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81 Results Found

  • Review
  • Open Access
359 Views
15 Pages

9 February 2026

Intergenerational wealth transfer represents a central mechanism through which genealogical bonds, family continuity, and economic stability are maintained across generations. This article examines inheritance law and financial regulation from a gene...

  • Review
  • Open Access
35 Citations
7,909 Views
15 Pages

Parental environmental experiences affect disease susceptibility in the progeny through epigenetic inheritance. Pesticides are substances or mixtures of chemicals—some of which are persistent environmental pollutants—that are used to cont...

  • Article
  • Open Access
2 Citations
2,809 Views
18 Pages

27 July 2023

The dilemma of aging and lack of successors must be understood to improve the scale efficiency and competitiveness of China’s agriculture. This paper uses a survey of 1347 farmers in Liaoning, Jiangsu, and Jiangxi and applies tobit and probit m...

  • Article
  • Open Access
6 Citations
3,746 Views
17 Pages

Intergenerational Inheritance of Hepatic Steatosis in a Mouse Model of Childhood Obesity: Potential Involvement of Germ-Line microRNAs

  • Francesc Ribas-Aulinas,
  • Sílvia Ribo,
  • Eduard Casas,
  • Marta Mourin-Fernandez,
  • Marta Ramon-Krauel,
  • Ruben Diaz,
  • Carles Lerin,
  • Susana G. Kalko,
  • Tanya Vavouri and
  • Josep C. Jimenez-Chillaron

1 March 2023

Childhood obesity increases the risk of developing metabolic syndrome later in life. Moreover, metabolic dysfunction may be inherited into the following generation through non-genomic mechanisms, with epigenetics as a plausible candidate. The pathway...

  • Communication
  • Open Access
58 Citations
6,216 Views
8 Pages

A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance

  • Linyuan Shen,
  • Mailin Gan,
  • Zhengdong Tan,
  • Dongmei Jiang,
  • Yanzhi Jiang,
  • Mingzhou Li,
  • Jinyong Wang,
  • Xuewei Li,
  • Shunhua Zhang and
  • Li Zhu

tRNA-derived fragments (tRFs) are a new class of non-coding RNA that play an important role in regulating cellular RNA processing and protein translation. However, there is currently no study reporting the influence of tRFs on myocardial hypertrophy....

  • Review
  • Open Access
7 Citations
20,307 Views
12 Pages

8 January 2024

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that causes debilitating functional impairment in patients. Observations from survivors of traumatic historical events solidify that this disease is not only associated with personal exp...

  • Article
  • Open Access
127 Views
17 Pages

28 February 2026

Among the Anaañ people in Akwa Ibom State, Southeastern Nigeria, the practice of naming serves as a central mechanism for communicating personal identity, recollecting memory and preserving social hierarchy across generations. The act of namin...

  • Review
  • Open Access
27 Citations
6,654 Views
23 Pages

There is mounting evidence that ancestral life experiences and environment can influence phenotypes in descendants. The parental environment regulates offspring phenotypes potentially via modulating epigenetic marks in the gametes. Here, we review ex...

  • Article
  • Open Access
6 Citations
2,919 Views
18 Pages

17 October 2022

This paper investigates the influence effects of government subsidies on the innovation of family-owned enterprises in China through a panel data model and Heckman two-stage model, and explores the possible influence mechanisms of government subsidie...

  • Review
  • Open Access
4 Citations
7,176 Views
25 Pages

Fetal alcohol spectrum disorder (FASD) results from teratogenic impacts of alcohol consumption during pregnancy. Trauma and prenatal alcohol exposure (PAE) can both cause neurodevelopmental impairment, and it has been proposed that FASD can amplify e...

  • Article
  • Open Access
11 Citations
4,367 Views
24 Pages

Intermediate Inheritance with Disomic Tendency in Tetraploid Intergeneric Citrus × Poncirus Hybrids Enhances the Efficiency of Citrus Rootstock Breeding

  • Leny Calvez,
  • Alexis Dereeper,
  • Pierre Mournet,
  • Yann Froelicher,
  • Saturnin Bruyère,
  • Raphaël Morillon and
  • Patrick Ollitrault

13 December 2020

Rootstocks are crucial for the sustainability of the citrus industry worldwide. Diploid intergeneric Citrus × Poncirus hybrids have contributed considerably to citrus rootstock improvement and their tetraploid (doubled-diploid) forms are import...

