Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (5,022)

Search Parameters:
Keywords = group preferences

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
12 pages, 1202 KiB  
Article
From Overweight to Severe Obesity: Physical Activity and Behavioural Profiles in a Large Clinical Cohort
by Francesca Campoli, Elvira Padua, Lucio Caprioli, Saeid Edriss, Giuseppe Annino, Vincenzo Bonaiuto and Mauro Lombardo
J. Funct. Morphol. Kinesiol. 2025, 10(3), 283; https://doi.org/10.3390/jfmk10030283 - 24 Jul 2025
Abstract
Background: Behavioural heterogeneity in obesity is increasingly recognised, but how specific dietary patterns, food preferences and physical activity vary between obesity classes remains poorly characterised. Methods: We analysed behavioural, dietary, and lifestyle data from 1366 adults attending a tertiary obesity clinic in Italy. [...] Read more.
Background: Behavioural heterogeneity in obesity is increasingly recognised, but how specific dietary patterns, food preferences and physical activity vary between obesity classes remains poorly characterised. Methods: We analysed behavioural, dietary, and lifestyle data from 1366 adults attending a tertiary obesity clinic in Italy. Participants were stratified into five obesity classes defined by BMI. Age-adjusted regression models and chi-square tests with Bonferroni correction were used to examine associations between obesity severity and key behavioural outcomes, including food preferences, eating behaviours, physical activity, and self-reported sleep quality. Results: The prevalence of uncontrolled eating, skipping meals, and fast eating significantly increased with obesity severity after adjusting for age (all p < 0.05). Preference for yoghurt and legumes declined with increasing BMI, whereas preferences for meat and dairy remained stable. Age-adjusted sport participation decreased progressively, with significantly lower odds in Obesity I, II, and IIIA compared to the Overweight group. Sleep quality was highest among overweight participants and declined with obesity severity; night-time awakenings were most frequent in Obesity IIIB. Conclusions: Distinct behavioural and lifestyle traits, including lower sport participation, reduced preference for fibre-rich foods, and greater frequency of uncontrolled, fast, and irregular eating, showed overall trends across obesity classes. While these findings suggest the presence of behavioural phenotypes, their interpretation is limited by the cross-sectional design and the use of self-reported, non-validated measures. Future studies should incorporate objective assessments to inform targeted obesity interventions. Full article
Show Figures

Figure 1

18 pages, 549 KiB  
Article
Extension of Poultry Meat Shelf Life Using Cynara cardunculus L. Leaf Extracts as a Natural Preservative
by Cássia H. Barbosa, Mariana A. Andrade, Fernanda Vilarinho, Ana Sanches Silva and Ana Luísa Fernando
Foods 2025, 14(15), 2592; https://doi.org/10.3390/foods14152592 - 24 Jul 2025
Abstract
Food additives are used to prevent food spoilage and extend its shelf life. However, concerns regarding the potential health implications associated with some synthetic additives have prompted research efforts aimed at identifying natural alternatives, such as plant extracts. Cynara cardunculus L. (cardoon) is [...] Read more.
Food additives are used to prevent food spoilage and extend its shelf life. However, concerns regarding the potential health implications associated with some synthetic additives have prompted research efforts aimed at identifying natural alternatives, such as plant extracts. Cynara cardunculus L. (cardoon) is known for its antimicrobial and antioxidant properties. The aim of this study was to evaluate the capability of ethanolic food-grade extracts from cultivated cardoon and globe artichoke leaves to preserve poultry breast meat during refrigerated storage. A total of seven treatment groups were tested: one control group (no extract) and six active groups with 0.5%, 1%, and 2% (w/w) of either cultivated cardoon or globe artichoke leaf extracts. Lipid oxidation, moisture, colour, pH, acidity, and microbial growth were assessed in poultry meat samples over 15 days. Both extracts were effective in extending shelf life, up to 11 days, by delaying lipid oxidation and microbial growth. Cardoon extract (1% w/w) displayed superior antimicrobial efficacy, maintaining microbial counts below 5 Log CFU/g meat until day 15, compared to the control. Cultivated cardoon leaf extract proves promising as a natural antimicrobial and antioxidant, extending the shelf life of poultry meat. This presents an opportunity to maintain the quality of meat products, aligning with consumer preferences for natural ingredients and sustainable practices. Full article
(This article belongs to the Special Issue Preservation and Shelf Life Extension of Food Products)
Show Figures

