Search Results (824)

Managing finances in a supply chain today is not as straightforward as it once was. The world is constantly shifting—markets fluctuate, risks emerge unexpectedly—and companies are continually trying to stay one step ahead. In all this, financial resilience has become more than just a strategy. It is a survival skill. In our research, we examined how newer technologies (such as blockchain and the Internet of Things) can make a difference. The idea was not to reinvent the wheel but to see if these tools could actually make financing more transparent, reduce some of the friction, and maybe even help companies breathe a little easier when it comes to liquidity. We employed two optimization methods (Non-dominated Sorting Genetic Algorithm II (NSGA-II) and Multi-Objective Particle Swarm Optimization (MOPSO)) to achieve a balanced outcome. The goal was lower financing costs, better liquidity, and stronger resilience. Blockchain did not just record transactions—it seemed to build trust. Meanwhile, the Internet of Things (IoT) provided companies with a clearer picture of what is happening in real-time, making financial outcomes a bit less of a guessing game. However, it gives financial managers a better chance at planning and not getting caught off guard when the economy takes a turn. Full article

Technological roadmaps are essential tools for managing and planning complex projects, especially in the rapidly evolving field of space exploration. Defined as dynamic schedules, they support strategic and long-term planning while coordinating current and future objectives with particular technology solutions. Currently, the available methodologies are mostly built on experts’ opinions and in just few cases, methodologies and tools have been developed to support the decision makers with a rational approach. In any case, all the available approaches are meant to draw “ideal” maturation plans. Therefore, it is deemed essential to develop an integrate new algorithms able to decision guidelines on “non-nominal” scenarios. In this context, Politecnico di Torino, in collaboration with the European Space Agency (ESA) and Thales Alenia Space–Italia, developed the Technology Roadmapping Strategy (TRIS), a multi-step process designed to create robust and data-driven roadmaps. However, one of the main concerns with its initial implementation was that TRIS did not account for time and budget estimates specific to the space exploration environment, nor was it capable of generating alternative development paths under constrained conditions. This paper discloses two main significant updates to TRIS methodology: (1) improved time and budget estimation to better reflect the specific challenges of space exploration scenarios and (2) the capability of generating alternative roadmaps, i.e., alternative technological maturation paths in resource-constrained scenarios, balancing financial and temporal limitations. The application of the developed routines to available case studies confirms the tool’s ability to provide consistent planning outputs across multiple scenarios without exceeding 20% deviation from expert-based judgements available as reference. The results demonstrate the potential of the enhanced methodology in supporting strategic decision making in early-phase mission planning, ensuring adaptability to changing conditions, optimized use of time and financial resources, as well as guaranteeing an improved flexibility of the tool. By integrating data-driven prioritization, uncertainty modeling, and resource-constrained planning, TRIS equips mission planners with reliable tools to navigate the complexities of space exploration projects. This methodology ensures that roadmaps remain adaptable to changing conditions and optimized for real-world challenges, supporting the sustainable advancement of space exploration initiatives. Full article

