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Keywords = large-scale induction heating

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15 pages, 3138 KiB  
Article
Casting Homogeneity of Scaled-Up Multiprincipal Component Alloys
by Gbenga. J. Adeyemi, Claire Utton, Yunus Azakli and Russell Goodall
J. Manuf. Mater. Process. 2025, 9(2), 41; https://doi.org/10.3390/jmmp9020041 - 29 Jan 2025
Viewed by 809
Abstract
High-entropy and multicomponent alloys are believed to offer opportunities for improved properties and are currently of great interest to the research community. Studies on these materials are largely conducted on small samples, but, for many practical applications, larger-scale processing would be needed. The [...] Read more.
High-entropy and multicomponent alloys are believed to offer opportunities for improved properties and are currently of great interest to the research community. Studies on these materials are largely conducted on small samples, but, for many practical applications, larger-scale processing would be needed. The processing of metallic parts of high dimensionality conventionally begins with casting, but an increase in the scale of the melt increases the potential for effects dependent on segregation, diffusion and thermal transport. The objective here is to determine the effect of scale-up on the as-cast condition of an example multicomponent alloy, Cu-Zn-Mn-Ni medium-entropy (ME) brass, in a larger quantity. The ingot was produced by metallic mould casting after induction melting. The hardness, microstructures and chemical composition were assessed in the as-cast state across a section through the material. A range of hardness values were found, particularly in the vertical direction, where the upper region was found to have a hardness of 188 ± 15 HV0.5, a middle of 161 ± 11 HV0.5 and a bottom of 184 ± 16 HV0.5. These values can be correlated with the casting conditions experienced locally, but the average hardness values are close to that of the original reports of the alloy. To overcome this, it is likely that a heat treatment would need to be used for this alloy in practical production before the products could be applied for engineering uses. Full article
(This article belongs to the Special Issue Additive Manufacturing of Copper-Based Alloys)
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20 pages, 28799 KiB  
Article
Early Detection and Suppression of Thermal Runaway in Large-Format Lithium-Ion Batteries: Insights from Experimental Analysis
by Sungsik Choi, Keunhyung Lee, Jaehoon Kim, Seun Oh, Jaehyun Joo, Eunsoo Bae, Hyeonu Lee and Misung Kim
Energies 2025, 18(1), 155; https://doi.org/10.3390/en18010155 - 2 Jan 2025
Cited by 1 | Viewed by 1783
Abstract
Lithium-ion batteries have been increasingly demonstrated in reuse applications for environmental and economic reasons, and stationary energy storage systems (ESS) and mobile ESS are emerging as reuse applications for electric vehicle batteries. Most mobile ESS deployments are at large scales, necessitating experimental data [...] Read more.
Lithium-ion batteries have been increasingly demonstrated in reuse applications for environmental and economic reasons, and stationary energy storage systems (ESS) and mobile ESS are emerging as reuse applications for electric vehicle batteries. Most mobile ESS deployments are at large scales, necessitating experimental data on thermal runaway (TR) to ensure comprehensive safety. In this study, TR induction and suppression experiments were conducted using fully charged NCM-based batteries at the cell (750 Wh), module (7.5 kWh), and pack (74 kWh) levels. The stepwise TR experiments measured changes in temperature, voltage, heat release rate, volatile organic compound concentrations, and vent gas composition. The suppression experiments assessed the effective water injection rate, timing, and volume required to mitigate TR propagation. The results demonstrate that in the case of TR caused by thermal abuse, early detection of battery abnormalities is possible through monitoring pre-TR indicators, such as temperature and vent gas concentration. It was also confirmed that CO2 injections can effectively cool the battery without causing damage. Furthermore, it is proposed that rapid water injection, directly contacting the battery immediately after the onset of TR, can successfully prevent TR propagation. Full article
(This article belongs to the Section J: Thermal Management)
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43 pages, 8526 KiB  
Article
Contribution to Active Thermal Protection Research—Part 1 Analysis of Energy Functions by Parametric Study
by Veronika Mučková, Daniel Kalús, Daniela Koudelková, Mária Kurčová, Zuzana Straková, Martin Sokol, Rastislav Ingeli, Patrik Šťastný and Peter Janík
Energies 2023, 16(11), 4391; https://doi.org/10.3390/en16114391 - 29 May 2023
Cited by 3 | Viewed by 1861
Abstract
The thermal energy consumption for heating objects is one of the main parameters deciding their technical and structural solution. Reducing energy consumption is realized in various ways. The most used method is passive thermal protection, that is, increasing the thermal insulation parameters of [...] Read more.
