Search Results (281)

Background: There is growing interest in the potential role of manganese (Mn) in the development of Alzheimer’s Disease and related dementias (ADRD). Methods: In this nested pilot study of a ferroalloy worker cohort, we investigated the impact of chronic occupational Mn exposure on cognitive function through β-amyloid (Aβ) deposition and multi-omics profiling. We evaluated six male Mn-exposed workers (median age 63, exposure duration 31 years) and five historical controls (median age: 60 years), all of whom had undergone brain PET scans. Exposed individuals showed significantly higher Aβ deposition in exposed individuals (p < 0.05). The average annual cumulative respirable Mn was 329.23 ± 516.39 µg/m³ (geometric mean 118.59), and plasma Mn levels were significantly elevated in the exposed group (0.704 ± 0.2 ng/mL) compared to controls (0.397 ± 0.18 in controls). Results: LC-MS/MS-based pathway analyses revealed disruptions in olfactory signaling, mitochondrial fatty acid β-oxidation, biogenic amine synthesis, transmembrane transport, and choline metabolism. Simoa analysis showed notable alterations in ADRD-related plasma biomarkers. Protein microarray revealed significant differences (p < 0.05) in antibodies targeting neuronal and autoimmune proteins, including Aβ (25–35), GFAP, serotonin, NOVA1, and Siglec-1/CD169. Conclusion: These findings suggest Mn exposure is associated with neurodegenerative biomarker alterations and disrupted biological pathways relevant to cognitive decline. Full article

Amid the global shift toward clean energy, wind power has emerged as a critical pillar of the modern energy matrix. To improve the reliability and maintainability of wind farms, this work proposes a novel hybrid fault detection approach that combines expert-driven diagnostic knowledge with data-driven modeling. The framework integrates autoencoder-based neural networks with Failure Mode and Symptoms Analysis, leveraging the strengths of both methodologies to enhance anomaly detection, feature selection, and fault localization. The methodology comprises five main stages: (i) the identification of failure modes and their observable symptoms using FMSA, (ii) the acquisition and preprocessing of SCADA monitoring data, (iii) the development of dedicated autoencoder models trained exclusively on healthy operational data, (iv) the implementation of an anomaly detection strategy based on the reconstruction error and a persistence-based rule to reduce false positives, and (v) evaluation using performance metrics. The approach adopts a fault-specific modeling strategy, in which each turbine and failure mode is associated with a customized autoencoder. The methodology was first validated using OpenFAST 3.5 simulated data with induced faults comprising normal conditions and a 1% mass imbalance fault on a blade, enabling the verification of its effectiveness under controlled conditions. Subsequently, the methodology was applied to a real-world SCADA data case study from wind turbines operated by EDP, employing historical operational data from turbines, including thermal measurements and operational variables such as wind speed and generated power. The proposed system achieved 99% classification accuracy on simulated data detect anomalies up to 60 days before reported failures in real operational conditions, successfully identifying degradations in components such as the transformer, gearbox, generator, and hydraulic group. The integration of FMSA improves feature selection and fault localization, enhancing both the interpretability and precision of the detection system. This hybrid approach demonstrates the potential to support predictive maintenance in complex industrial environments. Full article

Historical cross-sectional approaches examining cognitive aging consistently reveal a pattern of steady decline on nonverbal problem-solving, speeded tasks, and maintenance on verbal tasks. However, as measures developed and broadened the factor structure to align with Cattell–Horn–Carroll (CHC) theory, and age ranges were extended from 75 to 90 years, a more nuanced approach to cognitive aging emerged. The present study, using the Wechsler Adult Intelligence Scale, Fifth Edition (WAIS-5), examined the cognitive aging process through a cross-sectional approach. WAIS-5 normative sample data (aligned with the 2022 U.S. census) were obtained from the test publisher. The sample included adult participants aged 20–24 through 85–90 (n = 1660), which were mapped into 11 age groups. Using post-stratification weighting to control for educational attainment, cognitive decline was observed throughout aging; verbal skills were maintained longer than other abilities, while processing speed declined steadily and rapidly from young adulthood to old age. Working memory was vulnerable to the aging process but demonstrated slower patterns of decline than the other vulnerable abilities. Fluid reasoning and visual spatial skills (although aligning with separate CHC broad abilities theoretically) were strikingly similar in their pattern of decline across a person’s lifespan. Results are highly consistent with the large body of cross-sectional research conducted during the previous generation by Salthouse and his colleagues, as well as other teams of researchers. Full article

