Search Results (505)

In the face of escalating cyber threats to critical infrastructures, achieving robust cyber resilience has become paramount. This paper proposes an endogenous security-oriented framework for cyber resilience assessment, specifically tailored for critical infrastructures. Drawing on the principles of endogenous security, our framework integrates dynamic heterogeneous redundancy (DHR) and adaptive defense mechanisms to address both known and unknown threats. We model resilience across four key dimensions—Prevention, Destruction Resistance, Adaptive Recovery, and Evolutionary Learning—using a novel mathematical formulation that captures nonlinear interactions and temporal dynamics. The framework incorporates environmental threat entropy to dynamically adjust resilience scores, ensuring relevance in evolving attack landscapes. Through empirical validation on simulated critical infrastructure scenarios, we demonstrate the framework’s ability to quantify resilience trajectories and trigger timely defensive adaptations. Empiricalvalidation on a real-world critical infrastructure system yielded an overall resilience score of 82.75, revealing a critical imbalance between strong preventive capabilities (90/100) and weak Adaptive Recovery (66/100). Our approach offers a significant advancement over static risk assessment models by providing actionable metrics for strategic resilience investments. This work contributes to the field by bridging endogenous security theory with practical resilience engineering, paving the way for more robust protection of critical systems against sophisticated cyber threats. Full article

The demand for land monitoring information continues to increase, but the range and diversity of the available products to date have made their integrated use challenging and, at times, counterproductive. There has therefore been a growing need to enhance and harmonise the practice of land monitoring on a pan-European level with the formulation of a more consistent and standardised set of modelling criteria. The outcome has been a paradigm shift away from a “paper map”-based world where features are given a single, fixed label to one where features have a rich characterisation which is more informative, flexible and powerful. The approach allows the characteristics to be dynamic so that, over time, a feature may only change part of its description (i.e., a forest can be felled, but it may remain as forestry if replanted) or it can have multiple descriptors (i.e., a forest may be used for both timber production and recreation). The concept proposed by the authors has evolved since 2008 from first drafts to a comprehensive and powerful tool adopted by the European Union’s Copernicus programme. It provides for the semantic decomposition of existing nomenclatures, as well as supports a descriptive approach to the mapping of all landscape features in a flexible and object-oriented manner. In this way, the key move away from classification towards the characterisation of the Earth’s surface represents a novel and innovate approach to handling complex land surface information more suited to the age of distributed databases, cloud computing and object-oriented data modelling. In this paper, the motivation for and technical approach of the EAGLE concept with its matrix and UML model implementation are explained. This is followed by an update of the latest developments and the presentation of a number of experimental and operational use cases at national and European levels, and it then concludes with thoughts on the future outlook. Full article

This paper presents a meta-analysis of social research on water, offering a novel methodological contribution to the study of emerging interdisciplinary research fields. We propose and implement a mixed methods framework that integrates quantitative network analysis with qualitative research, aiming to enhance both to give access to new emerging empirical fields and enhance the analytical depth of empirical social research. Drawing on a dataset of publications from the Web of Science over four distinct time intervals, we identify thematic clusters through keyword co-occurrence networks that reveal the evolving structure and internal dynamics of the field. Our findings show a clear trend toward increasing interdisciplinarity, responsiveness to global events, and contemporary challenges such as the emergence of COVID-19 and the continued centrality of topics related to water management and evaluation. By uncovering latent structures, our approach not only maps the field’s development but also lays the foundation for targeted qualitative analysis of articles representative of identified clusters. This methodological design contributes to the broader discourse on mixed methods research in the social sciences by demonstrating how computational tools can enhance the transparency and reliability of qualitative inquiry without sacrificing its interpretive richness. Furthermore, this study opens new avenues for critically reflecting on the epistemic culture of social water research, particularly in relation to its proximity to applied science and governance-oriented perspectives. The proposed method holds potential relevance for both academic researchers and decision makers in the water sector, offering a means to systematically access dispersed knowledge and identify underrepresented subfields. Overall, the study showcases the potential of mixed methods designs for navigating and structuring complex interdisciplinary research landscapes. Full article