The thermal energy consumption for heating objects is one of the main parameters deciding their technical and structural solution. Reducing energy consumption is realized in various ways. The most used method is passive thermal protection, that is, increasing the thermal insulation parameters of the envelope constructions and optimizing the operation of the technical equipment of the buildings. There are also methods of active thermal protection to reduce heat leakage through non-transparent parts of the building envelope. Active thermal protection (ATP) is a dynamic process that applies primarily to building structures with integrated energetically active elements that fulfill one or more functions in mutually exclusive operating modes of energy systems and heat sources, such as thermal barriers (TB), large-scale heating/cooling, long-term heat/cool storage, capturing solar energy, and energy from the surroundings or even recovering heat in the cold season or cold in the warm season and other combinations. The research area focuses on analyzing active thermal protection’s energy potential. The methodology is based on a parametric study of dynamic thermal resistance (DTR), and heat flows to the interior and exterior from ATP for the investigated envelope of the experimental house EB2020 made of aerated concrete blocks. Such constructions generally show a consistently high DTR of 11.8 to 30.8 ((m2·K)/W) at a low mean heat transfer temperature of 10 to 16 °C, corresponding to the thermal insulation of 300 to 1000 mm. In the case of ATP storage heating with an average temperature of the heat-carrying substance of 30 °C, the heat flow into the interior of the investigated structure would be only 2.31 W/m2. Therefore, they are only suitable for a thermal barrier and heat/cold accumulation. Based on the synthesis and induction of analogical forms of the results of previous research into recommendations for the design of individual energy functions of ATP for perimeter structures of buildings, we present heat flows to the interior/exterior when changing the material of the layers towards the interior from ATP and describe possible variants of the development of building structures with integrated energetically active elements. Full article
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20 pages, 9327 KiB  
Article
Numerical Study of Ti6Al4V Alloy Tube Heated by Super-Frequency Induction Heating
by Cheng Liu, Jingtao Han, Ruilong Lu, Jiawei Liu and Xiaoyan Ma
Materials 2023, 16(11), 3938; https://doi.org/10.3390/ma16113938 - 24 May 2023
Cited by 2 | Viewed by 1581
Abstract
Ti6Al4V alloys have a narrow processing window, which complicates temperature control, especially during large-scale production. Therefore, a numerical simulation and experimental study on the ultrasonic induction heating process of a Ti6Al4V titanium alloy tube were conducted to obtain stable heating. The electromagnetic and [...] Read more.
Ti6Al4V alloys have a narrow processing window, which complicates temperature control, especially during large-scale production. Therefore, a numerical simulation and experimental study on the ultrasonic induction heating process of a Ti6Al4V titanium alloy tube were conducted to obtain stable heating. The electromagnetic and thermal fields in the process of ultrasonic frequency induction heating were calculated. The effects of the current frequency and current value on the thermal and current fields were numerically analyzed. The increase in current frequency enhances the skin and edge effects, but heat permeability was achieved in the super audio frequency range, and the temperature difference between the interior and exterior of the tube was less than 1%. An increase in the applied current value and current frequency caused an increase in the tube’s temperature, but the influence of current was more prominent. Therefore, the influence of stepwise feeding, reciprocating motion, and stepwise feeding superimposed motion on the heating temperature field of the tube blank was evaluated. The coil reciprocating with the roll can maintain the temperature of the tube within the target temperature range during the deformation stage. The simulation results were validated experimentally, which demonstrated good agreement between the results. The numerical simulation method can be used to monitor the temperature distribution of Ti6Al4V alloy tubes during the super-frequency induction heating process. This is an economical and effective tool for predicting the induction heating process of Ti6Al4V alloy tubes. Moreover, online induction heating in the form of reciprocating motion is a feasible strategy for processing Ti6Al4V alloy tubes. Full article
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20 pages, 4472 KiB  
Article
The Design of a Large-Scale Induction Heating Power Source for Organic Waste Digesters to Produce Fertilizer
by Thanaset Thosdeekoraphat, Kittisak Tanthai, Kachaporn Lhathum, Supawat Kotchapradit, Samran Santalunai and Chanchai Thongsopa
Energies 2023, 16(5), 2123; https://doi.org/10.3390/en16052123 - 22 Feb 2023
Cited by 3 | Viewed by 3383
Abstract
Heating induction is a new environmentally friendly, energy-saving technology that offers a more effective performance than other common heaters. The energy-use efficiency of an inductor circuit is greater than 80 percent, while a biomass tank and tungsten coil have 70 percent and 51.8 [...] Read more.
