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20 pages, 2760 KiB  
Article
Enhancing Iced 8-Bundled Conductor Galloping Prediction for UHV Transmission Line Infrastructure Through High-Fidelity Aerodynamic Modeling
by Bolin Zhong, Mengqi Cai, Maoming Hu and Jiahao Sun
Infrastructures 2025, 10(8), 201; https://doi.org/10.3390/infrastructures10080201 (registering DOI) - 1 Aug 2025
Abstract
Icing on eight-bundled conductors can significantly alter their aerodynamic behavior, potentially leading to structural instabilities such as galloping. This study employed wind tunnel experiments and numerical simulations to analyze the aerodynamic parameters of each iced conductor across various angles of attack. The simulations [...] Read more.
Icing on eight-bundled conductors can significantly alter their aerodynamic behavior, potentially leading to structural instabilities such as galloping. This study employed wind tunnel experiments and numerical simulations to analyze the aerodynamic parameters of each iced conductor across various angles of attack. The simulations incorporated detailed stranded conductor geometries to assess their influence on aerodynamic accuracy. Incorporating stranded geometry in simulations reduced average errors in lift and drag coefficients by 45–50% compared to smooth models. The Den Hartog coefficient prediction error decreased from 15.6% to 3.9%, indicating improved reliability in oscillation predictions. Additionally, conductors with larger windward areas exhibited more pronounced wake effects, with lower sub-conductors experiencing greater wake interference than upper ones. The above results illustrate that explicit modeling of stranded conductor surfaces enhances the precision of aerodynamic simulations, providing a more accurate framework for predicting icing-induced galloping in multi-bundled conductors. Full article
17 pages, 5553 KiB  
Article
Effects of Interspecific Competition on Habitat Shifts of Sardinops melanostictus (Temminck et Schlegel, 1846) and Scomber japonicus (Houttuyn, 1782) in the Northwest Pacific
by Siyuan Liu, Hanji Zhu, Jianhua Wang, Famou Zhang, Shengmao Zhang and Heng Zhang
Biology 2025, 14(8), 968; https://doi.org/10.3390/biology14080968 (registering DOI) - 1 Aug 2025
Abstract
As economically important sympatric species in the Northwest Pacific, the Japanese sardine (Sardinops melanostictus) and Chub mackerel (Scomber japonicus) exhibit significant biological interactions. Understanding the impact of interspecies competition on their habitat dynamics can provide crucial insights for the [...] Read more.
As economically important sympatric species in the Northwest Pacific, the Japanese sardine (Sardinops melanostictus) and Chub mackerel (Scomber japonicus) exhibit significant biological interactions. Understanding the impact of interspecies competition on their habitat dynamics can provide crucial insights for the sustainable development and management of these interconnected species resources. This study utilizes fisheries data of S. melanostictus and S. japonicus from the Northwest Pacific, collected from June to November between 2017 and 2020. We integrated various environmental parameters, including temperature at different depths (0, 50, 100, 150, and 200 m), eddy kinetic energy (EKE), sea surface height (SSH), chlorophyll-a concentration (Chl-a), and the oceanic Niño index (ONI), to construct interspecific competition species distribution model (icSDM) for both species. We validated these models by overlaying the predicted habitats with fisheries data from 2021 and performing cross-validation to assess the models’ reliability. Furthermore, we conducted correlation analyses of the habitats of these two species to evaluate the impact of interspecies relationships on their habitat dynamics. The results indicate that, compared to single-species habitat models, the interspecific competition species distribution model (icSDM) for these two species exhibit a significantly higher explanatory power, with R2 values increasing by up to 0.29; interspecific competition significantly influences the habitat dynamics of S. melanostictus and S. japonicus, strengthening the correlation between their habitat changes. This relationship exhibits a positive correlation at specific stages, with the highest correlations observed in June, July, and October, at 0.81, 0.80, and 0.88, respectively; interspecific competition also demonstrates stage-specific differences in its impact on the habitat dynamics of S. melanostictus and S. japonicus, with the most pronounced differences occurring in August and November. Compared to S. melanostictus, interspecific competition is more beneficial for the expansion of the optimal habitat (HIS ≥ 0.6) for S. japonicus and, to some extent, inhibits the habitat expansion of S. melanostictus. The variation in migratory routes and predatory interactions (with larger individuals of S. japonicus preying on smaller individuals of S. melanostictus) likely constitutes the primary factors contributing to these observed differences. Full article
(This article belongs to the Special Issue Adaptation of Living Species to Environmental Stress)
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34 pages, 3521 KiB  
Review
Overview of Water-Ice in Asteroids—Targets of a Revolution by LSST and JWST
by Ákos Kereszturi, Mohamed Ramy El-Maarry, Anny-Chantal Levasseur-Regourd, Imre Tóth, Bernadett D. Pál and Csaba Kiss
Universe 2025, 11(8), 253; https://doi.org/10.3390/universe11080253 - 30 Jul 2025
Viewed by 106
Abstract
Water-ice occurs inside many minor bodies almost throughout the Solar System. To have an overview of the inventory of water-ice in asteroids, beside the general characteristics of their activity, examples are presented with details, including the Hilda zone and among the Trojans. There [...] Read more.