The research is grounded in the perspective of urban historical landscape (HUL), exploring the connections between cultural heritage and a broader urban context, as well as the general public and communities. It also focuses on small cultural heritage sites (SCHSs) in urban areas that have been overlooked in previous studies. By integrating various types of data, an assessment framework and methodology comprising six dimensions and 24 indicators were established and applied to the empirical research of 30 SCHSs in the Beijing section of the Grand Canal. The empirical research demonstrated the operability, effectiveness, and flexibility of the HUL assessment for SCHSs. The research findings are as follows. (1) The method provides differentiated recommendations for the formulation of tailored policies and planning management schemes based on heritage types, conservation levels, and the urban districts in which they are located. (2) The comprehensive quality of the open spaces where SCHSs are situated is critical for the cognition of the general public and community residents. (3) The overall conservation of the community areas containing SCHSs is highly significant, and the linkage between social development levels and cultural resources enhances public cognition of the SCHSs. (4) Cluster analysis offers guidance for the refined improvement of different SCHSs. The research aims to establish an action-oriented assessment framework, with a dimensional framework responding to the requirements of HULs and allowing for indicator flexibility. This study is significant for supporting the conservation and utilization of SCHSs in urban areas and for promoting their sustainable development. Full article

Worldwide, lung cancer is one of the most common cancers, with non-small cell lung cancer (NSCLC) including up to 80–85% of all lung cancer diagnoses. The landscape of NSCLC is characterized by a heterogeneous spectrum of gene alterations, with tyrosine kinase inhibitors (TKIs) and targeted treatments that significantly improve survival outcomes for patients with oncogene-addicted NSCLC, offering superior efficacy, and often favorable safety and tolerability profiles compared to chemotherapy-based treatments. However, the complexity of NSCLC extends to co-occurring genomic alterations or amplifications in tumor suppressors and other oncogenes, such as TP53, STK11, KEAP1, PIK3CA, RB1, and others, that significantly influence disease progression, therapeutic resistance, and clinical outcomes. These co-mutations often contribute to the development of primary and acquired resistance to targeted therapies, complicating decision-making strategies. This review provides a timely and comprehensive synthesis of current insights into co-mutations in NSCLC, with a particular focus on their clinical implications, and offers a novel perspective by integrating recent molecular insights with therapeutic challenges, addressing existing knowledge gaps through a more integrative and clinically oriented analysis of co-mutations. Advances in next-generation sequencing (NGS) and molecular profiling have enabled the identification of these co-alterations, paving the way for more personalized therapeutic approaches. However, challenges remain in interpreting the functional interplay of co-mutations and translating these insights into effective clinical interventions. This review also highlights the significance of co-mutations in shaping NSCLC biology, and discusses their impact on current therapeutic paradigms, emphasizing the need for integrative biomarker-driven approaches to improve outcomes in NSCLC. Full article

This paper investigates how sustainable STEM education is being shaped within the pre-university systems of the 22 Arab countries. By categorizing these systems into four groups based on the Global Knowledge Index and two analytical tracks, this study examines in detail the factors that enable—or hinder—the development of long-term, sustainability-oriented competencies in science, technology, engineering, and mathematics. Beyond pedagogical dimensions, this study emphasizes STEM education as a strategic tool for achieving national sustainable development goals (SDGs), promoting workforce readiness, and informing education policy reform. The analysis highlights the policy efforts, systemic limitations, and the need for localized strategies to integrate sustainability into the STEM curricula and teacher training. It is structured in six sections: (1) an introduction to STEM and sustainability concepts, the Global Knowledge Index, and the Arab-region education landscape; (2) research questions, methodology, and data sources; (3) analysis of Groups 1 and 2, assessing their experiences in implementing sustainability-driven STEM initiatives; (4) analysis of Groups 3 and 4, evaluating their readiness for adopting sustainable STEM programs; (5) discussion of findings in light of sustainability policy frameworks; and (6) a concluding overview with actionable recommendations to align national education systems with global sustainability goals. Full article