Background and Objectives. Umbilical hernia is particularly common among patients with liver cirrhosis, affecting about 20% of this group, compared to 3–8.5% in healthy individuals. This increased prevalence is mainly due to weakened abdominal fascia, elevated intra-abdominal pressure, and malnutrition. The rapid progression of umbilical hernias often leads to complications such as skin necrosis, perforation, and strangulation. Historically, patients with liver cirrhosis and complicated umbilical hernia have faced high morbidity and mortality rates. However, recent advancements in perioperative management, especially in controlling ascites, have improved outcomes in elective treatments. Despite these advancements, managing patients with decompensated liver cirrhosis and complicated umbilical hernia in emergency settings remain a significant surgical challenge. Materials and Methods: We conducted a retrospective review of patients treated for complicated umbilical hernia at the University Medical Centre Ljubljana from 2015 to 2024, using prospectively collected data. This analysis involved implementing hernioplasty combined with incisional negative pressure wound therapy (iNPWT) as part of the surgical protocol. The primary endpoint of our study was the rate of local complications, while the secondary endpoints included the rate of systemic complications and 90-day mortality. Results: We treated 28 consecutive patients with complicated umbilical hernia and liver cirrhosis. Local wound complications were observed in three (10.7%) patients. Systemic complications developed in 10 patients (35.7%). The median duration of hospitalization was 8 days (range: 5–29), and no readmissions were recorded within the 30-day period. Two (7.1%) patients died within 90 days. Conclusions: Our experience indicates that iNPWT, when combined with surgical repair, can be safely utilized, yielding outcomes comparable to elective hernia repairs, even in emergency contexts. Further randomized controlled trials are necessary to validate these findings and optimize treatment protocols. Full article

Background: Suicidal behavior presents a significant dilemma in the context of Alzheimer’s disease. Numerous ethical discussions have emerged regarding euthanasia for patients suffering from neurodegenerative conditions, and research indicates an elevated incidence of suicide in the early stages of dementia. However, there remains a gap in knowledge concerning the historical prevalence of suicidal ideations or attempts among individuals diagnosed with Alzheimer’s disease. This study aims to investigate the historical patterns of suicidal behavior and the associated factors across the lifespan in patients with Alzheimer’s disease. Methods: This study is an excerpt from a case–control research study, where the sample size was calculated at 150 participants, with 75 in the case group and 75 in the control group. Here, the descriptive statistics for the first third of the sample, 50 participants, are discussed. Results: Among the participants in the case group, 12.5% reported having suicidal ideation throughout life, compared to 24% in the control group (OR for suicidal ideation = 0.432 [0.095–1.966]). Additionally, among the participants in the case group, 4% reported having attempted suicide at some point in their life, compared to 8% in the control group (OR for suicide attempts = 0.479 [0.41–5.652]). People with Alzheimer’s disease tended to have a worse quality of life but less suicidality. Conclusions: It appears that suicidal behavior is inversely related to the risk of developing suicidal intentions. The odds ratio data demonstrate the need for a larger sample size to determine whether there is a difference in the history of suicide throughout the lives of people with Alzheimer’s disease and among the general population. Full article