Water-ice occurs inside many minor bodies almost throughout the Solar System. To have an overview of the inventory of water-ice in asteroids, beside the general characteristics of their activity, examples are presented with details, including the Hilda zone and among the Trojans. There might be several extinct comets among the asteroids with only internal ice content, demonstrating the complex evolution of such bodies. To evaluate the formation of ice-hosting small objects, their migration and retention capacity by a surface covering dust layer are also overviewed to provide a complex picture of volatile occurrences. This review aims to support further work and search for sublimation-induced activity of asteroids by future missions and telescopic surveys. Based on the observed and hypothesized occurrence and characteristics of icy asteroids, future observation-related estimations were made regarding the low limiting magnitude future survey of LSST/Vera Rubin and also the infrared ice identification by the James Webb space telescope. According to these estimations, there is a high probability of mapping the distribution of ice in the asteroid belt over the next decade. Full article
(This article belongs to the Special Issue The Hidden Stories of Small Planetary Bodies)
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18 pages, 4703 KiB  
Article
Nanoparticle-Free 3D-Printed Hydrophobic Surfaces for Ice Mitigation Applications
by Ranim Zgaren, Maryam Hosseini, Reza Jafari and Gelareh Momen
Molecules 2025, 30(15), 3185; https://doi.org/10.3390/molecules30153185 - 30 Jul 2025
Viewed by 97
Abstract
Ice accumulation on exposed surfaces presents substantial economic and safety challenges across various industries. To overcome limitations associated with traditional anti-icing methods, such as the use of nanoparticles, this study introduces a novel and facile approach for fabricating superhydrophobic and anti-icing microstructures using [...] Read more.
Ice accumulation on exposed surfaces presents substantial economic and safety challenges across various industries. To overcome limitations associated with traditional anti-icing methods, such as the use of nanoparticles, this study introduces a novel and facile approach for fabricating superhydrophobic and anti-icing microstructures using cost-effective LCD 3D printing technology. The influence of diverse pillar geometries, including square, cylindrical, hexagonal, and truncated conical forms, was analyzed to assess their effects on the hydrophobic and anti-icing/icephobic performance in terms of wettability, ice adhesion strength, and icing delay time. The role of microstructure topography was further investigated through cylindrical patterns with varying geometric parameters to identify optimal designs for enhancing hydrophobic and icephobic characteristics. Furthermore, the effectiveness of surface functionalization using a low surface energy material was evaluated. Our findings demonstrate that the synergistic combination of tailored microscale geometries and surface functionalization significantly enhances anti-icing performance with reliable repeatability, achieving ice adhesion of 13.9 and 17.9 kPa for square and cylindrical pillars, respectively. Critically, this nanoparticle-free 3D printing and low surface energy treatment method offers a scalable and efficient route for producing high-performance hydrophobic/icephobic surfaces, opening promising avenues for applications in sectors where robust anti-icing capabilities are crucial, such as renewable energy and transportation. Full article
(This article belongs to the Special Issue Micro/Nano-Materials for Anti-Icing and/or De-Icing Applications)
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18 pages, 5270 KiB  
Article
Co-Pyrolysis of Bamboo and Rice Straw Biomass with Polyethylene Plastic: Characterization, Kinetic Evaluation, and Synergistic Interaction Analysis
by Munir Hussain, Vikul Vasudev, Shri Ram, Sohail Yasin, Nouraiz Mushtaq, Menahil Saleem, Hafiz Tanveer Ashraf, Yanjun Duan, Muhammad Ali and Yu Bin
Polymers 2025, 17(15), 2063; https://doi.org/10.3390/polym17152063 - 29 Jul 2025
Viewed by 240
Abstract
This study investigates the co-pyrolysis behavior of two lignocellulosic biomass blends, bamboo (B), and rice straw (R) with a plastic polyethylene (P). A total of 15 samples, including binary and ternary blends, were analyzed. Firstly, X-ray diffraction (XRD) analysis was performed to reveal [...] Read more.
