp–H) and outperform traditional Copula models in representing extreme joint risks. The ternary joint return periods reveal two distinct flood risk transmission modes, “jump” and “accumulation”, and joint exceedance probabilities under low, medium, high, and ultra-high-risk scenarios are 6.4%, 31.95%, 37.64%, and 5.75% at Zuanlongwan, and 4.7%, 35.24%, 45.78%, and 0.53% at Wangdaohengta, indicating concentration in medium-to-high risk ranges. The validation at Longtouguai Station showed an error RSME of 0.0630 and an R² of 0.905, confirming the reliability of the model framework. These results indicate that the proposed framework can effectively capture multivariate flood dependencies and provide a scientific basis for flood control design, risk zoning, and emergency management of small and medium rivers in arid and semi-arid regions. Full article

Wound healing in cosmetological and aesthetic surgery extends beyond tissue closure to achieving rapid regeneration, minimal scarring, and restoration of functional skin architecture. However, conventional wound care strategies inadequately regulate the complex wound microenvironment required for optimal cosmetic outcomes, leading to prolonged healing times and suboptimal aesthetic results, which can negatively impact patient satisfaction and increase the risk of complications. Phytochemicals exhibit multifunctional bioactivities, such as antioxidant, anti-inflammatory, antimicrobial, and pro-regenerative effects, but their clinical translation faces obstacles due to poor solubility, stability, and bioavailability. Nanotechnology-based delivery systems have emerged as a critical enabling strategy to overcome these limitations. This narrative review provides an updated, mechanistically integrated synthesis of phytochemical-loaded nanotherapeutics, including polymeric nanoparticles, nanohydrogels, nanofibers, and lipid- and vesicle-based systems, with a specific focus on their roles in modulating key wound-healing pathways, such as inflammation resolution, angiogenesis, collagen remodelling, and re-epithelialization. Evidence from preclinical studies consistently demonstrates that nano-enabled phytochemicals enhance therapeutic efficacy, improve skin penetration, and contribute to superior cosmetic outcomes, particularly by reducing fibrosis and scar formation. However, critical gaps remain, including limited high-quality clinical evidence, a lack of standardized formulation design, variability in reported outcomes, and unresolved concerns regarding long-term safety and regulatory translation. Taken together, the key insight of this review is that phytochemical-loaded nanotherapeutics represent a promising but still transitional strategy, biologically compelling at the preclinical level yet clinically under-validated. Bridging this gap requires rigorously designed clinical trials, quantitative outcome reporting, and balanced regulatory frameworks. Advancing these areas will be essential to translate nano-enabled phytochemicals from experimental systems into reliable, evidence-based solutions for cosmetological wound management. Full article

Groundwater is a critical lifeline for ecosystems and human settlements in arid and semi-arid regions, yet it is increasingly vulnerable to the dual pressures of extreme climatic conditions and intensifying anthropogenic activities. This study investigated 24 groundwater and 4 river water samples to discuss the hydrogeochemical evolution and water quality suitability in the Tianjun Basin, a typical high-altitude arid basin on the northeastern Tibetan Plateau. The results indicate that groundwater is mildly alkaline (pH: 7.65–8.35) and predominantly fresh (TDS: 233.77–1061.42 mg/L). Hydrochemical facies evolve from HCO₃-Ca type in upstream areas to Mixed HCO₃-Na·Ca and Cl-Na types. Hydrochemical analysis suggests that silicate weathering and carbonate dissolution are the dominant natural processes, while cation exchange further modifies the ionic composition. Notably, anthropogenic nitrogen (NO₃⁻ and NH₄⁺) contamination, primarily from domestic sewage in the Tianjun Basin, has significantly impacted groundwater quality. Health risk assessment shows that infants are the most vulnerable group, with 16.67% of samples posing a non-carcinogenic risk via the oral pathway. Regarding irrigation suitability, while sodium hazards are generally low, a significant salinity hazard is identified due to elevated electrical conductivity in the arid environment. This poses a substantial risk of secondary soil salinization, necessitating strict salt management strategies to preserve long-term land productivity. These findings provide critical insights for the sustainable management of fragile groundwater resources in extreme arid environments. Full article

The interaction between crude oil prices and exchange rates is central to understanding global financial stability and macro-economic balances. Contrary to traditional static analyses, the heterogeneous market hypothesis argues that market participants have different time horizons and that multi-scale analysis is necessary to capture dynamic changes in crisis periods. This study examines volatility spillovers between WTI crude oil and the Russian ruble using wavelet coherence, phase difference, and predictive information flow analysis in a time–frequency framework. The analysis separates short-term [2–32 days] transient shocks from long-term [32–256 days] structural changes. Findings show that a negative spillover, initially led by WTI, with evidence of dynamic, frequency-dependent leadership shifts during the 2020 shock, was interpreted as a result of the overnight price gap and a failure of microstructural synchronisation. With the outbreak of the 2022 Russia–Ukraine war, the relationship shifted to a strong, positive, and high-intensity risk transfer, consistent with contagion theory. Crucially, by 2024, a structural decoupling emerged due to geoeconomic fragmentation, signalling that the ruble no longer exhibits traditional petro-currency behaviour. These results offer critical signals for policymakers regarding reserve management and for market participants regarding new liquidity risks. Full article

Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a rare inherited disorder characterized by extreme epithelial fragility and progressive cicatrization, frequently leading to severe ocular surface disease and early visual impairment. Surgical interventions such as ocular surface reconstruction (OSR) in childhood are often delayed because of anesthetic risks and concerns regarding recurrence. Consequently, the effectiveness of OSR, including amniotic membrane transplantation (AMT), and its impact on visual development remain poorly documented. Methods: We report a case series of two pediatric patients (three eyes) with genetically confirmed RDEB who underwent single-step OSR using AMT. Clinical outcomes, long-term visual acuity, perioperative management, and histopathological findings were evaluated. Results: Ocular manifestations included corneal epithelial damage, symblepharon, and pseudopterygium extending over the cornea. One patient underwent symblepharon lysis, superficial keratectomy, and AMT onto the bare sclera in the right eye at age 4 and in the left eye at age 8, both under intubated general anesthesia. The other patient underwent the same procedure in the right eye at age 6. Best spectacle-corrected visual acuity improved from ≤20/300 to 20/30 in all eyes, and pupillary zone clarity was maintained during the follow-up period (up to 6 years). Histopathology confirmed pseudopterygium with squamous metaplasia, goblet cell loss, and fibrovascular stroma. Safe general anesthesia was achieved through meticulous multidisciplinary perioperative planning involving anesthesiologists, dermatologists, and pediatricians. No systemic complications related to anesthesia or perioperative management were observed. Conclusions: Single-step OSR with on-lay AMT can restore and preserve visual function in pediatric RDEB. Early surgical intervention may prevent profound amblyopia and provide durable ocular surface stability. A multidisciplinary approach enables safe general anesthesia and perioperative management. Full article

Background and Clinical Significance: Blunt ocular trauma is a significant but often underestimated cause of visual impairment, particularly among adolescents involved in high-risk activities such as horseback riding. While most equestrian injuries affect the head and extremities, ocular trauma, especially commotio retinae, can result in severe visual complications. Case Presentation: We report the case of a 15-year-old girl who sustained blunt ocular trauma to the left eye following a fall from a horse and presented with decreased visual acuity. Multimodal imaging revealed outer retinal abnormalities on spectral-domain optical coherence tomography (OCT), including ellipsoid zone irregularities. Early-phase fluorescein angiography showed central hypofluorescence in the foveal region with surrounding mild mottled hyperfluorescence, without clear vascular abnormalities. Fundus photography demonstrated subtle macular changes. Visual acuity improved significantly following treatment, with partial resolution of macular changes, although mild outer retinal irregularities persisted on follow-up imaging. Conclusions: These findings underscore the importance of early ophthalmic evaluation and advanced retinal imaging in blunt ocular trauma. Given the high risk of visual injury during equestrian activities, especially in pediatric and adolescent populations, preventive strategies such as mandatory helmet use and rider education are essential. Implementation of standardized follow-up protocols is also recommended to monitor long-term retinal changes in patients with traumatic maculopathy. Full article

This study analyzes whole-body vibration (WBV) exposure of an agricultural tractor operator during three different primary tillage systems: Standard Tillage (ST), Conservation Tillage Deep (CTD), and Conservation Tillage Shallow (CTS). Measurements were conducted in accordance with ISO 2631-1 and ISO 2631-4 along three orthogonal axes (x, y and z) at the operator’s seat. Descriptive and inferential statistical analyses indicate that while none of the mean vibration values exceeded the regulatory limit value of 1.15 m/s² defined in Directive 2002/44/EC, several measurements—particularly in the y-axis during ST (0.715 m/s²)—surpassed the exposure action value of 0.5 m/s². These findings suggest that prolonged daily exposure under similar operational conditions may pose long-term health risks for tractor operators. The highest mean WBV values were recorded in the x- and y-axes during CTS (0.354 m/s² and 0.446 m/s², respectively), whereas the z-axis exhibited the highest values during ST (0.426 m/s²). Conservation Tillage Deep (CTD) demonstrated the most favorable vibration profile in the vertical axis (0.344 m/s²), indicating its potential dual benefit for soil structure preservation and operator ergonomics. Although all measured values remained below the regulatory limit, the frequent exceedance of the action value underscores the importance of exposure time management, regular maintenance of suspension systems, and implement selection as practical mitigation strategies. This comparative assessment provides baseline WBV data for reduced-tillage systems on hydromorphic soils and offers axis-specific guidance for optimizing operator comfort in sustainable mechanization practices. Full article