  • Article
  • Open Access
7 Citations
4,029 Views
15 Pages

30 September 2021

We previously obtained two intergeneric hybrids with different ploidies, i.e., aneuploid (2n = 28) and eutriploid, from diploid−diploid crosses between ‘Kiyomi’ tangor (Citrus unshiu Marcow. × C. sinensis (L.) Osbeck) and Meiwa kumquat (Fortunella cr...

  • Review
  • Open Access
13 Citations
4,564 Views
21 Pages

The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility

  • Gemma Comas-Armangue,
  • Lela Makharadze,
  • Melisa Gomez-Velazquez and
  • Raffaele Teperino

While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment...

  • Review
  • Open Access
6 Citations
5,493 Views
31 Pages

While reports on the generational inheritance of a parental response to stress have been widely reported in animals, the molecular mechanisms behind this phenomenon have only recently emerged. The booming interest in epigenetic inheritance has been f...

  • Article
  • Open Access
1 Citations
2,593 Views
26 Pages

Genetic and Epigenetic Changes in Arabidopsis thaliana Exposed to Ultraviolet-C Radiation Stress for 25 Generations

  • Andres Lopez Virgen,
  • Narendra Singh Yadav,
  • Boseon Byeon,
  • Yaroslav Ilnytskyy and
  • Igor Kovalchuk

20 March 2025

Continuous exposure to stress contributes to species diversity and drives microevolutionary processes. It is still unclear, however, whether epigenetic changes, in the form of epimutations such as, for example, differential DNA methylation, are the p...

  • Review
  • Open Access
16 Citations
6,660 Views
20 Pages

During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer’s disease (AD). These complex diseases seem to have a heritable component; however, genome-wide association studies f...

  • Article
  • Open Access
3 Citations
2,838 Views
17 Pages

Adenomyotic Lesions Are Induced in the Mouse Uterus after Exposure to NSAID and EE2 Mixtures at Environmental Doses

  • Brigitte Boizet-Bonhoure,
  • Stéphanie Déjardin,
  • Mélissa Girard,
  • Quentin Durix,
  • Francis Poulat and
  • Pascal Philibert

7 February 2024

The aim of this study was to assess the long-term effect of exposure to environmentally relevant doses of non-steroidal anti-inflammatory drugs (NSAIDs; ibuprofen, and diclofenac) and 17β-ethinylestradiol (EE2) on the mouse uterus. NSAID-EE2 mix...

  • Article
  • Open Access
7 Citations
2,718 Views
26 Pages

Genomic and Epigenomic Changes in the Progeny of Cold-Stressed Arabidopsis thaliana Plants

  • Ashif Rahman,
  • Narendra Singh Yadav,
  • Boseon Byeon,
  • Yaroslav Ilnytskyy and
  • Igor Kovalchuk

28 February 2024

Plants are continuously exposed to various environmental stresses. Because they can not escape stress, they have to develop mechanisms of remembering stress exposures somatically and passing it to the progeny. We studied the Arabidopsis thaliana ecot...

  • Review
  • Open Access
5 Citations
3,497 Views
30 Pages

6 December 2023

Multiple lines of evidence suggest that paternal psychological stress contributes to an increased prevalence of neuropsychiatric and metabolic diseases in the progeny. While altered paternal care certainly plays a role in such transmitted disease ris...

  • Article
  • Open Access
26 Citations
6,179 Views
19 Pages

Alcohol use disorder is a devastating disease with a complex etiology. Recent preclinical studies have revealed that paternal preconception chronic intermittent ethanol (EtOH) exposure via vaporized EtOH altered drinking behaviors and sensitivity to...