This study investigates the co-pyrolysis behavior of two lignocellulosic biomass blends, bamboo (B), and rice straw (R) with a plastic polyethylene (P). A total of 15 samples, including binary and ternary blends, were analyzed. Firstly, X-ray diffraction (XRD) analysis was performed to reveal high crystallinity in the B25R75 blend (I/Ic = 13.39). Whereas, the polyethylene samples showed persistent ZrP2O7 and lazurite phases (I/Ic up to 3.12) attributed to additives introduced during the manufacturing of the commercial plastic feedstock. In addition, scanning electron microscopy with energy-dispersive X-ray (SEM-EDX) spectroscopy was performed to characterize the surface morphology and elemental composition of the feedstock. Moreover, thermogravimetric analysis (TGA) was employed at temperatures up to 700 °C at three different heating rates (5, 10, and 20 °C/min) under pyrolysis conditions. Kinetic analysis used TGA data to calculate activation energy via Friedman’s isoconversional method, and the blended samples exhibited a decrease in activation energy compared to the individual components. Furthermore, the study evaluated transient interaction effects among the components by assessing the deviation between experimental and theoretical weight loss. This revealed the presence of significant synergistic behavior in certain binary and ternary blends. The results demonstrate that co-pyrolysis of bamboo and rice straw with polyethylene enhances thermal decomposition efficiency and provides a more favorable energy recovery route. Full article
(This article belongs to the Topic Biomass for Energy, Chemicals and Materials)
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19 pages, 3137 KiB  
Article
Estimation of Footprint-Scale Across-Track Slopes Based on Elevation Frequency Histogram from Single-Track ICESat-2 Photon Data of Strong Beam
by Qianyin Zhang, Hui Zhou, Yue Ma, Song Li and Heng Wang
Remote Sens. 2025, 17(15), 2617; https://doi.org/10.3390/rs17152617 - 28 Jul 2025
Viewed by 199
Abstract
Topographic slope is a key parameter for characterizing landscape geomorphology. The Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) offers high-resolution along-track slopes based on the ground profiles generated by dense signal photons. However, the across-track slopes are typically derived using the ground photon [...] Read more.
Topographic slope is a key parameter for characterizing landscape geomorphology. The Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) offers high-resolution along-track slopes based on the ground profiles generated by dense signal photons. However, the across-track slopes are typically derived using the ground photon geolocations from the weak-beam and strong-beam pair, limiting the retrieval accuracy and losing valid results over rugged terrains. The goal of this study is to propose a new method to derive the across-track slope merely using single-track photon data of a strong beam based on the theoretical formula of the received signal pulse width. Based on the ICESat-2 photon data over the Walker Lake area, the specific purposes are to (1) extract the along-track slope and surface roughness from the signal photon data on the ground; (2) generate an elevation frequency histogram (EFH) and calculate its root mean square (RMS) width; and (3) derive the across-track slope from the RMS width of the EFH and evaluate the retrieval accuracy against the across-track slope from the ICESat-2 product and plane fitting method. The results show that the mean absolute error (MAE) obtained by our method is 11.45°, which is comparable to the ICESat-2 method (11.61°) and the plane fitting method (12.51°). Our method produces the least invalid data proportion of ~2.5%, significantly outperforming both the plane fitting method (10.29%) and the ICESat-2 method (32.32%). Specifically, when the reference across-track slope exceeds 30°, our method can consistently yield the optimal across-track slopes, where the absolute median, inter quartile range, and whisker range of the across-track slope residuals have reductions greater than 4.44°, 1.31°, and 0.10°, respectively. Overall, our method is well-suited for the across-track slope estimation over rugged terrains and can provide higher-precision, higher-resolution, and more valid across-track slopes. Full article
(This article belongs to the Section Satellite Missions for Earth and Planetary Exploration)
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25 pages, 8105 KiB  
Article
Monitoring Critical Mountain Vertical Zonation in the Surkhan River Basin Based on a Comparative Analysis of Multi-Source Remote Sensing Features
by Wenhao Liu, Hong Wan, Peng Guo and Xinyuan Wang
Remote Sens. 2025, 17(15), 2612; https://doi.org/10.3390/rs17152612 - 27 Jul 2025
Viewed by 290
Abstract
Amidst the intensification of global climate change and the increasing impacts of human activities, ecosystem patterns and processes have undergone substantial transformations. The distribution and evolutionary dynamics of mountain ecosystems have become a focal point in ecological research. The Surkhan River Basin is [...] Read more.
