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Article

9 Citations

4,378 Views

11 Pages

Characterization of Regulatory and Transporter Genes in the Biosynthesis of Anti-Tuberculosis Ilamycins and Production in a Heterologous Host

Jianqiao He,
Xin Wei,
Zhijie Yang,
Yan Li,
Jianhua Ju and
Junying Ma

Mar. Drugs2020, 18(4), 216;https://doi.org/10.3390/md18040216

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17 April 2020

Ilamycins are cyclopeptides with novel structures that have been isolated from different Actinomycetes. They showed strong anti-tuberculosis activity and could serve as important anti-tuberculosis drug leads. The functions of the pre-tailoring and th...

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Review

26 Citations

6,256 Views

27 Pages

Recent Developments on the Synthesis and Bioactivity of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides That Demonstrate Anti-Malaria and Anti-Tuberculosis Activity

Uli Kazmaier and
Lukas Junk

Mar. Drugs2021, 19(8), 446;https://doi.org/10.3390/md19080446

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3 August 2021

Ilamycins/rufomycins and cyclomarins are marine cycloheptapeptides containing unusual amino acids. Produced by Streptomyces sp., these compounds show potent activity against a range of mycobacteria, including multidrug-resistant strains of Mycobacter...

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Article

22 Citations

3,819 Views

28 Pages

Total Synthesis and Biological Evaluation of Modified Ilamycin Derivatives

Jennifer Greve,
Axel Mogk and
Uli Kazmaier

Mar. Drugs2022, 20(10), 632;https://doi.org/10.3390/md20100632

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3 October 2022

Ilamycins/rufomycins are marine cycloheptapeptides containing unusual amino acids. Produced by Streptomyces sp., these compounds show potent activity against a range of mycobacteria, including multidrug-resistant strains of Mycobacterium tuberculosis...

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