Search Results (341)

Background/Objectives: In many parts of the world, pharmacists hold the primary responsibility for providing safe and effective pharmacotherapy. A key aspect is the availability of appropriate medicines for each individual patient. When industrially manufactured medicines are unsuitable or unavailable, pharmacists can prepare tailor-made medicines. While this principle applies globally, practices vary between countries. In the Netherlands, the preparation of medicines in pharmacies is well-established and integrated into routine healthcare. This narrative review explores the role and significance of extemporaneous compounding, pharmacy preparations and related product care in the Netherlands. Methods: Pharmacists involved in pharmacy preparations across various professional sectors, including community and hospital pharmacies, central compounding facilities, academia, and the professional pharmacists’ organisation, provided detailed and expert insights based on the literature and policy documents while also sharing their critical perspectives. Results: We present arguments supporting the need for pharmacy preparations and examine their position and role in community and hospital pharmacies in the Netherlands. Additional topics are discussed, including the regulatory and legal framework, outsourcing, quality assurance, standardisation, education, and international context. Specific pharmacy preparation topics, often with a research component and a strong focus on product care, are highlighted, including paediatric dosage forms, swallowing difficulties and feeding tubes, hospital-at-home care, reconstitution of oncolytic drugs and biologicals, total parenteral nutrition (TPN), advanced therapy medicinal products (ATMPs), radiopharmaceuticals and optical tracers, clinical trial medication, robotisation in reconstitution, and patient-centric solid oral dosage forms. Conclusions: The widespread acceptance of pharmacy preparations in the Netherlands is the result of a unique combination of strict adherence to tailored regulations that ensure quality and safety, and patient-oriented flexibility in design, formulation, and production. This approach is further reinforced by the standardisation of a broad range of formulations and procedures across primary, secondary and tertiary care, as well as by continuous research-driven innovation to develop new medicines, formulations, and production methods. Full article

Over the past years, increasing attention has been drawn to the adverse effects of agricultural pesticide use on pollinators, with honeybees being especially vulnerable. The aim of this study was to evaluate the levels of residues detectable and/or quantifiable of neonicotinoid pesticides and other pesticides in biological materials (bees, bee brood, etc.) and beehive products (honey, pollen, etc.) applied as seed dressings in rapeseed and sunflower plants in two growing seasons (2020–2021) in fields located in three agro-climatic regions in Romania. The study involved the comparative sampling of hive products (honey, pollen, adult bees, and brood) from experimental and control apiaries, followed by pesticide residue analysis in an accredited laboratory (Primoris) using validated chromatographic techniques (LC-MS/MS and GC-MS). Toxicological analyses of 96 samples, including bees, bee brood, honey, and pollen, confirmed the presence of residues in 46 samples, including 10 bee samples, 10 bee brood samples, 18 honey samples, and 8 pollen bread samples. The mean pesticide residue concentrations detected in hive products were 0.032 mg/kg in honey, 0.061 mg/kg in pollen, 0.167 mg/kg in bees, and 0.371 mg/kg in bee brood. The results highlight the exposure of honeybee colonies to multiple sources of pesticide residue contamination, under conditions where legal recommendations for the controlled application of agricultural treatments are not followed. The study provides relevant evidence for strengthening the risk assessment framework and underscores the need for adopting stricter monitoring and regulatory measures to ensure the protection of honeybee colony health. Full article