The Controller Area Network (CAN) protocol is one of the important communication standards in autonomous vehicles, enabling real-time information sharing across in-vehicle (IV) components to realize smooth coordination and dependability in vital activities. Without encryption and authentication, CAN reveals several vulnerabilities related to message attacks within the IV Network (IVN). Traditional centralized Intrusion Detection Systems (IDS) where all the historical data is grouped on one node result in privacy risks and scalability issues, making them unsuitable for real-time intrusion detection. To address these challenges, we propose a Deep Federated Learning (FL) architecture for intrusion detection in IVN. We propose a Bidirectional Long Short Term Memory (BiLSTM) architecture to capture temporal dependencies in the CAN bus and ensure enhanced feature extraction and multi-class classification. By evaluating our framework on three real-world datasets, we show how our proposal outperforms a baseline LSTM model from the state of the art. Full article

Background: Telemonitoring aimed at detecting subclinical heart failure and facilitating medication up-titration offers a promising approach to reducing heart failure hospitalizations. Our team has recently developed a non-invasive metric called “respiratory stability time (RST)”, which quantifies respiratory instability, a surrogate marker of subclinical worsening heart failure. A decrease in RST below 20 s predicts the onset of worsening heart failure within 28 days. However, the clinical utility of RST-guided management in reducing mortality and heart failure hospitalizations remains uncertain. Methods: The Innovative Tele-Monitoring Environment To Halt Ongoing Deterioration of Heart Failure-III (ITMETHOD-HF-III) is a non-blinded, interventional, multicenter, single-arm study. Eighty heart failure patients with a history of at least two prior hospitalizations for heart failure will be enrolled. After validating the robustness of RST measurements, participants will be monitored for 1.5 years through daily RST measurements. Mandatory up-titration of heart failure medications will be started if RST values decrease below 20 s for two consecutive days or decrease progressively below 30 s over 10–90 days from RST values above 45 s maintained for over 1 month, irrespective of the presence of heart failure signs/symptoms. Medication adjustment will continue until RST exceeds 30 s. The study will compare a composite endpoint of heart failure hospitalization and cardiac death between the present RST-guided group and a historical control group from the ITMETHOD-HF-II trial, in which management was based on patients’ symptoms. Results: We anticipate that the precent ITMETHOD-HF-III study will demonstrate that mandatory, RST-guided heart failure management significantly reduces the incidence of the primary composite endpoint—heart failure hospitalization and cardiac death—compared with symptom-guided standard care in the historical control group (ITMETHOD-HF-II). Conclusions: The ITMETHOD-HF-III study aims to demonstrate the clinical efficacy of RST-guided management in reducing heart failure hospitalization rates and cardiac mortality by enabling early detection of subclinical heart failure and facilitating timely medication adjustments, irrespective of heart failure signs/symptoms. If successful, RST-guided management could establish a new standard for telemonitoring heart failure patients in outpatient settings. Full article

