Search Results (266)

In the context of advancing communication technologies and digital spaces, Moroccan youth are increasingly engaging with concepts of mobility, presenting both opportunities and challenges in a liquid modern digital landscape. While digital identities and mobility have been extensively studied among Western youth, non-Western youth, including those in Morocco, are often viewed through a lens of being “at risk,” which biases objective analysis. This study addresses this gap by examining how digital mobility fosters culturally hybrid identities among Moroccan youth in a globalised world. Methods: An interdisciplinary ethnographic content analysis was conducted on youth digital productions and interactions on platforms such as Facebook and YouTube. The study draws on Zygmunt Bauman’s theory of liquid modernity and Stuart Hall’s theory of representation to explore identity formation. Results: Digital mobility enables Moroccan youth to navigate between local cultural influences (Amazigh, Islamic, African, and Arab) and global Western narratives, leading to hybrid identities. Challenges include cultural erosion through practices like Western-style dating shows and sexual freedoms that challenge social norms, potentially widening generational gaps. Opportunities arise from platforms like SAWT, where youth discuss taboo topics, create hybrid cultural artefacts, and engage in glocalisation, enhancing agency and global integration. Conclusions: Digital mobility acts as a catalyst for cultural hybridity, supporting global integration while highlighting the need for addressing accessibility disparities and unsupervised interactions. This framework contributes to digital youth studies by emphasising mobility’s role in identity evolution, advocating for balanced glocality over cultural protectionism or homogenisation. Full article

The rapid development of Autonomous Underwater Vehicles (AUVs) has increased the demand for propulsion systems that balance thrust density, hydrodynamic efficiency, and acoustic discretion. This study presents a comprehensive numerical investigation of the performance of the Blue Robotics T500 thruster, embedded within the RAS-HA-X25 AUV’s internal conduit. Using transient Computational Fluid Dynamics (CFD) within the OpenFOAM framework, this research assesses the propulsive characteristics of the thruster across six distinct outlet geometries, including convergent jet nozzles and multi-lobed “daisy” configurations. To improve computational efficiency for parametric design, a calibrated actuator disc model was developed and validated against resolved-rotor simulations, revealing a 15% discrepancy attributed to tip leakage and hub vortex effects. Results show that at the operational advance ratio ($J=0.167$), the 60 mm convergent nozzle is the optimal configuration for maximising thrust, achieving a peak net thrust of 42 N. In contrast, the daisy-type lobed geometries, while causing a 50% reduction in absolute thrust compared to a standard cylindrical pipe, significantly homogenise the exit-plane velocity distribution and reduce swirl intensity. These findings indicate that lobed terminations provide a viable mechanism for reducing hydroacoustic signatures, offering a strategic “stealth” advantage for low-observable underwater platforms where acoustic discretion is prioritised over pure thrust density. This study establishes a robust methodology for optimising embedded propulsion modules in next-generation autonomous and hybrid underwater vehicles. Full article

Background: NexoBrid^® (NXB; MediWound Ltd., Yavne, Israel) (anacaulase-bcdb) is a bromelain-based enzymatic debriding agent approved for eschar removal in burn care. Despite widespread clinical use, histological evidence of tissue-level changes after enzymatic debridement remains limited. This systematic review aimed to evaluate preclinical and clinical studies describing histological findings following bromelain-based enzymatic debridement of thermal burns. Methods: Following PRISMA 2020 guidelines, we performed parallel systematic searches of preclinical (animal) and clinical (human) studies across PubMed, Embase, CENTRAL, Web of Science, and Scopus. Included studies reported thermal burns treated with bromelain-based enzymatic debridement and tissue biopsies with histological analysis. Quality was assessed using the SYRCLE Risk of Bias Tool (preclinical) and JBI Critical Appraisal Checklists (clinical). Results: Six preclinical studies (five porcine, one rat) met inclusion criteria. Findings included: selective eschar removal with dermal preservation; protection of the zone of stasis (67% partial- vs. 100% full-thickness necrosis; p = 0.05); viable dermal thickness of 1.1 ± 0.7 mm; and accelerated re-epithelialization (7.4 ± 0.8 vs. 9.1 ± 2.1 days; p < 0.05). Only two clinical studies (n = 9 patients) met the inclusion criteria: one case series (n = 8) and one case report. Clinical findings showed upper dermal homogenisation with preserved deep dermis, vascular congestion correlating with pinpoint bleeding, and pseudoeschar formation via transepidermal elimination. Conclusions: Preclinical evidence supports selective enzymatic debridement with dermal preservation. However, clinical histological data are limited to nine patients after over 13 years of use. This highlights a critical translational gap and underscores the need for prospective clinical histological studies. Full article