Background: Immunization is a highly effective intervention for controlling over 20 life-threatening infectious diseases, significantly reducing both morbidity and mortality rates. One notable achievement in vaccination efforts was the global eradication of smallpox, which the World Health Assembly declared on 8 May 1980. Additionally, there has been a remarkable 99.9% reduction in wild poliovirus cases since 1988, decreasing from more than 350,000 cases that year to just 30 cases in 2022. Objectives: The objective of this review was to assess the effects of various interventions designed to increase vaccination uptake among adults. Search Methods: A thorough search was conducted in the CENTRAL, Embase Ovid, Medline Ovid, PubMed, Web of Science, and Global Index Medicus databases for primary studies. This search was conducted in August 2021 and updated in November 2024. Selection Criteria: Randomized trials were eligible for inclusion in this review, regardless of publication status or language. Data Analysis: Two authors independently screened the search outputs to select potentially eligible studies. Risk ratios (RR) with 95% confidence intervals (CI) were calculated for each randomized controlled trial (RCT). A meta-analysis was conducted using a random-effects model, and the quality of the evidence was assessed using the GRADE approach. Main Results: A total of 35 randomized controlled trials met the inclusion criteria and were included in this review, with the majority conducted in the United States. The interventions targeted adults aged 18 and older who were eligible for vaccination, involving a total of 403,709 participants. The overall pooled results for interventions aimed at increasing influenza vaccination showed a risk ratio of 1.41 (95% CI: 1.15, 1.73). Most studies focused on influenza vaccination (18 studies), while the remaining studies examined various other vaccines, including those for hepatitis A, COVID-19, hepatitis B, pneumococcal disease, tetanus, diphtheria, pertussis (Tdap), herpes zoster, and human papillomavirus (HPV). The results indicate that letter reminders were slightly effective in increasing influenza vaccination uptake compared to the control group (RR: 1.75, 95% CI: 0.97, 1.16; 6 studies; 161,495 participants; low-certainty evidence). Additionally, participants who received education interventions showed increased levels of influenza vaccination uptake compared to those in the control group (RR: 1.88, 95% CI: 0.61, 5.76; 3 studies; 1318 participants; low-certainty evidence). Furthermore, tracking and outreach interventions also led to an increase in influenza vaccination uptake (RR: 1.87, 95% CI: 0.78, 4.46; 2 studies; 33,752 participants; low-certainty evidence). Conclusions: Letter reminders and educational interventions targeted at recipients are effective in increasing vaccination uptake compared to control groups. Full article

Background/Objectives: Respectful maternity care involves privacy, dignity, and informed choice within the process of delivery as stipulated by the World Health Organization (WHO). Informed consent is a cornerstone of patient-centered care, representing not just a formal document, but an ongoing ethical and clinical process through which women are offered objective, understandable information to support autonomous, informed decision-making. Methods: This narrative review critically examines the literature on informed consent in maternity care, with particular attention to both obstetric-led and midwifery-led models of care. In addition to identifying institutional, cultural, and systemic obstacles to its successful implementation, the review examines the definition and application of informed consent in perinatal settings and evaluates its effects on women’s autonomy and satisfaction with care. Results: Important conclusions emphasize that improving women’s experiences and minimizing needless interventions require active decision-making participation, a positive provider–patient relationship, and ongoing support from medical professionals. However, significant gaps persist between legal mandates and actual practice due to provider attitudes, systemic constraints, and sociocultural influences. Women’s experiences of consent can be more effectively understood through the use of instruments such as the Mothers’ Respect (MOR) Index and the Mothers’ Autonomy in Decision Making (MADM) Scale. Conclusions: To promote genuinely informed and considerate maternity care, this review emphasizes the necessity of legislative reform and improved provider education in order to close the gap between policy and practice. Full article

In G. E. M. Anscombe’s extensive correspondence with G. H. von Wright, one of the many topics that come up is the bombing of Hiroshima and Nagasaki at the end of World War II. What she says in these letters is significant because of the interest in what she wrote elsewhere about the use of atomic weapons. It is especially interesting because she might seem to imply here that only a person with religious faith is capable of being just. This paper quotes the relevant passages from the correspondence, explores what she might have meant, and concludes that she is not committed to the view that only the faithful can be just. Full article

The electrification of road vehicles is a relatively mature sector, while other areas of mobility, such as construction machinery, are just beginning their transition to electric solutions. This work presents the design and realization of an integrated drive system specifically developed for retrofitting fan drives in heavy machinery, like bulldozers and tractors, utilizing existing 48 VDC batteries. By replacing or complementing internal combustion and hydraulic technologies with electric solutions, significant advantages in efficiency, reduced environmental impact, and versatility can be achieved. Focusing on the fan drive system addresses the critical challenge of thermal management in high ambient temperatures and harsh environments, particularly given the high current requirements for $3\mathrm{k}\mathrm{W}$-class applications. A sensorless architecture has been selected to enhance reliability by eliminating mechanical position sensors. The developed fan drive has been extensively tested both on a braking bench and in real-world applications, demonstrating its effectiveness and robustness. Future work will extend this prototype to electrify additional onboard hydraulic motors in these machines, further advancing the electrification of heavy-duty equipment and improving overall efficiency and environmental impact. Full article