Figure 1

14 pages, 623 KiB  
Article
Forest- and Nature-Based Recreation for Older Adults: Preferences, Well-Being, and the Need for Inclusive Planning
by Yaara Spiegel, Noga Collins-Kreiner and Eran Ketter
Forests 2025, 16(8), 1213; https://doi.org/10.3390/f16081213 - 23 Jul 2025
Abstract
This study provides user-centered insights into how inclusive forest design can support the physical, emotional, and social well-being of older adults. It operationalizes universal design principles in natural settings and confirms their relevance through empirical evidence. With the acceleration of global population aging, [...] Read more.
This study provides user-centered insights into how inclusive forest design can support the physical, emotional, and social well-being of older adults. It operationalizes universal design principles in natural settings and confirms their relevance through empirical evidence. With the acceleration of global population aging, adapting forest recreation environments to meet the specific needs of older adults is increasingly urgent. This study investigates how infrastructure influences both participation and emotional well-being among older visitors to forest recreation areas. Data were collected from 446 participants aged 65 and older, using a structured survey distributed through in-person contact and digital snowball sampling. Participants reported their infrastructure preferences and their emotional responses related to forest visits. The findings show that older adults highly value site cleanliness, shaded seating, accessible restrooms, and clear signage. Expectations varied significantly according to health status, age group, and visitation frequency. Emotional well-being was positively associated with both comfort and visit frequency. These results demonstrate how inclusive infrastructure plays a vital role in supporting older adults’ access to and enjoyment of forest environments. The study affirms that universally designed forests not only reduce barriers but also promote psychological health and active aging, contributing to developing more equitable and sustainable nature-based recreation areas. Full article
(This article belongs to the Special Issue The Sustainable Use of Forests in Tourism and Recreation)
20 pages, 1195 KiB  
Article
Does Chemotherapy Have an Effect on the Treatment Success of Children and Adolescents with Unresectable Hepatocellular Carcinoma? Findings from the German Liver Tumour Registry
by Mark Rassner, Beate Häberle, Rebecca Maxwell, Julia von Frowein, Roland Kappler, Michael Rassner, Christian Vokuhl, Dietrich von Schweinitz and Irene Schmid
Cancers 2025, 17(15), 2444; https://doi.org/10.3390/cancers17152444 - 23 Jul 2025
Abstract
Background: Paediatric hepatocellular carcinoma (HCC), including its fibrolamellar variant (FLC), is a rare malignancy with distinct biological behaviour and limited therapeutic options. While complete surgical resection is a key determinant of survival, many patients present with unresectable tumours at diagnosis. The role [...] Read more.
Background: Paediatric hepatocellular carcinoma (HCC), including its fibrolamellar variant (FLC), is a rare malignancy with distinct biological behaviour and limited therapeutic options. While complete surgical resection is a key determinant of survival, many patients present with unresectable tumours at diagnosis. The role of neoadjuvant chemotherapy in improving resectability, particularly in histologically distinct subtypes, remains inconclusive. Methods: We retrospectively analysed 43 patients (<18 years) with histologically confirmed conventional HCC (cHCC, n = 27) or FLC (n = 16) enrolled in the German Pediatric Liver Tumour Registry. We assessed clinical characteristics, treatment response, surgical outcomes, and survival. Special focus was placed on the impact of neoadjuvant chemotherapy in initially unresectable tumours. Results: FLC and cHCC exhibited significant differences in clinical presentation, such as age of presentation, AFP elevation, or presence of underlying liver disease. Although overall survival did not significantly differ between groups, cHCC tumours showed a markedly higher response to chemotherapy (62.5% partial remission vs. 0% in FLC). Complete resection (R0) was achieved in 77% of all patients and was the strongest predictor of survival. Importantly, a subset of cHCC patients who initially had unresectable tumours became eligible for curative surgery following neoadjuvant chemotherapy. Notably, delayed resection after chemotherapy led to outcomes comparable to those with upfront surgery, whereas progression during chemotherapy was associated with a universally poor prognosis. Conclusions: This study supports upfront resection as the preferred strategy in paediatric HCC and FLC whenever feasible. In cHCC, neoadjuvant chemotherapy demonstrated a favourable response profile and contributed to secondary resectability in a subset of initially unresectable cases, supporting a potential role within a multimodal treatment approach. In contrast, FLC showed limited responsiveness to current systemic therapies. These findings emphasise the importance of histology-specific strategies and highlight the ongoing need for more effective systemic options, particularly for unresectable FLC. Full article
Show Figures