Metal–polymer hybrid joints are gaining importance as they combine high structural rigidity with a low weight. Additive manufacturing processes such as the laser powder bed fusion process (L-PBF) enable the production of complex metallic lattice structures that allow for form-fitting force transmission between the metal and polymer as mechanical interlock elements. In this work, metal–polymer hybrid compounds with additively manufactured transition zones are systematically investigated and mechanically evaluated. Three different lattice geometries (z4A, z8A, z8V) were fabricated from maraging steel (1.2709) using L-PBF and then hybridised with injection moulding using polypropylene (PP C7069-100NA). Mechanical characterisation was performed by tensile tests according to DIN EN ISO 527, in combination with statistical analyses and an analytical serial three-spring model to determine the homogenised elasticity modulus of the transition zone. The results show significant geometry-related differences in tensile strength, maximum force, and effective stiffness. The A-shaped transition zone geometry (z4A) achieves the highest mechanical performance and up to 82% of the tensile strength of the pure polymer, while the V-shaped transition zone geometry (z8V) has significantly lower load-bearing capacities. Variance analysis shows a dominant geometric influence with effect strength of η² ≈ 0.99. The analytically predicted stiffness values match the experimental results within 5–10%. This work demonstrates a reproducible, simulation-sparse approach to the analysis and design of metal–polymer hybrid connections. Full article

Macadamia husks are an underutilized by-product of nut processing and a rich source of phenolic compounds with strong antioxidant activity. However, their instability during processing, storage, and gastrointestinal digestion limits their application in food systems. This study aimed to encapsulate macadamia husk phenolic-rich extract (MHPE) in liposomes to improve stability, enable controlled release, and assess cytotoxicity for functional food applications. MHPE was encapsulated in soy lecithin liposomes using high-shear mixing followed by high-pressure homogenisation. Liposomes were characterized by particle size, polydispersity index (PDI), ζ-potential, encapsulation efficiency, and morphology. Cytotoxicity was evaluated using Caco-2 cells, and phenolic release was assessed under simulated gastrointestinal conditions. MHPE-loaded liposomes exhibited nano-sized particles (77–78 nm), low PDI (0.21), and high negative ζ-potential (−43.11 to −47.01 mV) during two months of storage at 4 °C. Transmission electron microscopy confirmed predominantly spherical vesicles with sizes consistent with dynamic light scattering measurements. Encapsulation efficiency remained high (81.50% initially; 73.60% after 28 days). Both free and extract-loaded liposomes were non-cytotoxic to Caco-2 cells. Encapsulated MHPE showed slower phenolic release compared with the free extract. Overall, liposomal encapsulation effectively enhanced the stability and controlled release of macadamia husk phenolics, supporting their potential use as functional food and nutraceutical ingredients. Full article

Background: Caffeine (CAF), whether extracted from plants or synthesised as a chemical compound, is considered the safest among other xanthine alkaloids. Novel nano-cream formulations have been successfully developed and evaluated to increase the potential of caffeine as a skin cosmeceutical, targeting the minimisation of cellulite appearance. Methods: Nano-cream formulations were prepared through a process of hot-temperature emulsification, in a variety of homogeniser combinations. Results: When chemical penetration enhancers (CPEs) (lanolin, transcutol, and propylene glycol), either alone or in combination, were incorporated into the nano-cream formulations, the permeation of CAF through skin increased. All nano-cream formulations achieved sustained delivery of CAF into and through the skin over 8 h (IVPT). Quantification of CAF from skin tissues was achieved using high-performance liquid chromatography (HPLC). The nano-cream formulation containing lanolin (LAN) showed the highest CAF permeation (8.829 ± 1.472 µg/cm²/h) through the skin compared to CAF in an aqueous solution (2.533 ± 0.480 µg/cm²/h) and a commercial CAF cellulite product with the same CAF concentration (2.827 ± 0.555 µg/cm²/h). Therefore, 2% CAF nano-cream formulation containing LAN was chosen for clinical testing. A double-blind, randomised, placebo-controlled paired trial was conducted, in which each volunteer applied active and placebo creams to the upper thighs twice daily for 12 weeks. The effect of the cream on skin appearance was monitored over 12 weeks. The primary outcome measures were reduced cellulite scores from 3.96 (95% CI: 3.16–4.76) to 2.50 (95% CI: 1.70–3.30) (active) compared with placebo from 3.88 (95% CI: 3.08–4.67) to 2.83 (95% CI: 2.03–3.63). The effect sizes (E.S.) indicated a moderate effect for the active CAF nano-cream formulation (E.S. = 0.475), while the placebo (E.S. = 0.286) had a small effect. Conclusion: We concluded that our optimised 2% CAF nano-cream formulation containing LAN offered an effective formulation strategy for enhancing skin penetration in the IVPT study. The LAN nano-cream formulation demonstrated efficacy and tolerability, both objectively and subjectively, in a human clinical trial. Full article