Lyssaviruses are RNA viruses in the Family Rhabdoviridae, Genus Lyssavirus. They represent the causative agents of acute, progressive encephalitis, known historically as rabies. Regardless of specific etiology, their collective viral morphology, biochemistry, pathobiology, associated clinical signs, diagnosis, epizootiology, and management are essentially the same. Despite centuries of clinical recognition, these quintessential neurotropic agents remain significant pathogens today, with substantive consequences to agriculture, public health, and conservation biology. Notably, the singular morbidity caused by lyssaviruses is incurable and constitutes the highest case fatality of any viral disease. All warm-blooded vertebrates are believed to be susceptible. The dog is the only domestic animal that serves as a reservoir, vector, and victim. In contrast, felids are effective vectors, but not reservoirs. All other rabid domestic species, such as livestock, constitute spillover infections, as a bellwether to local lyssavirus activity. Frequently, professional confusion abounds among the veterinary community, because although the viral species Lyssavirus rabies is inarguably the best-known representative in the Genus, at least 20 other recognized or putative members of this monophyletic group are known. Frequently, this is simply overlooked. Moreover, often the ‘taxonomic etiology’ (i.e., ‘Lyssavirus x’) is mistakenly referenced in a biopolitcal context, instead of the obvious clinical illness (i.e., ‘rabies’). Global consternation persists, if localities believe they are ‘disease-free’, when documented lyssaviruses circulate or laboratory-based surveillance is inadequate to support such claims. Understandably, professional chagrin develops when individuals mistake the epidemiological terminology of control, prevention, elimination, etc. Management is not simple, given that the only licensed veterinary and human vaccines are against rabies virus, sensu lato. There are no adequate antiviral drugs for any lyssaviruses or cross-reactive biologics developed against more distantly related viral members. While representative taxa among the mammalian Orders Chiroptera, Carnivora, and Primates exemplify the major global reservoirs, which mammalian species are responsible for the perpetuation of other lyssaviruses remains a seemingly academic curiosity. This zoonosis is neglected. Clearly, with such underlying characteristics as a fundamental ‘disease of nature’, rabies, unlike smallpox and rinderpest, is not a candidate for eradication. With the worldwide zeal to drive human fatalities from canine rabies viruses to zero by the rapidly approaching year 2030, enhanced surveillance and greater introspection of the poorly appreciated burden posed by rabies virus and diverse other lyssaviruses may manifest as an epidemiological luxury to the overall global program of the future. Full article

Background: Remote symptom monitoring via electronic platforms may identify patients at risk for unplanned acute care visits after surgery. Since 2016, the Memorial Sloan Kettering Cancer Center (MSKCC) has employed the Recovery Tracker (RT), a patient-reported outcome (PRO) system, for symptom monitoring after ambulatory procedures. In 2021, RT was extended to patients undergoing inpatient colorectal surgery. Objective: To evaluate the impact of RT implementation on urgent care utilization and readmission rates in patients undergoing elective inpatient colorectal surgery and to determine whether patient engagement with RT influences these outcomes. Methods: In this retrospective observational study at MSKCC, we compared patients undergoing elective colorectal surgery during the RT implementation period (March 2021–December 2022) to a historical control cohort (February 2019–February 2020). The primary outcome was a potentially unnecessary urgent care center (UCC) visits—defined as a visit not requiring inpatient admission. Secondary outcomes included 30-day readmission and survey engagement. Multivariable logistic regression was used for adjusted comparisons. Results: A total of 1941 patients in the RT cohort and 1206 in the control group met the inclusion criteria. The RT cohort had higher rates of UCC visits without admission (4.43% vs. 1.6%) and 30-day readmissions (9.74% vs. 6.88%). RT period surgery was independently associated with increased odds of UCC visits (OR 2.80, 95% CI 1.71–4.58, p < 0.0001) and readmissions (OR 1.43, 95% CI 1.09–1.88, p = 0.0098). Notably, RT users who completed at least one survey (70.2%) had significantly lower odds of readmission (OR 0.56, 95% CI 0.41–0.77, p = 0.0003) compared to non-responders. Discussion: Engagement with the RT system was associated with a 44% reduction in readmission risk, identifying non-responders as a vulnerable subgroup. While the overall rates of post-discharge care utilization increased after RT implementation, active participation in PRO reporting emerged as a protective factor. Conclusions: These findings highlight the need for strategies to promote engagement and support patients less likely to interact with remote monitoring tools. Non-response may signal barriers such as technological challenges or increased vulnerability, warranting proactive engagement strategies. Full article

