Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (126,642)

Search Parameters:
Keywords = industrialization

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
14 pages, 6472 KB  
Article
Processing–Property Relationships in Melt Processing of Polyamide–Elastane Textile Blends
by Sabrina Bianchi, Flavia Bartoli, Michele Pinna, Pierpaolo Minei, Daniele Filidei, Ilaria Canesi, Noemi Cei, Daniele Spinelli and Maria Beatrice Coltelli
AppliedChem 2026, 6(1), 19; https://doi.org/10.3390/appliedchem6010019 (registering DOI) - 9 Mar 2026
Abstract
The recycling of polyamide 6 (PA) and elastane (EL) from post-consumer textiles is increasingly relevant for sustainable materials development. This study investigates blends obtained from a commercial PA fabric containing 16% EL, processed via extrusion under various conditions to evaluate the influence of [...] Read more.
The recycling of polyamide 6 (PA) and elastane (EL) from post-consumer textiles is increasingly relevant for sustainable materials development. This study investigates blends obtained from a commercial PA fabric containing 16% EL, processed via extrusion under various conditions to evaluate the influence of temperature, screw type, and speed on phase morphology and thermo-mechanical performance. The results demonstrate that processing parameters, particularly temperature, significantly affect melt viscosity and the final mechanical properties of the blends. Enhanced ductility was observed in all recycled samples compared to pure PA, indicating that mechanical recycling is a promising strategy for PA/EL textile waste. These findings support the feasibility of this approach, while highlighting the need for further research into compatibilization techniques and industrial scalability. Full article
Show Figures

Graphical abstract

25 pages, 1804 KB  
Article
Data Asset Quality Evaluation Model Considering the Requirements of Circulation Scenarios
by Tao Xu, Lu Jiang, Jianxin You and Hengjia Zhang
Systems 2026, 14(3), 287; https://doi.org/10.3390/systems14030287 (registering DOI) - 9 Mar 2026
Abstract
High-quality datasets are increasingly recognized as foundational inputs to economic development, industrial upgrading, and public governance. A rigorous evaluation system for data asset quality is therefore needed to improve data governance and to enable value realization in circulation. Focusing on three representative circulation [...] Read more.
High-quality datasets are increasingly recognized as foundational inputs to economic development, industrial upgrading, and public governance. A rigorous evaluation system for data asset quality is therefore needed to improve data governance and to enable value realization in circulation. Focusing on three representative circulation scenarios—data interaction, data exchange, and data trading—this study develops an indicator system from technical, business, and benefit-oriented dimensions. The Decision-Making Trial and Evaluation Laboratory (DEMATEL) method is used to identify causal relationships among indicators and key drivers. To integrate multi-expert judgments under uncertainty, hesitant linguistic variables and evidence theory are adopted, and the Best–Worst Method (BWM) is applied to derive more consistent indicator weights. The resulting weights are combined with the Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) to obtain a comprehensive ranking of data asset quality with scenario-adjustable emphasis. A traffic-flow dataset from a data technology enterprise is used to demonstrate applicability and effectiveness. The proposed framework advances scenario-adaptive data quality evaluation and supports enterprise data governance, data transaction pricing, and the implementation of high-quality dataset policies. Full article
Show Figures

Figure 1

13 pages, 2240 KB  
Article
Pigs with CD163 Mutation Conferred PRRSV Resistance
by Changbao Wu, Heyao Wang, Wei Zhang, Miaomiao Cheng, Yang Wang, Lian Chen, Chao Tang, Yanfeng Dai and Liping Zhang
Animals 2026, 16(5), 850; https://doi.org/10.3390/ani16050850 (registering DOI) - 9 Mar 2026
Abstract
Porcine reproductive and respiratory syndrome (PRRS), which is caused by the porcine reproductive and respiratory syndrome virus (PRRSV), results in substantial economic losses for the global pig farming industry. A critical step in the infection process is the binding of PRRSV to the [...] Read more.
Porcine reproductive and respiratory syndrome (PRRS), which is caused by the porcine reproductive and respiratory syndrome virus (PRRSV), results in substantial economic losses for the global pig farming industry. A critical step in the infection process is the binding of PRRSV to the CD163 receptor on the surface of porcine alveolar macrophages. This study successfully generated CD163−/− Landrace pigs using CRISPR/Cas9 gene editing technology. Following an experimental challenge with two distinct Type II PRRSV strains, the edited pigs exhibited complete resistance to infection. Virological and pathological examinations confirmed the absence of viral replication and the presence of characteristic pulmonary lesions and other organ damage in CD163−/− pigs. In contrast, wild-type control pigs exhibited high viral loads and severe pulmonary lesions, as well as damage to other organs. Our findings provide direct evidence that CD163 is an essential receptor for PRRSV infection in vivo. The CD163−/− pig model offers an effective genetic strategy for breeding pigs with an inherent resistance to PRRSV. Full article
Show Figures

