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Article

51 Citations

8,815 Views

12 Pages

Discovery and in Vivo Evaluation of Novel RGD-Modified Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery

Yinbo Zhao,
Dayong Lin,
Fengbo Wu,
Li Guo,
Gu He,
Liang Ouyang,
Xiangrong Song,
Wei Huang and
Xiang Li

Int. J. Mol. Sci.2014, 15(10), 17565-17576;https://doi.org/10.3390/ijms151017565

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29 September 2014

In the current study, the lipid-shell and polymer-core hybrid nanoparticles (lpNPs) modified by Arg–Gly–Asp(RGD) peptide, loaded with curcumin (Cur), were developed by emulsification-solvent volatilization method. The RGD-modified hybrid nanoparticl...

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Article

24 Citations

4,344 Views

16 Pages

In Vitro and In Vivo Effect of pH-Sensitive PLGA-TPGS-Based Hybrid Nanoparticles Loaded with Doxorubicin for Breast Cancer Therapy

Renata S. Fernandes,
Raquel Gregório Arribada,
Juliana O. Silva,
Armando Silva-Cunha,
Danyelle M. Townsend,
Lucas A. M. Ferreira and
André L. B. Barros

Pharmaceutics2022, 14(11), 2394;https://doi.org/10.3390/pharmaceutics14112394

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6 November 2022

Doxorubicin (DOX) is an antineoplastic agent clinically employed for treating breast cancer patients. Despite its effectiveness, its inherent adverse toxic side effects often limit its clinical application. To overcome these drawbacks, lipid–po...

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