The invention of antibacterial agents (antibiotics) was a significant event in the history of the human race, and this invention changed the way in which infectious diseases were cured; as a result, many lives have been saved. Recently, antibiotic resistance has developed as a result of excessive use of antibiotics, and it has become a major threat to world health. ARGs are spread across biomes and taxa of bacteria via lateral or horizontal gene transfer (HGT), especially via conjugation, transformation, and transduction. This review concerns transduction, whereby bacteriophages or phages facilitate gene transfer in bacteria. Bacteriophages are just as common and many times more numerous than their bacterial prey, and these phages are much more influential in controlling the population of bacteria. It is estimated that 25% of overall genes of Escherichia coli have been copied by other species of bacteria due to the HGT process. Transduction may take place via a generalized or specialized mechanism, with phages being ubiquitous in nature. Phage and virus-like particle (VLP) metagenomics have uncovered the emergence of ARGs and mobile genetic elements (MGEs) of bacterial origins. These genes, when transferred to bacteria through transduction, confer resistance to antibiotics. ARGs are spread through phage-based transduction between the environment and bacteria related to people or animals, and it is vital that we further understand and tackle this mechanism in order to combat antimicrobial resistance. Full article

The increasing complexity of urban structures has significantly elevated the risk and severity of façade fires in high-rise buildings. Unlike traditional models assuming continuous fuel beds, real-world fire scenarios often involve discrete combustible materials arranged in discrete fuel matrices. This study presents a systematic investigation into the influence of lateral spacing on vertical flame propagation behavior. Laboratory-scale experiments were conducted using vertically oriented polymethyl methacrylate (PMMA) fuel arrays under nine different spacing configurations. Results reveal that lateral spacing plays a critical role in determining flame spread paths and intensities. Specifically, with a vertical spacing fixed at 8 cm, a lateral spacing of 10 mm resulted in rapid flame growth, reaching a peak flame height of approximately 96.5 cm within 450 s after ignition. In contrast, increasing the lateral spacing to 15 mm significantly slowed flame development, achieving a peak flame height of just under 90 cm at approximately 600 s. This notable transition in flame dynamics is closely associated with the critical thermal boundary layer thickness (~11.5 mm). Additionally, at 10 mm spacing, a chimney-like effect was observed, enhancing upward air entrainment and resulting in intensified combustion. These findings reveal the coupled influence of geometric configuration and heat transfer mechanisms on façade flame propagation. The insights gained provide guidance for cladding system design, suggesting that increasing lateral separation between combustible elements may be an effective strategy to limit flame spread and enhance fire safety performance in buildings. Full article

Personal relative deprivation (PRD) is closely linked to a range of mental health problems. In the digital era, the association between social media use and PRD has received increasing attention. However, most studies have been conducted in Western contexts, and the underlying mechanisms in China remain unclear. This study examined the relationship between social media use and PRD among 2504 adult urban residents in China. Based on relative deprivation theory, it further explored the mediating role of subjective social status and the moderating role of belief in a just world. Results revealed that social media use was negatively associated with PRD. Subjective social status mediated this relationship: social media use was positively associated with subjective social status, while subjective social status was negatively associated with PRD. Moreover, belief in a just world strengthened the direct negative link between social media use and PRD, as well as the positive link between social media use and subjective social status. These findings suggest that social media are not always a risk factor for mental health. Their impact should be considered within specific cultural contexts and regulatory policies. Full article

Background: Antimicrobial resistance (AMR) is a global threat that affects humans, animals, plants, the environment, societies, and economies—requiring urgent coordinated action. In May 2015, the World Health Assembly (WHA) adopted the Global Action Plan (GAP) on AMR, urging member states to develop and implement their own National Action Plans (NAPs) using a One Health approach. Objective: Both South Africa and Eswatini have developed NAPs and are currently in the implementation phase. However, no study has explored policymakers’ perceptions regarding NAP implementation particularly concerning coordination, accountability, resourcing, regulation and ownership. Methods: This qualitative study employed a narrative approach to explore these perceptions in South Africa and Eswatini. A total of 36 key informants were recruited using purposive and snowball sampling methods. Data was collected between November 2018 and March 2019 and transcribed verbatim. Results: Findings revealed that while governance structures for implementing NAPs exist in South Africa and Eswatini, several critical areas require urgent attention. These include limited accountability across One Health sectors, the absence of dedicated national budgets for NAP implementation, poor intra- and inter- ministerial coordination, weak medicine regulation and enforcement, and delayed multisectoral ownership of the NAPs. Conclusions: To address AMR effectively, both countries must allocate dedicated budgets, improve multisectoral integration, and strengthen regulatory frameworks regarding antimicrobial access and use across all One Health sectors. A firm commitment from all sectors is required—not just formal endorsement of the NAPs—to ensure sustainable implementation and ownership. Full article