Amidst the intensification of global climate change and the increasing impacts of human activities, ecosystem patterns and processes have undergone substantial transformations. The distribution and evolutionary dynamics of mountain ecosystems have become a focal point in ecological research. The Surkhan River Basin is located in the transitional zone between the arid inland regions of Central Asia and the mountain systems, where its unique physical and geographical conditions have shaped distinct patterns of vertical zonation. Utilizing Landsat imagery, this study applies a hierarchical classification approach to derive land cover classifications within the Surkhan River Basin. By integrating the NDVI (normalized difference vegetation index) and DEM (digital elevation model (30 m SRTM)), an “NDVI-DEM-Land Cover” scatterplot is constructed to analyze zonation characteristics from 1980 to 2020. The 2020 results indicate that the elevation boundary between the temperate desert and mountain grassland zones is 1100 m, while the boundary between the alpine cushion vegetation zone and the ice/snow zone is 3770 m. Furthermore, leveraging DEM and LST (land surface temperature) data, a potential energy analysis model is employed to quantify potential energy differentials between adjacent zones, enabling the identification of ecological transition areas. The potential energy analysis further refines the transition zone characteristics, indicating that the transition zone between the temperate desert and mountain grassland zones spans 1078–1139 m with a boundary at 1110 m, while the transition between the alpine cushion vegetation and ice/snow zones spans 3729–3824 m with a boundary at 3768 m. Cross-validation with scatterplot results confirms that the scatterplot analysis effectively delineates stable zonation boundaries with strong spatiotemporal consistency. Moreover, the potential energy analysis offers deeper insights into ecological transition zones, providing refined boundary identification. The integration of these two approaches addresses the dimensional limitations of traditional vertical zonation studies, offering a transferable methodological framework for mountain ecosystem research. Full article
(This article belongs to the Special Issue Temporal and Spatial Analysis of Multi-Source Remote Sensing Images)
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19 pages, 3200 KiB  
Article
Polyphosphoramidate Glycohydrogels with Biorecognition Properties and Potential Antibacterial Activity
by Zornica Todorova, Oyundari Tumurbaatar, Violeta Mitova, Neli Koseva, Iva Ugrinova, Penka Petrova and Kolio Troev
Molecules 2025, 30(15), 3140; https://doi.org/10.3390/molecules30153140 - 26 Jul 2025
Viewed by 210
Abstract
In the present study, for the first time, a biodegradable and non-toxic polyphosphoramidate glycohydrogel (PPAGHGel) was prepared by crosslinking a polyphosphoramidate glycoconjugate (PPAG) with hexamethylene diisocyanate (HMDI) under mild conditions. Poly(oxyethylene H-phosphonate) (POEHP) was used as a precursor and was converted into PPAG [...] Read more.