Figure 1

18 pages, 703 KiB  
Article
Social Preference Parameters Impacting Financial Decisions Among Welfare Recipients
by Jorge N. Zumaeta
J. Risk Financial Manag. 2025, 18(8), 408; https://doi.org/10.3390/jrfm18080408 - 23 Jul 2025
Abstract
This research study focuses on the social preference parameters and financial decisions among welfare populations receiving social benefits in Miami, Florida. Understanding the attitudes and primary motivations that shape financial decision-making is of great interest to economists, marketers, and other social scientists. The [...] Read more.
This research study focuses on the social preference parameters and financial decisions among welfare populations receiving social benefits in Miami, Florida. Understanding the attitudes and primary motivations that shape financial decision-making is of great interest to economists, marketers, and other social scientists. The implications of developing a solid understanding of these attitudes and motivations are vast in terms of erecting tangible and sensitive workforce development policies to assist the specific population studied. This study is designed to determine whether significant differences exist in the strength of preference parameters between welfare participants and other populations. The preference parameters assessed in this paper were self-interest, altruism, trust, and reciprocity, both positive and negative. The control group in this study is college students. The results from the experiments show that welfare recipients exhibit similar behavioral patterns and make financial decisions in a manner similar to the general population. In other words, the control group and the experimental group did not differ significantly in their financial decision processes. This finding has several implications for how economists and policymakers assess and approach policymaking; nevertheless, the question remains whether or not there are other preference parameters that differ between the two groups. Full article
(This article belongs to the Special Issue Behavioral Influences on Financial Decisions)
Show Figures

Figure 1

20 pages, 1153 KiB  
Article
Economic Attitudes and Financial Decisions Among Welfare Recipients: Considerations for Workforce Policy
by Jorge N. Zumaeta
J. Risk Financial Manag. 2025, 18(8), 407; https://doi.org/10.3390/jrfm18080407 - 22 Jul 2025
Viewed by 58
Abstract
This study investigates economic decision-making behaviors among welfare recipients in Miami, Florida, by leveraging well-established experimental protocols: the Guessing Game, the Prudence Measurement Task, the Risk Aversion Task, and the Stag Hunt Game. For this purpose, our study defines financial decisions as the [...] Read more.
This study investigates economic decision-making behaviors among welfare recipients in Miami, Florida, by leveraging well-established experimental protocols: the Guessing Game, the Prudence Measurement Task, the Risk Aversion Task, and the Stag Hunt Game. For this purpose, our study defines financial decisions as the underlying individual preferences that serve as validated proxies for savings behavior, debt management, job-search intensity, and participation in cooperative finance. A central objective is to compare the behavior of welfare recipients to that of undergraduate students, a cohort typically used in experimental economics research. The analysis reveals significant differences between the two groups in strategic thinking and coordination, particularly across ethnic and gender lines. Non-Hispanic/Latino participants in Miami displayed significantly higher average guesses in the Guessing Game compared to their counterparts in Tucson, indicating potential discrepancies in the depth of strategic reasoning. Additionally, female participants in Tucson exhibited higher levels of coordination in the Stag Hunt Game compared to females in Miami, suggesting variance in cooperative behavior between these groups. Despite these findings, regression models demonstrate that location, gender, and ethnicity collectively account for only a small fraction of the observed variance, as evidenced by low R2 values and substantial mean squared errors across all games. These results suggest that individual heterogeneity, rather than broad demographic variables, may be more influential in shaping economic decisions. This study underscores the complexity of generalizing findings from traditional student samples to more diverse populations, highlighting the need for further investigation into the socioeconomic factors that drive financial decision-making. Full article
(This article belongs to the Special Issue Behavioral Influences on Financial Decisions)
Show Figures