The widespread rise of misinformation across digital platforms has increased the demand for accurate and efficient Fake News Detection (FND) systems. This study introduces an enhanced transformer-based architecture for FND, developed through comprehensive ablation studies and empirical evaluations on multiple benchmark datasets. The proposed model combines improved multi-head attention, dynamic positional encoding, and a lightweight classification head to effectively capture nuanced linguistic patterns, while maintaining computational efficiency. To ensure robust training, techniques such as label smoothing, learning rate warm-up, and reproducibility protocols were incorporated. The model demonstrates strong generalization across three diverse datasets, such as FakeNewsNet, ISOT, and LIAR, achieving an average accuracy of 79.85%. Specifically, it attains 80% accuracy on FakeNewsNet, 100% on ISOT, and 59.56% on LIAR. With just 3.1 to 4.3 million parameters, the model achieves an 85% reduction in size compared to full-sized BERT architectures. These results highlight the model’s effectiveness in balancing high accuracy with resource efficiency, making it suitable for real-world applications such as social media monitoring and automated fact-checking. Future work will explore multilingual extensions, cross-domain generalization, and integration with multimodal misinformation detection systems. Full article

Since 1957, the near-Earth population of trackable space objects has grown in number to over 36,000. Of these 36,000+ trackable objects now in low Earth orbit, just a few thousand are working spacecraft. The rest are Earth-orbiting objects which are no longer operational and are considered to be space junk. Because this junk can no longer receive maneuvering commands from its Earth-based owners, the survivability of other spacecraft traveling through or operating in Earth orbit can be jeopardized by the impacts of any number of pieces of this space junk, whose origins can usually be traced back to defunct satellites. As a result, a major design parameter for Earth-orbiting spacecraft is the possibility of such high-speed impacts and the damage they can cause. Furthermore, several private companies are now launching several thousand spacecraft into Earth orbit, many of which are satellites built for communication purposes. Other satellites have been launched to expand the reach of the World Wide Web and to provide better tools for disaster management. Two questions quickly become evident, namely, what is the beneficial purpose of these large satellite constellations, and what are some of the deleterious consequences of their proliferation? Numerous topics related to space debris will be discussed in this paper, including issues in space law that concern the growing problem of orbital debris. In the end, several areas of concern will be noted that are vital to the continuing presence of humans in near-Earth space and must be addressed as the near-Earth orbital environment becomes more congested and space traffic management becomes more difficult. Full article

Multi-view classification (MVC) typically focuses on categorizing objects into distinct classes by employing multiple perspectives of the same objects. However, in numerous real-world applications, such as industrial inspection and quality control, there is an increasing need to distinguish particular objects from a pool of similar ones while simultaneously disregarding unknown objects. In these scenarios, relying on a single image may not provide sufficient information to effectively identify the scrutinized object, as different perspectives may reveal distinct characteristics that are essential for accurate classification. Most existing approaches operate within closed-set environments and are focused on generalization, which makes them less effective in distinguishing individual objects from others. This limitations are particularly problematic in industrial quality assessment, where distinguishing between specific objects and discarding unknowns is crucial. To address this challenge, we introduce a View-Compatible Feature Fusion (VCFF) method that utilizes images from predetermined positions as an accurate solution for multi-view classification of specific objects. Unlike other approaches, VCFF explicitly integrates pose information during the fusion process. It does not merely use pose as auxiliary data but employs it to align and selectively fuse features from different views. This mathematically explicit fusion of rotations, based on relative poses, allows VCFF to effectively combine multi-view information, enhancing classification accuracy. Through experimental evaluations, we demonstrate that the proposed VCFF method outperforms state-of-the-art MVC algorithms, especially in open-set scenarios, where the set of possible objects is not fully known in advance. Remarkably, VCFF achieves an average precision of 1.0 using only 8 cameras, whereas existing methods require 20 cameras to reach a maximum of 0.95. In terms of AUC-ROC under the constraint of fewer than 3$\sigma$ false positives—a critical metric in industrial inspection—current state-of-the-art methods achieve up to 0.72, while VCFF attains a perfect score of 1.0 with just eight cameras. Furthermore, our approach delivers highly accurate rotation estimation, maintaining an error margin slightly above 2° when sampling at 4° intervals. Full article