Polyurethane (PU) is a highly versatile class of polymer utilised in many industries, including the aerospace sector. In conjunction with its superior mechanical properties, chemical resistance, and durability, it can be highly flammable depending on its form. This poses a risk aboard aircraft, which contain numerous fire hazards and cramped cabin spaces, proving an obstacle for the evacuation of passengers in an emergency. Flame-retardant additives have proven to enhance the thermal properties of polyurethane, but their toxicity and tendency to degrade mechanical performance make them unappealing. This review addresses three main topics: (1) the basic synthesis and structure of PU and modification through additives; (2) types of PU, their properties, and applications in the aerospace industry; and (3) evaluation methodologies for characterising PU performance, studying mechanical properties and thermal degradation. Several key challenges remain, including understanding the long-term durability of modified PU, optimising between fire performance and mechanical properties, improving the sustainability of PU throughout its lifetime, and validating numerical simulation as a viable testing method. This review aims to guide future research on modified PU technology to achieve safer, high-performing, and sustainable solutions for the aerospace industry and beyond. Full article

The Bacillus Calmette–Guérin (BCG) vaccine, originally developed for tuberculosis (TB) prevention, has recently attracted attention due to its broader immunomodulatory properties. In addition to its role in TB control, BCG induces trained immunity, a process involving epigenetic and metabolic reprogramming of innate immune cells that leads to altered systemic inflammatory responses. Increasing evidence suggests that these long-term immune adaptations may influence the central nervous system by modulating microglial activation and neuroinflammatory pathways implicated in neurodegenerative diseases. In parallel, chronic infections such as TB are associated with persistent systemic inflammation and immune dysregulation, which may contribute to microglial priming and increased vulnerability to neurodegeneration. This narrative review, based on a targeted literature search of PubMed, Scopus, Web of Science, Embase, and relevant preprint servers, synthesizes current evidence on the relationships between BCG vaccination, trained immunity, and neuroimmune interactions. We focus on studies addressing systemic immune reprogramming, microglial responses, and neuroinflammatory mechanisms relevant to neurodegenerative disorders. The available data suggest that BCG-induced immune modulation may exert context-dependent effects on the brain, with potential neuroprotective implications under certain conditions. However, the evidence remains heterogeneous and largely observational, and causality cannot yet be established. Further mechanistic and prospective studies are required to clarify whether BCG-induced trained immunity can modify the risk or progression of age-related neurodegenerative diseases. Full article

Background: Standardised Ashwagandha root extract (SARE), characterised by its content of bioactive withanolides, is widely used for its antioxidant and adaptogenic properties; however, recent case reports have raised safety concerns, primarily involving non-standardised or multi-ingredient formulations. This systematic review evaluated the safety and tolerability of SARE in healthy adults, with a focus on clinical biomarkers and adverse event reporting. Methods: Randomised trials were identified through searches of PubMed, Web of Science and Google Scholar, published from 2010 to April 2026. Studies administering single-ingredient, standardised root-only extracts to generally healthy populations were included. Risk of bias was assessed using the Cochrane RoB 2 tool. Results: Twenty-three studies with a total of 2317 participants met the inclusion criteria, with doses ranging from 125 to 600 mg/day and intervention durations from a single dose to 180 days. Across studies, hepatic, renal, haematological, endocrine, and cardiovascular biomarkers remained within normal clinical ranges, with no clinically meaningful adverse alterations reported. Reductions in cortisol were consistently observed, while increases in testosterone remained within physiological ranges. No serious adverse events attributable to SARE were reported. Mild adverse events, including gastrointestinal discomfort, headache, and transient drowsiness, were infrequently reported and occurred in both intervention and comparator groups. Conclusions: SARE was well tolerated in healthy adults at the studied doses and durations. However, limited long-term data (>180 days) and heterogeneity in study design and reporting warrant further large-scale, standardised trials to confirm safety across extended use and diverse populations. The review is registered in the PROSPERO database with ID CRD420261337116. Full article