This study proposes a computational framework that transforms eye-tracking analysis from statistical description to cognitive structure modeling, aiming to reveal the organizational features embedded in the viewing process. Using the designers’ observation of a traditional Chinese landscape painting as an example, the study draws on the goal-oriented nature of design thinking to suggest that such visual exploration may exhibit latent structural tendencies, reflected in patterns of fixation and transition. Rather than focusing on traditional fixation hotspots, our four-dimensional framework (Region, Relation, Weight, Time) treats viewing behavior as structured cognitive networks. To operationalize this framework, we developed a data-driven computational approach that integrates fixation coordinate transformation, K-means clustering, extremum point detection, and linear interpolation. These techniques identify regions of concentrated visual attention and define their spatial boundaries, allowing for the modeling of inter-regional relationships and cognitive organization among visual areas. An adaptive buffer zone method is further employed to quantify the strength of connections between regions and to delineate potential visual nodes and transition pathways. Three design-trained participants were invited to observe the same painting while performing a think-aloud task, with one participant selected for the detailed demonstration of the analytical process. The framework’s applicability across different viewers was validated through consistent structural patterns observed across all three participants, while simultaneously revealing individual differences in their visual exploration strategies. These findings demonstrate that the proposed framework provides a replicable and generalizable method for systematically analyzing viewing behavior across individuals, enabling rapid identification of both common patterns and individual differences in visual exploration. This approach opens new possibilities for discovering structural organization within visual exploration data and analyzing goal-directed viewing behaviors. Although this study focuses on method demonstration, it proposes a preliminary hypothesis that designers’ gaze structures are significantly more clustered and hierarchically organized than those of novices, providing a foundation for future confirmatory testing. Full article

Evaluating performance is a necessary and specific process across all sectors and organizational levels, shaped by context, indicators, and purpose. Considering global sustainability transitions, understanding financial performance entails a deeper perspective on technical accuracy, conceptual clarity, and systemic integration. This study investigates how financial performance is assessed and interpreted in sustainability-focused research, drawing on a bibliometric analysis of 490 articles indexed in the Web of Science from 2007 to 2023. Using SciMAT, we traced thematic evolutions and revealed a fragmented research landscape marked by competing theoretical, methodological, and practical orientations. To address this conceptual dispersion, we applied the Analytic Hierarchy Process (AHP) to evaluate five key alternatives to financial-performance assessment (quantitative measurement, definition-oriented reasoning, theoretical frameworks, experiential comparison, and integration with sustainability and ethics) against three conceptual criteria (philosophical depth, holistic scope, and multidisciplinary relevance). The results highlight a strong preference for holistic and integrative models of financial performance, with quantitative measurement ranking highest in practical terms, followed by experiential and sustainability-driven approaches. These results underscore the need to align financial evaluation more closely with sustainability values, bridging short-term metrics with long-term societal impact. By combining diachronic thematic mapping with structured decision analysis, this study advances a more reflective and forward-looking framework for performance research. It contributes to sustainability research by identifying underexplored epistemological pathways and supporting the development of financial evaluation models that are inclusive, ethically grounded, and aligned with sustainable development goals. Full article

Ancient temple complexes in China’s mountainous landscapes exemplify a profound synthesis of environmental adaptation and cultural expression. This research investigates the spatial logic underlying the Wudang Mountain temple complex—a UNESCO World Heritage site—through integrated geospatial analysis of environmental factors. Using GIS-based modeling, GeoDetector, and regression analysis, we systematically assess how terrain, hydrology, climate, vegetation, and soil conditions collectively influenced site selection. The results reveal a clear hierarchical clustering pattern, with dense temple cores in the southwestern highlands, ridge-aligned belts, and a dominant southwest–northeast orientation that reflects intentional alignment with mountain ridgelines. Temples consistently occupy zones with moderate thermal, hydrological, and vegetative stability while avoiding geotechnical extremes such as lowland humidity or unstable slopes. Regression analysis confirms that site preferences vary across temple types, with soil pH, porosity, and bulk density emerging as significant influencing factors, particularly for cliffside temples. These findings suggest that ancient temple planning was not merely a passive response to sacred geography but a deliberate process that actively considered terrain, climate, soil, and other environmental factors. While environmental constraints strongly shaped spatial decisions, cultural and symbolic considerations also played an important role. This research deepens our understanding of how environmental factors influenced the formation of historical landscapes and offers theoretical insights and ecologically informed guidance for the conservation of mountain cultural heritage sites. Full article