Figure 1

19 pages, 3695 KB  
Article
Low Reynolds Number Settling of Bent Rods in Quiescent Fluid
by Amirhossein Hamidi, Daniel Daramsing, Mark D. Gordon and Ronald E. Hanson
Fluids 2026, 11(3), 72; https://doi.org/10.3390/fluids11030072 (registering DOI) - 9 Mar 2026
Abstract
This study experimentally investigates the settling behavior of bent (V-shaped and curved) and straight rods in a quiescent fluid at low and finite Reynolds numbers (Re<3). The impact of the rod morphology on the terminal settling velocity and drag [...] Read more.
This study experimentally investigates the settling behavior of bent (V-shaped and curved) and straight rods in a quiescent fluid at low and finite Reynolds numbers (Re<3). The impact of the rod morphology on the terminal settling velocity and drag coefficient was examined, with a particular focus on V-shaped rods compared to straight rods of the same dimensions (diameter and length) and curved rods of the same dimensions and projected area. The results show that V-shaped rods consistently settle faster than straight rods, with velocity differences influenced by the bend angle. This velocity difference reaches a maximum of 57% for a V-shaped rod with a diameter of 0.50 mm, an aspect ratio of 90, and a bend angle of 45 degrees. When compared to curved rods, V-shaped rods exhibit slightly higher terminal velocities, with a maximum difference of 4% in this study, attributed to differences in mean inclination angles. Furthermore, the drag coefficient trends reflect the interplay between the settling velocity and projected area changes with the rod geometry. A new semi-empirical model with an RMS error of 7.1% was also developed to predict the drag coefficients and terminal velocities of straight and bent rods within the ranges studied. These findings and the model presented underscore the significance of the fibre shape in accurately predicting settling dynamics, with implications for atmospheric transport modeling and industrial applications involving fibrous particles. Full article
(This article belongs to the Section Flow of Multi-Phase Fluids and Granular Materials)
Show Figures

Figure 1

10 pages, 592 KB  
Opinion
Propylene Glycol Ethers: Widespread Use and Missing Neurotoxicity Testing
by Nancy B. Hopf and Hélène P. De Luca
Toxics 2026, 14(3), 232; https://doi.org/10.3390/toxics14030232 (registering DOI) - 9 Mar 2026
Abstract
Organic solvents are known to affect the nervous system, but neurotoxicity testing is not routinely required for industrial chemicals under current European regulations. Glycol ethers are widely used in consumer and industrial products. They can cross skin and lung barriers, distribute systemically, and [...] Read more.
Organic solvents are known to affect the nervous system, but neurotoxicity testing is not routinely required for industrial chemicals under current European regulations. Glycol ethers are widely used in consumer and industrial products. They can cross skin and lung barriers, distribute systemically, and penetrate the blood–brain barrier due to their physicochemical properties, while their neurotoxic potential remains poorly characterized. P-series glycol ethers now dominate the European market, making exposure assessment critical for public health. We compiled and integrated data from five authoritative sources to build an inventory of glycol ethers currently used in Europe and performed a structured descriptive analysis of high-volume propylene glycol ether compounds. Six high-volume compounds (≥1000 t/year) were selected for analysis. Production volumes, Swiss product registrations, occupational exposure limits, and product categories were compiled. Propylene glycol methyl ether (PGME) showed the highest tonnage (100,000–1,000,000 t/year) and was present in 9497 registered products, followed by propylene glycol ethyl ether (PGEE) (10,000–100,000 t/year; 1333 products). Paints/coatings and cleaning agents were the most frequent product categories, while additional presence in personal care and indoor-use products was observed. These products may lead to exposure depending on use conditions, such as spraying or inadequate ventilation, which can increase inhalation and skin contact. Their presence in diverse products suggests potential for both occupational and chronic low-level exposures. By providing an integrated overview of market presence, use patterns, and available neurotoxicity evidence for propylene glycol ethers, our findings highlight a critical gap in chemical risk assessment: the absence of neurotoxicity testing despite high production volumes and widespread use. Integrating neurotoxicity endpoints and new approach methodologies into regulatory frameworks is essential to strengthen public health protection. Full article
Show Figures