Figure 1

10 pages, 470 KiB  
Review
Emergency Department Discharges Following Falls in Residential Aged Care Residents: A Scoping Review
by Gigi Guan, Kadison Michel, Charlie Corke and Geetha Ranmuthugala
J. Clin. Med. 2025, 14(14), 5169; https://doi.org/10.3390/jcm14145169 - 21 Jul 2025
Viewed by 115
Abstract
Background: Falls in residential aged care facilities (RACFs) have a significant impact, often leading to costly and unnecessary emergency department (ED) transfers. This scoping review examined the ED discharge proportions and patient characteristics of RACF residents presenting to the ED following a fall, [...] Read more.
Background: Falls in residential aged care facilities (RACFs) have a significant impact, often leading to costly and unnecessary emergency department (ED) transfers. This scoping review examined the ED discharge proportions and patient characteristics of RACF residents presenting to the ED following a fall, to identify factors that could reduce unnecessary ED transfers. Methods: The databases MEDLINE, CINAHL, Scopus, and Web of Science were searched, resulting in an initial 1385 articles. Nine of these articles met the inclusion criteria and were included in this review. Results: The median age of patients reported in the nine papers ranged from 80.8 to 88 years. Discharge proportions from ED back to RACF ranged from 36% to 91%, with an average of 63%. The studies that reported on computed tomography of the brain (CTB) showed that CTB findings did not significantly influence discharge decisions. Conclusions: Many RACF residents transferred to EDs following falls are discharged without hospital admission. The heterogeneity of study methods makes it challenging to draw definitive conclusions about factors that may help identify patient groups that do not require transfer to the ED following a fall. However, this scoping review highlights potential opportunities to reduce ED transfers from RCAFs. These findings highlight a need for geriatric-specific, person-centred protocols that reduce unnecessary ED transfers while safeguarding quality of care and respecting residents’ advance care preferences. Full article
(This article belongs to the Special Issue Geriatric Diseases: Management and Epidemiology)
Show Figures

Figure 1

14 pages, 787 KiB  
Article
Preimplantation Genetic Testing for Aneuploidy Versus Morphological Selection in Women Aged 35–42: Results of a Pilot Randomized Controlled Trial
by Yusuf Beebeejaun, Daniela Bakalova, Anastasia Mania, Timothy Copeland, Ippokratis Sarris, Kypros Nicolaides, Antonio Capalbo and Sesh K. Sunkara
J. Clin. Med. 2025, 14(14), 5166; https://doi.org/10.3390/jcm14145166 - 21 Jul 2025
Viewed by 172
Abstract
Background/Objectives: Embryo selection in IVF is traditionally based on morphology, yet many high-quality embryos fail to implant. Preimplantation genetic testing for aneuploidy (PGT-A) using next-generation sequencing (NGS) has been proposed to improve selection by identifying euploid embryos. However, its effectiveness in women [...] Read more.
Background/Objectives: Embryo selection in IVF is traditionally based on morphology, yet many high-quality embryos fail to implant. Preimplantation genetic testing for aneuploidy (PGT-A) using next-generation sequencing (NGS) has been proposed to improve selection by identifying euploid embryos. However, its effectiveness in women of advanced maternal age remains unclear due to limited randomized data. This pilot trial assessed the feasibility of a full-scale RCT comparing PGT-A to morphology-based selection in women aged 35–42. Methods: This single-centre, two-arm parallel RCT (NCT05009745) enrolled women aged 35–42 undergoing IVF/ICSI with ≥3 good-quality day-3 embryos. Participants were randomized (1:1) to either embryo selection by morphology with fresh transfer or PGT-A with frozen transfer of a single euploid embryo. Allocation concealment was achieved via a secure web-based randomization platform; patients and clinicians were unblinded, but the biostatistician remained blinded. The primary outcome was feasibility of recruitment, randomization, and adherence. Results: Between June 2021 and January 2023, 138 women consented (recruitment rate: 55.8%, 95% CI: 49.7–62.0%) and 100 were randomized. Protocol adherence was 94%. Barriers to recruitment included preference for private PGT-A (19%) or fresh transfer (6%). Among biopsied embryos, 51.4% were euploid and 6.6% low-level mosaic. Intention-to-treat analysis showed no significant differences between PGT-A and control groups in clinical pregnancy rate (50% vs. 40%), live birth rate (50% vs. 38%), or miscarriage rate (12% vs. 8%). Cumulative live birth rate after up to three SETs was 72% vs. 52%, respectively (p > 0.05). No multiple pregnancies occurred. Conclusions: RCTs of PGT-A in older women are feasible. A multicentre design with broader inclusion criteria could improve recruitment and allow better assessment of clinical benefit. Full article
(This article belongs to the Special Issue Female Infertility: Clinical Diagnosis and Treatment)
Show Figures

