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3 Results Found

  • Article
  • Open Access
1 Citations
1,503 Views
14 Pages

Inhibitory Potential of the Drimane Sesquiterpenoids Isotadeonal and Polygodial in the NF-kB Pathway

  • Víctor Marín,
  • Cecilia Villegas,
  • Ayorinde Víctor Ogundele,
  • Jaime R. Cabrera-Pardo,
  • Bernd Schmidt,
  • Cristian Paz and
  • Viviana Burgos

31 March 2025

Inflammation contributes to the onset and development of many diseases, including neurodegenerative diseases, caused by the activation of microglia, leading to neurological deterioration. Nuclear factor-κB (NF-κB) is one of the most relev...

  • Article
  • Open Access
4 Citations
2,888 Views
12 Pages

Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients

  • Víctor Marín,
  • Bryan Bart,
  • Nicole Cortez,
  • Verónica A. Jiménez,
  • Víctor Silva,
  • Oscar Leyton,
  • Jaime R. Cabrera-Pardo,
  • Bernd Schmidt,
  • Matthias Heydenreich and
  • Viviana Burgos
  • + 1 author

4 October 2022

Drimys winteri J.R. (Winteraceae) produce drimane sesquiterpenoids with activity against Candida yeast. In this work, drimenol, polygodial (1), isotadeonal (2), and a new drimane α,β-unsaturated 1,4-dialdehyde, named winterdial (4), were p...

  • Article
  • Open Access
2,729 Views
12 Pages

Drimane Sesquiterpene Alcohols with Activity against Candida Yeast Obtained by Biotransformation with Cladosporium antarcticum

  • Nicole Cortez,
  • Víctor Marín,
  • Verónica A. Jiménez,
  • Víctor Silva,
  • Oscar Leyton,
  • Jaime R. Cabrera-Pardo,
  • Bernd Schmidt,
  • Matthias Heydenreich,
  • Viviana Burgos and
  • Paola Duran
  • + 1 author

27 October 2022

Fungal biotransformation is an attractive synthetic strategy to produce highly specific compounds with chemical functionality in regions of the carbon skeleton that are not easily activated by conventional organic chemistry methods. In this work, Cla...