Small-Molecule Antibiotic Drug Development

A special issue of Targets (ISSN 2813-3137).

Deadline for manuscript submissions: 20 December 2025 | Viewed by 1774

Special Issue Editor


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Guest Editor
Centro María Zambrano, Universidad Nacional de Educación a Distancia (UNED), Málaga, Spain
Interests: organic chemistry; organic synthesis; medicinal chemistry; methodology development; antibiotics; nanotechnology
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Special Issue Information

Dear Colleagues,

Bacterial infections constitute one of the major cases of primary medical incidences worldwide. Historically, the fight against bacterial infections in humans has been an ongoing battle due to the ability of bacteria to adapt and to survive. After a century of engagement in the fight against bacterial infections, the scientific community continues to intensively search for new therapeutic agents, especially those active against resistant bacteria.

In this Special Issue, we are looking for all kinds of articles regarding the development of antibiotics based on small molecules. From the synthetic to the medical community, going through biological studies of new mechanisms of action, we aim to collect interesting and novel ideas around antibiotic drug discovery. In addition, we open the door to new technologies and treatments to overcome the classical resistance exhibited by bacteria.

Dr. Miguel Garcia-Castro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • small molecules
  • antibiotic drug discovery
  • bacterial infections

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Published Papers (1 paper)

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Review

12 pages, 722 KB  
Review
Bacteriophages: Potential Candidates for the Dissemination of Antibiotic Resistance Genes in the Environment
by Shahid Sher, Husnain Ahmad Khan, Zaman Khan, Muhammad Sohail Siddique, Dilara Abbas Bukhari and Abdul Rehman
Targets 2025, 3(3), 25; https://doi.org/10.3390/targets3030025 - 22 Jul 2025
Viewed by 1068
Abstract
The invention of antibacterial agents (antibiotics) was a significant event in the history of the human race, and this invention changed the way in which infectious diseases were cured; as a result, many lives have been saved. Recently, antibiotic resistance has developed as [...] Read more.
The invention of antibacterial agents (antibiotics) was a significant event in the history of the human race, and this invention changed the way in which infectious diseases were cured; as a result, many lives have been saved. Recently, antibiotic resistance has developed as a result of excessive use of antibiotics, and it has become a major threat to world health. ARGs are spread across biomes and taxa of bacteria via lateral or horizontal gene transfer (HGT), especially via conjugation, transformation, and transduction. This review concerns transduction, whereby bacteriophages or phages facilitate gene transfer in bacteria. Bacteriophages are just as common and many times more numerous than their bacterial prey, and these phages are much more influential in controlling the population of bacteria. It is estimated that 25% of overall genes of Escherichia coli have been copied by other species of bacteria due to the HGT process. Transduction may take place via a generalized or specialized mechanism, with phages being ubiquitous in nature. Phage and virus-like particle (VLP) metagenomics have uncovered the emergence of ARGs and mobile genetic elements (MGEs) of bacterial origins. These genes, when transferred to bacteria through transduction, confer resistance to antibiotics. ARGs are spread through phage-based transduction between the environment and bacteria related to people or animals, and it is vital that we further understand and tackle this mechanism in order to combat antimicrobial resistance. Full article
(This article belongs to the Special Issue Small-Molecule Antibiotic Drug Development)
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