Energy-intensive industries (EIIs) face mounting pressure to reduce greenhouse gas emissions while maintaining international competitiveness—a balance that is central to achieving the EU’s 2030 and 2050 climate objectives. In this context, energy management (EM) emerges as a strategic instrument to decouple industrial growth from fossil energy consumption. This study proposes a redefinition of EM to support carbon-neutral supply chains within the European Union’s EIIs, addressing critical limitations of conventional EM frameworks under increasingly stringent carbon regulations. Using a modified systematic literature review based on PRISMA methodology, complemented by expert insights from EU Member States, this research identifies structural gaps in current EM practices and highlights opportunities for integrating sustainable innovations across the whole industrial value chain. The proposed EM concept is validated through an analysis of 24 EM definitions, over 170 scientific publications, and over 80 EU legal and strategic documents. The framework incorporates advanced digital technologies—including artificial intelligence (AI), the Internet of Things (IoT), and big data analytics—to enable real-time optimisation, predictive control, and greater system adaptability. Going beyond traditional energy efficiency, the redefined EM encompasses the entire energy lifecycle, including use, transformation, storage, and generation. It also incorporates social dimensions, such as corporate social responsibility (CSR) and stakeholder engagement, to cultivate a culture of environmental stewardship within EIIs. This holistic approach provides a strategic management tool for optimising energy use, reducing emissions, and strengthening resilience to regulatory, environmental, and market pressures, thereby promoting more sustainable, inclusive, and transparent supply chain operations. Full article

Video surveillance systems have become pervasive in contemporary society, prompting growing concerns about their psychological and behavioral effects on individuals. This study investigates how perceived surveillance influences self-censorship and behavioral regulation in monitored environments, drawing on the conceptual framework of panoptic self-regulation and surveillance-induced anxiety. A structured questionnaire was administered to 358 university students, and data were analyzed using exploratory and confirmatory factor analysis to validate latent constructs, followed by ordinal logistic regression and mediation analysis to test key hypotheses. The results indicate that individuals who perceive higher psychological pressure due to surveillance are more likely to modify their behavior, exhibiting heightened self-awareness and restraint. Additionally, belief in the active monitoring of surveillance footage significantly amplifies behavioral vigilance. The perception of the technological omnipresence of surveillance further intensifies psychological discomfort, which mediates behavioral change. These findings conceptualize video surveillance as a socio-technical system that exerts behavioral influence through internalized psychological mechanisms. The study highlights the importance of considering the unintended consequences of surveillance technologies on autonomy and freedom, and it suggests that regulatory frameworks should account not only for legal compliance but also for the psychological impact of surveillance. The results provide empirical support for viewing surveillance systems as dynamic regulators of human behavior. Full article

This article examines how governance structures and procedural timing influence the effectiveness of Territorial Management Instruments (TMIs) in Portugal. Anchored in a comparative analysis of two key legal reforms (Decree-Law No. 380/1999 and Decree-Law No. 80/2015), the study explores the tensions between democratic legitimacy and regulatory complexity. While the 1999 framework emphasized vertical coordination and participatory rights, it often led to procedural rigidity and institutional inertia. Conversely, the 2015 reform promoted digital tools and streamlined processes but introduced new governance gaps, reduced stakeholder diversity, and compressed consultation timelines. Drawing on a qualitative analysis of legal texts, policy documents, and technical documentation, the article introduces the concept of temporal governance, the idea that planning time is not merely a constraint but a governable resource. Through this lens, planning delays are reframed as either pathological (caused by inefficiency and fragmentation) or productive (used strategically to enhance environmental assessment and stakeholder engagement). A new conceptual framework is proposed to classify types of planning time, differentiate delays, and support temporal calibration in governance design. Findings show that effective planning outcomes hinge not only on legal architecture or participatory norms but also on the institutional ability to balance speed with deliberation and strategic foresight with procedural pragmatism. The paper concludes by calling for adaptive governance models that integrate time as a dynamic dimension of spatial planning, with implications for environmental resilience, democratic value, and, above all, institutional trust. Full article

This article examines the level of inconsistency in work, health and safety (WHS) laws across Australia’s mining sector. Despite general efforts towards national harmonisation through model WHS legislation, significant inconsistencies persist because individual states and territories retain primary regulatory control. A critical analysis of each jurisdiction’s legislative framework reveals a fragmented legal landscape. Queensland, especially, exhibits notable divergence. Key findings highlight a considerable variation in legislative approaches to risk management principles and specific obligations. In particular, a disjointed and incremental approach to serious offences such as industrial manslaughter and provisions concerning imputed conduct are evident. These inconsistencies suggest that corporations operating in multiple Australian mining regions must develop a nuanced understanding of the varying WHS requirements in each jurisdiction. This study underscores the need for caution when assessing risk management strategies aimed at preventing serious incidents because the presumption of a harmonised system can be misleading, especially concerning mining-specific legislation. Full article

