Search Results (2,937)

Background/Objectives: Malnutrition in cancer adversely affects treatment outcomes and survival. Early intervention through oral nutritional supplements (ONSs) and dietary counseling can improve outcomes. This study evaluated the evolution of nutritional and morphofunctional parameters over three months in malnourished patients with cancer undergoing a comprehensive nutritional support program comprising dietary counseling, physical activity, and a novel concentrated high-protein, high-calorie ONS (cHPHC-ONS) with a high intrinsic leucine content. Methods: A prospective, observational, multicenter cohort study was conducted across 18 public hospitals in Spain. Two hundred thirty malnourished patients with cancer were enrolled: 147 naïve (no ONS treatment in the last three months) and 83 non-naïve (who transitioned to cHPHC-ONS after inadequate response to initial ONSs). Nutritional status was assessed using Global Leadership Initiative on Malnutrition (GLIM) criteria and morphofunctional parameters via bioelectrical impedance analysis, nutritional ultrasound, handgrip strength, the Timed Up and Go (TUG) test, and analysis of biochemical parameters. Results: After three months, 23.8% achieved normal GLIM nutritional status (p < 0.0001), with a greater improvement seen in non-naïve patients (28.4%, p < 0.0001). Weight loss ceased in 42.6% (p < 0.0001). and inflammation resolved for 10.3% (p = 0.0015). Non-naïve patients experienced a significant increase in fat-free mass index (p = 0.0159), appendicular skeletal muscle index (p = 0.0248), and rectus femoris cross-sectional area (p = 0.0016). Muscle strength increased significantly by +1.7 kg (p = 0.0025), and TUG test time decreased by 1.13 s (p = 0.0003) overall. Conclusions: The comprehensive nutritional support program—including a novel cHPHC-ONS, along with dietary and physical activity guidance—significantly improved the nutritional and morphofunctional status of malnourished patients with cancer, with benefits particularly evident in non-naïve individuals. Limitations: Observational design, no control group, short follow-up, and unadjusted non-multivariable comparisons, limiting causal inference. Full article

This work introduces a wideband four-element multiple-input multiple-output (MIMO) antenna system with four rectangular patches arranged in a sequentially rotated configuration. Wideband frequency operation is realized by exploiting the TM₁₀, TM₀₁ and TM_11δ modes through the utilization of a slot and metallized vias in the patch design. Another group of metallized vias are used to control coupling between the antenna elements, achieving an isolation level of over 17 dB. A prototype is fabricated and measured, demonstrating −6 dB impedance bandwidth ranging from 4.23 GHz to 5.96 GHz, enabling coverage of the N79 (4.4–5 GHz), V2X (5.905–5.925 GHz) and Wi-Fi 5/6 (5.150–5.850 GHz) frequency bands. The MIMO antenna features an efficiency of over 45% and a low envelope correlation coefficient (ECC) lower than 0.25. Owing to its broad bandwidth, compact geometry, and good isolation, the proposed MIMO antenna provides an efficient and practical solution for 5G MIMO applications integrated within mobile terminal back covers. Full article

Designing materials with superior corrosion resistance is critical for seawater electrolysis systems to achieve efficient and long-term stable hydrogen production. In the current study, CrAlN coatings were deposited on TA1 titanium substrates by reactive magnetron sputtering with nitrogen flow ratios ranging from 40%–70% to investigate the effect of nitrogen stoichiometry on corrosion behavior in simulated alkaline seawater (pH ≈ 14, chloride-containing). Microstructural characterization (Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), Grazing Incidence X-Ray Diffraction (GIXRD), Transmission Electron Microscopy (TEM), X-Ray Photoelectron Spectroscopy (XPS), Atomic Force Microscopy (AFM)) reveals that a 60% nitrogen ratio promotes grain refinement, improved CrN/AlN phase stoichiometry, and reduced oxygen-related defects, resulting in a dense columnar structure with minimized diffusion pathways. Electrochemical measurements show that this condition yields the lowest corrosion current density (0.297 μA·cm⁻²) and the highest polarization resistance (123.9 kΩ·cm²). Electrochemical impedance spectroscopy confirms enhanced charge transfer resistance and suppressed ionic transport at the coating/electrolyte interface. The results establish a clear correlation between nitrogen-controlled phase evolution, defect density, and passivation kinetics in highly alkaline chloride environments relevant to seawater electrolysis. This study targets the fabrication of protective coatings for alkaline seawater electrolysis via nitrogen flow ratio optimization. The optimized CrAlN coating achieves remarkably improved corrosion resistance compared with existing coatings, showing promising practical value for long-term stable seawater electrolysis. Full article