This study presents a gradient-based topology optimisation framework for heat sinks embedded with phase-change material (PCM) that targets the mitigation of temperature oscillations under cyclic thermal loads. The approach couples transient thermal diffusion modelling in FEniCS with automatic adjoint sensitivities and GCMMA, and uses a simple analytical homogenisation to parametrise a composite of PCM and conductive material. With latent-heat buffering using PCM, the optimised layouts reduce the temperature variance by 41% when the full time history is used and by 32% when only the quasi-steady-state cycle is used. To improve physical manufacturability, explicit penalisation yields near-discrete designs with only ∼10% performance loss, preserving most oscillation reduction benefits. The results demonstrate that adjoint-driven PCM topology optimisation can systematically suppress thermal oscillations. Full article

The increasing trend in the consumption of milk and dairy products, as well as meat and meat-derived products, may be one of the factors contributing to the growing popularity of cheese-added frankfurters, which combine these two product categories. The aim of this study was to compare the textural, colour, and sensory properties of commercially available cheese-containing frankfurters using instrumental measurements and descriptive sensory analysis. The study focused on ready-to-eat products with naturally varying formulations to identify measurable differences in quality attributes and explore potential associations between composition and product characteristics. Instrumental methods were applied, including texture profile analysis (TPA), the Warner–Bratzler shear force test (WBSF), and CIE L*a*b* colour measurement, along with quantitative descriptive analysis. The results confirmed significant differences between the samples in terms of texture and flavour. Notably, Sample B showed the highest shear force (2.91 N), while Sample C exhibited the lowest (1.82 N). Samples A and D, both containing 12% processed cheddar cheese, had the highest b* values (30.1 and 22.4, respectively), which corresponded to their more intense yellow colour and higher scores for cheese flavour. The addition of cheese had a beneficial effect on product acceptability; however, the final outcome depended on the form and amount of cheese, as well as other ingredients. These findings suggest that cheese may serve as a valuable additive to homogenised meat products, enhancing sensory appeal without compromising technological quality. Future studies will compare different cheese types and concentrations and include consumer testing on a larger sample. Full article

Background/Objectives: Postoperative cognitive dysfunction (POCD) is a serious complication of anaesthesia/surgery. The present study investigated the effects of nicardipine—a calcium channel blocker—on neuroinflammation and POCD in rats. Methods: Following ethical approval, 30 Wistar albino rats were divided into three groups: control (Group C), surgery (Group S), and surgery and nicardipine (a single intraperitoneal dose of 5 mg/kg nicardipine) (Group N). Cognitive function was assessed 48 h postoperatively using the MWM test. The rats were sacrificed on the 5th day, and hippocampi were isolated and frozen at −80 °C on the same d ay. Hippocampal tissues were homogenised; ELISA and Western blot tests were performed to assess IL-1, IL-6, TNF-α, and caspase-3. Results: All groups showed a significant decrease in the time required to locate the hidden platform from day 1 to day 4. In the probe trial of the Morris water maze test, Group C spent more time in the target quadrant compared with Group S, indicating surgery-related cognitive impairment. The ELISA and Western blot analyses demonstrated that the hippocampal levels of IL-1, IL-6, TNF-α, and caspase-3 were significantly elevated in both Groups S and N compared with the controls. No statistically significant differences were observed between Groups S and N, indicating that the measured cognitive performance and hippocampal inflammatory responses were comparable between these groups. Conclusions: This study showed that a single intraperitoneal dose of 5 mg/kg of nicardipine did not measurably improve early postoperative cognitive performance or reduce hippocampal inflammation. In particular, nicardipine did not have a detectable effect on early postoperative neuroinflammation or cognition at the tested dose and timing in this rat model. Further studies exploring different doses and timing or repeated administration would help to clarify its potential role. Full article