Graphical abstract

29 pages, 3019 KB  
Article
An Intelligent Framework for Implementing AIAG–VDA FMEA and Action Priority (AP) Assessment
by Alexandru-Vasile Oancea, Laurențiu-Mihai Ionescu, Corneliu Rontescu, Nadia Ionescu, Agnieszka Misztal, Ana-Maria Bogatu, Cosmin Știrbu, Dumitru-Titi Cicic and Elena-Manuela Stanciu
Appl. Sci. 2026, 16(5), 2591; https://doi.org/10.3390/app16052591 (registering DOI) - 9 Mar 2026
Abstract
The paper presents the Failure Mode and Effects Analysis (FMEA) method applied to a process-based case study, together with an approach for implementing the AIAG & VDA harmonized FMEA standard by using modern digital tools. While classical FMEA is widely used in the [...] Read more.
The paper presents the Failure Mode and Effects Analysis (FMEA) method applied to a process-based case study, together with an approach for implementing the AIAG & VDA harmonized FMEA standard by using modern digital tools. While classical FMEA is widely used in the industry, risk assessment based on the Risk Priority Number (RPN) often leads to the inconsistent ranking of failures and unclear prioritization of corrective actions. This paper explores the shift from the traditional Risk Priority Number (RPN) approach to the Action Priority (AP) concept introduced in the AIAG & VDA FMEA Handbook and explains why this change leads to clearer, more consistent risk-based decisions. Rather than focusing only on the methodological differences, the paper also outlines a practical framework for full implementation, showing how Industry 4.0 technologies can strengthen traceability, improve response time, and ensure greater consistency in PFMEA development. It also examines how Artificial Intelligence (AI) and Large Language Models (LLMs) can support engineers in everyday practice—for example, by helping identify potential failure modes, standardizing documentation, and guiding the definition of prevention and detection controls. In parallel, IoT-based monitoring and real-time data collection can provide valuable feedback to validate occurrence and detection ratings. Over time, this data-driven feedback loop can improve the accuracy and reliability of risk assessments. The proposed framework contributes to improved responsiveness in process optimization activities, reduces the probability of recurring failures, and supports continuous quality improvement in manufacturing organizations. The solution is discussed in relation to classical FMEA practices and recent trends in the digital transformation of quality management systems. Full article
(This article belongs to the Section Electrical, Electronics and Communications Engineering)
Show Figures

Figure 1

36 pages, 1683 KB  
Article
A Novel Binary Dream Optimization Algorithm with Data-Driven Repair for the Set Covering Problem
by Broderick Crawford, Hugo Caballero, Gino Astorga, Felipe Cisternas-Caneo, Marcelo Becerra-Rozas, Alan Baeza, Gabriel Bernales, Pablo Puga, Giovanni Giachetti and Ricardo Soto
Biomimetics 2026, 11(3), 197; https://doi.org/10.3390/biomimetics11030197 (registering DOI) - 9 Mar 2026
Abstract
The Set Covering Problem is a fundamental NP-hard problem in combinatorial optimization and plays a central role in a wide range of industrial decision-making processes, including logistics planning, scheduling, facility location, network design, and resource allocation. In many real-world contexts, problems of this [...] Read more.
The Set Covering Problem is a fundamental NP-hard problem in combinatorial optimization and plays a central role in a wide range of industrial decision-making processes, including logistics planning, scheduling, facility location, network design, and resource allocation. In many real-world contexts, problems of this type are large in scale and highly constrained, which makes exact solution methods computationally impractical and encourages the use of metaheuristic approaches capable of producing high-quality solutions within limited time budgets. In this work, we propose a discrete adaptation of the Dream Optimization Algorithm, focusing on the challenges that emerge when algorithms originally designed for continuous search spaces are applied to binary and strongly constrained models. The continuous search process is mapped onto the binary decision space through a fixed discretization scheme. As a consequence of this transformation, some constraints may not be met, underscoring the importance of effective feasibility restoration mechanisms. Because the discretization stage may produce infeasible solutions and frequently induces plateaus that hinder further improvement, an explicit repair phase becomes necessary to restore feasibility and promote effective search progression. To strengthen this process, the study introduces an adaptive control mechanism based on bandit driven operator selection, which dynamically chooses among different repair procedures during the search. Experimental results on benchmark instances show that the proposed approach consistently achieves high quality solutions with low relative deviation from known optima and stable behavior across independent runs. Full article
(This article belongs to the Special Issue Advances in Biological and Bio-Inspired Algorithms)
Show Figures