Sodium-ion batteries (SIBs) represent a compelling alternative to lithium-ion batteries for grid-scale energy storage, owing to the high natural abundance and low cost of sodium resources, as well as their strategic alignment with national energy security priorities. Nevertheless, the sluggish Na⁺ diffusion kinetics and limited specific capacity of anode materials continue to impede practical deployment. Herein, nitrogen-doped carbon-coated TiO₂ nanofibers (TiO₂/C-N) were rationally engineered through a facile electrospinning route integrated with synergistic defect and coating engineering. The in situ-formed N-doped carbon shell establishes a continuous, high-conductivity electron-transport network while simultaneously buffering volumetric strain during repeated (de)sodiation, thereby preserving long-term structural integrity. Electrochemical assessments demonstrate that the TiO₂/C-N electrode delivers a reversible specific capacity of 233.64 mAh g⁻¹ at 0.1 A g⁻¹ (initial Coulombic efficiency 54.13%). Quantitative kinetic analysis reveals a pronounced pseudocapacitive contribution of 41.4% at 1.2 mV s⁻¹, confirming a surface-controlled Na⁺ storage pathway that markedly enhances rate capability. Moreover, the electrode retains 245.5 mAh g⁻¹ after 150 cycles at 1 A g⁻¹, underscoring exceptional cycling stability. This work elucidates the synergistic regulation of N-doped carbon coating and pseudocapacitive kinetics in TiO₂-based anodes, offering a robust design strategy for high-rate, long-cycle-life SIB anodes. Full article

State of Health (SOH) estimation of lithium-ion batteries is a critical and challenging requirement in advanced battery management technologies. As an important parameter, battery impedance contains significant electrochemical information that can reflect the state of health of batteries. In this study, a SOH estimation method is proposed based on alternating electrical signals. First, an aging test was carried out using commercial 18650-type batteries. Considering the current uncertainty in practical applications, tests under different discharge conditions were conducted to obtain the capacity and wide frequency band impedance data of each battery throughout its life cycle. Then, important features at specific frequencies were extracted from the impedance data, and an interpretable analysis of the features was performed using the distribution of relaxation times (DRTs). Finally, the impedance features were combined with the Gaussian process regression algorithm in machine learning to estimate and validate the SOH. The results show that using fixed-frequency impedance features can achieve accurate estimation. The average value of the maximum absolute error of each battery under different working conditions can be controlled within 1.59%. With the development of embedded chips and online measurement technology, battery management systems can obtain important impedance features by applying alternating electrical signals within a certain frequency range, thus achieving online estimation of SOH. Full article

In the parallel operation of islanded microgrids, line impedance mismatches and random load fluctuations, along with the dynamic response lag and difficulty in multidimensional parameter tuning of traditional control strategies, lead to power sharing imbalances and instability in frequency and voltage. To address these issues, this paper proposes a hierarchical cooperative control strategy based on consistency that integrates load-observation-based dynamic reference feedforward (LODRF) and adaptive particle swarm optimization (APSO). First, an improved adaptive virtual impedance (IAVI) strategy based on consistency is introduced into the virtual synchronous generator control framework. Second, an LODRF mechanism is applied at the secondary control layer to actively reconstruct the power baseline by observing the load status at the point of common coupling (PCC) in real time. Furthermore, an APSO algorithm utilizing the integral of time-weighted absolute error (ITAE) as a global performance index is constructed to optimize key proportional–integral controller parameters cooperatively. Simulation results from a four-unit heterogeneous parallel system in MATLAB/Simulink demonstrate that the IAVI strategy enables stable convergence of frequency and voltage and proportional power sharing. Compared with the system without LODRF, the proposed strategy reduces maximum frequency and voltage dynamic deviations under load disturbances by 78.5% and 53.3%, respectively, and shortens effective recovery times by 0.01 s and 0.09 s, respectively. Moreover, compared with the standard PSO algorithm, the APSO-optimized system reduces maximum frequency and voltage deviations by 3.1% and 36.4%, respectively. Additionally, average active and reactive power sharing errors in the steady state are kept below 0.9%, verifying the significant advantages of the strategy in improving dynamic disturbance rejection and steady-state precision. Full article