This study presents a digital twin–based framework for assessing rockfall hazards at the immediate vicinity of the Rumkale Archaeological Site, a geologically sensitive and culturally significant location in southeastern Türkiye. Historically associated with early Christianity and strategically located along the Euphrates, Rumkale is a protected heritage site that attracts increasing numbers of visitors. Here, high-resolution photogrammetric models were generated using imagery acquired from a remotely piloted aircraft system and post-processed with ground control points to produce a spatially accurate 3D digital twin. Field-based geomechanical measurements including discontinuity orientations, joint classifications, and strength parameters were integrated with digital analyses to identify and evaluate hazardous rock blocks. Kinematic assessments conducted in the study revealed susceptibility to planar, wedge, and toppling failures. The results showed the role of lithological structure, active tectonics, and environmental factors in driving slope instability. The proposed methodology demonstrates effective use of digital twin technologies in conjunction with traditional geotechnical techniques, offering a replicable and non-invasive approach for site-scale hazard evaluation and conservation planning in heritage contexts. This work contributes to the advancement of interdisciplinary methods for geohazard-informed management of cultural landscapes. Full article

As a core element of comprehensive land consolidation, cultivated land serves as both a fundamental resource and strategic platform for driving rural revitalization and advancing ecological civilization development. Based on the five periods of remote sensing monitoring data of land use from the 1980 to 2020 in Beichuan Qiang Autonomous County, this study systematically examines cultivated land transfer dynamics and quantitatively assesses fragmentation levels through landscape metrics analysis, with the ultimate objective of informing strategic land consolidation planning at the county scale. The results indicate that (1) the cultivated land transformation in Beichuan Qiang Autonomous County exhibited distinct temporal patterns demarcated by 2010. During the initial phase, limited land transfers predominantly involved woodland transfers, characterized by cross-regional occupation–compensation dynamics and a northwest-oriented spatial shift. The subsequent phase witnessed substantial transfer intensification, incorporating grassland and construction land transfers alongside woodland. This period demonstrated balanced intra-township occupation–compensation mechanisms and a marked southeastward migration of transfer concentration; (2) cultivated land transfer dynamics demonstrated greater intensity in topographically moderate townships, whereas northwestern mountainous townships characterized by elevated altitudes and pronounced gradients maintained comparative spatial stability in transfer patterns; (3) cultivated land fragmentation exhibited topographic modulation, with reduced spatial disaggregation in low-lying plains contrasting elevated indices across northwestern highland terrains; and (4) the cultivated land area showed a predominant reduction in low-elevation and gentle-slope regions, accompanied by a decrease in landscape fragmentation. Conversely, in areas with higher elevations and steeper slopes, expansions in both cultivated land area and fragmentation were observed. Full article

The B Corp certification is a voluntary designation granted by B Lab. This nonprofit organization evaluates two main aspects of a company’s operations: the positive impact generated by its daily activities and how its business model reflects unique practices that yield positive outcomes for its stakeholders. Sistema B is at the forefront of the B movement in Latin America and the Caribbean, working to develop an ecosystem that enables B Corps to harness market forces to address social and environmental challenges. However, the B Corp movement in this region faces significant challenges, primarily due to a lack of government support, including tax benefits and legal recognition. This study aims to advance the existing literature on B Corps by examining sustainability-oriented hybrid organizations that strive to reconcile profit generation with social impact within the context of Mexico’s socioeconomic landscape. Additionally, it seeks to enhance the understanding of how ventures navigate trade-offs between financial and social objectives, and to identify factors that can help address these challenges. Twenty semi-structured interviews were conducted with Mexican B Corps to explore the entrepreneurial motivations related to social objectives, the B Corp movement, and the internal organizational dynamics of balancing social and economic logics. We discuss how tensions arise and are managed, as well as the issues regarding regulatory tensions in Mexico and the challenges that stem from organizational complexities. Future research directions are also outlined. Full article