Figure 1

8 pages, 787 KB  
Proceeding Paper
Production System Analysis and Scenario Development Using FlexSim: A Case-Based Study
by Stefani Prima Dias Kristiana, Vivi Triyanti, Nova Eka Budiyanta and Riana Magdalena Silitonga
Eng. Proc. 2026, 128(1), 9; https://doi.org/10.3390/engproc2026128009 (registering DOI) - 9 Mar 2026
Abstract
A production system comprises a series of interconnected processes involving planning, processing, and product distribution. The effectiveness and efficiency of such systems play a vital role in reducing operational costs, enhancing productivity, and improving product quality. As such, regular evaluation of production systems [...] Read more.
A production system comprises a series of interconnected processes involving planning, processing, and product distribution. The effectiveness and efficiency of such systems play a vital role in reducing operational costs, enhancing productivity, and improving product quality. As such, regular evaluation of production systems is essential to identify inefficiencies, waste, and bottlenecks, and to develop targeted strategies for improvement. This research aims to construct a simulation model of a production system using FlexSim software as a decision-support tool to facilitate performance evaluation and the development of scenario-based solutions. By employing a simulation-based approach, this study enables the analysis of the production process without interfering with actual operations, thereby minimizing associated risks and reducing the consumption of time and resources. Furthermore, simulation allows for virtual testing of various operational scenarios, including modifications in production capacity, workforce allocation, workflow configurations, and the implementation of emerging technologies. In this case study, the production process was predominantly constrained by operator waiting time, which constituted approximately 30% of the total processing time. In response, an alternative scenario was developed wherein operators with lower utilization rates were reassigned to workstations characterized by high operator wait times. The implementation of this scenario yielded a 29.5% reduction in average queue waiting time and a 31.7% decrease in total production time. These findings demonstrate a substantial improvement in production efficiency. Therefore, the outcomes of this study are expected to provide valuable insights for strategic decision-making and support the optimization of production systems in industrial environments. Full article
Show Figures

Figure 1

36 pages, 3273 KB  
Systematic Review
Integrating IoT and Blockchain for Real-Time Inventory Visibility and Traceability: A Bibliometric–Systematic Review
by Blessing Takawira and Babra Duri
Logistics 2026, 10(3), 57; https://doi.org/10.3390/logistics10030057 (registering DOI) - 9 Mar 2026
Abstract
Background: The accelerated convergence of the Internet of Things (IoT) and Blockchain is reconfiguring logistics, yet knowledge regarding their operationalisation for real-time inventory management remains fragmented. Methods: A Bibliometric–Systematic Literature Review (B-SLR) was conducted on peer-reviewed sources from Scopus and Web of Science [...] Read more.
Background: The accelerated convergence of the Internet of Things (IoT) and Blockchain is reconfiguring logistics, yet knowledge regarding their operationalisation for real-time inventory management remains fragmented. Methods: A Bibliometric–Systematic Literature Review (B-SLR) was conducted on peer-reviewed sources from Scopus and Web of Science (2019–2025), utilising science mapping to visualise intellectual and conceptual structures. Results: The analysis reveals a steep rise in publications during 2024–2025, identifying traceability, smart contracts, and integrity mechanisms as central themes. The synthesis supports a layered theoretical model linking transparency (sensing) and trust (ledger validation) to efficiency and supply chain resilience in Industry 5.0. The review highlights unresolved issues, including interoperability and privacy-by-design, alongside emerging directions such as digital twins. Conclusions: While scholarship has expanded rapidly, it remains weighted toward adoption mapping, underscoring the need for empirical, context-aware models that explain socio-technical integration and its measurable impacts on logistics performance. Full article
(This article belongs to the Section Artificial Intelligence, Logistics Analytics, and Automation)
Show Figures