Translating preclinical findings into effective clinical cancer immunotherapies remains a major challenge, mainly because conventional in vitro and animal models often fail to capture the complexity, dynamics, and species-specific features of human immune responses. Organ-on-a-chip (OoC) technologies that combine engineered tissue architectures with precisely controlled microfluidic transport provide human-relevant microphysiological platforms for mechanistic studies of immune–tumor interactions and evaluation of therapeutic efficacy and immunotoxicity under defined microenvironmental conditions. However, immune responses involve time-dependent and interconnected processes, including immune cell trafficking, cytokine programs, metabolic shifts, and cytolysis, that are not adequately resolved by static or endpoint assays. Engineering immune-competent OoC systems therefore requires coordinated design of platform architectures, immune cell incorporation strategies, and integrated measurement workflows capable of capturing dynamic and state-dependent responses. In this review, we summarize engineering strategies for building immune-competent OoC platforms for cancer immunotherapy, focusing on platform architectures, immune cell incorporation methods, and fit-for-purpose assay workflows. Emphasis is placed on embedded sensing modalities (e.g., cytokine, oxygen, and impedance readouts) that provide valuable kinetic and state-variable data. Finally, we discuss key translational challenges, including reproducibility, standardization, and benchmarking, and outline near-term priorities to accelerate the adoption of immune-competent OoC systems in immunotherapy research and development. Full article

The proliferation of renewable energy resources has brought numerous challenges to conventional power systems, as grid integration is predominantly achieved through inverter-interfaced technologies such as photovoltaic (PV) plants and Type-IV wind turbines. Unlike synchronous generators (SGs), inverter-based resources (IBRs) exhibit fundamentally different fault behavior by limiting fault current magnitudes, typically within 1.0–1.2 per unit. Furthermore, the phase angle and sequence composition of the injected fault current are largely dictated by the inverter control strategy rather than by the network impedance. Consequently, distance protection schemes developed under assumptions of system homogeneity, a fixed source-to-impedance ratio (SIR), high fault current contribution, and large inertia may exhibit unreliable performance in inverter-dominated power networks. In this work, the influence of IBRs on key distance protection elements, such as starting elements, fault classification techniques, and impedance calculation with or without inter-feed, is reviewed and evaluated using simulations in PSCAD 5.0 software. Further, reduced grid inertia introduces operational limitations in power swing blocking (PSB) schemes, which are discussed in this paper. This work presents an overview of IBR fault responses and critically summarizes prior work on distance protection in IBR-dominated grids, highlighting key challenges, probable solutions, and the current research status to enhance understanding for further research. Full article