Freshwater ecosystems face escalating degradation, demanding real-time, scalable, and biodiversity-aware monitoring solutions. This review proposes an integrated framework combining artificial intelligence (AI), geographic information systems (GISs), and environmental DNA (eDNA) to overcome these limitations and support next-generation river health assessment. The AI-GIS-eDNA system was applied to four representative river basins—the Mississippi, Amazon, Yangtze, and Danube—demonstrating enhanced predictive accuracy (up to 94%), spatial pollution mapping precision (85–95%), and species detection sensitivity (+18–30%) compared to conventional methods. Furthermore, the framework reduces operational costs by up to 40%, highlighting its potential for cost-effective deployment in low-resource regions. Despite its strengths, challenges persist in the areas of regulatory acceptance, data standardization, and digital infrastructure. We recommend legal recognition of AI and eDNA indicators, investment in explainable AI (XAI), and global data harmonization initiatives. The integrated AI-GIS-eDNA framework offers a scalable and policy-relevant tool for adaptive freshwater governance in the Anthropocene. Full article

The use of artificial intelligence (AI) in dermatology is skyrocketing, but a comprehensive overview integrating regulatory, ethical, validation, and clinical issues is lacking. This work aims to review current research, map applicable legal regulations, identify ethical challenges and methods of verifying AI models in dermatology, assess publication trends, compare the most popular neural network architectures and datasets, and identify good practices in creating AI-based applications for dermatological use. A systematic literature review is conducted in accordance with the PRISMA guidelines, utilising Google Scholar, PubMed, Scopus, and Web of Science and employing bibliometric analysis. Since 2016, there has been exponential growth in deep learning research in dermatology, revealing gaps in EU and US regulations and significant differences in model performance across different datasets. The decision-making process in clinical dermatology is analysed, focusing on how AI is augmenting skin imaging techniques such as dermatoscopy and histology. Further demonstration is provided regarding how AI is a valuable tool that supports dermatologists by automatically analysing skin images, enabling faster diagnosis and the more accurate identification of skin lesions. These advances enhance the precision and efficiency of dermatological care, showcasing the potential of AI to revolutionise the speed of diagnosis in modern dermatology, sparking excitement and curiosity. Then, we discuss the regulatory framework for AI in medicine, as well as the ethical issues that may arise. Additionally, this article addresses the critical challenge of ensuring the safety and trustworthiness of AI in dermatology, presenting classic examples of safety issues that can arise during its implementation. The review provides recommendations for regulatory harmonisation, the standardisation of validation metrics, and further research on data explainability and representativeness, which can accelerate the safe implementation of AI in dermatological practice. Full article

Legal requirements for minimum distances between vehicles are often not met for short periods of time, especially when changing lanes on multi-lane roads. These situations are typically non-hazardous, as human drivers anticipate surrounding traffic, allowing for shorter headways and improved traffic flow. Automated vehicles (AVs), however, are typically designed to maintain strict headway limits, potentially reducing traffic efficiency. Therefore, legal questions arise as to whether mandatory gap and headway limits for AVs may be violated during periods of non-compliance. While traffic flow simulation is a common method for analyzing AV impacts, previous studies have typically modeled AV behavior using driver models originally designed to replicate human driving. These models are not well suited for representing clearly defined, structured non-compliant maneuvers, as they cannot simulate intentional, rule-deviating strategies. This paper addresses this gap by introducing a concept for AV non-compliant behavior and implementing it as a module within a pre-existing AV driver model. Simulations were conducted on a three-lane highway with an on-ramp under varying traffic volumes and AV penetration rates. The results showed that, with an AV-penetration rate of more than 25%, road capacity at highway entrances could be increased and travel times reduced by over 20%, provided that AVs were allowed to merge with a legal gap of 0.9 s and a minimum non-compliant gap of 0.6 s lasting up to 3 s. This suggests that performance gains are achievable under adjusted legal requirements. In addition, the proposed framework can serve as a foundation for further development of AV driver models aiming at improving traffic efficiency while maintaining regulatory compliance. Full article