Figure 1

16 pages, 594 KB  
Article
A Conceptual Framework for Risk-Adjusted Investment Attractiveness Assessment of Manufacturing Companies
by George Abuselidze, Adina Zharlikenova and Beibit Korabayev
J. Risk Financial Manag. 2026, 19(3), 201; https://doi.org/10.3390/jrfm19030201 (registering DOI) - 9 Mar 2026
Abstract
Assessing the investment attractiveness of companies is essential for effective capital allocation under conditions of uncertainty and heterogeneous risk–return profiles. Investors typically face multiple financing alternatives, making comparative evaluation impossible without robust and specialized assessment methodologies. This study proposes a refined conceptual model [...] Read more.
Assessing the investment attractiveness of companies is essential for effective capital allocation under conditions of uncertainty and heterogeneous risk–return profiles. Investors typically face multiple financing alternatives, making comparative evaluation impossible without robust and specialized assessment methodologies. This study proposes a refined conceptual model for assessing the investment attractiveness of production companies, with a specific focus on the manufacturing sector of Kazakhstan. The research is based on a modeling-oriented methodological framework that integrates a modified discounted cash flow (DCF) approach with elements of environmental controlling. The proposed model incorporates sector-specific characteristics, including resource utilization patterns, regulatory requirements and the potential “green” premium observed in capital markets. To capture investment-related uncertainty and risk, the study employs material flow cost accounting, scenario-based modeling and probabilistic decision tree analysis. Particular attention is given to improving the determination of the discount rate, recognizing its critical influence on present value-based investment assessments. The model accounts for macroeconomic and sectoral factors specific to Kazakhstan’s production industry and offers alternative discount rate estimation scenarios under different initial conditions. The study contributes to the literature on investment attractiveness assessment by integrating financial, environmental and risk dimensions into a unified framework. The proposed model enhances transparency in investment decision-making and provides new insights into investment evaluation practices in emerging industrial economies. Full article
(This article belongs to the Special Issue Sustainable Finance and Policy Frameworks in Emerging Markets)
Show Figures

Figure 1

19 pages, 3692 KB  
Article
Automated Processing and Deviation Analysis of 3D Pipeline Point Clouds Based on Geometric Features
by Shaofeng Jin, Kangrui Fu, Chengzhen Yang and Huanhuan Rui
J. Imaging 2026, 12(3), 115; https://doi.org/10.3390/jimaging12030115 (registering DOI) - 9 Mar 2026
Abstract
To meet the strict non-contact measurement requirements for the assembly of aircraft engine pipelines and to overcome the limitations of the traditional three-dimensional laser scanning workflow, this study proposes an automated pipeline point cloud processing and deviation analysis framework. Through a standardized three-dimensional [...] Read more.
To meet the strict non-contact measurement requirements for the assembly of aircraft engine pipelines and to overcome the limitations of the traditional three-dimensional laser scanning workflow, this study proposes an automated pipeline point cloud processing and deviation analysis framework. Through a standardized three-dimensional laser scanning procedure, high-resolution pipeline point clouds are obtained and preprocessed. Based on the geometric characteristics of the pipeline, automated algorithms for point cloud feature segmentation, axis extraction, and model registration are developed. Particularly, the three-dimensional extended Douglas–Peucker (DP) algorithm is introduced to achieve efficient point cloud downsampling while retaining necessary geometric and structural features. These algorithms are fully integrated into a unified software platform, supporting one-click operation, and can automatically analyze and obtain five key types of pipeline deviations: angular deviation, radial deviation, axial deviation, roundness error, and diameter error. The platform also provides intuitive visualization effects and comprehensive report generation functions to facilitate quantitative inspection and analysis. Test results show that the proposed method significantly improves the processing efficiency and measurement reliability of complex pipeline systems. The developed framework provides a powerful practical solution for the automated geometric inspection of aircraft engine pipelines and lays a solid foundation for subsequent quality assessment tasks. Full article
Show Figures

