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Review

16 Citations

7,573 Views

15 Pages

Total Synthesis of Bioactive Marine Meroterpenoids: The Cases of Liphagal and Frondosin B

Yan Zong,
Weijia Wang and
Tao Xu

Mar. Drugs2018, 16(4), 115;https://doi.org/10.3390/md16040115

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31 March 2018

Liphagal and frondosin B are two marine-derived secondary metabolites sharing a very similar polyfused-benzofuran skeleton. The two tetracyclic meroterpenoids were isolated from marine sponges, both featuring a 6-5-7-6 fused ring system. A preliminar...

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Article

11 Citations

6,171 Views

12 Pages

Molecular Dynamics Simulations to Investigate the Binding Mode of the Natural Product Liphagal with Phosphoinositide 3-Kinase α

Yanjuan Gao,
Ying Ma,
Guangde Yang and
Yiping Li

Molecules2016, 21(7), 857;https://doi.org/10.3390/molecules21070857

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29 June 2016

Phosphatidylinositol 3-kinase α (PI3Kα) is an attractive target for anticancer drug design. Liphagal, isolated from the marine sponge Aka coralliphaga, possesses the special “liphagane” meroterpenoid carbon skeleton and has been demonstrated as a PI3...

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