Artificial Intelligence (AI) is transforming smart healthcare by enhancing diagnostic precision, automating clinical workflows, and enabling personalized treatment strategies. This review explores the current landscape of AI in healthcare from two key perspectives: capability types (e.g., Narrow AI and AGI) and functional architectures (e.g., Limited Memory and Theory of Mind). Based on capabilities, most AI systems today are categorized as Narrow AI, performing specific tasks such as medical image analysis and risk prediction with high accuracy. More advanced forms like General Artificial Intelligence (AGI) and Superintelligent AI remain theoretical but hold transformative potential. From a functional standpoint, Limited Memory AI dominates clinical applications by learning from historical patient data to inform decision-making. Reactive systems are used in rule-based alerts, while Theory of Mind (ToM) and Self-Aware AI remain conceptual stages for future development. This dual perspective provides a comprehensive framework to assess the maturity, impact, and future direction of AI in healthcare. It also highlights the need for ethical design, transparency, and regulation as AI systems grow more complex and autonomous, by incorporating cross-domain AI insights. Moreover, we evaluate the viability of developing AGI in regionally specific legal and regulatory frameworks, using South Korea as a case study to emphasize the limitations imposed by infrastructural preparedness and medical data governance regulations. Full article

This study analyzes forest fire legislation and policies in the Andean Community of Nations (ACN)—Colombia, Ecuador, Peru, and Bolivia—focusing on prevention and control. Using a comparative law approach, similarities, differences, and implementation challenges were identified. Ecuador and Peru have more comprehensive legal structures, while Colombia’s is simpler, and Bolivia falls in between. To address these gaps, this study proposes an Andean Directive for Integrated Fire Management (ADIFM) to harmonize policies and incorporate fire ecology, ancestral knowledge, education, monitoring technologies, and post-fire restoration. This regulatory framework, tailored to Andean ecological and sociocultural conditions, would optimize fire management and strengthen ecosystem resilience. Additionally, harmonizing sanctions and regulations at the regional level would ensure more coherent and effective governance. The ADIFM would provide strategic guidance for policymakers, fostering sustainable fire management and environmental restoration across Andean ecosystems. Full article

Blockchain technology is being increasingly deployed to store and process transactions and information in the global financial sector. Blockchain underpins cryptocurrencies such as Bitcoin and facilitates decentralized finance (DeFi), representing a paradigm shift in the global financial landscape, offering alternative solutions to traditional banking, and fostering financial inclusion. In developing economies such as Morocco, where a significant portion of the population remains unbanked, these digital financial innovations present both opportunities and challenges. This study examines the potential role of cryptocurrencies and DeFi in enhancing financial inclusion in Morocco, where cryptocurrencies have been banned since 2017. However, the public continues to use cryptocurrencies, circumventing restrictions, and the Moroccan Central Bank is now preparing to introduce new regulations to legalize their use within the country. In this context, this article analyses the potential of cryptocurrencies to mitigate barriers such as high transaction costs, restricted access to financial services in rural areas, and limited financial literacy in the country. The study pursues a mixed-methods approach, which combines a quantitative survey with qualitative expert interviews and adapts the Unified Theory of Acceptance and Use of Technology (UTAUT) model to the Moroccan context. The findings reveal that while cryptocurrencies offer cost-efficient financial transactions and improved accessibility, their adoption may be constrained by regulatory uncertainty, security risks, and technological limitations. The novelty of the article thus lies in its focus on the key mechanisms that influence the adoption of cryptocurrencies and their potential impact in a specific national context. In so doing, the study highlights the need for a structured regulatory framework, investment in digital infrastructure, and targeted financial literacy initiatives to optimize the potential role of cryptocurrencies in progressing financial inclusion in Morocco. This underscores the need for integrated models and guidelines for policymakers, financial institutions, and technology providers to ensure the responsible introduction of cryptocurrencies in developing world environments. Full article

