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Kujigamberol Inhibits IFN-γ and IL-2 mRNA Expression and NFATc2 Binding to Their Promoters in Response to a Phorbol Ester and Ionomycin Stimulation
- Tanpitcha Yodweerapong,
- Yuto Ueno,
- Rikako Yamaguchi,
- Piimwara Yarangsee,
- Ken-ichi Kimura and
- Takao Kataoka
Kujigamberol, a dinorlabdane compound isolated from Kuji amber, exerts multiple biological effects, including anti-allergic and anti-inflammatory activities. The present study demonstrated that kujigamberol inhibited cytokine production by T cells. I...