In the present study, for the first time, a biodegradable and non-toxic polyphosphoramidate glycohydrogel (PPAGHGel) was prepared by crosslinking a polyphosphoramidate glycoconjugate (PPAG) with hexamethylene diisocyanate (HMDI) under mild conditions. Poly(oxyethylene H-phosphonate) (POEHP) was used as a precursor and was converted into PPAG via the Staudinger reaction with glucose-containing azide (2-p-azidobenzamide-2-deoxy-1,3,4,6-tetra-O-trimethylsilyl-α-D-glucopyranose). Then, crosslinking of PPAG was performed to yield PPAGHGel, which was thoroughly characterized. The gel showed a gel fraction of 83%, a swelling degree of 1426 ± 98%, and G″ = 1560 ± 65 Pa. The gel was fully degraded by alkaline phosphatase (400 U/L, pH 9) in 19 days, while hydrolytically, up to 52% degradation was observed under similar conditions. Multivalent studies of the obtained hydrogel with lectin–Concanavalin A were performed. PPAGHGel binds 92% of Concanavalin A within 24 h and the complex remains stable until the amount of glucose reaches 0.3 mM. PPAGHGel acts as a stabilizer for silver nanoparticles (12 nm). SEM shows pores measuring 10 µm (surface) and 0.1 mm (interior) with capillary channels, confirming the gel’s suitability for biosensors, drug delivery, or wound dressings. The cytotoxic (IC50) and cell-adhesive properties of the obtained hydrogel were investigated on human cell lines (HeLa). Antibacterial activity tests were also performed with gel containing silver nanoparticles against skin-associated pathogenic bacteria. The results show that PPAGHGel possesses excellent biocompatibility, non-adhesive properties and antibacterial activity. Full article
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20 pages, 3985 KiB  
Article
Activity Analysis and Inhibition Mechanism of Four Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Prepared from Flammulina velutipes by Enzymatic Hydrolysis
by Yajie Zhang, Xueqi Zhao, Xia Ma, Jiaqi Li, Xiaoyu Ye, Xuerui Wang, Wenwei Zhang and Jianmin Yun
Foods 2025, 14(15), 2619; https://doi.org/10.3390/foods14152619 - 26 Jul 2025
Viewed by 203
Abstract
In order to innovatively develop high-activity ACE inhibitory peptides from edible fungi, the conditions for a double-enzymatic hydrolysis preparation of ACE inhibitory peptides from Flammulina velutipes were optimized by response surface methodology. After purification by macroporous resin, gel chromatography, and RP-HPLC, a crude [...] Read more.
In order to innovatively develop high-activity ACE inhibitory peptides from edible fungi, the conditions for a double-enzymatic hydrolysis preparation of ACE inhibitory peptides from Flammulina velutipes were optimized by response surface methodology. After purification by macroporous resin, gel chromatography, and RP-HPLC, a crude peptide fraction was obtained; its ACE inhibition rate was 85.73 ± 0.95% (IC50 = 0.83 ± 0.09 mg/mL). Based on LC-MS/MS sequencing, the four novel peptides, namely, FAGGP, FDGY, FHPGY, and WADP, were screened by computer analysis and molecular docking technology. The four peptides exhibited a binding energy between −9.4 and −10.3 kcal/mol, and formed hydrogen bonds with Tyr523, Ala354, and Glu384 in the S1 pocket, Tyr520 and His353 in the S2 pocket, and His383 in the HEXXH zinc-coordinating motif of ACE, indicating their good affinity with the ACE active site. The IC50 values of the four ACE inhibitory peptides were 29.17, 91.55, 14.79, and 41.27 μM, respectively, suggesting that these peptides could potentially contribute to the development of new antihypertensive products. Full article
(This article belongs to the Special Issue Bioactive Peptides and Probiotic Bacteria: Modulators of Human Health)
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27 pages, 4348 KiB  
Article
Valorization of Riceberry Broken Rice and Soybean Meal for Optimized Production of Multifunctional Exopolysaccharide by Bacillus tequilensis PS21 with Potent Bioactivities Using Response Surface Methodology
by Thipphiya Karirat, Worachot Saengha, Nantaporn Sutthi, Pheeraya Chottanom, Sirirat Deeseenthum, Nyuk Ling Ma and Vijitra Luang-In
Polymers 2025, 17(15), 2029; https://doi.org/10.3390/polym17152029 - 25 Jul 2025
Viewed by 295
Abstract
This study explores the valorization of agro-industrial by-products—riceberry broken rice (RBR) and soybean meal (SBM)—as cost-effective substrates for enhancing exopolysaccharide (EPS) production by Bacillus tequilensis PS21. Eight Bacillus strains were screened, and B. tequilensis PS21 demonstrated the highest EPS yield (2.54 g/100 mL [...] Read more.