This review investigates the influence of European Union regulations on the adoption of artificial intelligence in smart city solutions, with a structured emphasis on regulatory barriers, technological challenges, and societal benefits. It offers a comprehensive analysis of the legal frameworks in effect by 2025, including the Artificial Intelligence Act, General Data Protection Regulation, Data Act, and sector-specific directives governing mobility, energy, and surveillance. This study critically assesses how these regulations affect the deployment of AI systems across urban domains such as traffic optimization, public safety, waste management, and energy efficiency. A comparative analysis of regulatory environments in the United States and China reveals differing governance models and their implications for innovation, safety, citizen trust, and international competitiveness. The review concludes that although the European Union’s focus on ethics and accountability establishes a solid basis for trustworthy artificial intelligence, the complexity and associated compliance costs create substantial barriers to adoption. It offers recommendations for policymakers, municipal authorities, and technology developers to align regulatory compliance with effective innovation in the context of urban digital transformation. Full article

This research is focused on housing stock rehabilitation and construction in Urban Rehabilitation Areas located in diverse contexts in the Portuguese territory. The main objective of this research is to show how the local actors have managed the ARUs’ opportunities to restore and develop the housing in these areas in the Portuguese territory. An analytical national legal framework is made to show that the diffuse criteria at national and regional levels are reflected in the limited effectiveness of the ARUs’ flexible criteria in local implementation. A national legislative and regulatory framework in Portugal, focusing on urban rehabilitation and housing promotion themes, is discussed to emphasize the potential role of Urban Rehabilitation Area (ARU) particularities and housing provision and preservation in diverse contexts in Portugal. A comparative analysis is conducted of five ARUs—Belmonte, Soure, Penacova, Vila Real, and Devesas—located in Portugal, in the North and Center regions, to highlight the particularities/diversity of urban contexts, including towns, small to medium-sized cities, and historic centres. The analysis assesses the effectiveness of ARU urban rehabilitation strategy implementation over time. The analysis of five ARUs will discuss the following: (i) ARU physical characteristics; (ii) ARU population profile; (iii) ARU urban rehabilitation strategies progress (initial, intermediate, and final); and (iv) ARU alignment with PDM priorities in urban rehabilitation. The findings underscore the pivotal role that ARUs and their actors can have in housing rehabilitation provision and preservation on different scales and contexts within the territory. The outcomes show different strategies that each ARU has used to prioritize building rehabilitation. Full article

Tropical peatlands store approximately 105 gigatons of carbon (GtC), serving as vital long-term carbon sinks, yet remain critically underrepresented in climate policy. Indonesia peatlands contain 57GtC—the largest tropical peatland carbon stock in the Asia–Pacific. However, decades of drainage, fires, and lax enforcement practices have degraded vast peatland areas, turning them from carbon sinks into emission sources—as evidenced by the 1997 and 2015 peatland fires which emitted 2.57 Gt CO₂eq and 1.75 Gt CO₂eq, respectively. Using system theory validated against historical data (1997–2023), we develop a causal loop model revealing three interconnected feedback loops driving irreversible collapse: (1) drainage–desiccation–oxidation, where water table below −40 cm triggers peat oxidation (2–5 cm subsistence) and fires; (2) fire–climate–permafrost, wherein emissions intensify radiative forcing, destabilizing monsoons and accelerating Arctic permafrost thaw (+15% since 2000); and (2) economy–governance failure, perpetuated by palm oil’s economic dominance and slack regulatory oversight. To break these vicious cycles, we propose a precautionary framework featuring IoT-enforced water table (≤40 cm), reducing emissions by 34%, legally protected “Global Climate Stabilization Zones” for peat domes (>3 m depth), safeguarding 57 GtC, and ASEAN transboundary enforcement funded by a 1–3% palm oil levy. Without intervention, annual emissions may reach 2.869 GtCO₂e by 2030 (Nationally Determined Contribution’s business-as-usual scenario). Conversely, rewetting 590 km²/year aligns with Indonesia’s FOLU Net Sink 2030 target (−140 Mt CO₂e) and mitigates 1.4–1.6 MtCO₂ annually. We conclude that integrating peatlands as irreplaceable climate infrastructure into global policy is essential for achieving Paris Agreement goals and SDGs 13–15. Full article