At around 8:40 a.m. on 17 July 2024, the Wanshuitian landslide in the Three Gorges Reservoir Area (TGRA) experienced a deformation failure characterized by thrust load-caused deformations and high-speed sliding. Using geological surveys and unmanned aerial vehicle (UAV) photography, this study divided the Wanshuitian landslide area into five zones: sliding initiation (A1), secondary disintegration (A2), main accumulation (B1), right falling (B2), and left falling (B3) zones. Through monitoring data analysis and GeoStudio-based numerical simulations, this study revealed the mechanisms behind the landslide failure mode characterized by slope sliding approximately along the strike of the rock formation under the coupling effect of hydrological and geological conditions. The results indicate that factors inducing the landslide failure include the geomorphic feature of alternating grooves and ridges, the lithologic assemblage characterized by interbeds of soft and hard rocks, the slope structure with well-developed joints, and the sustained heavy rains in the preceding period. In the Wanshuitian landslide area, mudstone valleys are prone to accumulate rainwater, which can infiltrate directly into the weak interlayers of rock masses and soften the rock masses. Multi-peak rain events with a short time interval serve as a critical factor in groundwater recharge. Within 17 days preceding its failure, the Wanshuitian landslide experienced a superimposed process of heavy and secondary rain events with a short interval (four days). Rainwater from the first heavy rain event failed to completely discharge during the short interval, while the secondary rain event also caused rainwater accumulation. These led to a continuous rise in the groundwater table, a constant decrease in the shear strength of the slope, and ultimately the landslide instability. Since the landslide sliding in the dip direction of the rock formation was impeded, the main sliding direction of the landslide formed an angle of 88° with this direction. This led to a unique failure mode characterized by slope sliding approximately along the strike of the rock formation. Based on these findings, this study proposed characteristics for the early identification of the failure of similar landslides, aiming to provide a robust scientific basis for the monitoring, early warning, and prevention and control of the failure of similar landslides. Full article

Weak-grid operation, with a low short-circuit ratio (SCR), degrades voltage and frequency regulation and impacts the power control performance of inverter-based resources, triggering oscillations. This paper proposes a community-scale battery energy storage system (BESS)-supported grid-forming control scheme, where the grid-forming inverter acts a virtual synchronous generator (VSG). A grid-connected BESS-powered VSG model with cascaded voltage-current dual-loop control is developed to assess the impacts of line impedance and P-Q coupling on weak-grid connection and stability. In addition to the conventional VSG, dq-axis decoupling, virtual impedance, and adaptive inertia-damping (J-D) are incorporated and evaluated through multi-scenario MATLAB/Simulink simulations. The results indicate that virtual impedance effectively suppresses coupled oscillations, and the coordinated J-D adaptation yields the most pronounced peak mitigation during edge disturbances (e.g., fault clearance and load shedding). In particular, under a 50% three-phase voltage sag, the coordinated strategy reduces the post-clearance peaks of $v_{pcc,rm\mathrm{s \; \; }}$ and $i_{pcc,rm\mathrm{s \; }}$ by approximately 79.9% and 93.5%, respectively, and decreases the intensity of frequency fluctuations by approximately 97.6%. Overall, the proposed community-scale BESS-VSG scheme enhances the dynamic stability of voltage and frequency under weak-grid conditions and provides a practical control framework for engineeringoriented weak-grid support studies. Full article

Background/Objectives: Triple-negative breast cancer (TNBC) is frequently characterized by notably elevated Ki-67 expression, a hallmark of uncontrolled rapid cell-cycle progression. However, the underlying mechanisms remain unclear, leading to limited therapeutic options. Methods: In this study, hub gene was identified through integrated bioinformatic analysis of public datasets (TCGA-BRCA and METABRIC). Subsequent functional validation was performed both in vitro and in vivo using siRNA-mediated knockdown and small-molecule inhibitors. Phenotypic effects—including cell viability, cell cycle distribution, DNA synthesis, and clonogenic survival—were comprehensively assessed using MTT assays, flow cytometry, EdU, and colony formation assays. Protein-level changes were confirmed by Western blotting and immunohistochemistry (IHC). To dissect the transcriptional regulation of the key hub gene TTK, we first predicted potential upstream transcription factors using the JASPAR database; binding specificity was then validated through in silico motif analysis, luciferase reporter assays, and chromatin immunoprecipitation followed by quantitative PCR (ChIP-qPCR). Results: The mitotic kinase TTK is significantly overexpressed in TNBC compared with non-TNBC breast cancers. Notably, TTK overexpression exhibited a strong positive correlation with elevated Ki-67 indices and reduced overall survival in TNBC patients. Functional validation demonstrated that pharmacological or genetic inhibition of TTK effectively induced G2/M cell-cycle arrest and potently suppressed TNBC proliferation in both in vitro cell cultures and in vivo xenograft models. Mechanistically, TTK overexpression stems from enhanced transcriptional initiation driven by the transcription factor NFYA binding to the CCAAT box in the TTK promoter—an interaction newly identified here. Concurrently, TTK blockade disrupted spindle assembly checkpoint (SAC) signaling via BUB1B/MAD1L1 downregulation, triggering mitotic arrest and catastrophe. Conclusions: Collectively, these findings establish TTK as a key cell-cycle regulator driving TNBC proliferation. More importantly, targeting mitotic control through TTK inhibition represents an efficient strategy to impede the aberrantly fast cell cycle progression in TNBC. Full article