Figure 1

46 pages, 9773 KiB  
Review
Visceral Arterial Pseudoaneurysms—A Clinical Review
by Ashita Ashish Sule, Shreya Sah, Justin Kwan, Sundeep Punamiya and Vishal G. Shelat
Medicina 2025, 61(7), 1312; https://doi.org/10.3390/medicina61071312 - 21 Jul 2025
Viewed by 239
Abstract
Background and Objectives: Visceral arterial pseudoaneurysms (VAPAs) are rare vascular lesions characterized by the disruption of partial disruption of the arterial wall, most commonly involving the intima and media. They have an estimated incidence of 0.1–0.2%, with the splenic artery most commonly [...] Read more.
Background and Objectives: Visceral arterial pseudoaneurysms (VAPAs) are rare vascular lesions characterized by the disruption of partial disruption of the arterial wall, most commonly involving the intima and media. They have an estimated incidence of 0.1–0.2%, with the splenic artery most commonly affected. Their management poses unique challenges due to the high risk of rupture. Timely recognition is crucial, as unmanaged pseudoaneurysms have a mortality rate of 90%. This narrative review aims to synthesize current knowledge regarding the epidemiology, etiology, clinical presentation, diagnostic methods, and management strategies for VAPAs. Materials and Methods: A literature search was performed across Pubmed for articles reporting on VAPAs, including case reports, review articles, and cohort studies, with inclusion of manuscripts that were up to (date). VAPAs are grouped by embryological origin—foregut, midgut, and hindgut. Results: Chronic pancreatitis is a primary cause of VAPAs, with the splenic artery being involved in 60–65% of cases. Other causes include acute pancreatitis, as well as iatrogenic trauma from surgeries, trauma, infections, drug use, and vascular diseases. VAPAs often present as abdominal pain upon rupture, with symptoms like nausea, vomiting, and gastrointestinal hemorrhage. Unruptured pseudoaneurysms may manifest as pulsatile masses or bruits but are frequently asymptomatic and discovered incidentally. Diagnosis relies on both non-invasive imaging techniques, such as CT angiography and Doppler ultrasound, and invasive methods like digital subtraction angiography, which remains the gold standard for detailed evaluation and treatment. A range of management options exists that are tailored to individual cases based on the aneurysm’s characteristics and patient-specific factors. This encompasses both surgical and endovascular approaches, with a growing preference for minimally invasive techniques due to lower associated morbidity. Conclusions: VAPAs are a critical condition requiring prompt early recognition and intervention. This review highlights the need for ongoing research to improve diagnostic accuracy and refine treatment protocols, enhancing patient outcomes in this challenging domain of vascular surgery. Full article
(This article belongs to the Section Surgery)
Show Figures