This article introduces the Third Space of Indian child welfare to theorize how Indigenous nations simultaneously engage and disrupt settler legal systems while building sovereign, care-based alternatives. Drawing from legal analysis, Indigenous political thought, and sociohistorical synthesis, I trace the historical continuity from boarding schools to today’s foster care removals, showing how child welfare operates as a colonial apparatus of family separation. In response, Native nations enact governance through three interrelated strategies: strategic legal engagement, kinship-based care, and tribally controlled family collectives. Building on Bruyneel’s theory of third space sovereignty, Simpson’s nested sovereignty, and Lightfoot’s global Indigenous rights framework, I conceptualize the Third Space as a dynamic field of Indigenous governance that transcends binary settler logics. These practices constitute sovereign abolitionist praxis. They reclaim kinship, resist carceral systems, and build collective futures beyond settler rule. Thus, rather than treating the Indian Child Welfare Act (ICWA) as a federal safeguard, I argue that tribes have repurposed ICWA as a legal and political vehicle for relational governance. This reframing challenges dominant crisis-based narratives and positions Indigenous child welfare as the center of a “global Indigenous politics of care” with implications for theories of sovereignty, family, and abolitionist futures across disciplines, geographies, and social groups. The article concludes by reflecting on the broader implications of the Third Space for other Indigenous and minoritized communities navigating state control and asserting self-determined care. Full article

This study focuses on the issue of visual sustainability of colors in commercial historical districts, taking the historical area of Xueshi Street–Wuzoufang Street in Suzhou, China as a case study. It explores how to balance modern commercial development with the protection of historical culture. Due to the impact of commercialization and the introduction of various immature protection policies, historical districts often face the dilemma of coexisting “color conflict” and “color poverty”. Traditional color protection methods are either overly subjective or excessively quantitative, making it difficult to balance scientific rigor and adaptability. Therefore, this study provides a detailed literature review, compares and selects current quantitative color research methods, and proposes a comprehensive color analysis framework based on ViT (Vision Transformer), the CIEDE2000 color difference model, and K-means clustering (V-C-K framework). Using this framework, we conducted an in-depth analysis of the color-harmony situation in the studied area, aiming to accurately identify color issues in the district and provide optimization strategies. The experimental results show that the commercial colors of the Xueshi Street–Wuzoufang Street historical district exhibit a clear phenomenon of polarization: some areas have colors that are overly bright, leading to visual conflict, while others have colors that are too dull, lacking vitality and energy; furthermore, some areas display a mix of both conditions. Based on this situation, we then compared the extracted negative colors to the prohibited colors in the mainstream Munsell color system’s urban-color management guidelines. We found that colors with “high lightness and high saturation”, which are strictly limited by traditional color criteria, are not necessarily disharmonious, while “low lightness and low saturation” colors that are not restricted may not guarantee harmony either and could exacerbate the area’s “dilapidated feeling”. In other words, traditional color-protection standards often emphasize the safety of “low saturation and low lightness” colors unilaterally, ignoring that they can also cause dullness and discordance in certain environments. Under the $\Delta E$ (color difference value) threshold framework, color recognition is relatively more sensitive, balancing the inclusivity of “vibrant” colors and the caution against “dull” colors. Based on the above experimental results, this study proposes the following recommendations: (1) use the $\Delta E00$ threshold to control the commercial colors in the district, ensuring that the colors align with the historical atmosphere while possessing commercial vitality; (2) in protection practices, comprehensively utilize the ViT, CIEDE2000, and K-means quantitative methods (i.e., the V-C-K framework) to reduce subjective errors; (3) based on the above quantitative framework, while referencing the reasonable parts of existing protection guidelines, combine cooperative collaboration, cultural group color preference surveys, policy incentives, and continuous monitoring and feedback to construct an operable plan for the entire “recognition–analysis–control” process. Full article

Even at historically low levels of air pollution, epidemiological time series studies carried out in cities across the globe have documented its substantial detrimental health effects. A time series analysis of counts of respiratory hospital admissions in Gjakova and outdoor air pollutants was performed, applying a General Additive Model with a Poisson distribution, controlling for time trends and meteorological factors over a 4-year period (2020–2023) with different time lags (0–7 days). The effects were further analyzed per age group (children and adults). We found significant associations between gaseous pollutants, mainly NO₂, and respiratory disease-related hospital admissions in the city. The strongest association between NO₂ and total hospital admissions was observed after a lag of 6 days, with an increase of 0.14 cases per 10 μg/m³ increase in concentration. The effects were stronger in adults. An adverse effect was also seen with SO₂, but not particulate pollution. Our findings call for greater awareness regarding environmental protection and the implementation of effective measures to improve air quality, which may reduce the risk of adverse health effects. Full article