Neurovascular coupling (NVC) maintains appropriate cerebral blood flow (CBF) in response to neuronal activity, and its disturbance, known as neurovascular uncoupling (NVU), is increasingly recognised as a major contributor to neurodegenerative disease. Alzheimer’s disease (AD) NVU is caused by Aβ buildup, tau pathology, endothelial dysfunction, and persistent neuroinflammation, leading to poor CBF control and blood–brain barrier (BBB) disintegration. Parkinson’s disease (PD) is characterised by α-synuclein aggregation, oxidative stress, mitochondrial dysfunction, and dopaminergic neuronal loss, all of which impede cerebrovascular regulation. These disease-specific mechanisms interact via similar vascular pathways, establishing NVU as a critical connection between neuronal degeneration and cerebrovascular dysfunction. This study highlights the critical role of NVU in neurodegeneration by investigating shared and disease-specific processes in AD and PD. Tau pathology disturbs vascular regulation in AD, whereas dopaminergic neuron loss impairs cerebrovascular control in PD. Both Aβ and α-synuclein are linked to endothelial dysfunction and oxidative stress, albeit originating in different pathologies. Comparative analysis reveals distinct vascular abnormalities in each condition, as well as shared processes such as inflammation and BBB disruption. The study also covers developments in biomarker discovery and neuroimaging techniques that allow for exact characterisation of NVU, facilitating early diagnosis and treatments. In addition, lifestyle changes and pharmacological treatments for oxidative stress and endothelial injury are being examined. This study highlights the significance of NVU as a fundamental pathogenic mechanism, underscoring its importance for comprehending disease development and formulating novel therapeutic strategies. Full article

Background/Objectives: Beyond glycemic control, oral antidiabetic drugs (OADs) may exert class-specific effects on muscle mass and hematologic parameters. However, real-world evidence comparing these effects across OAD classes remains limited. This study aimed to evaluate the differential effects of commonly prescribed OADs on skeletal muscle mass (SMM) and hemoglobin (Hb) levels in adults with type 2 diabetes mellitus (T2DM). Methods: In this prospective observational cohort study, 60 adults with newly initiated OAD therapy were followed for six months at a tertiary care center in Türkiye. Patients were classified according to the OAD class newly added to their regimen (metformin, sulfonylureas, dipeptidyl peptidase-4 inhibitors, pioglitazone, or sodium–glucose cotransporter-2 inhibitors [SGLT2-i]). Multi-frequency bioelectrical impedance analysis was used to evaluate body composition, and hematologic parameters including Hb were obtained at both time points. To account for potential confounders—including age, sex, BMI, baseline Hb, and eGFR—binary logistic regression analyses were performed. Results: Patients initiated on pioglitazone (n = 11) demonstrated a borderline within-group increase in SMM in unadjusted analysis (median delta +0.17 kg, IQR −0.55 to +0.50; p = 0.050); however, this association was attenuated and no longer statistically significant after multivariable adjustment (OR 2.16, 95% CI 0.60–7.83; p = 0.240). In contrast, SGLT2-i users (n = 28) showed a significant increase in Hb (median delta +0.10 g/dL, IQR −0.30 to +0.50; p = 0.022), which remained significant after adjustment (OR 4.22, 95% CI 1.32–13.44; p = 0.015). Other OAD classes were not associated with meaningful changes in SMM or Hb. Conclusions: In this real-world prospective cohort, pioglitazone showed a trend toward increased SMM in unadjusted analysis that did not reach significance after adjustment, suggesting a hypothesis-generating signal warranting further investigation. SGLT2 inhibitors were independently associated with increased Hb levels, though the observed median increment was modest in absolute terms. These findings highlight potentially clinically relevant, non-glycemic effects of OAD classes and may inform individualized treatment selection, particularly in patients at risk of sarcopenia or anemia. Adequately powered, prospective studies are needed to validate and extend these preliminary observations. Full article