  • Review
  • Open Access
14 Citations
17,347 Views
31 Pages

Trauma can impact individuals within a generation (intragenerational) and future generations (transgenerational) through a complex interplay of biological and environmental factors. This review explores the epigenetic mechanisms that have been correl...

  • Review
  • Open Access
3 Citations
2,409 Views
22 Pages

The Father’s Microbiome: A Hidden Contributor to Fetal and Long-Term Child Health

  • Enrica Zambella,
  • Annalisa Inversetti,
  • Silvia Salerno,
  • Martin Müller and
  • Nicoletta Di Simone

5 August 2025

The microbiota refers to the entire community of microorganisms, including bacteria, viruses, fungi, archaea, and protozoa, that inhabit various anatomical sites and exert complex influences on human health and disease [...]

  • Article
  • Open Access
1 Citations
2,989 Views
28 Pages

12 June 2024

Recent scholarship has highlighted the heterogeneity of second-generation Irish identities in Great Britain, yet the varieties of self-identification espoused by the English-raised children of Northern Irish parents remain almost wholly unexplored. T...

  • Review
  • Open Access
8 Citations
6,919 Views
19 Pages

Preventive Epigenetic Mechanisms of Functional Foods for Type 2 Diabetes

  • Bilyaminu Abubakar,
  • Dawoud Usman,
  • Kamaldeen Olalekan Sanusi,
  • Nur Hanisah Azmi and
  • Mustapha Umar Imam

Type 2 diabetes (T2D) is a growing global health problem that requires new and effective prevention and management strategies. Recent research has highlighted the role of epigenetic changes in the development and progression of T2D, and the potential...

  • Article
  • Open Access
18 Citations
4,639 Views
23 Pages

Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring

  • Richa S. Rathod,
  • Carolyn Ferguson,
  • Amit Seth,
  • Annalisa M. Baratta,
  • Sonja L. Plasil and
  • Gregg E. Homanics

22 September 2020

We and others previously reported that paternal preconception chronic ethanol exposure leads to molecular, physiological, and behavioral changes in offspring including reduced ethanol consumption and preference relative to controls. The goal of the p...

  • Entry
  • Open Access
8 Citations
6,412 Views
16 Pages

Generational Effects of Opioid Exposure

  • Katherine E. Odegaard,
  • Gurudutt Pendyala and
  • Sowmya V. Yelamanchili

18 January 2021

The inheritance of substance abuse, including opioid abuse, may be influenced by genetic and non-genetic factors related to the environment, such as stress and socioeconomic status. These non-genetic influences on the heritability of a trait can be a...

  • Article
  • Open Access
15 Citations
6,293 Views
26 Pages

Genomic Instability in Somatic Hybridization between Poncirus and Citrus Species Aiming to Create New Rootstocks

  • Dominique Dambier,
  • Pascal Barantin,
  • Gabriel Boulard,
  • Gilles Costantino,
  • Pierre Mournet,
  • Aude Perdereau,
  • Raphaël Morillon and
  • Patrick Ollitrault

Rootstocks are an important component for citrus adaptation to increasing biotic and abiotic stresses resulting from global climate change. There is a strong complementarity between Citrus species, which adapt to abiotic stresses, and Poncirus trifol...

  • Article
  • Open Access
1 Citations
697 Views
16 Pages

Comparative Analysis of Embryonic Development and Mitochondrial Genome of a New Intergeneric Hybrid Grouper (Epinephelus fasciatus ♀ × Plectropomus leopardus ♂)

  • Xinlu Jiao,
  • Tangtang Ding,
  • Yongsheng Tian,
  • Yongjun Guo,
  • Yimeng Wang,
  • Shihao Wang,
  • Chunbai Zhang,
  • Fengfan Yang,
  • Linna Wang and
  • Yang Liu
  • + 3 authors

28 November 2025

To develop superior grouper aquaculture varieties, in this study, a intergeneric hybrid breed was constructed by crossing a male Plectropomus leopardus, with a female parent Epinephelus fasciatus. Here, we researched embryonic development and mitocho...