Heating induction is a new environmentally friendly, energy-saving technology that offers a more effective performance than other common heaters. The energy-use efficiency of an inductor circuit is greater than 80 percent, while a biomass tank and tungsten coil have 70 percent and 51.8 percent efficiency, respectively. This method also produces more heat than any other forms of heating using gas or coal. The induction heating method has attracted significant interest and has seen application worldwide. Based on this important source of heating, we have designed and developed a large induction-heating machine with high energy to heat up a tank directly. The aim is to degrade organic waste as much as possible and convert it into an effective fertilizer by adding mesophilic microorganisms; the fertilizer transforming process takes no more than 24 h. The tank featured in our design has a 100-cm radius and is 155 in length; this is very large. The aim of this process is to reduce the amount of organic waste and thereby provide environmental benefits. To this end, we have designed a large, high-energy induction-heating machine (approximately 9.6 kilowatt) and used two machines in order to appropriately heat the tank for a large amount of organic-waste degradation. This research can be effectively applied to many heating methods in industry. Full article
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16 pages, 12152 KiB  
Article
Design and Test of Duckbill Welding Robot for Cotton Seeder
by Yu Ren, Wensong Guo, Xufeng Wang, Can Hu, Long Wang, Xiaowei He and Jianfei Xing
Agriculture 2023, 13(1), 31; https://doi.org/10.3390/agriculture13010031 - 22 Dec 2022
Cited by 2 | Viewed by 2812
Abstract
To improve the automation, welding efficiency, and welding quality of duckbill welding of the cotton seeder, this study designed a cotton seeder duckbill welding robot. According to the characteristics of the duckbill weldment and welding requirements, the overall structure of the welding robot [...] Read more.
To improve the automation, welding efficiency, and welding quality of duckbill welding of the cotton seeder, this study designed a cotton seeder duckbill welding robot. According to the characteristics of the duckbill weldment and welding requirements, the overall structure of the welding robot was determined, including the girdle feeding mechanism, static duckbill feeding mechanism, hinge feeding mechanism, welding fixture, welding actuator, and control system. To realize the continuous automatic feeding, positioning, fixing, welding, and unloading of the workpiece in the duckbill welding, the feeding mechanism adopts the method of cooperative cooperation of inductive proximity switch, electromagnet, and cylinder. The main body of the welding fixture adopts the pneumatic clamping method; the welding actuator adopts the synchronous belt module electric drive so that the welding torch can move in a straight line along the X axis and the Z axis. The welding process of the duckbill was simulated by Simufact Welding software, and the deformation and stress changes of the weldment were compared and analyzed when the single-sided single welding, the bilateral symmetrical double welding torch, two welding forms, and two welding process parameters were used to determine the welding process parameters of the welding robot. The prototype was made and the welding test was carried out. The test results show that the duckbill welding robot of the cotton seeder has stable feeding, solid clamping, accurate positioning, and high welding efficiency. According to the national standard, the appearance of the duckbill weld is inspected. The surface of the duckbill weld and the heat-affected zone has no cracks, incomplete fusion, slag inclusion, crater, and porosity. The forming quality of the welded parts is good. The design of the duckbill welding robot for cotton seeder is helpful in solving the problems of cumbersome positioning and clamping and low efficiency in manual and semi-automatic duckbill welding robots, which provides a strong guarantee for the large-scale and standardized welding production of the dibbler duckbill. Full article
(This article belongs to the Special Issue Robots and Autonomous Machines for Agriculture Production)
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18 pages, 4336 KiB  
Article
Study of an Optimized Micro-Grid’s Operation with Electrical Vehicle-Based Hybridized Sustainable Algorithm
by Muhammad Shahzad Nazir, Zhang Chu, Ahmad N. Abdalla, Hong Ki An, Sayed M. Eldin, Ahmed Sayed M. Metwally, Patrizia Bocchetta and Muhammad Sufyan Javed
Sustainability 2022, 14(23), 16172; https://doi.org/10.3390/su142316172 - 3 Dec 2022
Cited by 5 | Viewed by 1876
Abstract
Recently, the expansion of energy communities has been aided by the lowering cost of storage technologies and the appearance of mechanisms for exchanging energy that is driven by economics. An amalgamation of different renewable energy sources, including solar, wind, geothermal, tidal, etc., is [...] Read more.