The use of agricultural waste fibres and natural binders is being investigated as alternatives to synthetic indoor acoustic materials. However, few studies have compared the fibre type, biopolymer type, and fibre-to-binder ratio for both sound absorption and sound transmission within a single controlled composite system. This study investigated the acoustic performance of sugarcane fibre (SF) and coconut fibre (CF) with a fixed thickness of 20 mm and density of 200 kg/m³, mixed with cassava, corn and potato starch binders with fibre–binder ratios from 1:1.0 to 1:0.1. Sound absorption coefficient was measured with an impedance tube, according to ISO 10534-2, and the sound transmission coefficient was determined using a four-microphone impedance tube system, according to ASTM E2611. Porosity was also tested for its relation to acoustic behaviour. The results showed that the coconut fibre composite recorded higher peak absorption, including α = 0.95 for cassava 1:0.6 to 1:0.7 and corn 1:0.6, while sugarcane fibre showed stronger transmission resistance, with SF-CAS-200-1:0.3 decreasing from τ = 0.11 at 160 Hz to 0.02 at 5000 Hz, and SF-PT-200-1:0.4 from τ = 0.10 to 0.03. The highest porosity values were 85.29%, recorded for SC-CAS-200-1:0.1, and 84.13% for CF-CAS-200-1:0.1. Overall, sugarcane fibre composites offered the best balance of absorption and low transmission, indicating strong potential for sustainable indoor acoustic panels, such as ceiling linings and wall systems. Further research should evaluate mechanical strength, fire performance, durability, and moisture resistance to support practical building applications. Full article

The increasing penetration of renewable energy has led to the large-scale integration of power electronic devices into the power grid. In weakly connected grids, such devices are connected to the grid via voltage source converters (VSCs) using grid-forming (GFM) control strategies. Ideally, the point of common coupling (PCC) with the grid is treated as a purely inductive circuit. However, in weak grids, the resistance-to-inductance ratio (R/X) cannot be ignored, which leads to the power coupling problem between active power (P) and reactive power (Q). This phenomenon impedes the precise control of P and Q, potentially resulting in steady-state power deviations and even system instability. Traditional power-decoupling methods based on virtual inductance (VI) have inherent limitations and fail to achieve complete decoupling between P and Q. To address this issue, this paper first analyzes the influencing factors of power coupling through an established power coupling model. Comparisons between the output voltage and the degree of power coupling demonstrate that power decoupling can be achieved by compensating the output voltage. Consequently, an improved power-decoupling strategy based on apparent power feedforward (APPFF) is proposed. The proposed APPFF method realizes complete P-Q decoupling, with a steady-state reactive power error of less than 1% of the rated value. Compared with the PI-decoupling method, the reactive power overshoot is reduced by about 24%, and no additional active power overshoot is introduced. Compared with the conventional virtual inductance method that only reduces coupling by up to 35%, APPFF eliminates the power coupling fundamentally while retaining the reactive power–voltage droop characteristics and fast dynamic response. By directly compensating the reference voltage to the ideal value using apparent power as the feedforward variable, the proposed method is essentially different from the existing voltage/angle compensation schemes. The feasibility and effectiveness of the proposed decoupling method are verified under various working conditions, such as different R/X ratios, line resistances and power references, through both Simulink simulations and experimental results. Full article