Figure 1

15 pages, 1017 KB  
Article
A DNA Prime-Inactivated Boost Regimen Enhances Immunogenicity Against Pigeon Newcastle Disease: A Comparative Study and Analysis of Synergistic Effects
by Shuai Luo, Yiyi Ren, Nikolai Vladimirovich Tarlavin, Dmitrii Andreevich Kraskov, Edward Javadovich Javadov, Da Xu, Houqiang Luo and Suzhen Liu
Vet. Sci. 2026, 13(3), 251; https://doi.org/10.3390/vetsci13030251 (registering DOI) - 9 Mar 2026
Abstract
Pigeon Newcastle disease poses a persistent threat to the global pigeon industry, underscoring the need for effective vaccination strategies. While both inactivated and DNA vaccines offer distinct advantages, the immunogenicity of a combined heterologous regimen remains underexplored. This study evaluated and compared three [...] Read more.
Pigeon Newcastle disease poses a persistent threat to the global pigeon industry, underscoring the need for effective vaccination strategies. While both inactivated and DNA vaccines offer distinct advantages, the immunogenicity of a combined heterologous regimen remains underexplored. This study evaluated and compared three immunization strategies in pigeons: a DNA vaccine encoding the NDV F protein fused with chicken IL-18, an inactivated vaccine from a local virulent strain, and a DNA prime-inactivated boost regimen. The preparation workflows for both vaccine platforms are described in detail to provide methodological context for the immunological comparison. Critically, the prime–boost regimen elicited significantly higher hemagglutination inhibition (HI) antibody titers than either vaccine administered alone, demonstrating a clear synergistic effect. These findings highlight the complementary roles of the two platforms and provide a strong immunological rationale for further evaluation of this sequential strategy. Future studies incorporating viral challenge experiments and long-term immune monitoring are needed to determine whether the enhanced HI antibody response translates into protective efficacy under field conditions. Full article
Show Figures

Figure 1

31 pages, 4300 KB  
Article
Determinants of Wellness Tourism Development in Emerging Hot Spring Destinations: Evidence from Allelobad Hot Spring, Ethiopia Using SEM
by Wondemsew Mesafint Kebadie and Ihtisham Ullah
Tour. Hosp. 2026, 7(3), 75; https://doi.org/10.3390/tourhosp7030075 (registering DOI) - 9 Mar 2026
Abstract
Wellness tourism represents a significant growth sector within the global tourism industry; however, empirical research examining development determinants in resource-constrained, emerging African destinations remains limited. This study investigates the structural relationships among infrastructure development, community involvement, marketing and promotion, and visitor expectations/service quality [...] Read more.
Wellness tourism represents a significant growth sector within the global tourism industry; however, empirical research examining development determinants in resource-constrained, emerging African destinations remains limited. This study investigates the structural relationships among infrastructure development, community involvement, marketing and promotion, and visitor expectations/service quality in advancing wellness tourism at Allelobad Hot Spring in Ethiopia’s Afar Region. Using a quantitative methodology, structured questionnaires were administered to 210 respondents (visitors, local community members, and tourism stakeholders), resulting in 186 valid responses. Data were analyzed through Confirmatory Factor Analysis (CFA) and Partial Least Squares Structural Equation Modeling (PLS-SEM). Results demonstrate that all four determinants exert statistically significant positive effects on wellness tourism development (p < 0.001), with visitor expectations and service quality emerging as the strongest predictor (β = 0.35), followed by infrastructure development (β = 0.32), marketing and promotion (β = 0.30), and community involvement (β = 0.27). The structural model explains 68% of the variance in wellness tourism development, indicating substantial explanatory power. These findings underscore that sustainable wellness tourism growth in emerging destinations necessitates integrated, multidimensional strategies that simultaneously address physical infrastructure, stakeholder engagement, strategic positioning, and experiential excellence, rather than isolated sector-specific interventions. Full article
Show Figures

