Search Results (450)

Background: Crystalline glucosamine sulfate (cGS) claims to be a stabilized form of glucosamine sulfate with a defined crystalline structure intended to enhance chemical stability. It is proposed to offer pharmacokinetic advantages over regular glucosamine sulfate (rGS) which is stabilized with potassium or sodium chloride. However, comparative human bioavailability data are limited. Since both forms dissociate in gastric fluid into constituent ions, the impact of cGS formulation on absorption remains uncertain. This pilot study aimed to compare the bioavailability of cGS and rGS using a randomized, double-blind, crossover design. Methods: Ten healthy adults received a single 1500 mg oral dose of either cGS or rGS with a 7-day washout between interventions. Capillary blood samples were collected over 24 h. Glucosamine and its metabolite concentrations were quantified by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS), and pharmacokinetic parameters—including maximum concentration (C_max), time to reach C_max (T_max), and area under the curve (AUC)—were calculated. Results: Mean AUC_0–24, C_max, T_max, and T_½ values for glucosamine and glucosamine-6-sulfate (GlcN-6-S) were comparable between cGS and rGS. Although the AUC_0–24 for glucosamine was modestly higher with rGS (18,300 ng·h/mL) than with cGS (12,900 ng·h/mL), the difference was not statistically significant (p = 0.136). GlcN-6-S exposure was also similar between formulations (rGS: 50,700 ng·h/mL; cGS: 50,600 ng·h/mL), with a geometric mean ratio of 1.39, a delayed T_max (6–8 h) and longer half-life, consistent with its role as a downstream metabolite. N-acetylglucosamine levels remained stable, indicating potential homeostatic regulation. Conclusions: This pilot study found no significant pharmacokinetic advantage of cGS over rGS. These preliminary findings challenge claims of cGS’ pharmacokinetic superiority, although the small sample size limits definitive conclusions. Larger, adequately powered studies are needed to confirm these results. Full article

The stabilization of heavy metal elements, such as zinc, in the form of ions within the glass-ceramics represents a valuable approach to addressing environmental pollution caused by heavy metals. This study investigates the feasibility and physicochemical properties of diopside-based glass-ceramics synthesized from zinc-containing smelting slag. The zinc-rich smelting slag is abundant in SiO₂, Al₂O₃, CaO, and other constituents, thereby providing cost-effective and efficient raw materials for glass-ceramic production. The conversion of zinc-containing smelting slag into glass-ceramics was achieved through a melting process. We analyzed the effects of varying doping levels on the properties of the resulting glass-ceramics. The results indicated that as the doping level of smelting slag increases, the crystallization temperature of the glass-ceramics decreases while the crystal phases of diopside and anorthite progressively increase, significantly enhancing both mechanical strength and chemical stability. Notably, when the doping level reaches 60%, these glass-ceramics exhibit remarkable physical properties, including high density (3.12 g/cm³), Vickers hardness (16.60 GPa), and excellent flexural strength (150.75 MPa). Furthermore, with increasing amounts of doped smelting slag, there are substantial improvements in acid resistance, alkali resistance, and corrosion resistance in these materials. Raman spectroscopy and EDS analysis further verified a uniform distribution of the crystal phase and effective immobilization of heavy metal zinc. Full article

With the large-scale closure of coal mines leading to groundwater pollution, in order to systematically identify the sources of major chemical ions in surface water and groundwater. This study comprehensively applied methods such as Piper’s trilinear diagram, linear fitting, and correlation analysis to quantitatively analyze the hydrochemical characteristics of closed coal mining areas in southwest Shandong and to clarify the sources of geochemical components in surface water and groundwater, and the PMF model was used to analyze the sources of chemical components in mine water and karst water. The results show that the concentrations of TDS ( Total Dissolved Solids), SO₄²⁻, Fe, and Mn in the mine water of the closed coal mine area are higher than in the karst water. Both water bodies are above groundwater quality standards. Ca²⁺, SO₄²⁻, and HCO₃⁻ dominate the ionic components in surface water and different types of groundwater. The hydrochemical types of surface, pore, and mine waters are mainly SO₄-HCO₃-Ca, whereas SO₄-HCO₃-Ca and HCO₃-SO₄-Ca dominate karst waters. SO₄²⁻ is the leading ion in the TDS of water bodies. The mineralization process of surface water is mainly controlled by the weathering of silicate minerals, while that of the groundwater is mainly controlled by the dissolution of carbonate minerals. The impact of mining activities on surface water and groundwater is significant, while the impact of agricultural activities on surface water and groundwater is relatively small. The degree of impact of coal mining activities on SO₄²⁻ concentrations in surface water, pore water, and karst water, in descending order, is karst water, surface water, and pore water. The PMF (Positive Matrix Factorization) model analysis results indicate that dissolution of carbonate minerals with sulphate and oxidation dissolution of sulfide minerals are the main sources of chemical constituents in mine waters. Carbonate dissolution, oxidation dissolution of sulfide minerals, domestic sewage, and dissolution of carbonate minerals with sulphate are ranked as the main sources of chemical constituents in karst water from highest to lowest. These findings provide a scientific basis for the assessment and control of groundwater pollution in the areas of closed coal mines. Full article