Recently, the expansion of energy communities has been aided by the lowering cost of storage technologies and the appearance of mechanisms for exchanging energy that is driven by economics. An amalgamation of different renewable energy sources, including solar, wind, geothermal, tidal, etc., is necessary to offer sustainable energy for smart cities. Furthermore, considering the induction of large-scale electric vehicles connected to the regional micro-grid, and causes of increase in the randomness and uncertainty of the load in a certain area, a solution that meets the community demands for electricity, heating, cooling, and transportation while using renewable energy is needed. This paper aims to define the impact of large-scale electric vehicles on the operation and management of the microgrid using a hybridized algorithm. First, with the use of the natural attributes of electric vehicles such as flexible loads, a large-scale electric vehicle response dispatch model is constructed. Second, three factors of micro-grid operation, management, and environmental pollution control costs with load fluctuation variance are discussed. Third, a hybrid gravitational search algorithm and random forest regression (GSA-RFR) approach is proposed to confirm the method’s authenticity and reliability. The constructed large-scale electric vehicle response dispatch model significantly improves the load smoothness of the micro-grid after the large-scale electric vehicles are connected and reduces the impact of the entire grid. The proposed hybridized optimization method was solved within 296.7 s, the time taken for electric vehicle users to charge from and discharge to the regional micro-grid, which improves the economy of the micro-grid, and realizes the effective management of the regional load. The weight coefficients λ1 and λ2 were found at 0.589 and 0.421, respectively. This study provides key findings and suggestions that can be useful to scholars and decisionmakers. Full article
(This article belongs to the Special Issue Smart Grid Analytics for Sustainability and Urbanization in Big Data)
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26 pages, 7185 KiB  
Article
Low Concentrations of Oxidized Phospholipids Increase Stress Tolerance of Endothelial Cells
by Christina Mauerhofer, Taras Afonyushkin, Olga V. Oskolkova, Klara Hellauer, Bernd Gesslbauer, Jasmin Schmerda, Yunbo Ke, Andreas Zimmer, Anna A. Birukova, Konstantin G. Birukov and Valery Bochkov
Antioxidants 2022, 11(9), 1741; https://doi.org/10.3390/antiox11091741 - 1 Sep 2022
Cited by 3 | Viewed by 2965
Abstract
Oxidized phospholipids (OxPLs) are generated by enzymatic or autooxidation of esterified polyunsaturated fatty acids (PUFAs) residues. OxPLs are present in circulation and atherosclerotic plaques where they are thought to induce predominantly proinflammatory and toxic changes in endothelial (ECs) and other cell types. Unexpectedly, [...] Read more.
Oxidized phospholipids (OxPLs) are generated by enzymatic or autooxidation of esterified polyunsaturated fatty acids (PUFAs) residues. OxPLs are present in circulation and atherosclerotic plaques where they are thought to induce predominantly proinflammatory and toxic changes in endothelial (ECs) and other cell types. Unexpectedly, we found that low concentrations of OxPLs were not toxic but protected ECs from stress induced by serum deprivation or cytostatic drugs. The protective effect was observed in ECs obtained from different vessels and was monitored using a variety of readouts based on different biological and chemical principles. Analysis of the structure–activity relationship identified oxidized or missing fatty acid residue (OxPLs or Lyso-PLs, respectively) as a prerequisite for the protective action of a PL. Protective OxPLs or Lyso-PLs acquired detergent-like properties and formed in solution aggregates <10 nm in diameter (likely micelles), which were in striking contrast with large aggregates (>1000 nm, likely multilayer liposomes) produced by nonoxidized precursor PLs. Because surfactants, OxPLs, and Lyso-PLs are known to extract membrane cholesterol, we tested if this effect might trigger the protection of endothelial cells. The protective action of OxPLs and Lyso-PLs was inhibited by cotreatment with cholesterol and mimicked by cholesterol-binding beta-cyclodextrin but not inactive α-cyclodextrin. Wide-scale mRNA expression analysis in four types of ECs showed the induction of genes encoding for heat shock proteins (HSPs) and secreted prosurvival peptides and proteins. Inducers of HSPs, chemical chaperones, and pure prosurvival factors mimicked the protective action of OxPLs/Lyso-PLs. We hypothesize that oxidation changes the physicochemical properties of PLs, thus promoting membrane cholesterol redistribution or extraction leading to the expression of intra- and extracellular prosurvival factors. Full article
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12 pages, 21467 KiB  
Article
Magnetic Induction Assisted Heating Technique in Hydrothermal Zeolite Synthesis
by Supak Tontisirin, Chantaraporn Phalakornkule, Worawat Sa-ngawong and Supachai Sirisawat
Materials 2022, 15(2), 689; https://doi.org/10.3390/ma15020689 - 17 Jan 2022
Cited by 3 | Viewed by 2805
Abstract
The magnetic induction assisted technique is an alternative heating method for hydrothermal zeolite synthesis with a higher heat-transfer rate than that of the conventional convection oil bath technique. The research demonstrates, for the first time, the application of the magnetic induction heating technique [...] Read more.