This study explores the valorization of agro-industrial by-products—riceberry broken rice (RBR) and soybean meal (SBM)—as cost-effective substrates for enhancing exopolysaccharide (EPS) production by Bacillus tequilensis PS21. Eight Bacillus strains were screened, and B. tequilensis PS21 demonstrated the highest EPS yield (2.54 g/100 mL DW). The EPS displayed a strong antioxidant capacity with 65.5% DPPH and 80.5% hydroxyl radical scavenging, and a FRAP value of 6.51 mg Fe2+/g DW. Antimicrobial testing showed inhibition zones up to 10.07 mm against Streptococcus agalactiae and 7.83 mm against Staphylococcus aureus. Optimization using central composite design (CCD) and the response surface methodology (RSM) revealed the best production at 5% (w/v) RBR, 3% (w/v) SBM, pH 6.66, and 39.51 °C, yielding 39.82 g/L EPS. This EPS is a moderate-molecular-weight (11,282 Da) homopolysaccharide with glucose monomers. X-ray diffraction (XRD) showed an amorphous pattern, favorable for solubility in biological applications. Thermogravimetric analysis (TGA) demonstrated thermal stability up to ~250 °C, supporting its suitability for high-temperature processing. EPS also exhibited anticancer activity with IC50 values of 226.60 µg/mL (MCF-7) and 224.30 µg/mL (HeLa) at 72 h, reduced colony formation, inhibited cell migration, and demonstrated anti-tyrosinase, anti-collagenase, and anti-elastase effects. This study demonstrates the successful valorization of agro-industrial by-products—RBR and SBM—for the high-yield production of multifunctional EPS with potent antioxidant, antimicrobial, and anticancer properties. The findings highlight the sustainable potential of these low-cost substrates in supporting the development of green and value-added bioproducts, with promising utilizations across the food, pharmaceutical, and cosmetic sectors. Full article
(This article belongs to the Topic Microbes and Their Products for Sustainable Human Life)
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19 pages, 474 KiB  
Review
A Review on the Technologies and Efficiency of Harvesting Energy from Pavements
by Shijing Chen, Luxi Wei, Chan Huang and Yinghong Qin
Energies 2025, 18(15), 3959; https://doi.org/10.3390/en18153959 - 24 Jul 2025
Viewed by 352
Abstract
Dark asphalt surfaces, absorbing about 95% of solar radiation and warming to 60–70 °C during summer, intensify urban heat while providing substantial prospects for energy extraction. This review evaluates four primary technologies—asphalt solar collectors (ASCs, including phase change material (PCM) integration), photovoltaic (PV) [...] Read more.
Dark asphalt surfaces, absorbing about 95% of solar radiation and warming to 60–70 °C during summer, intensify urban heat while providing substantial prospects for energy extraction. This review evaluates four primary technologies—asphalt solar collectors (ASCs, including phase change material (PCM) integration), photovoltaic (PV) systems, vibration-based harvesting, thermoelectric generators (TEGs)—focusing on their principles, efficiencies, and urban applications. ASCs achieve up to 30% efficiency with a 150–300 W/m2 output, reducing pavement temperatures by 0.5–3.2 °C, while PV pavements yield 42–49% efficiency, generating 245 kWh/m2 and lowering temperatures by an average of 6.4 °C. Piezoelectric transducers produce 50.41 mW under traffic loads, and TEGs deliver 0.3–5.0 W with a 23 °C gradient. Applications include powering sensors, streetlights, and de-icing systems, with ASCs extending pavement life by 3 years. Hybrid systems, like PV/T, achieve 37.31% efficiency, enhancing UHI mitigation and emissions reduction. Economically, ASCs offer a 5-year payback period with a USD 3000 net present value, though PV and piezoelectric systems face cost and durability challenges. Environmental benefits include 30–40% heat retention for winter use and 17% increased PV self-use with EV integration. Despite significant potential, high costs and scalability issues hinder adoption. Future research should optimize designs, develop adaptive materials, and validate systems under real-world conditions to advance sustainable urban infrastructure. Full article
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24 pages, 4295 KiB  
Article
Acrocomia aculeata Oil-Loaded Nanoemulsion: A Promising Candidate for Cancer and Diabetes Management
by Ariadna Lafourcade Prada, Jesus Rafael Rodríguez Amado, Renata Trentin Perdomo, Giovanna Bicudo Gomes, Danielle Ayr Tavares de Almeida, Leandro Fontoura Cavalheiro, Arquimedes Gasparotto Junior, Serafim Florentino Neto and Marco Antonio Utrera Martines
Pharmaceuticals 2025, 18(8), 1094; https://doi.org/10.3390/ph18081094 - 24 Jul 2025
Viewed by 280
Abstract
Background: Diabetes and cancer are two of the most life-threatening disorders affecting individuals of all ages worldwide. This study aimed to develop a novel Acrocomia aculeata (bocaiuva) fruit pulp oil-loaded nanoemulsion and evaluate its inhibitory effects on α-glucosidase and pancreatic lipase, as well [...] Read more.