The increasing adoption of Light Electric Vehicles (LEVs) in urban areas, driven by the micromobility wave, raises significant safety concerns, particularly regarding battery fire incidents. This research investigates the electromechanical performance of aged 18650 lithium-ion batteries (LIBs) from LEVs under mechanical impact conditions. For this study, a battery module from a used e-scooter was disassembled, and its constituent cells were reconfigured into compact modules for testing. To characterize their initial condition, the cells underwent cycling tests to evaluate their state of health (SOH). Although a slight majority of the cells retained an SOH greater than 80%, a notable increase in their internal resistance (IR) was also observed, indicating degradation due to aging. The mechanical impact tests were conducted in adherence to the UL 2271:2018 standard, employing a semi-sinusoidal acceleration pulse. During these tests, linear kinematics were analyzed using videogrammetry, while key electrical and thermal parameters were monitored. Additionally, strain gauges were installed on the central cells to measure stress and deformation. The results from the mechanical shock tests revealed characteristic acceleration and velocity patterns. These findings clarify the electromechanical behavior of aged LIBs under impact, providing critical data to enhance the safety and reliability of these vehicles. Full article

Saffron spice is obtained from the flower’s stigmas through a labor-intensive process. However, other organs (particularly the leaves and tepals) are often regarded as waste. To investigate the health benefits of saffron leaf by-products, an optimized methodology was developed to obtain a phenol-enriched fraction. The main components of this fraction were identified by HPLC-DAD/ESI-MS and the antiproliferative and metal-chelating effects on colon cancer cells (Caco-2) and Fe²⁺ and Cu²⁺ ions, respectively, were evaluated. The process involved the extraction of saffron leaves with a 70% hydroalcoholic solution, followed by purification using liquid chromatography. Chemical characterization revealed the presence of several phenolic compounds, including flavonoids (kaempferol, luteolin and quercetin glycosides) as major constituents; whereas, in vitro assays revealed a strong dose-dependent inhibition of cell proliferation. Likewise, the sample exhibited significant iron- and copper-chelating activity, suggesting its potential as a natural chelator to help mitigate the carcinogenic effects of metal accumulation in humans. In summary, this study underscores the potential of the saffron leaf fraction as a promising natural and complementary chemoprotective agent in colorectal cancer. Additionally, these results underscore the value of agricultural by-products, supporting a circular bioeconomy by reducing environmental impact and promoting the sustainable use of natural resources. Full article

Semiconductor device fabrication is conducted through highly precise manufacturing processes. An essential component of the semiconductor package is the lead frame on which the silicon dies are assembled. Impurities such as oxides or organic matter on the surfaces have an impact on the process yield. Plasma cleaning is a vital process in semiconductor manufacturing, employed to enhance production yield through precise and efficient surface preparation essential for device fabrication. This paper explores the various facets of plasma cleaning, with a particular emphasis on its application in the cleaning of lead frames used in semiconductor packaging. To provide comprehensive context, this paper also reviews the critical role of plasma in advanced and emerging packaging technologies. This study investigates the fundamental physics governing plasma generation, the design of plasma systems, and the composition of the plasma medium. A central focus of this work is the comparative analysis of different plasma systems in terms of their effectiveness in removing organic contaminants and oxide residues from substrate surfaces. By utilizing reactive species generated within the plasma—such as oxygen radicals, hydrogen ions, and other chemically active constituents—these systems enable a non-contact, damage-free cleaning method that offers significant advantages over conventional wet chemical processes. Additionally, the role of non-reactive species, such as argon, in sputtering processes for surface preparation is examined. Sputtering is the ejection of individual atoms from a target surface due to momentum transfer from an energetic particle (usually an ion). Sputtering is therefore a physical process driven by momentum transfer. Energetic ions, such as argon (Ar⁺), are accelerated from the plasma to bombard a target surface. Upon impact, these ions transfer sufficient kinetic energy to atoms within the material’s lattice to overcome their surface binding energy, resulting in their physical ejection. This paper also provides a comparative assessment of various plasma sources, including direct current, dielectric barrier discharge, radio frequency, and microwave-based systems, evaluating their suitability and efficiency for lead frame cleaning applications. Furthermore, it addresses critical parameters affecting plasma cleaning performance, such as gas chemistry, power input, pressure regulation, and substrate handling techniques. The ultimate aim of this paper is to provide a concise yet comprehensive resource that equips technical personnel with the essential knowledge required to make informed decisions regarding plasma cleaning technologies and their implementation in semiconductor manufacturing. This paper provides various tables which provide the reader with comparative assessments of the various plasma sources and gases used. Scoring mechanisms are also introduced and utilized in this paper. The scores achieved by both the sources and the plasma gases are then summarized in this paper’s conclusions. Full article