The magnetic induction assisted technique is an alternative heating method for hydrothermal zeolite synthesis with a higher heat-transfer rate than that of the conventional convection oil bath technique. The research demonstrates, for the first time, the application of the magnetic induction heating technique with direct surface contact for zeolite synthesis. The magnetic induction enables direct contact between the heat source and the reactor, thereby bypassing the resistance of the heating medium layer. A comparative heat-transfer analysis between the two methods shows the higher heat-transfer rate by the magnetic induction heating technique is due to (1) eight-time higher overall heat-transfer coefficient, attributed to the absence of the resistance of the heating medium layer and (2) the higher temperature difference between the heating source and the zeolite gel. Thereby, this heating technique shows promise for application in the large-scale synthesis of zeolites due to its associated efficient heat transfer. Thus, it can provide more flexibility to the synthesis method under the non-stirred condition, which can create possibilities for the successful large-scale synthesis of a broad range of zeolites. Full article
(This article belongs to the Special Issue Heat and Mass Transfer in Porous Materials)
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25 pages, 41821 KiB  
Article
Shielded Active Gas Forge Welding of an L80 Steel in a Small Scale Shielded Active Gas Forge Welding Machine
by Vinothkumar Palanisamy, Jan Ketil Solberg and Per Thomas Moe
J. Manuf. Mater. Process. 2021, 5(1), 16; https://doi.org/10.3390/jmmp5010016 - 8 Feb 2021
Cited by 3 | Viewed by 3883 | Correction
Abstract
The Shielded Active Gas Forge Welding (SAG-FW) method is a solid-state welding technique in which the mating surfaces are heated by induction heating or direct electrical heating before being forged together to form a weld. In this article, an API 5CT L80 grade [...] Read more.
The Shielded Active Gas Forge Welding (SAG-FW) method is a solid-state welding technique in which the mating surfaces are heated by induction heating or direct electrical heating before being forged together to form a weld. In this article, an API 5CT L80 grade carbon steel alloy has been welded using the SAG-FW method. A small-scale forge welding machine has been used to join miniature pipes extracted from a large pipe wall. The welding was performed at three different forging temperatures, i.e., 1300 °C, 1150 °C and 950 °C, in some cases followed by one or two post weld heat treatment cycles. In order to qualify the welds, mechanical and corrosion testing was performed on miniature samples extracted from the welded pipes. In addition, the microstructure of the welds was analysed, and electron probe microanalysis was carried out to control that no oxide film had formed along the weld line. Based on the complete set of experimental results, promising parameters for SAG-FW welding of the API 5CT L80 grade steel are suggested. The most promising procedure includes forging at relative high temperature (1150 °C) followed by rapid cooling and a short temper. This procedure was found to give a weld zone microstructure dominated by tempered martensite with promising mechanical and corrosion properties. The investigation confirmed that small scale forge welding testing is a useful tool in the development of welding parameters for full size SAG-FW welding. Full article
(This article belongs to the Special Issue Metal Forming and Joining)
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24 pages, 7549 KiB  
Article
A New Physics-Based Modeling Approach for a 0D Turbulence Model to Reflect the Intake Port and Chamber Geometries and the Corresponding Flow Structures in High-Tumble Spark-Ignition Engines
by Yirop Kim, Myoungsoo Kim, Sechul Oh, Woojae Shin, Seokwon Cho and Han Ho Song
Energies 2019, 12(10), 1898; https://doi.org/10.3390/en12101898 - 18 May 2019
Cited by 6 | Viewed by 5023
Abstract
Turbulence is one of the most important aspects in spark-ignition engines as it can significantly affect burn rates, heat transfer rates, and combustion stability, and thus the performance. Turbulence originates from a large-scale mean motion that occurs during the induction process, which mainly [...] Read more.