Figure 1

13 pages, 1058 KiB  
Article
Pilonidal Sinus Recurrence Rates in Young Adults—Similar to Children or Adults?
by Christina Oetzmann von Sochaczewski, Theo Hackmann, Henrike Heitmann, Myriam Braun-Münker, Matthias Maak and Dietrich Doll
Surgeries 2025, 6(3), 60; https://doi.org/10.3390/surgeries6030060 - 21 Jul 2025
Viewed by 217
Abstract
Background/Objectives: Treatment strategies in pilonidal sinus disease differ substantially between adults and children. While a single surgery with off-midline flap closure is recommended for adults, minimally invasive procedures are preferred in children due to their much higher recurrence rates. Recently, this strategy has [...] Read more.
Background/Objectives: Treatment strategies in pilonidal sinus disease differ substantially between adults and children. While a single surgery with off-midline flap closure is recommended for adults, minimally invasive procedures are preferred in children due to their much higher recurrence rates. Recently, this strategy has been extended to young adults, but long-term recurrence rates in this age group are unknown. Methods: An established database of studies on pilonidal sinus disease was used for the present study. All entries providing information on age and recurrence over time were included. We compared recurrence rates between children (<18 years), young adults (18 to 21 years), and older adults (>21 years) using Kaplan–Meier curves. Between-groups testing employed the two-tailed log rank test. Results: We included 856 entries with 88,348 patients, of which 5635 were children and 3999 young adults. The 5-year recurrence rate in children was 45.1% (95% confidence interval: 40.2–49.7%). For older adults it was 11.5% (95% confidence interval: 11.1–11.8%) and 8.7% (95% confidence interval: 7.4–10%) in young adults. The recurrence rate in young adults was lower than in children (log rank p < 0.001) and comparable, albeit slightly lower, to older adults (log rank p < 0.001). Conclusions: Our results indicate that recurrence rates between young and older adults are similar. Consequently, treatment strategies for young adults could follow the recommendations for adults instead of those for children. Due to the limited quality of available evidence, this requires validation in primary studies with sufficiently long follow-up. Full article
Show Figures

Figure 1

28 pages, 8123 KiB  
Article
Human Metabolism of Sirolimus Revisited
by Baharak Davari, Touraj Shokati, Alexandra M. Ward, Vu Nguyen, Jost Klawitter, Jelena Klawitter and Uwe Christians
Metabolites 2025, 15(7), 489; https://doi.org/10.3390/metabo15070489 - 20 Jul 2025
Viewed by 290
Abstract
Background: Sirolimus (SRL, rapamycin) is a clinically important mTOR inhibitor used in immunosuppression, oncology, and cardiovascular drug-eluting devices. Despite its long-standing FDA approval, the human metabolic profile of SRL remains incompletely characterized. SRL is primarily metabolized by CYP3A enzymes in the liver and [...] Read more.
Background: Sirolimus (SRL, rapamycin) is a clinically important mTOR inhibitor used in immunosuppression, oncology, and cardiovascular drug-eluting devices. Despite its long-standing FDA approval, the human metabolic profile of SRL remains incompletely characterized. SRL is primarily metabolized by CYP3A enzymes in the liver and intestine, but the diversity, pharmacokinetics, and biological activity of its metabolites have been poorly explored due to the lack of structurally identified standards. Methods: To investigate SRL metabolism, we incubated SRL with pooled human liver microsomes (HLM) and isolated the resulting metabolites. Structural characterization was performed using high-resolution mass spectrometry (HRMS) and ion trap MSn. We also applied Density Functional Theory (DFT) calculations to assess the energetic favorability of metabolic transformations and conducted molecular dynamics (MD) simulations to model metabolite interactions within the CYP3A4 active site. Results: We identified 21 unique SRL metabolites, classified into five major structural groups: O-demethylated, hydroxylated, didemethylated, di-hydroxylated, and mixed hydroxylated/demethylated derivatives. DFT analyses indicated that certain demethylation and hydroxylation reactions were energetically preferred, correlating with metabolite abundance. MD simulations further validated these findings by demonstrating the favorable orientation and accessibility of key sites within the CYP3A4 binding pocket. Conclusions: This study provides a comprehensive structural map of SRL metabolism, offering mechanistic insights into the formation of its metabolites. Our integrated approach of experimental and computational analyses lays the groundwork for future investigations into the pharmacodynamic and toxicodynamic effects of SRL metabolites on the mTOR pathway. Full article
(This article belongs to the Section Pharmacology and Drug Metabolism)
Show Figures