Figure 1

16 pages, 761 KB  
Article
Addressing Unmet Medical Needs in Drug Development: Assessment and Implications for Regulatory and Clinical Development Strategies
by Carla Domingo-Esteban, Inka Heikkinen and Nanco Hefting
J. Mark. Access Health Policy 2026, 14(1), 15; https://doi.org/10.3390/jmahp14010015 (registering DOI) - 9 Mar 2026
Abstract
Unmet need is a core component of many Health Technology Assessment (HTA) processes at EU and national level. Most visibly, it is a core selection criterion for Joint Scientific Consultations (JSC) and Joint Clinical Assessment (JCA) for medical devices. This qualitative study explored [...] Read more.
Unmet need is a core component of many Health Technology Assessment (HTA) processes at EU and national level. Most visibly, it is a core selection criterion for Joint Scientific Consultations (JSC) and Joint Clinical Assessment (JCA) for medical devices. This qualitative study explored how Unmet Medical Needs (UMNs) are understood and applied in drug development, with an emphasis on the European regulatory, HTA and access context, and examined their impact on regulatory and clinical development strategies. Twenty semi-structured interviews were conducted with representatives from regulatory authorities, HTA bodies, clinical development, industry, and patient insight roles. Data was analyzed using a thematic content approach combining deductive and inductive coding. Thematic analysis revealed general agreement on the importance of addressing UMNs, but also substantial variation in how they are defined and prioritized. Regulators often stressed disease severity and clinical evidence, while patients and clinicians emphasized quality of life. HTA representatives highlighted comparative benefit and long-term outcomes. These differing perspectives shaped how UMNs were integrated into development strategies, trial design, and regulatory planning. The findings indicate that clearer yet adaptable criteria could support earlier and more consistent alignment. Based on the analysis, a five-part roadmap to guide drug development is proposed, focusing on internal coordination, structured stakeholder engagement, collaboration between regulators and HTA bodies, adaptable definitions, and transparent decision-making. Together, these elements aim to support more systematic and predictable approaches to identifying and addressing unmet needs in drug development. Full article
(This article belongs to the Collection European Health Technology Assessment (EU HTA))
Show Figures

Figure 1

30 pages, 14380 KB  
Article
An Explainable Intelligent Fault Diagnosis for Rotating Machinery via Multi-Source Information Fusion Under Noisy Environments and Small Sample Conditions
by Gaolei Mao, Jinhua Wang and Yali Sun
Sensors 2026, 26(5), 1713; https://doi.org/10.3390/s26051713 (registering DOI) - 8 Mar 2026
Abstract
In modern industrial systems, the fault diagnosis of rotating machinery is crucial for ensuring safe equipment operation. However, practical fault data are often contaminated by noise, and the scarcity of samples across fault conditions makes effective feature extraction challenging. Moreover, single-sensor measurements provide [...] Read more.
In modern industrial systems, the fault diagnosis of rotating machinery is crucial for ensuring safe equipment operation. However, practical fault data are often contaminated by noise, and the scarcity of samples across fault conditions makes effective feature extraction challenging. Moreover, single-sensor measurements provide limited and incomplete information, further degrading the accuracy and reliability of diagnostic models. To address these challenges, this paper proposes an explainable intelligent fault diagnosis for rotating machinery via multi-source information fusion under noisy environments and small sample conditions. Firstly, a multi-sensor data intelligent fusion module (MSDIFM) is developed. It converts multi-sensor vibration signals into time–frequency maps via continuous wavelet transform (CWT). Pixel-level cross-channel fusion is then performed using a variance-driven dynamic weighting strategy to generate a unified fusion map, adaptively highlighting high information channels. Secondly, a multi-dimensional adaptive asymmetric soft-threshold residual shrinkage block (MASRSB) is proposed to implement differentiated and dynamic threshold control for positive and negative features, enhancing representation and discrimination capabilities. Thirdly, the multi-scale Swin Transformer (MSSwin-T) is designed. This module significantly enhances the model’s feature extraction capability by expanding multi-level receptive fields, strengthening key channel representations, and reinforcing cross-window feature interactions. Finally, to validate the effectiveness of the proposed method, experiments are conducted on both the Case Western Reserve University (CWRU) dataset and the self-created PT890 dataset. Results demonstrate that the proposed method exhibits outstanding diagnostic performance and robustness under noisy conditions and with small sample sizes. Full article
(This article belongs to the Special Issue Deep Learning Based Intelligent Fault Diagnosis)
Show Figures

Figure 1

Back to TopTop