Salicornia species are halophytic plants that thrive in environments with moderate to high salinity. Owing to its high nutritional value and diverse bioactive constituents, Salicornia holds promise for applications in the food, feed, pharmaceutical, cosmetic, and bioenergy sectors. Understanding its salt tolerance mechanisms is important for developing crops suited to saline soils and water. Recent studies have revealed that Salicornia adapts to salinity through diverse physiological, biochemical, and molecular strategies. Despite these advances, a comprehensive synthesis of existing knowledge remains absent, hindering its effective application in crop improvement. In this review, recent advances in the understanding of Salicornia’s salinity tolerance are synthesized, with emphasis placed on key mechanisms: cell wall nano-mechanics, ion regulation and compartmentation, antioxidant defense, osmotic balance, phytohormonal control, signal transduction, transcriptional regulation, and the expression of salt-responsive proteins. The interactions among these mechanisms are also examined, along with their roles in conferring tolerance to additional abiotic stresses such as drought, submergence, and extreme temperatures. Finally, the potential applications of these findings in genetic engineering for improving salt tolerance in crops are discussed, along with proposed directions for future research to promote the use of halophytes in sustainable agriculture. Full article

Fine particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM_2.5) has been extensively studied due to its adverse health effects. Most research has focused on its impact on the respiratory system; however, increasing attention is being directed toward its effects on the brain. Associations between air pollution and neurological disorders—such as Alzheimer’s disease, cerebral infarction, and autism spectrum disorder—have been reported, with mechanism-based studies in animal models providing further insights. PM_2.5 comprises a complex mixture of thousands of chemical constituents. To elucidate its neurotoxicity mechanisms, it is essential to investigate both its transport pathways to the brain and the specific actions of its individual components. This review highlights key PM_2.5 components—water-soluble ions, metals, carbonaceous particles, polycyclic aromatic hydrocarbons, quinones, plastics, and bioaerosols—and outlines their potential routes of entry into the central nervous system, along with their associated mechanisms of action. By integrating these findings, this review contributes to a deeper understanding of the neurological effects mediated by PM_2.5, which represent one of the most critical aspects of its health impact. Full article

Arthrospira platensis, a filamentous photosynthetic cyanobacterium, is widely recognized for its high nutritional value, broad spectrum of bioactive compounds, and excellent safety profile, making it a promising natural source for health-promoting applications. This study aimed to profile the phenolic constituents of an ethanolic extract of A. platensis (EAP) using HPLC-DAD-ESI-MS and to investigate its pharmacological effects in attenuating acute and sub-chronic experimental colitis, as well as its antioxidant and antifungal properties. Colitis was induced in BALB/c mice by intrarectal administration of 2,4-dinitrobenzenesulfonic acid (DNBS), followed by oral administration of EAP at doses of 50, 100, and 200 mg/kg. Phenolic profiling revealed eight major compounds, with a cumulative content of 6.777 mg/g of extract, with Pyrogallol, Ferulic acid, and Chlorogenic acid being the most abundant. In vivo, EAP treatment significantly reduced the Disease Activity Index (DAI), alleviated macroscopic colonic damage, and preserved colonic mucosal integrity in both inflammatory phases. Biochemical analyses revealed significant reductions in myeloperoxidase (MPO) activity, nitric oxide (NO), and malondialdehyde (MDA) levels, accompanied by increased reduced glutathione (GSH) content and catalase activity. In vitro, EAP demonstrated notable antioxidant effects, including 56% DPPH and 47% ABTS radical scavenging activities, and an 81% ferrous ion-chelating capacity. Furthermore, it exhibited antifungal activity, with inhibition zones of 20 mm against Candida albicans and 15 mm against Aspergillus flavus, respectively. These findings highlight the multitarget bioactivity of EAP and support its potential as a natural agent for managing intestinal inflammation and oxidative stress across both acute and sub-chronic phases. Full article