Background: Diabetes and cancer are two of the most life-threatening disorders affecting individuals of all ages worldwide. This study aimed to develop a novel Acrocomia aculeata (bocaiuva) fruit pulp oil-loaded nanoemulsion and evaluate its inhibitory effects on α-glucosidase and pancreatic lipase, as well as its antiglycant activity and cytotoxicity against cancer cells. Additionally, this study assessed the impact of both the oil and the nanoemulsion on blood cells. Methods: The pulp oil was extracted by cold pressing. The oil’s physicochemical properties were determined according to the AOAC and the Brazilian Pharmacopeia. The lipid profile was performed by GC-MS. The nanoemulsion was prepared by the phase inversion method using ultrasonic stirring for particle size reduction and for homogenization. Response Surface Methodology was used for optimizing nanoemulsion preparation. Enzyme inhibition tests were conducted using assay kits. Cytotoxicity in cancer cells was evaluated using the Sulforhodamine B assay. Results: Comprehensive physicochemical and chemical characterization of bocaiuva oil was performed, identifying oleic acid (71.25%) as the main component. The oil contains 23.04% saturated fatty acids, 73.79% monounsaturated acids, and 3.0% polyunsaturated fatty acids. The nanoemulsion (particle size 173.6 nm; zeta potential −14.10 mV) inhibited α-glucosidase (IC50: 43.21 µg/mL) and pancreatic lipase (IC50: 41.99 µg/mL), and revealed a potent antiglycation effect (oxidative IC50: 18.36 µg/mL; non-oxidative pathway IC50: 16.33 µg/mL). The nanoemulsion demonstrated good cytotoxicity and selectivity against prostate cancer cells (IC50: 19.13 µg/mL) and breast cancer cells (IC50: 27.22 µg/mL), without inducing hemolysis, platelet aggregation, or anticoagulant effects. Conclusions: In this study, a comprehensive physical and chemical characterization of bocaiuva fruit pulp oil was conducted for the first time as a preliminary step toward its future standardization as an active ingredient in cosmetic and pharmaceutical formulations. The resulting nanoemulsion represents a novel alternative for managing diabetes and cancer. Although the nanoemulsion exhibited lower cytotoxicity compared to doxorubicin, it remains promising due to its composition of essential fatty acids, phenols, and carotenoids, which offer multiple health benefits. Further studies are needed to validate its efficacy and safety in clinical applications. Full article
(This article belongs to the Special Issue Nanotechnology in Biomedical Applications)
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18 pages, 5469 KiB  
Article
Site Application of Thermally Conductive Concrete Pavement: A Comparison of Its Thermal Effectiveness with Normal Concrete Pavement
by Joo-Young Kim and Jae-Suk Ryou
Materials 2025, 18(15), 3444; https://doi.org/10.3390/ma18153444 - 23 Jul 2025
Viewed by 262
Abstract
In this study, the thermal effectiveness of thermally conductive concrete pavements (TCPs) using silicon carbide (SiC) as a fine aggregate replacement was investigated, compared with that of ordinary Portland cement pavements (OPCPs). The most important purpose of this study is to improve the [...] Read more.