Turbulence is one of the most important aspects in spark-ignition engines as it can significantly affect burn rates, heat transfer rates, and combustion stability, and thus the performance. Turbulence originates from a large-scale mean motion that occurs during the induction process, which mainly consists of tumble motion in modern spark-ignition engines with a pentroof cylinder head. Despite its significance, most 0D turbulence models rely on calibration factors when calculating the evolution of tumble motion and its conversion into turbulence. In this study, the 0D tumble model has been improved based on the physical phenomena, as an attempt to develop a comprehensive model that predicts flow dynamics inside the cylinder. The generation and decay rates of tumble motion are expressed with regards of the flow structure in a realistic combustion chamber geometry, while the effects of port geometry on both charging efficiency and tumble generation rate are reflected by supplementary steady CFD. The developed tumble model was integrated with the standard k-ε model, and the new turbulence model has been validated with engine experimental data for various changes in operating conditions including engine speed, load, valve timing, and engine geometry. The calculated results showed a reasonable correlation with the measured combustion duration, verifying this physics-based model can properly predict turbulence characteristics without any additional calibration process. This model can suggest greater insights on engine operation and is expected to assist the optimization process of engine design and operating strategies. Full article
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4 pages, 569 KiB  
Proceeding Paper
Top-Down Fabrication of Arrays of Vertical GaN Nanorods with Freestanding Top Contacts for Environmental Exposure
by Nicolai Markiewicz, Olga Casals, Muhammad Fahlesa Fatahilah, Klaas Strempel, Alaaeldin Gad, Hutomo Suryo Wasisto, Andreas Waag and Joan Daniel Prades
Proceedings 2018, 2(13), 845; https://doi.org/10.3390/proceedings2130845 - 3 Dec 2018
Cited by 2 | Viewed by 1843
Abstract
Arrays of 1D-vertically arranged gallium nitride (GaN) nanorods (NRs) are fabricated on sapphire and connected to both bottom and freestanding top contacts. This shows a fully validated top-down method to obtain ordered arrays of high-surface-to-volume elements that can be electrically interrogated and used, [...] Read more.
Arrays of 1D-vertically arranged gallium nitride (GaN) nanorods (NRs) are fabricated on sapphire and connected to both bottom and freestanding top contacts. This shows a fully validated top-down method to obtain ordered arrays of high-surface-to-volume elements that can be electrically interrogated and used, e.g., for sensing applications. Specifically, these will be used as highly integrated heating elements for conductometric gas sensors in self-heating operation. Detailed fabrication and processing steps involving inductively coupled plasma reactive ion etching (ICP-RIE), KOH-etching, interspace filling, and electron-beam physical vapor deposition technologies are discussed, in which they can be well adjusted and combined to obtain vertical GaN NRs as thin as 300 nm in arbitrarily large and regular arrays (e.g., 1 × 1, 3 × 3, 9 × 10 elements). These developed devices are proposed as a novel sensor platform for temperature-activated measurements that can be produced at a large scale offering low-power, and very stable temperature control. Full article
(This article belongs to the Proceedings of EUROSENSORS 2018)
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27 pages, 10091 KiB  
Review
Graphene Nanoribbon as Potential On-Chip Interconnect Material—A Review
by Arnab Hazra and Sukumar Basu
C 2018, 4(3), 49; https://doi.org/10.3390/c4030049 - 30 Aug 2018
Cited by 42 | Viewed by 12735
Abstract
In recent years, on-chip interconnects have been considered as one of the most challenging areas in ultra-large scale integration. In ultra-small feature size, the interconnect delay becomes more pronounced than the gate delay. The continuous scaling of interconnects introduces significant parasitic effects. The [...] Read more.