Aqueous zinc–ion batteries (AZIBs) have garnered considerable attention owing to their inherent safety, cost-effectiveness, and promising electrochemical performance. However, challenges associated with Zn metal anodes, such as dendrite formation, corrosion, and hydrogen evolution, continue to impede their widespread adoption. To overcome these limitations, a flexible and self-standing composite film anode (denoted ZCN) is engineered from a synergistic combination of Zn powder, nanocellulose, and carbon fiber to serve as a high-performance alternative to conventional Zn foil. These three constituents play the roles of enhancing the active area, improving mechanical properties and electrolyte affinity, and establishing a conductive network, respectively. This innovative design effectively mitigates dendrite growth and suppresses parasitic side reactions, thereby significantly improving the cycling stability of ZCN. As a result, this electrode enables the Zn//Zn cell to offer an ultralong lifespan of 2000 h. And the Zn-MnO₂ battery with ZCN anode demonstrates remarkable performance, realizing over 80% capacity retention after 1000 cycles. This study presents a straightforward, scalable, and cost-effective strategy for the development of dendrite-free metal electrodes, paving the way for durable and high-performance AZIBs. Full article

Ammonium nitrate (NH₄NO₃) is a major constituent of fine particulate matter (PM_2.5), playing a critical role in air quality and atmospheric chemistry. However, the dual regulatory role of ammonia (NH₃) in both the formation and volatilization of NH₄NO₃ under ambient atmospheric conditions remains inadequately understood. To address this gap, we conducted high-resolution field measurements at a clean tropical coastal site in China using an integrated system of Aerosol Ion Monitor-Ion Chromatography, a Scanning Mobility Particle Sizer, and online OC/EC analyzers. These observations were complemented by thermodynamic modeling (E-AIM) and source apportionment via a Positive Matrix Factorization (PMF) model. The E-AIM simulations revealed persistent thermodynamic disequilibrium, with particulate NO₃⁻ tending to volatilize even under NH_3gas-rich conditions during the northeast monsoon. This suggests that NH₄NO₃ in PM_2.5 forms rapidly within fresh combustion plumes and/or those modified by non-precipitation clouds and then undergoes substantial evaporation as it disperses through the atmosphere. Under the southeast monsoon conditions, reactions constrained by sea salt aerosols became dominant, promoting the formation of particulate NO₃⁻ while suppressing NH₄NO₃ formation despite ongoing plume influence. In scenarios of regional accumulation, elevated NH₃ concentrations suppressed NH₄NO₃ volatilization, thereby enhancing the stability of particulate NO₃⁻ in PM_2.5. PMF analysis identified five source factors, with NO₃⁻ in PM_2.5 primarily associated with emissions from local power plants and the large-scale regional background, showing marked seasonal variability. These findings highlight the complex and dynamic interplay between the formation and evaporation of NH₄NO₃ in NH_3gas-rich coastal atmospheres. Full article

Rapid progress in lithium-ion batteries and AI-powered autonomous driving is poised to propel electric vehicles to a 50% share of the global automotive market by the year 2035. Today, there is a major focus on recycling electric vehicle motors, particularly on extracting rare earth elements (REEs) from NdFeB permanent magnets (PMs). This research is based on a single-furnace process concept designed to separate metal components within PM motors by exploiting the varying melting points of the constituent materials, simultaneously extracting REEs present within the PMs and transferring them into the slag phase. Thermodynamic modeling, via Factsage Equilib stream calculations, optimized the experimental process. Simulated materials substituted the PM motor, which optimized modeling-directed melting within an induction furnace. The 2FeO·SiO₂ fayalite flux can oxidize rare earth elements, resulting in slag. The neodymium oxidation reaction by fayalite exhibits a ΔG° of −427 kJ when subjected to an oxygen partial pressure ($P_{O_2}$) of 1.8 × 10⁻⁹, which is lower than that required for FeO decomposition. Concerning the FeO–SiO₂ system, neodymium, in Nd³⁺, exhibits a strong bonding with the ${\mathrm{S}\mathrm{i}\mathrm{O}}_4^{4^{-}}$ matrix, leading to its incorporation within the slag as the silicate compound, Nd₂Si₂O₇. When 30 wt.% fayalite flux was added, the resulting experiment yielded a neodymium extraction degree of 91%, showcasing the effectiveness of this fluxing agent in the extraction process. Full article