In this study, the thermal effectiveness of thermally conductive concrete pavements (TCPs) using silicon carbide (SiC) as a fine aggregate replacement was investigated, compared with that of ordinary Portland cement pavements (OPCPs). The most important purpose of this study is to improve the thermal performance of concrete pavement. Additionally, this study utilized improved thermal properties to enhance the efficiency of pavement heating to prevent icing and snow stacking. Both mixtures met the Korean standards for air content (4.5–6%) and slump (80–150 mm), demonstrating adequate workability. TCP exhibited a higher mechanical performance, with average compressive and flexural strengths of 42.88 MPa and 7.35 MPa, respectively, exceeding the required targets of a 30 MPa compressive strength and a 4.5 MPa flexural strength. The improved strength was mainly attributed to the filler effect and partly due to the van der Waals interactions of the SiC particles. Thermal conductivity tests showed a significant improvement in the TCP (3.20 W/mK), which was approximately twice that of OPCP (1.59 W/mK), indicating an enhanced heat transfer efficiency. In winter field tests, TCP effectively maintained high surface temperatures, overcoming heat loss and outperforming the OPCP. In the site experiment, thermal efficiency was clearly shown in the temperature at the center of the TCP, which was 3.5 °C higher than at the center of the OPCP at the coldest time. These improvements suggest that SiC-reinforced concrete pavements can be practically utilized for effective snow removal and ice mitigation in road systems. Full article
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10 pages, 637 KiB  
Proceeding Paper
Improving Industrial Control System Cybersecurity with Time-Series Prediction Models
by Velizar Varbanov and Tatiana Atanasova
Eng. Proc. 2025, 101(1), 4; https://doi.org/10.3390/engproc2025101004 - 22 Jul 2025
Viewed by 208
Abstract
Traditional security detection methods struggle to identify zero-day attacks in Industrial Control Systems (ICSs), particularly within critical infrastructures (CIs) integrated with the Industrial Internet of Things (IIoT). These attacks exploit unknown vulnerabilities, leveraging the complexity of physical and digital system interconnections, making them [...] Read more.
Traditional security detection methods struggle to identify zero-day attacks in Industrial Control Systems (ICSs), particularly within critical infrastructures (CIs) integrated with the Industrial Internet of Things (IIoT). These attacks exploit unknown vulnerabilities, leveraging the complexity of physical and digital system interconnections, making them difficult to detect. The integration of legacy ICS networks with modern computing and networking technologies has expanded the attack surface, increasing susceptibility to cyber threats. Anomaly detection systems play a crucial role in safeguarding these infrastructures by identifying deviations from normal operations. This study investigates the effectiveness of deep learning-based anomaly detection models in revealing operational anomalies that could indicate potential cyber-attacks. We implemented and evaluated a hybrid deep learning architecture combining Convolutional Neural Networks (CNNs) and Long Short-Term Memory (LSTM) networks to analyze ICS telemetry data. The CNN-LSTM model excels in identifying time-dependent anomalies and enables near real-time detection of cyber-attacks, significantly improving security monitoring capabilities for IIoT-integrated critical infrastructures. Full article
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24 pages, 50503 KiB  
Article
Quantifying the Influence of Sea Surface Temperature Anomalies on the Atmosphere and Precipitation in the Southwestern Atlantic Ocean and Southeastern South America
by Mylene Cabrera, Luciano Pezzi, Marcelo Santini and Celso Mendes
Atmosphere 2025, 16(7), 887; https://doi.org/10.3390/atmos16070887 - 19 Jul 2025
Viewed by 217
Abstract
Oceanic mesoscale activity influences the atmosphere in the southwestern and southern sectors of the Atlantic Ocean. However, the influence of high latitudes, specifically sea ice, on mid-latitudes and a better understanding of mesoscale ocean–atmosphere thermodynamic interactions still require further study. To quantify the [...] Read more.
Oceanic mesoscale activity influences the atmosphere in the southwestern and southern sectors of the Atlantic Ocean. However, the influence of high latitudes, specifically sea ice, on mid-latitudes and a better understanding of mesoscale ocean–atmosphere thermodynamic interactions still require further study. To quantify the effects of oceanic mesoscale activity during the periods of maximum and minimum Antarctic sea ice extent (September 2019 and February 2020), numerical experiments were conducted using a coupled regional model and an online two-dimensional spatial filter to remove high-frequency sea surface temperature (SST) oscillations. The largest SST anomalies were observed in the Brazil–Malvinas Confluence and along oceanic fronts in September, with maximum SST anomalies reaching 4.23 °C and −3.71 °C. In February, the anomalies were 2.18 °C and −3.06 °C. The influence of oceanic mesoscale activity was evident in surface atmospheric variables, with larger anomalies also observed in September. This influence led to changes in the vertical structure of the atmosphere, affecting the development of the marine atmospheric boundary layer (MABL) and influencing the free atmosphere above the MABL. Modulations in precipitation patterns were observed, not only in oceanic regions, but also in adjacent continental areas. This research provides a novel perspective on ocean–atmosphere thermodynamic coupling, highlighting the mesoscale role and importance of its representation in the study region. Full article
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