This study investigates the relationship between architectural colour and cultural identity in the ancient villages of Hebei Province, emphasising the role of colour in cultural heritage preservation and sustainable development. The research aims to (1) identify the dominant chromatic attributes of Hebei’s village architecture, (2) interpret their cultural and symbolic meanings, and (3) construct a colour model applicable to heritage conservation. A qualitative case study approach was employed across four representative villages, combining field surveys, semi-structured interviews, and digital colour analysis using the COLORO system. The findings reveal that the prevailing hues—ranging from red and yellow to ochre and brown—derive from local stone and timber, embodying values of stability, humility, and harmony with the environment. Decorative elements in bright red and gold signify celebration and community vitality, contrasting with the subdued architectural tones. Integrating these empirical and cultural insights, this study proposes the Colour Symbol System for Hebei Ancient Villages (CSSHAV)—a model that unites quantitative colour parameters with qualitative cultural interpretation. The CSSHAV serves as a practical framework for guiding colour conservation, policy development, and sustainable design in rural heritage contexts. The originality of this study lies in bridging scientific colour measurement with cultural semiotics, providing both theoretical advancement and actionable guidance for the preservation of regional chromatic identity. The findings identify increasing risks of colour homogenisation under the pressures of globalisation. Through the CSSHAV model, it proposes strategies to preserve Hebei’s traditional chromatic identity by integrating digital colour analysis with cultural interpretation. This balance between conservation and innovation contributes to sustaining both the aesthetic integrity and cultural vitality of ancient villages. Full article

This work presents a comparative study on the mechanical homogenisation of Triply Periodic Minimal Surface (TPMS) lattice structures in the linear elastic regime, which have attracted significant interest for their unique ability to combine lightweight design with tailored properties. The study investigates the effective mechanical behaviour of Representative Unit Cells (RUCs) generated using the open-source Python tool Microgen. Two homogenisation strategies are considered: (i) Finite Element (FE)-based homogenisation carried out in Abaqus, and (ii) the Mechanics of Structure Genome (MSG), a unified theory for multi-scale constitutive modelling, implemented in an in-house software tool. The comparison encompasses multiple TPMS topologies, including well-studied cases used for validation, namely gyroid and diamond, as well as less-explored ones, such as PMY and F-Rhombic Dodecahedron, to provide new insights. RUCs are analysed across relative densities ranging from 10 to 50%. Equivalent linear elastic properties (Young’s moduli, shear moduli, and Poisson’s ratios) are derived and compared to assess the consistency, accuracy, and computational efficiency of the two approaches. The results show that both methods yield effective properties with less than 1% difference between them, and less than 5% deviation from experimental data reported in the literature for the effective Young’s modulus. Furthermore, the anisotropy of each TPMS topology across the range of relative densities is examined through the directional distribution of Young’s moduli. The outcomes are expected to clarify the strengths and limitations of FE versus MSG in capturing the effective behaviour of architected cellular solids, thus supporting the selection of homogenisation strategies for the design of lattice-based lightweight structures. Full article

The growing demand for sustainable proteins has driven interest in Limnospira platensis (Spirulina) due to its high protein content. However, the presence of the cell wall limits the availability and recovery of proteins within it. Conventional alkaline extraction is widely applied but often results in low yields and excessive solvent consumption. This study compares the efficiency and functional properties of Spirulina proteins extracted using an alkaline method and high-pressure homogenisation (HPH) at 20, 50, 80 and 100 MPa. Following isoelectric precipitation, proteins were collected in precipitate and supernatant fractions and characterized for yield, solubility, phycobiliproteins content, emulsifying and foaming properties, water– and oil–holding capacity, thermal stability and rheological behaviour. Microscopy confirmed progressive cell disruption with increasing homogenization pressures. HPH at 50 MPa increased protein extraction by 28% compared to alkaline extraction and significantly (p < 0.05) improved solubility, oil-holding capacity, foaming and emulsion properties. Phycobiliproteins, particularly C–phycocyanin, were more efficiently recovered in HPH supernatants, achieving a higher purity index than the alkaline method. Rheological analysis showed weak gel-like network formation, whereas excessive mechanical stress reduced functionality. Overall, HPH emerges as an interesting method for obtaining Spirulina proteins with enhanced technological properties; however, pressure optimisation is required to avoid denaturation and functionality loss. Full article