This study investigates an Adaptive Feedback System (AFS) that integrates deep learning (a recurrent neural network trained with historical student data) and GPT-4 to provide personalized feedback in a Digital Art course. In a quasi-experimental design, the intervention group (n = 42) received weekly feedback generated from model predictions, while the control group (n = 39) followed the same program without this intervention across four learning blocks or levels. The results revealed (1) a cumulative effect with a significant performance difference in the fourth learning block (+12.63 percentage points); (2) a reduction in performance disparities between students with varying levels of prior knowledge in the experimental group (−56.5%) versus an increase in the control group (+103.3%); (3) an “overcoming effect” where up to 42.9% of students surpassed negative performance predictions; and (4) a positive impact on active participation, especially in live class attendance (+30.21 points) and forum activity (+9.79 points). These findings demonstrate that integrating deep learning with LLMs can significantly improve learning outcomes in online educational environments, particularly for students with limited prior knowledge. Full article

The ability of a nucleic acid molecule to self-replicate is the driving force behind the evolution of cellular life and the transition from RNA to DNA as the genetic material. Thus, the physicochemical properties of genome replication, such as the requirement for a terminal hydroxyl group for de novo DNA synthesis, are conserved in all three domains of life: eukaryotes, bacteria, and archaea. Canonical DNA replication is initiated from specific chromosomal sequences termed origins. Early bacterial models of DNA replication proposed origins as regulatory points for spatiotemporal control, with replication factors acting on a single origin on the chromosome. In eukaryotes and archaea, however, replication initiation usually involves multiple origins, with complex spatiotemporal regulation in the former. An alternative replication initiation mechanism, recombination-dependent replication, is observed in every cellular domain (and viruses); DNA synthesis is initiated instead from the 3′ end of a recombination intermediate. In the domain archaea, species including Haloferax volcanii are not only capable of initiating DNA replication without origins but grow faster without them. This raises questions about the necessity and nature of origins. Why have archaea retained such an alternative DNA replication initiation mechanism? Might recombination-dependent replication be the ancestral mode of DNA synthesis that was used during evolution from the primordial RNA world? This review provides a historical overview of major advancements in the study of DNA replication, followed by a comparative analysis of replication initiation systems in the three domains of life. Our current knowledge of origin-dependent and recombination-dependent DNA replication in archaea is summarised. Full article

The percentage of historical heritage buildings in Italy is substantial. Many of these buildings are abandoned or not adequately restored for public access due to safety concerns. However, some are managed by city councils and made available to local communities. These heritage buildings, valued for their historical significance, are now frequently used for live events, including musical performances by ensembles and small groups. This paper deals with the acoustics of two rooms provided with barrel-vaulted ceilings: Sisto V Hall in Naples and Aula Magna at the University of Parma. These spaces are structurally very similar, differing mainly in length. Acoustic measurements conducted in both halls reveal reverberation times of approximately 4.5 s at mid frequencies, resulting in poor speech clarity. This is primarily due to the presence of reflective surfaces, as the walls and ceilings are plastered, and the floors are tiled. To optimize their acoustic properties for functions such as celebrations, gatherings, and conferences, an acoustic design intervention was proposed. Digital models of the halls were calibrated and used to correct the acoustics by incorporating absorbing panels on the walls and carpeting on the floors of the central walk path. This treatment successfully balanced the reverberation time to approximately 1.3–1.4 s at mid frequencies, making speech more intelligible. Additionally, an amplified audio system was analyzed to enhance sound distribution, ensuring uniform coverage, even in the last rows of seating. Under amplified conditions, sound pressure levels (SPLs) range between 90 dB and 93 dB, with appropriate gain control applied to the column array speakers. Full article