Figure 1

19 pages, 1536 KiB  
Systematic Review
Effectiveness of Ozone Therapy in Non-Surgical Periodontal Treatment: A Meta-Analysis of Topical Applications
by Alessia Pardo, Annarita Signoriello, Gabriele Brancato, Raffaele Brancato, Elena Messina, Paolo Faccioni, Stefano Marcoccia, Gianna Maria Nardi and Giorgio Lombardo
J. Clin. Med. 2025, 14(14), 5124; https://doi.org/10.3390/jcm14145124 - 18 Jul 2025
Viewed by 164
Abstract
Background: Additional therapies (e.g., laser, photodynamic therapy, and ozone) have been reported to improve mechanical instrumentation and immune response in non-surgical periodontal therapy (NSPT). With this systematic review we evaluated the effectiveness of ozone therapy in reducing inflammation and progression of periodontal disease. [...] Read more.
Background: Additional therapies (e.g., laser, photodynamic therapy, and ozone) have been reported to improve mechanical instrumentation and immune response in non-surgical periodontal therapy (NSPT). With this systematic review we evaluated the effectiveness of ozone therapy in reducing inflammation and progression of periodontal disease. Methods: Three electronic databases (PubMed, Scopus, and Cochrane Library) were searched for randomized and clinical trials on ozone therapy (gas, liquid, gel/oil) combined with NSPT. The study design followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines and the risk of bias was assessed using the RoB-2 tool. Results: Eight of the twenty-two studies reviewed reported on gaseous ozone, nine on ozone water, and five on ozonated oil/gel as an adjunct to mechanical periodontal instrumentation, often with scaling and root planing (SRP). Ozone was found to be more effective than SRP alone in treating inflammation, as measured with the gingival index (VMD −0.32; 95% confidence interval (CI) (−0.41; −0.24); p < 0.00001) and compared to chlorhexidine (CHX) (ozone gel; VMD −0.10; 95% CI (−0.20; −0.01); p = 0.03). The study findings were inconsistent, however, with several reporting clinical and microbiological benefit while others observed no marked improvement with the addition of ozone therapy to NSPT. Conclusions: While ozone therapy may represent a useful adjunct to NSPT, further research with larger study groups is warranted to determine its effectiveness. Full article
(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Show Figures

Figure 1

20 pages, 2832 KiB  
Article
Knowledge Transmission and Transformation of Chinese Architecture by Expatriates and Missionaries in Late Qing English and Chinese Newspapers
by Mingqi Lu
Religions 2025, 16(7), 926; https://doi.org/10.3390/rel16070926 - 18 Jul 2025
Viewed by 188
Abstract
Expatriates and missionaries in China played a significant role in the development and transformation of Chinese architecture in the Late Qing period. However, a systematic comparison of their discourses and proposals on Chinese architecture has been hindered by a lack of historical literature [...] Read more.
Expatriates and missionaries in China played a significant role in the development and transformation of Chinese architecture in the Late Qing period. However, a systematic comparison of their discourses and proposals on Chinese architecture has been hindered by a lack of historical literature and the complexities of fragmented data and methodologies. This article examines and compares the two most influential non-native newspapers: The North-China Daily News in English, edited by expatriates, and The Review of the Times in Chinese, founded by missionaries. By analyzing these two groups’ discourses and narratives on Chinese architecture, the study explores their similarities and distinctions, revealing the characteristics, strategies, attitudes, interests, and opinions of expatriates, missionaries, and non-missionaries in China on the transmission and transformation of architecture knowledge. The research highlights differences in their preferences for specific text types, subjects, and themes on Chinese architecture, as well as their attitudes toward native and foreign architecture, professional education, and architecture regulations in individual and official spheres. Despite these differences, overlapping characteristics and proposals existed among the three groups. The study further investigates the underlying reasons and mechanisms for their similar or divergent mindsets and behavioral patterns, drawing on human responsive psychology rather than relying on postcolonial or cultural theories. Full article
(This article belongs to the Special Issue Chinese Christianity and Knowledge Development)
Show Figures