Formaldehyde (HCHO) is a typical volatile organic compound (VOC) that poses significant risks to human health. Long-term exposure, even at low concentrations, has been associated with various malignant diseases, including nasopharyngeal, colon, and brain cancers. Common technologies for HCHO abatement include ventilation, adsorption, photocatalysis, and catalytic oxidation. Among these methods, catalytic oxidation is regarded as the most promising due to its high removal efficiency, low cost, minimal energy consumption, and no toxic by-products. In recent years, supported catalysts with excellent room-temperature activity and high dispersibility have attracted considerable attention. These catalysts can usually be divided into two categories: noble metal catalysts and non-noble metal catalysts. Zirconia (ZrO₂) has become an ideal support owing to its advantages of high specific surface area, abundant and tunable acid–base sites, and strong metal–support interaction (SMSI). Various modification strategies have been developed to improve the catalytic performance of ZrO₂-based systems, such as the construction of phase interfaces and the stabilization of single-atom species. This review summarizes the recent research progress of ZrO₂-based systems for the catalytic oxidation of formaldehyde. It provides a detailed discussion of the physicochemical properties of ZrO₂ supports and the reaction mechanisms involved, and highlights achievements in crystal phase regulation, elemental doping, metal–support interaction, and composite modification. Finally, future challenges and development directions for these catalysts are also outlined. Full article

As life expectancy for people living with human immunodeficiency virus (HIV) (PLWH) increases, long-term comorbidities, such as bone mineral density (BMD) loss, have emerged as significant clinical challenges. This study evaluated the prevalence and determinants of skeletal demineralization in a contemporary Romanian HIV cohort. A cross-sectional study was conducted among 180 PLWH (mean age 41.86 ± 12.69 years) undergoing stable antiretroviral therapy. Bone health was assessed via dual-energy X-ray absorptiometry (DXA), while body composition and metabolic status were evaluated using bioelectrical impedance analysis (BIA) and serum lipid profiling. A high prevalence of reduced skeletal mass (58.3%) was observed, with 10% of the cohort diagnosed with osteoporosis at a mean age of only 45.7 years. Significant correlations were identified between osteoporosis and a history of AIDS, active smoking, and hypertriglyceridemia. Notably, women with osteoporosis exhibited significantly lower current CD4+ T-cell counts (268.4 ± 180.5 cells/μL) compared to those with normal BMD. While the body mass index was an inconsistent predictor of bone health, BIA-derived bone mass effectively identified subclinical depletion. Our findings underscore a phenotype of premature skeletal aging in PLWH, driven by an interplay of immunological history, metabolic disturbances, and lifestyle factors. Early screening via DXA and BIA, alongside aggressive management of modifiable risks, is essential for mitigating fragility fractures in this aging population. Full article

Hypertension is a major risk factor for cardiovascular disease and requires effective long-term monitoring. Photoplethysmography (PPG), acquired from wearable optical sensors, offers a convenient and non-invasive signal source for cuffless blood pressure (BP) estimation, but existing studies have mainly emphasized model architecture optimization, with limited systematic investigation of signal representation. This study systematically compares seven one-dimensional-to-two-dimensional signal transformation methods and evaluates multiple architectural variants for PPG-based cuffless BP estimation under a unified framework. Experiments were conducted using PPG and arterial BP signals from the UCI Open Blood Pressure Database. The best-performing configuration, based on continuous wavelet transform (CWT), achieved estimation errors of 3.80 ± 5.02 mmHg for systolic BP and 1.65 ± 2.70 mmHg for diastolic BP. Further real-world validation on 26 participants using an Omron cuff-based monitor as the reference showed good consistency, with correlation coefficients of R = 0.96 for SBP and R = 0.74 for DBP. The results demonstrate that appropriate signal representation, particularly CWT, plays a critical role in improving estimation accuracy and robustness, and may facilitate the development of wearable cuffless BP monitoring systems. Full article

Background: Cotton straw returning (CSR) is widely implemented in Xinjiang to achieve in situ residue utilization and ameliorate saline–alkali soils. However, its long-term efficacy in improving soil fertility without inducing secondary salinization remains poorly understood. Methods: This study evaluated the effects of different CSR durations on soil physicochemical properties and cotton yield across four major cotton-growing regions of Xinjiang, China (Shawan, Wusu, Manas, and Shihezi). Cotton fields with different CSR durations were classified into four treatments: CK (0 years), T1 (5 years), T2 (10 years), and T3 (20 years). Soil bulk density (BD), exchangeable sodium percentage (ESP), and key soil fertility indicators were measured to assess comprehensive soil fertility and soil secondary salinization risk. Results: CSR generally enhanced soil physicochemical properties, but responses exhibited spatial heterogeneity. Soil BD decreased in Wusu and Shihezi but showed temporary increases in Manas and Shawan. SFI increased continuously with CSR duration in Shawan and Wusu, whereas it peaked at around 10 years in Shihezi and Manas. Cotton yield was highest under the 20-year treatment in Manas but peaked under the 10-year treatment in the other regions. Notably, prolonged CSR (>10 years) elevated ESP in some areas, suggesting an increased risk of secondary salinization. Conclusions: A CSR duration of roughly 10 years appears optimal for balancing soil amelioration and salinity control in saline–alkali cotton fields of Xinjiang. Full article