  • Review
  • Open Access
1 Citations
699 Views
21 Pages

This study examines the impact of Kosovo’s matrimonial property and inheritance laws on intergenerational inheritance and family connections. It explores how the division of property during marriage or upon divorce influences inheritance outcom...

  • Article
  • Open Access
18 Citations
5,317 Views
31 Pages

12 February 2020

Why does an industrial alliance upgrade sometimes quickly and sometimes very slowly? The answer to this question can scientifically reveal the key driving forces of the sustainable intergenerational evolution of industrial alliance innovation ecosyst...

  • Article
  • Open Access
5 Citations
3,073 Views
12 Pages

Characterisation of Non-Pathogenic Premutation-Range Myotonic Dystrophy Type 2 Alleles

  • Jan Radvanszky,
  • Michaela Hyblova,
  • Eva Radvanska,
  • Peter Spalek,
  • Alica Valachova,
  • Gabriela Magyarova,
  • Csaba Bognar,
  • Emil Polak,
  • Tomas Szemes and
  • Ludevit Kadasi

31 August 2021

Myotonic dystrophy type 2 (DM2) is caused by expansion of a (CCTG)n repeat in the cellular retroviral nucleic acid-binding protein (CNBP) gene. The sequence of the repeat is most commonly interrupted and is stably inherited in the general population....

  • Review
  • Open Access
33 Citations
10,404 Views
32 Pages

Epigenetic information is transmitted from one generation to the next, modulating the phenotype of offspring non-genetically in organisms ranging from plants to mammals. For intergenerational non-genetic inheritance to occur, epigenetic information m...

  • Article
  • Open Access
1 Citations
2,017 Views
22 Pages

Genetic Analyses of Flower, Fruit, and Stem Traits of Intergeneric Hybrids Between ‘Honghuagqinglong’ and ‘Heilong’ Pitayas

  • Xinyue Pu,
  • Imran Khan,
  • Tiantian Zhang,
  • Guohua Huang,
  • Jiayi Chen,
  • Yu Ding,
  • Xuewu Ji,
  • Zhike Zhang,
  • Jietang Zhao and
  • Yonghua Qin
  • + 2 authors

19 December 2024

Pitaya is renowned for its delicious taste, high nutritional value, and economic as well as ornamental appeal. Breeding new pitaya varieties can boost economic returns by appealing to consumers with diverse morphological traits. However, the genetic...

  • Essay
  • Open Access
159 Citations
20,643 Views
22 Pages

Epigenetics increasingly occupies a pivotal position in our understanding of inheritance, natural selection and, perhaps, even evolution. A survey of the PubMed database, however, reveals that the great majority (>93%) of epigenetic papers have an...

  • Article
  • Open Access
2,525 Views
13 Pages

2 December 2022

In the post-pandemic era, it will become normal for family enterprises to seek innovative development. They have become more committed to building socially responsible companies and are more willing to actively promote corporate values in order to cr...

  • Review
  • Open Access
27 Citations
26,899 Views
20 Pages

1 January 2023

In recent years, we have seen an increasing amount of evidence pointing to the existence of a non-genetic heredity of the effects of events such as separation from parents, threat to life, or other traumatising experiences such as famine. This heredi...

  • Article
  • Open Access
1,348 Views
15 Pages

Verification of the Introgression of Narenga porphyrocoma Germplasm into Saccharum officinarum Using Molecular Markers and GISH Analysis

  • Gang Wang,
  • Wei Zhang,
  • Yuanxia Qin,
  • Qingdan Wu,
  • Qinggan Liang,
  • Jiantao Wu,
  • Shengren Sun,
  • Zhuqing Wang,
  • Yuxing An and
  • Hailong Chang
  • + 2 authors

6 January 2025

Sugarcane (Saccharum spp.), a critical crop for sugar and bioenergy production, faces challenges in genetic improvement due to limited genetic diversity from selective breeding. Expanding genetic resources through intergeneric hybridization, particul...

  • Article
  • Open Access
2,639 Views
10 Pages

7 July 2022

The Christian New Testament contains surprisingly few references to age and aging, and what readers do encounter is usually read through the lens of their own experiences and assumptions about age. In this article, I approach the New Testament from m...