In the context of cultural tourism integration, tourists’ spatial perception intention is an important carrier of spatial evaluation. In historic cultural districts represented by Jinan Mingfu City, tourists’ perceptual depth remains underexplored, leading to a misalignment between cultural tourism development and spatial quality needs. Taking Jinan Mingfu City as a representative case of a historic cultural district, while the living heritage model has revitalized local economies, the absence of a tourist perspective has resulted in misalignment between cultural tourism development and spatial quality requirements. This study establishes a technical framework encompassing “data crawling-factor aggregation-human-machine collaborative optimization”. It integrates Python web crawlers, SnowNLP sentiment analysis, and TF-IDF text mining technologies to extract physical elements; constructs a three-dimensional evaluation framework of “visual perception-spatial comfort-cultural experience” through SPSS principal component analysis; and quantifies physical element indicators such as green vision rate and signboard clutter index through street view semantic segmentation (OneFormer framework). A synergistic mechanism of machine scoring and manual double-blind scoring is adopted for correlation analysis to determine the impact degree of indicators and optimization strategies. This study identified that indicators such as green vision rate, shading facility coverage, and street enclosure ratio significantly influence tourist evaluations, with a severe deficiency in cultural spaces. Accordingly, it proposes targeted strategies, including visual landscape optimization, facility layout adjustment, and cultural scenario implementation. By breaking away from traditional qualitative evaluation paradigms, this study provides data-based support for the spatial quality enhancement of historic districts, thereby enabling the transformation of these areas from experience-oriented protection to data-driven intelligent renewal and promoting the sustainable development of cultural tourism. Full article

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal dystrophies characterized by progressive photoreceptor degeneration and vision loss. While current management is largely supportive—relying on visual aids, orientation training, and nutritional supplementation—these interventions offer only symptomatic relief and do not halt disease progression. Advances in molecular genetics have led to the development of targeted treatments, including gene replacement therapy, RNA-based therapies, and CRISPR/Cas9 gene editing, offering promising strategies for disease modification. The approval of voretigene neparvovec for RPE65-associated RP marked a milestone in gene therapy, while ongoing trials targeting mutations in RPGR, USH2A, and CEP290 are expanding therapeutic options. Optogenetic therapy and stem cell transplantation represent additional strategies, particularly for patients with advanced disease. Challenges persist in delivery efficiency, immune responses, and treating large or dominant-negative mutations. Non-viral vectors, nanoparticle systems, and artificial intelligence-guided diagnostics are being explored to address these limitations and support personalized care. This review summarizes the current and emerging therapeutic landscape for RP, highlighting the shift toward precision medicine and the need for continued innovation to overcome genetic and phenotypic variability. Full article

Context plays a critical role in talent development, yet most national analyses continue to rely on individual-centered talent concepts. This paper highlights the limitations of traditional models for assessing how countries support talent and proposes a resource-oriented, systemic alternative. Building on the Educational and Learning Capital Approach (ELCA), this study argues that national talent development depends on the availability, accessibility, and orchestration of both endogenous and exogenous learning resources across systemic levels. By analyzing the clumping patterns of excellence in STEM, the arts, sports, and innovation, this paper illustrates the unequal global distribution of talent-supportive environments. Seven key principles for effective resource orchestration are outlined, offering a framework for evaluating and strengthening national talent ecosystems. The paper concludes that systematic assessment and strategic enhancement of national resource landscapes are critical for sustainable talent development and for ensuring that human potential can flourish more equitably across countries. Full article