Figure 1

22 pages, 2531 KiB  
Article
Canopy Cover Drives Odonata Diversity and Conservation Prioritization in the Protected Wetland Complex of Thermaikos Gulf (Greece)
by Dimitris Kaltsas, Lydia Alvanou, Ioannis Ekklisiarchos, Dimitrios I. Raptis and Dimitrios N. Avtzis
Forests 2025, 16(7), 1181; https://doi.org/10.3390/f16071181 - 17 Jul 2025
Viewed by 174
Abstract
Odonata constitute an important invertebrate group that is strongly dependent on water conditions and sensitive to habitat disturbances, rendering them reliable indicators of habitat quality of both aquatic and terrestrial habitats. We studied the compositional and diversity patterns of Odonates in total, and [...] Read more.
Odonata constitute an important invertebrate group that is strongly dependent on water conditions and sensitive to habitat disturbances, rendering them reliable indicators of habitat quality of both aquatic and terrestrial habitats. We studied the compositional and diversity patterns of Odonates in total, and separately for the two suborders (Zygoptera, Anisoptera) in relation to geographic and ecological parameters at the riparian zone of four rivers and one canal within the Axios Delta National Park and the Natura 2000 SAC GR1220002 in northern Greece, using the line transect technique. In total, 6252 individuals belonging to 28 species were identified. The compositional and diversity patterns were significantly different between agricultural and natural sites. Odonata assemblages at croplands were comparatively poorer, dominated by a few, widely distributed, taxonomically proximal species, tolerant to environmental changes, as a result of modifications and consequent alterations of abiotic conditions at croplands, which also led to higher local contribution to β-diversity and species turnover. The absence of several percher, endophytic, and threatened species from agricultural sites led to significantly lower diversity, as a result of environmental filtering due to ecophysiological restrictions. Taxonomic and functional diversity, uniqueness, and Dragonfly Biotic Index (DBI) were significantly higher in riparian forests, due to the sensitivity of damselflies to dehydration, and the avoidance of habitat loss and extreme temperatures by dragonflies, which prefer natural shelters near the ecotone. The newly introduced Conservation Value Index (CVI) revealed 21 conservation hotspots of Odonata (14 at canopy cover sites), widely distributed within the borders of NATURA 2000 SAC GR1220002. Full article
(This article belongs to the Section Forest Biodiversity)
Show Figures

Figure 1

23 pages, 10278 KiB  
Article
Natural-Based Solution for Sewage Using Hydroponic Systems with Water Hyacinth
by Lim Yen Yen, Siti Rozaimah Sheikh Abdullah, Muhammad Fauzul Imron and Setyo Budi Kurniawan
Water 2025, 17(14), 2122; https://doi.org/10.3390/w17142122 - 16 Jul 2025
Viewed by 271
Abstract
Domestic wastewater discharge is the major source of pollution in Malaysia. Phytoremediation under hydroponic conditions was initiated to treat domestic wastewater and, at the same time, to resolve the space limitation issue by installing a hydroponic system in vertical space at the site. [...] Read more.
Domestic wastewater discharge is the major source of pollution in Malaysia. Phytoremediation under hydroponic conditions was initiated to treat domestic wastewater and, at the same time, to resolve the space limitation issue by installing a hydroponic system in vertical space at the site. Water hyacinth (WH) was selected in this study to identify its performance of water hyacinth in removing nutrients in raw sewage under batch operation. In the batch experiment, the ratio of CODinitial/plantinitial was identified, and SPSS ANOVA analysis shows that the number of plant size factors was not statistically different in this study. Therefore, four WH, each with an initial weight of 60 ± 20 g, were recommended for this study. Throughout the 10 days of the batch experiment, the average of COD, BOD, TSS, TP, NH4, and color removal was 73%, 73%, 86%, 79%, 77%, and 54%, respectively. The WH biomass weight increased by an average of 78%. The plants have also improved the DO level from 0.24 mg/L to 4.88 mg/L. However, the pH of effluent decreased from pH 7.05 to pH 4.88 below the sewage Standard B discharge limit of pH 9–pH 5.50. Four WH plant groups were recommended for future study, as the COD removal among the other plant groups is not a statistically significant difference (p < 0.05). Furthermore, the lower plant biomass is preferable for the high pollutant removal performance due to the fact that it can reduce the maintenance and operating costs. Full article
(This article belongs to the Section Wastewater Treatment and Reuse)
Show Figures

Figure 1

Back to TopTop