  • Article
  • Open Access
630 Views
15 Pages

Establishment and Biological Characteristics Analysis of a Hybrid Culter Lineage from Megalobrama amblycephala (♀) and Culter alburnus (♂)

  • Jinhui Huang,
  • Yingying Yang,
  • Jiawang Huang,
  • Xiaoyu Huang,
  • Jiaxuan Zhu,
  • Yanran Xiong,
  • Lang Qin,
  • Hongxuan Liang,
  • Ming Wen and
  • Shaojun Liu
  • + 5 authors

10 December 2025

Culter alburnus (topmouth culter, TC) is extensively distributed in various rivers and lakes in China. As a widely adaptive fish species, they have significant economic value and special ecological roles. Intergeneric hybridization is a pivotal strat...

  • Article
  • Open Access
2,069 Views
18 Pages

Zimbabwe’s 2008 electoral violence created lasting societal impacts, yet the psychological consequences for youth, particularly through intergenerational effects, remain under-explored. This study examines how memories of this violence are tran...

  • Article
  • Open Access
4 Citations
2,381 Views
18 Pages

22 August 2024

Environmental stressors can induce paternal epigenetic modifications that are a key determinant of the intergenerational inheritance of acquired phenotypes in mammals. Some of them can affect phenotypic expression through inducing changes in tRNA-der...

  • Feature Paper
  • Article
  • Open Access
392 Views
18 Pages

29 December 2025

Materiality has emerged as a significant theme in Holocaust literature as well as in Holocaust studies scholarship, highlighting the pivotal role of physical objects. This materiality has been conceptualized in various ways in recent scholarship, inc...

  • Article
  • Open Access
249 Views
12 Pages

16 February 2026

Our Fairytales: The Cost of Migration, National Myth, and Creative Labor in Unser Deutschlandmärchen is a performance analysis that examines lived cultural narratives through the lens of the Maxim Gorki Theatre’s production of Dinçe...

  • Article
  • Open Access
624 Views
17 Pages

24 December 2025

Since the Ming and Qing dynasties, local Daoism in southeastern Hebei Province has developed in a complex and intertwined manner, characterized by the multiplicity and interpenetration of Daoist lineages. The inheritance of contemporary local Daoism...

  • Review
  • Open Access
22 Citations
6,304 Views
27 Pages

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

  • Maria Nicol Arroyo,
  • Jonathan Alex Green,
  • Miriam Cnop and
  • Mariana Igoillo-Esteve

The global rise in type 2 diabetes results from a combination of genetic predisposition with environmental assaults that negatively affect insulin action in peripheral tissues and impair pancreatic β-cell function and survival. Nongenetic herita...

  • Article
  • Open Access
2 Citations
2,890 Views
23 Pages

The Old, the New, and the Used One—Assessing Legacy in Family Firms

  • Alexandrina Maria Pauceanu,
  • Rodica Milena Zaharia and
  • Melisa Petra Benchis

17 March 2025

The current study aims to determine the meaning and the role of legacy in the development of family businesses from the perspective of multigenerational family businesses. Employing Thematic Analysis (TA) and Gioia methodology, the transcript of in-d...

  • Article
  • Open Access
184 Views
44 Pages

26 January 2026

Traditional vehicle routing problems focus primarily on cost minimization. This paper addresses the unbalanced transportation problem, aiming to minimize both costs and carbon emissions. We propose a Cost–Carbon Emissions Adaptive Genetic Algor...

  • Article
  • Open Access
2 Citations
3,649 Views
17 Pages

This article addresses the inherently relational nature of musical agency, drawing upon interdisciplinary research. It argues that music does not exist in isolation but within social and emotional contexts shaped by a network of relationships among m...

  • Communication
  • Open Access
4 Citations
3,932 Views
10 Pages

31 March 2024

Background: Noonan syndrome (NS)/Noonan syndrome with multiple lentigines (NSML) is commonly characterized by distinct facial features, a short stature, cardiac problems, and a developmental delay of variable degrees. However, as many as 50% of indiv...

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