This study investigated the chemical composition, antibacterial activity and antifungal mechanisms of Cinnamomum burmannii essential oil (CBEO) obtained from leaves and branches through pilot-scale steam molecular distillation after D-borneol crystallization, focusing on its inhibitory effects against Malassezia furfur (M. furfur). GC-MS analysis identified 78 chemical constituents in CBEO, with the monoterpenoid D-borneol predominating. CBEO exhibited potent antifungal activity against M. furfur, with MIC and MFC values of 0.88 mg/mL and 1.75 mg/mL, respectively. Synergistic effects were observed when combined with ketoconazole (FICI = 0.5). At 2 × MIC concentration, CBEO suppressed 85.6% of biofilm formation (p < 0.01) as determined by crystal violet assay. SEM imaging revealed that CBEO treatment induced the formation of surface invaginations and pore structures on fungal cells. Quantitative detection of intracellular protein, nucleic acid, and ion leakage levels confirmed CBEO enhanced membrane permeability, resulting in cytoplasmic content leakage. Ergosterol binding assays confirmed cell membrane disruption (8-fold MIC increase), while UPLC quantification demonstrated dose-dependent suppression of ergosterol synthesis. Correspondingly, squalene epoxidase (SE) activity was significantly inhibited in treated cells. These findings systematically elucidate CBEO’s anti-M. furfur mechanisms, highlighting its potential as a natural antifungal agent for cosmeceutical applications. Full article

Borlotto bean pods, a by-product of Phaseolus vulgaris processing, represent a promising yet underexplored source of bioactive compounds. This study aimed to characterize the nutritional composition, phytochemical profile, and biological properties of a food-grade extract obtained from borlotto bean pods (BPE). Nutritional parameters were assessed using standard AOAC methods, while primary and secondary metabolites were identified and semi-quantified via ¹H-NMR and LC-DAD-ESI-MS/MS. Antioxidant activity was evaluated through six complementary assays: DPPH, TEAC, FRAP, ORAC, ferrous ion-chelating activity, and β-carotene bleaching inhibition. Anti-inflammatory potential was assessed in vitro by evaluating the inhibition of bovine serum albumin (BSA) denaturation and protease activity. BPE showed significant antioxidant capacity across all assays, indicating both hydrogen atom transfer and electron transfer mechanisms, along with metal chelation and lipid peroxidation inhibition. Additionally, BPE inhibited protein denaturation and protease activity in a concentration-dependent manner. These results highlight the potential of borlotto bean pods as a sustainable source of nutritionally and functionally relevant compounds. Future studies should focus on the bioavailability of active constituents, formulation into delivery systems, and in vivo validation to support potential nutraceutical applications. Full article

Background/Objectives: Haloxylon griffithii is a medicinal plant possessing therapeutic effects in disorders associated with the gastrointestinal (GIT) system. This research aims to study the pharmacological activity of Haloxylon griffithii in a multidimensional manner, involving phytochemistry screening and in vitro and in vivo experiments. Methods: The whole dried plant was extracted with 80% methanol and further fractionation using solvents of increasing polarity. GC-MS analysis was performed on the crude extract to discover volatile compounds. The spasmolytic/spasmogenic effect was assessed in isolated rabbit jejunum using spontaneous and K⁺-induced contractions, as well as contractions induced by increasing concentrations of calcium ions in depolarized tissue. Antidiarrheal activity was evaluated in Swiss albino rats/mice (n = 6/group) using castor oil-induced diarrhea and peristaltic index models. In silico ADMET screening was conducted via SwissADME and pkCSM. Results: The GC-MS profiling of H. griffithii revealed the presence of 59 phytochemicals and a rare azulene derivative and constituents, including α-santonin and hexadecanoic acid esters, with favorable pharmacokinetic profiles, as predicted using SwissADME and pkCSM computational tools. The in vitro and in vivo experiments revealed the significant calcium channel blocking activity in non-polar fractions (n-hexane and ethyl acetate), while the polar extracts (ethanolic, aqueous) exhibited cholinergic effects, indicating a dual mode of action. Conclusions: This was a first-time demonstration of both antidiarrheal and smooth muscle-relaxant activity in H. griffithii, supported by GC-MS profiling and pharmacological assay. The findings lend scientific credibility to the traditional use of the plant in community healthcare, while also reinforcing the need for further pharmacological and clinical studies to explore its potential in drug development. Full article