In recent years, on-chip interconnects have been considered as one of the most challenging areas in ultra-large scale integration. In ultra-small feature size, the interconnect delay becomes more pronounced than the gate delay. The continuous scaling of interconnects introduces significant parasitic effects. The resistivity of interconnects increases because of the grain boundary scattering and side wall scattering of electrons. An increased Joule heating and the low current carrying capability of interconnects in a nano-scale dimension make it unreliable for future technology. The devices resistivity and reliability have become more and more serious problems for choosing the best interconnect materials, like Cu, W, and others. Because of its remarkable electrical and its other properties, graphene becomes a reliable candidate for next-generation interconnects. Graphene is the lowest resistivity material with a high current density, large mean free path, and high electron mobility. For practical implementation, narrow width graphene sheet or graphene nanoribbon (GNR) is the most suitable interconnect material. However, the geometric structure changes the electrical property of GNR to a small extent compared to the ideal behavior of graphene film. In the current article, the structural and electrical properties of single and multilayer GNRs are discussed in detail. Also, the fabrication techniques are discussed so as to pattern the graphene nanoribbons for interconnect application and measurement. A circuit modeling of the resistive-inductive-capacitive distributed network for multilayer GNR interconnects is incorporated in the article, and the corresponding simulated results are compared with the measured data. The performance of GNR interconnects is discussed from the view of the resistivity, resistive-capacitive delay, energy delay product, crosstalk effect, stability analysis, and so on. The performance of GNR interconnects is well compared with the conventional interconnects, like Cu, and other futuristic potential materials, like carbon nanotube and doped GNRs, for different technology nodes of the International Technology Roadmap for Semiconductors (ITRS). Full article
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16 pages, 4670 KiB  
Article
Combining Low Temperature Fluorescence DNA-Hybridization, Immunostaining, and Super-Resolution Localization Microscopy for Nano-Structure Analysis of ALU Elements and Their Influence on Chromatin Structure
by Matthias Krufczik, Aaron Sievers, Annkathrin Hausmann, Jin-Ho Lee, Georg Hildenbrand, Wladimir Schaufler and Michael Hausmann
Int. J. Mol. Sci. 2017, 18(5), 1005; https://doi.org/10.3390/ijms18051005 - 7 May 2017
Cited by 24 | Viewed by 6284
Abstract
Immunostaining and fluorescence in situ hybridization (FISH) are well established methods for specific labelling of chromatin in the cell nucleus. COMBO-FISH (combinatorial oligonucleotide fluorescence in situ hybridization) is a FISH method using computer designed oligonucleotide probes specifically co-localizing at given target sites. In [...] Read more.
Immunostaining and fluorescence in situ hybridization (FISH) are well established methods for specific labelling of chromatin in the cell nucleus. COMBO-FISH (combinatorial oligonucleotide fluorescence in situ hybridization) is a FISH method using computer designed oligonucleotide probes specifically co-localizing at given target sites. In combination with super resolution microscopy which achieves spatial resolution far beyond the Abbe Limit, it allows new insights into the nano-scaled structure and organization of the chromatin of the nucleus. To avoid nano-structural changes of the chromatin, the COMBO-FISH labelling protocol was optimized omitting heat treatment for denaturation of the target. As an example, this protocol was applied to ALU elements—dispersed short stretches of DNA which appear in different kinds in large numbers in primate genomes. These ALU elements seem to be involved in gene regulation, genomic diversity, disease induction, DNA repair, etc. By computer search, we developed a unique COMBO-FISH probe which specifically binds to ALU consensus elements and combined this DNA–DNA labelling procedure with heterochromatin immunostainings in formaldehyde-fixed cell specimens. By localization microscopy, the chromatin network-like arrangements of ALU oligonucleotide repeats and heterochromatin antibody labelling sites were simultaneously visualized and quantified. This novel approach which simultaneously combines COMBO-FISH and immunostaining was applied to chromatin analysis on the nanoscale after low-linear-energy-transfer (LET) radiation exposure at different doses. Dose-correlated curves were obtained from the amount of ALU representing signals, and the chromatin re-arrangements during DNA repair after irradiation were quantitatively studied on the nano-scale. Beyond applications in radiation research, the labelling strategy of immunostaining and COMBO-FISH with localization microscopy will also offer new potentials for analyses of subcellular elements in combination with other specific chromatin targets. Full article
(This article belongs to the Section Biochemistry)
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