This paper advances two interrelated theses. As for the first thesis, it distinguishes well-being, on the one hand, from happiness, on the other hand. As for the second thesis, it differentiates between two important facets of happiness: what this paper calls “happiness-as-tranquility” and “happiness-as-aspiration”. Actually, in order to differentiate the two facets of happiness, we first need to distinguish happiness from well-being. This is the case because happiness, after all, is a by-product of reflecting upon and ruminating over well-being. Given it is the same well-being, how could it give rise to different facets of happiness? It can only do so if we stop conflating happiness with well-being. This entails taking to task the widely accepted concept of “subjective wellbeing”. Such concept is expressly designed to obfuscate the difference between well-being and happiness. As for the two facets of happiness (the second thesis), this paper relies upon the contrast of two famous works of literature: the story of Job and the story of Faust. The contrast uncovers the criticality of the temporal dimension in the acts of reflection upon and rumination over well-being. If people reflect on past accomplishments, they experience backward-looking happiness along the Job story—i.e., happiness-as-tranquility. If people reflect on desire, they experience forward-looking happiness along the Faust story—i.e., happiness-as-aspiration. While the two facets of happiness seem contradictory, they are indeed complementary if we recognize the temporal element when one reflects upon and ruminates over well-being. Full article

One of the world’s most sustainable solutions is to replace fossil-based polymers with biopolymers. The production of xanthan gum can be optimized using various renewable and cost-effective raw materials, which is a key focus in industrial biotechnology. Xanthan gum is a bioengineered thickening, stabilizing, and emulsifying agent. It has unique properties for use in many industries (food, biotechnology, petrochemicals, agricultural, cosmetics, wastewater treatment) and medical applications. It is tasteless, environmentally safe, non-toxic, and biodegradable. The biotechnological production of xanthan gum depends on several factors: bacterial strain development, culture medium preparation, carbon sources, fermentation parameters and modes, pH, temperature, recovery, purification, and quality control regulations. Bio-innovative strategies have been developed to optimize the production of xanthan gum. A variety of carbon and nitrogen sources, as well as alternative renewable sources, have been used in the production of xanthan gum. The aim of the present study was to optimize the xanthan gum yield using Xanthomonas campestris bacteria and different carbon (D-glucose, D-sorbitol, lactose, sucrose, D-mannitol, D-fructose, erythritol, coconut palm sugar, L-arabinose, unrefined cane sugar), various nitrogen (bacterial peptone, casein peptone, L-glutamic acid, L-arginine, L-methionine, L-tryptophan, malt extract, meat extract, L-phenylalanine, soy peptone) and alternative carbon (orange peels, tangerine peels, lemon peels, avocado peels, melon peels, apple peels, cellulose, xylose, xylitol) sources. The xanthan gum samples were analyzed using antioxidant methods. Our study showed that using L-glutamic acid as the carbon source for 72 h of bacterial fermentation of Xanthomonas campestris resulted in the highest xanthan gum yield: 32.34 g/L. However, using renewable resources, we achieved a very high concentration of xanthan gum in just 24 h of fermentation. According to the reducing power and DPPH methods, the highest antioxidant activities were measured for xanthan gum whose biosynthesis was based on renewable resources. Xanthan gum structures have been verified by FT-IR and ¹H NMR analysis. The sustainable biotechnology study has the advantage of increasing the sustainable production of xanthan gum by using renewable alternative resources compared to other production processes. Xanthan gum continues to be a valuable biopolymer with a wide range of industrial applications while promoting environmentally friendly production practices. Full article