This study investigates the elastic properties of bio-epoxy composites reinforced with natural fibres (flax, hemp) and synthetic fibres (S-glass), with particular focus on the effect of the fibre volume fraction (VF) ranging from 10% to 70%. Three-dimensional representative volume element (RVE) models were developed for single-fibre, hybrid, and multi-fibre systems. The mean-field homogenisation (MF) approach, based on the Mori–Tanaka scheme, and finite element analysis (FEA) with periodic boundary conditions were employed to predict the effective elastic properties, including longitudinal, transverse, and shear moduli, as well as Poisson’s ratio. These numerical predictions were validated against analytical models, including the rule of mixtures, Chamis, and composite cylinder assemblage (CCA) methods. The results demonstrate that increasing the VF enhances longitudinal, transverse, and shear moduli while reducing Poisson’s ratio in natural fibre composites. The good agreement between numerical, semi-analytical, and analytical methods validates the 3D RVE models as useful tools for predicting the properties of multi-hybrid natural fibre composites, supporting their design for lightweight structural applications. Full article

Docetaxel (DTX)-loaded polymeric nanoparticles composed of Eudragit RL and RS 100 were developed by solvent evaporation using D-α-tocopheryl polyethene glycol 1000 succinate as an emulsifier and optimised by Central Composite Design. The effects of homogenisation and sonication times on entrapment efficiency (%EE) and drug release (%DR) were statistically analysed across nine batches. Particle size (PS) ranged from 302 ± 1.0 to 502 ± 2.0 nm, and zeta potential (ZP) from 25.8 ± 2.5 to 42.9 ± 1.7 mV. %EE and %DR (pH 1.2 for 2 h, then pH 7.4 for 22 h, 40 mL medium at 37 ± 0.5 °C) ranged from 69.32 ± 3.77 to 92.71 ± 0.16% and 19.24 ± 3.03 to 49.17 ± 1.98%, respectively. Optimised DTX nanoparticles (DNPs) showed EE of 78.18 ± 0.56%, DR of 46.21 ± 1.41% at 24 h, PS of 357.9 ± 2.4 nm, and ZP of 42.9 ± 3.7 mV. Scanning electron microscopy revealed ~300 nm cuboidal particles with smooth surfaces. X-Ray Diffraction and Differential Scanning Colorimetry confirmed reduced drug crystallinity in DNPs. In vitro haemolysis assays showed ~11.5-fold lower haemolytic potential (p < 0.0001) versus DTX, confirming improved safety. Fluorescence microscopy indicated enhanced cellular uptake of DNPs in MDA-MB-231 cells, while cytotoxicity assays of DNPs showed a lower IC₅₀ (39.52 µM) compared to DTX (60.81 µM), demonstrating superior anticancer efficacy. Overall, DNPs represent a promising oral chemotherapy platform for breast cancer management. Full article

Post-translational modifications (phosphorylation and glutathionylation) not only assure protein diversity but are also responsible for the controlling of the biological activity of selected proteins in health and disease. The aim of the study was to monitor the profile of changes in molecular weight of proteins undergoing selected post-translational modifications by measurement of the intensity of phosphorylation and glutathionylation within the pregnancy course and parturition in cows with and without the retention of foetal membranes. The intensity of selected post-translational modifications was measured in bovine placental tissues collected during pregnancy (2nd, 4th, 5th, and 7th month, n = 4 per month) and parturition (not-retained foetal membranes (NRFM, n = 6) and retained foetal membranes (RFM, n = 6). Placental tissues were homogenised and used for the Phosphoprotein Phosphate Estimation Assay Kit and Western blotting analyses with adequate antibodies. The content of phosphorylated proteins was significantly higher (p < 0.05) in the 2nd month as compared to other months, both in the maternal and foetal parts of the placenta. Moreover, no significant differences were observed between NRFM and RFM samples. The results of Western blotting showed the shift in molecular weight and indirect content of phosphorylated selected amino acids. Further research on the role of post-translational modifications in pregnancy and parturition may give new insight into their biochemical regulation. Full article